MX343996B - Human antibodies that bind human tnfa. - Google Patents
Human antibodies that bind human tnfa.Info
- Publication number
- MX343996B MX343996B MX2013008395A MX13008395A MX343996B MX 343996 B MX343996 B MX 343996B MX 2013008395 A MX2013008395 A MX 2013008395A MX 13008395 A MX13008395 A MX 13008395A MX 343996 B MX343996 B MX 343996B
- Authority
- MX
- Mexico
- Prior art keywords
- htnfalpha
- antibodies
- human antibodies
- human
- activity
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor alpha (hTNFalpha) are disclosed. These antibodies have high affinity for hTNFalpha (e.g., Kd=10-8 M or less), a slow off rate for hTNFalpha dissociation (e.g., Koff=10-3 sec-1 or less) and neutralize hTNFalpha activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNFalpha and for inhibiting hTNFalpha activity, e.g., in a human subject suffering from a disorder in which hTNFalpha activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/599,226 US6090382A (en) | 1996-02-09 | 1996-02-09 | Human antibodies that bind human TNFα |
| US3147696A | 1996-11-25 | 1996-11-25 | |
| US3147696P | 1996-11-25 | 1996-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX343996B true MX343996B (en) | 2016-12-02 |
Family
ID=58737874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013008395A MX343996B (en) | 1996-02-09 | 1998-08-06 | Human antibodies that bind human tnfa. |
Country Status (1)
| Country | Link |
|---|---|
| MX (1) | MX343996B (en) |
-
1998
- 1998-08-06 MX MX2013008395A patent/MX343996B/en unknown
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