MX358684B - Peptidos como agonistas de oxitocina. - Google Patents
Peptidos como agonistas de oxitocina.Info
- Publication number
- MX358684B MX358684B MX2015007365A MX2015007365A MX358684B MX 358684 B MX358684 B MX 358684B MX 2015007365 A MX2015007365 A MX 2015007365A MX 2015007365 A MX2015007365 A MX 2015007365A MX 358684 B MX358684 B MX 358684B
- Authority
- MX
- Mexico
- Prior art keywords
- lower alkyl
- hydroxy
- hydrogen
- cycloalkyl
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychiatry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a un compuesto de la fórmula (I) caracterizado porque: R1 es hidroxi o amino; R2 es sec-butilo o isobutilo; R3 es alquilo inferior, alquilo inferior sustituido por hidroxi, -(CH2)2C(O)-NH2, -(CH2)3-NH2 o -CH2-grupo heterocíclico aromático de cinco miembros; R4 es hidrógeno o alquilo inferior; R5 es hidrógeno o alquilo inferior; o R4 y R5 junto con los átomos de N y C a los que están unidos pueden formar un anillo de pirrolidina, opcionalmente sustituido por hidroxi o halógeno, un anillo de piperidina o un anillo de azetidina; R6 es hidrógeno, alquilo inferior, alquilo inferior sustituido por hidroxi, -(CH2)2C(O)OH, - (CH2)2C(O)NH2, bencilo opcionalmente sustituido por amino o hidroxi, -CH2-grupo heterocíclico aromático de cinco miembros, indolilo, -CH2-ciclo-alquilo, cicloalquilo, -(CH2)2- S-alquilo inferior o es -(CH2)1-4-NH2 R6' es hidrógeno o alquilo inferior; o R6 y R6´ juntos son cicloalquilo; X es - C(O)-CHR-NR´-C(O)-; R/R´ independientemente uno de otro son hidrógeno o alquilo inferior; m es 2; o es 0 ó 1; o a una sal de adición de ácido farmacéuticamente aceptable, a una mezcla racémica o a sus enantiómeros correspondientes y/o isómeros ópticos de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12199012 | 2012-12-21 | ||
| PCT/EP2013/076783 WO2014095773A1 (en) | 2012-12-21 | 2013-12-17 | Peptides as oxytocin agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015007365A MX2015007365A (es) | 2015-10-14 |
| MX358684B true MX358684B (es) | 2018-08-31 |
Family
ID=47471593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015007365A MX358684B (es) | 2012-12-21 | 2013-12-17 | Peptidos como agonistas de oxitocina. |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US9868766B2 (es) |
| EP (1) | EP2935312B1 (es) |
| JP (1) | JP6067878B2 (es) |
| KR (1) | KR101819804B1 (es) |
| CN (1) | CN104870466B (es) |
| AR (1) | AR094225A1 (es) |
| AU (1) | AU2013363768B2 (es) |
| BR (1) | BR112015014010A2 (es) |
| CA (1) | CA2895150C (es) |
| CL (1) | CL2015001724A1 (es) |
| CR (1) | CR20150271A (es) |
| DK (1) | DK2935312T3 (es) |
| EA (1) | EA026687B1 (es) |
| ES (1) | ES2690317T3 (es) |
| HK (1) | HK1208477A1 (es) |
| HR (1) | HRP20181569T1 (es) |
| HU (1) | HUE039848T2 (es) |
| IL (1) | IL239519A (es) |
| LT (1) | LT2935312T (es) |
| MA (1) | MA38272A1 (es) |
| MX (1) | MX358684B (es) |
| MY (1) | MY176398A (es) |
| NZ (1) | NZ708175A (es) |
| PE (1) | PE20151446A1 (es) |
| PH (1) | PH12015501145B1 (es) |
| PL (1) | PL2935312T3 (es) |
| PT (1) | PT2935312T (es) |
| RS (1) | RS57690B1 (es) |
| SG (1) | SG11201504883PA (es) |
| SI (1) | SI2935312T1 (es) |
| TW (1) | TWI558726B (es) |
| UA (1) | UA119034C2 (es) |
| WO (1) | WO2014095773A1 (es) |
