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MX342212B - Inhibidores de neprilisina. - Google Patents

Inhibidores de neprilisina.

Info

Publication number
MX342212B
MX342212B MX2013009499A MX2013009499A MX342212B MX 342212 B MX342212 B MX 342212B MX 2013009499 A MX2013009499 A MX 2013009499A MX 2013009499 A MX2013009499 A MX 2013009499A MX 342212 B MX342212 B MX 342212B
Authority
MX
Mexico
Prior art keywords
compounds
neprilysin inhibitors
derivatives
substituted
substituted aminobutyric
Prior art date
Application number
MX2013009499A
Other languages
English (en)
Other versions
MX2013009499A (es
Inventor
Fleury Melissa
Gendron Roland
d hughes Adam
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of MX2013009499A publication Critical patent/MX2013009499A/es
Publication of MX342212B publication Critical patent/MX342212B/es

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    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

Compuestos de la fórmula: en donde R1-R6, a, b, Z y X tienen los valores que se definen en la memoria descriptiva, o una sal farmacéuticamente aceptable de los mismos. Estos compuestos tienen actividad de inhibición de la neprilisina. Composiciones farmacéuticas que comprenden dichos compuestos; métodos para usar dichos compuestos; y procesos e intermediarios para preparar dichos compuestos.
MX2013009499A 2011-02-17 2012-02-16 Inhibidores de neprilisina. MX342212B (es)

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US201161443827P 2011-02-17 2011-02-17
PCT/US2012/025365 WO2012112742A1 (en) 2011-02-17 2012-02-16 Substituted aminobutyric derivatives as neprilysin inhibitors

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MX342212B true MX342212B (es) 2016-09-20

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