MX361039B - Métodos para reducir o eliminar modificación de proteína y degradación que surge de la exposición a luz ultravioleta. - Google Patents
Métodos para reducir o eliminar modificación de proteína y degradación que surge de la exposición a luz ultravioleta.Info
- Publication number
- MX361039B MX361039B MX2014004880A MX2014004880A MX361039B MX 361039 B MX361039 B MX 361039B MX 2014004880 A MX2014004880 A MX 2014004880A MX 2014004880 A MX2014004880 A MX 2014004880A MX 361039 B MX361039 B MX 361039B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- reducing
- exposure
- light
- protein modification
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 230000009145 protein modification Effects 0.000 title abstract 2
- 230000017854 proteolysis Effects 0.000 title abstract 2
- 238000006731 degradation reaction Methods 0.000 title 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 235000004252 protein component Nutrition 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/24—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a un método para inactivar un virus en una muestra que comprende un componente de proteína, caracterizado porque comprende: (a) proporcionar una muestra que comprende el componente de proteína, en donde la muestra es una corriente de efluente de un paso de purificación y se conoce o se sospecha que la muestra contiene un virus; (b) agregar un protector a la corriente de efluente para formar una mezcla estabilizada; (c) medir la absorbancia de la mezcla estabilizada; (d) pasar la mezcla estabilizada a través de un dispositivo configurado para proporcionar exposición continua de luz UV, tal que se suministra a la mezcla una dosis objetivo de luz UV bajo la cual el virus es inactivado; y ( e) con base en la medida de absorbancia, ajustar la exposición a la luz UV tal que tal que la dosis objetivo de luz UV se suministra continuamente a la mezcla estabilizada que pasa a través del dispositivo, en donde los pasos (c), (d) y ( e) son realizados como parte de un ciclo de retroalimentación automático.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161551822P | 2011-10-26 | 2011-10-26 | |
| PCT/US2012/061965 WO2013063298A1 (en) | 2011-10-26 | 2012-10-25 | Methods of reducing or eliminating protein modification and degradation arising from exposure to uv light |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014004880A MX2014004880A (es) | 2014-09-15 |
| MX361039B true MX361039B (es) | 2018-11-26 |
Family
ID=47138200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014004880A MX361039B (es) | 2011-10-26 | 2012-10-25 | Métodos para reducir o eliminar modificación de proteína y degradación que surge de la exposición a luz ultravioleta. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10634589B2 (es) |
| EP (1) | EP2771038B1 (es) |
| JP (2) | JP6526414B2 (es) |
| KR (1) | KR102091294B1 (es) |
| CN (1) | CN104136047B (es) |
| AU (1) | AU2012328753A1 (es) |
| BR (1) | BR112014010027A2 (es) |
| CA (1) | CA2853371A1 (es) |
| EA (2) | EA201992617A1 (es) |
| ES (1) | ES2693508T3 (es) |
| HK (1) | HK1203423A1 (es) |
| IL (1) | IL232019A0 (es) |
| MX (1) | MX361039B (es) |
| SG (1) | SG11201401739YA (es) |
| WO (1) | WO2013063298A1 (es) |
| ZA (1) | ZA201402923B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9603956B2 (en) * | 2013-12-12 | 2017-03-28 | Paul Newham | Dynamic enhanced and diffuse broad spectrum UVC or alternative controlled ionizing radiation source emitters for mobile and fixed placement disinfection of clinical surfaces |
| GB201403775D0 (en) * | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| CN106687575B (zh) | 2014-06-04 | 2021-04-30 | 美国安进公司 | 用于收获哺乳动物细胞培养物的方法 |
| EP3227454B1 (en) | 2014-12-01 | 2020-01-29 | Amgen Inc. | Process for manipulating the level of glycan content of a glycoprotein |