| ZA (1) | ZA201504186B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013139861A1 (en) | 2012-03-20 | 2013-09-26 | Luc Montagnier | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| EP2935303B1 (en) | 2012-12-21 | 2021-02-17 | Janssen BioPharma, Inc. | 4'-fluoro-nucleosides, 4'-fluoro-nucleotides and analogs thereof for the treatment of hcv |
| MX358684B (es) | 2012-12-21 | 2018-08-31 | Hoffmann La Roche | Peptidos como agonistas de oxitocina. |
| UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
| KR102116107B1 (ko) | 2013-12-30 | 2020-05-28 | 삼성디스플레이 주식회사 | 표시 장치 |
| WO2015106200A2 (en) | 2014-01-10 | 2015-07-16 | Cornell University | Dipeptides as inhibitors of human immunoproteasomes |
| SG11201610073PA (en) | 2014-06-03 | 2016-12-29 | Hoffmann La Roche | Peptides as oxytocin agonists |
| EA031892B1 (ru) | 2014-06-17 | 2019-03-29 | Пфайзер Инк. | Замещенные дигидроизохинолиноновые соединения для лечения аномального клеточного роста, ассоциированного с активностью ezh2 |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| MX369345B (es) * | 2014-08-07 | 2019-11-06 | Hoffmann La Roche | Procesos para la preparacion de analogos de oxitocina. |
| EP3193904A4 (en) * | 2014-08-18 | 2018-04-11 | Cornell University | Dipeptidomimetics as inhibitors of human immunoproteasomes |
| FI3666258T3 (fi) * | 2014-09-19 | 2024-02-09 | Ferring Bv | Menetelmä prader-willin oireyhtymän hoitamiseksi |
| ES2905008T3 (es) | 2015-10-15 | 2022-04-06 | Univ Cornell | Inhibidores de proteasomas y usos de los mismos |
| EP3694605A4 (en) | 2017-10-11 | 2021-10-27 | Cornell University | PEPTIDOMIMETIC INHIBITORS OF PROTEASOME |
| EP3852724A4 (en) | 2018-09-20 | 2022-07-06 | Levo Therapeutics, Inc. | CARBETOCIN DRUG PRODUCT AND PROCESS FOR ITS MANUFACTURE |
| TW202031283A (zh) | 2018-09-20 | 2020-09-01 | 馬克 Ｃ 曼寧 | 穩定卡貝縮宮素鼻內製劑 |
| WO2021126990A1 (en) * | 2019-12-16 | 2021-06-24 | The Scripps Research Institute | Oxytocin derivatives with improved properties |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5539310B2 (ja) | 2008-03-31 | 2014-07-02 | フェリング ベスローテン フェンノートシャップ | オキシトシン類似体 |
| TWI463990B (zh) | 2009-09-21 | 2014-12-11 | Ferring Bv | 催產素受體促進劑 |
| WO2011038451A1 (en) * | 2009-10-01 | 2011-04-07 | The University Of Sydney | Therapy and prevention of problem drinking |
| MX358684B (es) | 2012-12-21 | 2018-08-31 | Hoffmann La Roche | Peptidos como agonistas de oxitocina. |
-
2013
- 2013-12-17 MX MX2015007365A patent/MX358684B/es active IP Right Grant
- 2013-12-17 SI SI201331190T patent/SI2935312T1/sl unknown
- 2013-12-17 AU AU2013363768A patent/AU2013363768B2/en not_active Ceased
- 2013-12-17 DK DK13814079.3T patent/DK2935312T3/en active
- 2013-12-17 WO PCT/EP2013/076783 patent/WO2014095773A1/en active Application Filing
- 2013-12-17 EP EP13814079.3A patent/EP2935312B1/en not_active Not-in-force
- 2013-12-17 PE PE2015001058A patent/PE20151446A1/es unknown
- 2013-12-17 MY MYPI2015001585A patent/MY176398A/en unknown
- 2013-12-17 HU HUE13814079A patent/HUE039848T2/hu unknown
- 2013-12-17 KR KR1020157016376A patent/KR101819804B1/ko active IP Right Grant
- 2013-12-17 UA UAA201506906A patent/UA119034C2/uk unknown
- 2013-12-17 MA MA38272A patent/MA38272A1/fr unknown
- 2013-12-17 CN CN201380066617.7A patent/CN104870466B/zh not_active Expired - Fee Related
- 2013-12-17 PT PT13814079T patent/PT2935312T/pt unknown
