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MX347475B - Anticuerpos para pcsk9 y usos de los mismos. - Google Patents

Anticuerpos para pcsk9 y usos de los mismos.

Info

Publication number
MX347475B
MX347475B MX2014003175A MX2014003175A MX347475B MX 347475 B MX347475 B MX 347475B MX 2014003175 A MX2014003175 A MX 2014003175A MX 2014003175 A MX2014003175 A MX 2014003175A MX 347475 B MX347475 B MX 347475B
Authority
MX
Mexico
Prior art keywords
pcsk9
antibodies
same
antigen
binding fragments
Prior art date
Application number
MX2014003175A
Other languages
English (en)
Other versions
MX2014003175A (es
Inventor
Davies Julian
Allan Barrett
James Darling Ryan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2014003175A publication Critical patent/MX2014003175A/es
Publication of MX347475B publication Critical patent/MX347475B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a anticuerpos para proproteína convertasa subtilisina/hexina tipo 9 (PCSK9), o fragmentos de unión de antígeno de la misma, composiciones que comprende dichos anticuerpos PCSK9 o fragmentos de unión de antígeno, y métodos para utilizar los mismos para el tratamiento de hiperlipidemia o hipercolesterolemia.
MX2014003175A 2011-09-16 2012-09-12 Anticuerpos para pcsk9 y usos de los mismos. MX347475B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161535625P 2011-09-16 2011-09-16
PCT/US2012/054737 WO2013039958A1 (en) 2011-09-16 2012-09-12 Antibodies to pcsk9 and uses thereof

Publications (2)

Publication Number Publication Date
MX2014003175A MX2014003175A (es) 2015-03-05
MX347475B true MX347475B (es) 2017-04-27

Family

ID=46881177

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003175A MX347475B (es) 2011-09-16 2012-09-12 Anticuerpos para pcsk9 y usos de los mismos.

Country Status (29)

Country Link
US (1) US8530414B2 (es)
EP (1) EP2756003A1 (es)
JP (1) JP6013487B2 (es)
KR (1) KR101607783B1 (es)
CN (1) CN103781802B (es)
AP (1) AP2014007499A0 (es)
AR (1) AR087715A1 (es)
AU (1) AU2012308786B2 (es)
BR (1) BR112014005799A2 (es)
CA (1) CA2845706C (es)
CL (1) CL2014000590A1 (es)
CO (1) CO6910164A2 (es)
CR (1) CR20140087A (es)
DO (1) DOP2014000041A (es)
EA (1) EA024430B1 (es)
EC (1) ECSP14013242A (es)
GT (1) GT201400049A (es)
IL (1) IL231282A0 (es)
MA (1) MA35433B1 (es)
MX (1) MX347475B (es)
MY (1) MY168961A (es)
PE (1) PE20141147A1 (es)
PH (1) PH12014500576A1 (es)
SG (1) SG2014014187A (es)
TN (1) TN2014000094A1 (es)
TW (1) TWI586687B (es)
UA (1) UA114604C2 (es)
WO (1) WO2013039958A1 (es)
ZA (1) ZA201401267B (es)

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US20130064834A1 (en) 2008-12-15 2013-03-14 Regeneron Pharmaceuticals, Inc. Methods for treating hypercholesterolemia using antibodies to pcsk9
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RU2604139C2 (ru) 2011-01-28 2016-12-10 Санофи Байотекнолоджи Фармацевтические композиции, содержащие антитела к pcsk9 человека
AR087305A1 (es) 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
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US9045548B1 (en) 2014-07-15 2015-06-02 Kymab Limited Precision Medicine by targeting rare human PCSK9 variants for cholesterol treatment
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US9067998B1 (en) 2014-07-15 2015-06-30 Kymab Limited Targeting PD-1 variants for treatment of cancer
US8986694B1 (en) 2014-07-15 2015-03-24 Kymab Limited Targeting human nav1.7 variants for treatment of pain
US8992927B1 (en) 2014-07-15 2015-03-31 Kymab Limited Targeting human NAV1.7 variants for treatment of pain
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CN105085684B (zh) * 2014-05-14 2020-04-17 上海亨臻实业有限公司 Pcsk9靶向重组疫苗设计及其应用
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Also Published As

Publication number Publication date
CO6910164A2 (es) 2014-03-31
BR112014005799A2 (pt) 2017-03-28
MA35433B1 (fr) 2014-09-01
KR20140044939A (ko) 2014-04-15
CN103781802B (zh) 2016-08-24
CA2845706A1 (en) 2013-03-21
ZA201401267B (en) 2015-11-25
KR101607783B1 (ko) 2016-03-30
SG2014014187A (en) 2014-05-29
WO2013039958A1 (en) 2013-03-21
AU2012308786B2 (en) 2016-12-15
UA114604C2 (uk) 2017-07-10
TN2014000094A1 (en) 2015-07-01
EA024430B1 (ru) 2016-09-30
MX2014003175A (es) 2015-03-05
NZ622393A (en) 2015-11-27
EP2756003A1 (en) 2014-07-23
IL231282A0 (en) 2014-04-30
CN103781802A (zh) 2014-05-07
JP2014530188A (ja) 2014-11-17
GT201400049A (es) 2015-05-28
CA2845706C (en) 2016-03-22
ECSP14013242A (es) 2014-07-31
AP2014007499A0 (en) 2014-03-31
US8530414B2 (en) 2013-09-10
AU2012308786A1 (en) 2014-02-27
EA201490470A1 (ru) 2014-06-30
MY168961A (en) 2019-01-28
AR087715A1 (es) 2014-04-09
TW201323444A (zh) 2013-06-16
US20130071405A1 (en) 2013-03-21
JP6013487B2 (ja) 2016-10-25
DOP2014000041A (es) 2014-06-30
CR20140087A (es) 2014-05-02
CL2014000590A1 (es) 2014-10-17
TWI586687B (zh) 2017-06-11
PH12014500576A1 (en) 2014-04-28
PE20141147A1 (es) 2014-09-22

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