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MX343048B - Oligodesoxinucleotidos inmunoestimulantes. - Google Patents

Oligodesoxinucleotidos inmunoestimulantes.

Info

Publication number
MX343048B
MX343048B MX2013007657A MX2013007657A MX343048B MX 343048 B MX343048 B MX 343048B MX 2013007657 A MX2013007657 A MX 2013007657A MX 2013007657 A MX2013007657 A MX 2013007657A MX 343048 B MX343048 B MX 343048B
Authority
MX
Mexico
Prior art keywords
oligodeoxynucleotides
immunostimulatory oligodeoxynucleotides
immunostimulatory
vaccines
medicament
Prior art date
Application number
MX2013007657A
Other languages
English (en)
Other versions
MX2013007657A (es
Inventor
Carla Christina Schrier
Thomas Simon Ilg
Original Assignee
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of MX2013007657A publication Critical patent/MX2013007657A/es
Publication of MX343048B publication Critical patent/MX343048B/es

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/17—Immunomodulatory nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
    • C—CHEMISTRY; METALLURGY
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18311—Metapneumovirus, e.g. avian pneumovirus
    • C12N2760/18334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a oligodesoxinucleótidos inmunoestimulantes, vectores y vacunas que comprende dichos oligodesoxinucleótidos, para su uso como un medicamento, a su uso en la prevención o la lucha contra enfermedades infecciosas, a los métodos para la detección de tales oligodesoxinucleótidos y a las células para ser utilizadas en estos métodos.
MX2013007657A 2010-12-30 2011-12-29 Oligodesoxinucleotidos inmunoestimulantes. MX343048B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10197435A EP2471926A3 (en) 2010-12-30 2010-12-30 Immunostimulatory oligodeoxynucleotides
US201161430301P 2011-01-06 2011-01-06
PCT/EP2011/074211 WO2012089800A1 (en) 2010-12-30 2011-12-29 Immunostimulatory oligodeoxynucleotides

Publications (2)

Publication Number Publication Date
MX2013007657A MX2013007657A (es) 2013-08-29
MX343048B true MX343048B (es) 2016-10-21

Family

ID=44913150

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013007657A MX343048B (es) 2010-12-30 2011-12-29 Oligodesoxinucleotidos inmunoestimulantes.

Country Status (10)

Country Link
US (1) US9364531B2 (es)
EP (2) EP2471926A3 (es)
JP (2) JP5876889B2 (es)
CN (1) CN103270159B (es)
BR (1) BR112013016683A2 (es)
CA (1) CA2823065C (es)
MX (1) MX343048B (es)
RU (1) RU2615457C2 (es)
WO (1) WO2012089800A1 (es)
ZA (1) ZA201304712B (es)

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EP2471926A3 (en) * 2010-12-30 2012-07-11 Intervet International BV Immunostimulatory oligodeoxynucleotides
PL2714908T3 (pl) * 2011-05-26 2018-07-31 Intervet International B.V. Oligodeoksynukleotydy immunostymulacyjne
AR091569A1 (es) * 2012-06-28 2015-02-11 Intervet Int Bv Receptores de tipo toll
EP2754714A1 (en) * 2013-01-14 2014-07-16 Sarepta Therapeutics, Inc. Inhibitory oligonucleotides and their use in therapy
BR112015030989A2 (pt) 2013-06-14 2019-09-24 Intervet Int Bv composição farmacêutica, e, uso de uma composição
AR097029A1 (es) * 2013-07-26 2016-02-17 Intervet Int Bv Aceleración de la respuesta inmune inducida por virus vectorial en aves, composición, uso, método para la vacunación y método para acelerar la respuesta inmune
HUE063529T2 (hu) 2014-10-03 2024-01-28 Intervet Int Bv Szélesspektrumú vakcina madár reovírus ellen
CN105816868B (zh) * 2016-03-21 2020-01-03 青岛易邦生物工程有限公司 一种鸡滑液囊支原体灭活疫苗
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CN106177956B (zh) * 2016-08-29 2019-11-26 东北农业大学 提高鸡抗ndv病毒效果的方法
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EP3897710A1 (en) 2018-12-20 2021-10-27 Intervet International B.V. Prime-boost vaccination regimen
WO2021123104A1 (en) 2019-12-20 2021-06-24 Intervet International B.V. Multivalent hvt vector vaccine
MX2023007634A (es) 2020-12-24 2023-07-14 Intervet Int Bv Vacuna de vector hvt multivalente.
EP4518893A1 (en) 2022-05-05 2025-03-12 Intervet International B.V. New multivalent hvt vector vaccine

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Also Published As

Publication number Publication date
WO2012089800A1 (en) 2012-07-05
CN103270159A (zh) 2013-08-28
EP2471926A2 (en) 2012-07-04
EP2658974B1 (en) 2016-07-20
BR112013016683A2 (pt) 2017-07-11
ZA201304712B (en) 2014-03-26
US9364531B2 (en) 2016-06-14
RU2615457C2 (ru) 2017-04-04
US20140205633A1 (en) 2014-07-24
CN103270159B (zh) 2016-10-26
JP2016105707A (ja) 2016-06-16
CA2823065C (en) 2019-03-05
MX2013007657A (es) 2013-08-29
CA2823065A1 (en) 2012-07-05
RU2013135485A (ru) 2015-02-10
JP5876889B2 (ja) 2016-03-02
EP2658974A1 (en) 2013-11-06
EP2471926A3 (en) 2012-07-11
JP2014507131A (ja) 2014-03-27

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