| BR112018076281A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | imunocitocina, uso de uma imunocitocina, método, composição farmacêutica, método para tratar uma doença proliferativa em um animal, ácido nucleico, vetor, hospedeiro e anticorpo ou fragmento do mesmo |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CN107496950B (zh) * | 2017-08-18 | 2021-02-02 | 广州市众为生物技术有限公司 | 一种紫外线照射灭活蛋白溶液中病毒的方法 |
| WO2022024589A1 (ja) | 2020-07-27 | 2022-02-03 | 国立研究開発法人理化学研究所 | 感染防止装置及び感染防止方法 |
| EP4189064A1 (en) | 2020-07-30 | 2023-06-07 | Amgen Inc. | Cell culture media and methods of making and using the same |
| JP7272557B2 (ja) * | 2020-12-24 | 2023-05-12 | 国立大学法人神戸大学 | 紫外線照射を用いたウイルス不活化方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981163A (en) | 1990-05-15 | 1999-11-09 | New York Blood Center, Inc. | Process for the sterilization of biological compositions using irradiation and quenchers of type I and type II photodynamic reactions |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| JP3426237B2 (ja) * | 1993-05-28 | 2003-07-14 | ニューヨーク ブラッド センター，インコーポレイティド | 生物学的組成物の滅菌方法及びこの方法によって生成される製剤 |
| JPH0758031A (ja) * | 1993-08-18 | 1995-03-03 | Nissin Electric Co Ltd | イオン蒸着薄膜形成装置及び該装置を用いた成膜方法 |
| US5925885A (en) * | 1996-05-22 | 1999-07-20 | Purepulse Technologies, Inc. | Parametric control in pulsed light sterilization of packages and their contents |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| JPH11286453A (ja) * | 1998-03-31 | 1999-10-19 | Yoshitomi Pharmaceut Ind Ltd | 紫外線照射によるタンパク質含有組成物のウイルス不活化処理方法 |
| GB9821342D0 (en) | 1998-10-02 | 1998-11-25 | Common Services Agency | Device for treatment of biological fluids |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| CN1390112A (zh) | 1999-10-08 | 2003-01-08 | 布里特斯迈尔公司 | 同步照射牙齿的装置 |
| GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
| EA005977B1 (ru) * | 2000-03-23 | 2005-08-25 | Клиарант, Инк. | Способы стерилизации биологических материалов |
| GB0025144D0 (en) | 2000-10-13 | 2000-11-29 | Medical Res Council | Concatenated nucleic acid sequences |
| US6682695B2 (en) | 2001-03-23 | 2004-01-27 | Clearant, Inc. | Methods for sterilizing biological materials by multiple rates |
| US20030064001A1 (en) * | 2001-05-17 | 2003-04-03 | Fries William M. | System for the decontamination of fluid products using light |
| WO2002092138A1 (en) | 2001-05-17 | 2002-11-21 | Purepulse Technologies, Inc. | Methods and apparatus relating to treatment systems using light for the treatment of fluid products |
| EP1404379A2 (en) * | 2001-05-30 | 2004-04-07 | Gambro, Inc. | Viral inactivation process using antioxidant |
| US6696060B2 (en) | 2001-06-14 | 2004-02-24 | Clearant, Inc. | Methods for sterilizing preparations of monoclonal immunoglobulins |
| GB0117571D0 (en) * | 2001-07-19 | 2001-09-12 | Common Services Agency | UV irradiation control |
| US20030059338A1 (en) | 2001-09-24 | 2003-03-27 | Mann David M. | Methods for sterilizing biological materials using flavonoid/flavonol stabilizers |
| US20030064000A1 (en) * | 2001-09-24 | 2003-04-03 | Wilson Burgess | Methods of sterilizing biological mixtures using stabilizer mixtures |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| SI1501369T1 (sl) * | 2002-04-26 | 2015-10-30 | Genentech, Inc. | Neafinitetno čiščenje proteinov |
| EP1415669A1 (en) * | 2002-09-19 | 2004-05-06 | Aventis Behring GmbH | Process for sterilization of protein containing biological compositions |
| ATE496938T1 (de) | 2002-12-20 | 2011-02-15 | Amgen Inc | Myostatin hemmende bindungsstoffe |
| US20040202995A1 (en) | 2003-04-09 | 2004-10-14 | Domantis | Nucleic acids, proteins, and screening methods |
| US20050264236A1 (en) | 2004-05-25 | 2005-12-01 | Purepulse Technologies, Inc | Apparatus and method for use in triggering a flash lamp |