- 2013-12-17 PL PL13814079T patent/PL2935312T3/pl unknown
- 2013-12-17 ES ES13814079.3T patent/ES2690317T3/es active Active
- 2013-12-17 EA EA201591078A patent/EA026687B1/ru not_active IP Right Cessation
- 2013-12-17 RS RS20181124A patent/RS57690B1/sr unknown
- 2013-12-17 CA CA2895150A patent/CA2895150C/en not_active Expired - Fee Related
- 2013-12-17 NZ NZ708175A patent/NZ708175A/en not_active IP Right Cessation
- 2013-12-17 SG SG11201504883PA patent/SG11201504883PA/en unknown
- 2013-12-17 BR BR112015014010A patent/BR112015014010A2/pt not_active IP Right Cessation
- 2013-12-17 JP JP2015548420A patent/JP6067878B2/ja not_active Expired - Fee Related
- 2013-12-17 LT LTEP13814079.3T patent/LT2935312T/lt unknown
- 2013-12-20 TW TW102147655A patent/TWI558726B/zh not_active IP Right Cessation
- 2013-12-20 AR ARP130104962A patent/AR094225A1/es unknown
-
2015
- 2015-05-21 CR CR20150271A patent/CR20150271A/es unknown
- 2015-05-22 PH PH12015501145A patent/PH12015501145B1/en unknown
- 2015-06-10 ZA ZA2015/04186A patent/ZA201504186B/en unknown
- 2015-06-18 CL CL2015001724A patent/CL2015001724A1/es unknown
- 2015-06-18 IL IL239519A patent/IL239519A/en active IP Right Grant
- 2015-06-18 US US14/743,009 patent/US9868766B2/en active Active
- 2015-09-18 HK HK15109189.5A patent/HK1208477A1/xx not_active IP Right Cessation
-
2018
- 2018-10-02 HR HRP20181569TT patent/HRP20181569T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12015501145A1 (en) | Peptides as oxytocin agonists | |
| PH12016502251A1 (en) | Peptides as oxytocin agonists | |
| PH12018500106A1 (en) | Ethynyl derivatives as metabotropic glutamate receptor modulators | |
| MX2015017491A (es) | Derivados de indolin-2-ona o pirrolo-piridin/pirimidin-2-ona. | |
| MY167396A (en) | Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament | |
| EA201692558A1 (ru) | Производные индолин-2-она или пирролопиридин-2-она | |
| AR070130A1 (es) | Compuestos moduladores de beta-amiloide, un proceso para su obtencion, el uso del compuesto para la fabricacion de un medicamento y dicho medicamento | |
| EA201590438A1 (ru) | 2-оксо-2,3-дигидроиндолы для лечения расстройств центральной нервной системы | |
| SI2875011T1 (en) | 5-HT3 receptor antagonists | |
| PH12014500775A1 (en) | Ethynyl derivatives as mglur5 allosteric modulators | |
| PH12016502232A1 (en) | Peptides as oxytocin agonists | |
| PH12013501895A1 (en) | Ethynyl derivatives as positive allosteric modulators of the mglur5 | |
| MX2012002256A (es) | Antagonistas carbociclicos de receptores de inhibidores de transportador de glicina 1 (glty1). | |
| MX2015008830A (es) | Agonistas del receptor de oxitocina para el tratamiento de enfermedades del sistema nervioso central. | |
| IL202236A0 (en) | Prolinamide derivatives as nk3 antagonists | |
| WO2013058681A3 (ru) | Замещенные феноксиуксусные кислоты их эфиры и амиды, включающие 2,6-диоксо-2,3,6,7-тетрагидро-1н-пурин-8-иловый фрагмент-антагонисты аденозинового а2а рецептора и их применение | |
| MX2011007272A (es) | Piperidinas de aroilamino y heteroaroilamino sustituidas como inhibidores de glyt-1. | |
| WO2012093411A3 (en) | Process for the preparation of r-(-)-3- (carbamoylmethyl)-5-methylhexanoic acid and the intermediates | |
| PH12012502339A1 (en) | Amido-tropane derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |