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MX363051B - Metodo para producir un polisacárido capsular con un serotipo de neumococo. - Google Patents

Metodo para producir un polisacárido capsular con un serotipo de neumococo.

Info

Publication number
MX363051B
MX363051B MX2015002950A MX2015002950A MX363051B MX 363051 B MX363051 B MX 363051B MX 2015002950 A MX2015002950 A MX 2015002950A MX 2015002950 A MX2015002950 A MX 2015002950A MX 363051 B MX363051 B MX 363051B
Authority
MX
Mexico
Prior art keywords
production method
capsular polysaccharide
pneumococcal serotype
present
pneumococcal
Prior art date
Application number
MX2015002950A
Other languages
English (en)
Other versions
MX2015002950A (es
Inventor
Shin Jin-Hwan
Kim Hun
Noh Myeong-Ju
Park Su-Jin
Park Mahn-Hoon
Original Assignee
Sk Bioscience Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sk Bioscience Co Ltd filed Critical Sk Bioscience Co Ltd
Publication of MX2015002950A publication Critical patent/MX2015002950A/es
Publication of MX363051B publication Critical patent/MX363051B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un método mejorado para producir un polisacárido capsular con un serotipo de neumococo. El método de acuerdo con la presente invención incluye un paso de cultivo adicional de células bacterianas que producen un serotipo de neumococo sin ajustar el ph y de este modo se prescinde de un proceso de precipitación de proteínas por acidificación con u n regulador del ph.
MX2015002950A 2012-09-07 2013-09-06 Metodo para producir un polisacárido capsular con un serotipo de neumococo. MX363051B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20120099348 2012-09-07
PCT/KR2013/008048 WO2014038879A1 (ko) 2012-09-07 2013-09-06 폐렴 구균 혈청형을 갖는 협막 다당류의 제조방법

Publications (2)

Publication Number Publication Date
MX2015002950A MX2015002950A (es) 2016-04-26
MX363051B true MX363051B (es) 2019-03-06

Family

ID=50237413

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015002950A MX363051B (es) 2012-09-07 2013-09-06 Metodo para producir un polisacárido capsular con un serotipo de neumococo.

Country Status (14)

Country Link
US (1) US9636392B2 (es)
EP (1) EP2894225B1 (es)
JP (1) JP5905649B2 (es)
KR (1) KR101944960B1 (es)
CN (1) CN104781413B (es)
AU (1) AU2013313794B2 (es)
BR (1) BR112015005081B1 (es)
CA (1) CA2884241C (es)
CO (1) CO7400875A2 (es)
ES (1) ES2651415T3 (es)
MX (1) MX363051B (es)
PH (1) PH12015500497B1 (es)
RU (1) RU2606022C2 (es)
WO (1) WO2014038879A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3096783T3 (da) 2014-01-21 2021-08-02 Pfizer Streptococcus pneumoniae-kapselpolysaccharider og konjugater deraf
CN107624070A (zh) 2015-05-04 2018-01-23 辉瑞大药厂 B族链球菌多糖‑蛋白质缀合物、制造缀合物的方法、含缀合物的免疫原性组合物及其用途
WO2016204265A1 (ja) * 2015-06-18 2016-12-22 一般財団法人阪大微生物病研究会 肺炎球菌補体依存性殺菌能測定方法
CN105131139B (zh) * 2015-07-31 2018-02-13 兰州生物制品研究所有限责任公司 一种肺炎链球菌荚膜多糖的纯化方法
CN107936128B (zh) * 2017-11-22 2020-07-03 成都欧林生物科技股份有限公司 一种简便有效的细菌疫苗纯化方法
CN109336989B (zh) * 2018-10-22 2022-05-13 北京智飞绿竹生物制药有限公司 一种通过粘度控制制备肺炎球菌荚膜多糖的方法
JP7239509B6 (ja) * 2019-02-22 2023-03-28 ファイザー・インク 細菌多糖類を精製するための方法
CA3159535A1 (en) * 2019-11-29 2021-06-03 Andreas Zurbriggen Method of purifying polysaccharides
CN112608392B (zh) * 2020-12-23 2023-03-31 北京民海生物科技有限公司 肺炎球菌荚膜多糖的制备
CN114106209A (zh) * 2021-11-09 2022-03-01 北京智飞绿竹生物制药有限公司 一种纯化17f型肺炎球菌多糖的方法
CN116693706B (zh) * 2022-02-24 2024-10-11 成都生物制品研究所有限责任公司 一种肺炎链球菌荚膜多糖的纯化方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2059693C (en) * 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
RS52249B (en) 2005-04-08 2012-10-31 Wyeth Llc MULTIVALENT COMPOSITION WITH CONJUGATE OF PNEUMOCOCOCH POLISACCHARIDE AND PROTEIN
US7709001B2 (en) * 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
CA2604362C (en) * 2005-04-08 2013-11-12 Wyeth Separation of contaminants from streptococcus pneumoniae polysaccharide by ph manipulation
KR101467002B1 (ko) 2006-10-10 2014-12-01 와이어쓰 엘엘씨 스트렙토코쿠스 뉴모니애 제3형 다당류의 정제 방법
EP2436700B8 (en) * 2007-03-23 2018-08-01 Wyeth LLC Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides
KR101045881B1 (ko) * 2008-09-11 2011-07-01 전남대학교산학협력단 연쇄상구균으로부터의 협막다당 생산 배지, 생산 방법 및 정제 방법
US8795689B2 (en) * 2008-12-18 2014-08-05 Wyeth Llc Method for controlling Streptococcus pneumoniae serotype 19A polysaccharide molecular weight
WO2011151841A1 (en) * 2010-05-31 2011-12-08 Panacea Biotec Limited Fermentation process for streptococcus pneumoniae

Also Published As

Publication number Publication date
EP2894225A1 (en) 2015-07-15
CN104781413B (zh) 2018-01-23
KR101944960B1 (ko) 2019-02-07
US9636392B2 (en) 2017-05-02
CN104781413A (zh) 2015-07-15
RU2606022C2 (ru) 2017-01-10
CO7400875A2 (es) 2015-09-30
AU2013313794A1 (en) 2015-04-23
PH12015500497A1 (en) 2015-04-27
EP2894225B1 (en) 2017-11-22
BR112015005081A2 (pt) 2017-07-04
AU2013313794B2 (en) 2016-10-20
PH12015500497B1 (en) 2018-10-03
KR20140032912A (ko) 2014-03-17
WO2014038879A1 (ko) 2014-03-13
ES2651415T3 (es) 2018-01-26
RU2015109997A (ru) 2016-10-27
CA2884241A1 (en) 2014-03-13
BR112015005081B1 (pt) 2021-10-26
MX2015002950A (es) 2016-04-26
CA2884241C (en) 2018-11-20
US20150231225A1 (en) 2015-08-20
EP2894225A4 (en) 2016-04-27
JP2015527079A (ja) 2015-09-17
JP5905649B2 (ja) 2016-04-20
BR112015005081A8 (pt) 2018-07-31

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