| US7993580B2 (en) * | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
| CA2614329C (en) * | 2005-07-06 | 2013-01-29 | Navigant Biotechnologies, Llc | Methods for reducing pathogens in biological samples |
| US7998717B2 (en) * | 2005-12-02 | 2011-08-16 | Pacific Biosciences Of California, Inc. | Mitigation of photodamage in analytical reactions |
| WO2007075283A2 (en) * | 2005-12-06 | 2007-07-05 | Amgen Inc. | Polishing steps used in multi-step protein purification processes |
| CA2681743A1 (en) * | 2007-03-22 | 2008-09-25 | Imclone Llc | Stable antibody formulations |
| PL2173861T5 (pl) * | 2007-06-15 | 2017-10-31 | Amgen Inc | Sposoby obróbki nośnika kultury komórkowej do zastosowania w bioreaktorze |
| US8547536B2 (en) * | 2007-12-10 | 2013-10-01 | Novartis Ag | Analysis of mixtures including proteins |
| US7585679B1 (en) * | 2008-02-22 | 2009-09-08 | Dionex Corporation | Ion chromatography system with flow-delay eluent recycle |
| ES2564202T3 (es) * | 2008-02-29 | 2016-03-18 | Universiteit Gent | Método para determinar la antigenicidad de un virus PRRSV inactivado |
| FI4269578T3 (fi) * | 2008-03-06 | 2024-06-07 | Halozyme Inc | Liukoisen hyaluronidaasin suurimittainen tuotanto |
| EP2684570A1 (en) * | 2008-09-10 | 2014-01-15 | F. Hoffmann-La Roche AG | Compositions and methods for the prevention of oxidative degradation of proteins |
| CN102470251B (zh) * | 2009-07-09 | 2015-08-05 | 皇家飞利浦电子股份有限公司 | 皮肤辐射设备和方法 |
-
2012
- 2012-10-25 MX MX2014004880A patent/MX361039B/es active IP Right Grant
- 2012-10-25 SG SG11201401739YA patent/SG11201401739YA/en unknown
- 2012-10-25 EP EP12781248.5A patent/EP2771038B1/en active Active
- 2012-10-25 EA EA201992617A patent/EA201992617A1/ru unknown
- 2012-10-25 WO PCT/US2012/061965 patent/WO2013063298A1/en active Application Filing
- 2012-10-25 AU AU2012328753A patent/AU2012328753A1/en not_active Abandoned
- 2012-10-25 KR KR1020147012934A patent/KR102091294B1/ko active IP Right Grant
- 2012-10-25 ES ES12781248.5T patent/ES2693508T3/es active Active
- 2012-10-25 CN CN201280064731.1A patent/CN104136047B/zh active Active
- 2012-10-25 JP JP2014539012A patent/JP6526414B2/ja active Active
- 2012-10-25 US US14/353,704 patent/US10634589B2/en active Active
- 2012-10-25 CA CA2853371A patent/CA2853371A1/en not_active Abandoned
- 2012-10-25 BR BR112014010027A patent/BR112014010027A2/pt not_active Application Discontinuation
- 2012-10-25 EA EA201490867A patent/EA034347B1/ru not_active IP Right Cessation
-
2014
- 2014-04-09 IL IL232019A patent/IL232019A0/en unknown
- 2014-04-22 ZA ZA2014/02923A patent/ZA201402923B/en unknown
-
2015
- 2015-05-05 HK HK15104253.7A patent/HK1203423A1/xx unknown
-
2016
- 2016-10-06 JP JP2016197842A patent/JP6539246B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1203423A1 (en) | 2015-10-30 |
| JP2017061462A (ja) | 2017-03-30 |
| KR20140079829A (ko) | 2014-06-27 |
| US20140329227A1 (en) | 2014-11-06 |
| BR112014010027A2 (pt) | 2017-04-25 |
| CN104136047B (zh) | 2018-02-06 |
| KR102091294B1 (ko) | 2020-04-16 |
| SG11201401739YA (en) | 2014-05-29 |
| US10634589B2 (en) | 2020-04-28 |
| CN104136047A (zh) | 2014-11-05 |
| ZA201402923B (en) | 2015-04-29 |
| WO2013063298A1 (en) | 2013-05-02 |
| AU2012328753A1 (en) | 2014-04-24 |
| JP2014533942A (ja) | 2014-12-18 |
| IL232019A0 (en) | 2014-05-28 |
| EP2771038B1 (en) | 2018-10-10 |
| EA201490867A1 (ru) | 2014-12-30 |
| MX2014004880A (es) | 2014-09-15 |
| EP2771038A1 (en) | 2014-09-03 |
| CA2853371A1 (en) | 2013-05-02 |
| JP6526414B2 (ja) | 2019-06-05 |
| EA034347B1 (ru) | 2020-01-30 |
| HK1203423B (es) | 2018-08-17 |
| EA201992617A1 (ru) | 2020-03-10 |
| ES2693508T3 (es) | 2018-12-12 |
| JP6539246B2 (ja) | 2019-07-03 |
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant or registration |