MX340924B - Composiciones farmaceuticas. - Google Patents
Composiciones farmaceuticas.Info
- Publication number
- MX340924B MX340924B MX2013012975A MX2013012975A MX340924B MX 340924 B MX340924 B MX 340924B MX 2013012975 A MX2013012975 A MX 2013012975A MX 2013012975 A MX2013012975 A MX 2013012975A MX 340924 B MX340924 B MX 340924B
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical compositions
- pharmaceutical solution
- ethanol
- propellant
- drug
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical compound CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 abstract 2
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 abstract 2
- 229950000210 beclometasone dipropionate Drugs 0.000 abstract 2
- 229960000289 fluticasone propionate Drugs 0.000 abstract 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 abstract 2
- 239000003186 pharmaceutical solution Substances 0.000 abstract 2
- 239000003380 propellant Substances 0.000 abstract 2
- 229940051271 1,1-difluoroethane Drugs 0.000 abstract 1
- 229940071648 metered dose inhaler Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a una solución farmacéutica para un aparato de suministro de la medicación, especialmente un inhalador de dosis medida. La solución farmacéutica comprende: (a) un componente propulsor licuado que consiste esencialmente de, y que consiste completamente de manera preferible de 1,1-difluoroetano (R-152a); (b) etanol; y (c) un componente farmacéutico disuelto en la mezcla del propulsor/etanol que consiste de al menos un fármaco seleccionado del grupo que consiste de dipropionato de beclometasona (BDP) y propionato de fluticasona (FP).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1108039.7A GB201108039D0 (en) | 2011-05-13 | 2011-05-13 | Compositions |
PCT/GB2012/051059 WO2012156711A1 (en) | 2011-05-13 | 2012-05-11 | Pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013012975A MX2013012975A (es) | 2013-12-12 |
MX340924B true MX340924B (es) | 2016-08-01 |
Family
ID=44260493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013012975A MX340924B (es) | 2011-05-13 | 2012-05-11 | Composiciones farmaceuticas. |
Country Status (12)
Country | Link |
---|---|
US (4) | US20140234229A1 (es) |
EP (1) | EP2706987B8 (es) |
JP (2) | JP5904613B2 (es) |
CN (2) | CN107252415B (es) |
AU (1) | AU2012257546C1 (es) |
BR (1) | BR112013029202B1 (es) |
CA (1) | CA2835810C (es) |
ES (1) | ES2541417T3 (es) |
GB (1) | GB201108039D0 (es) |
MX (1) | MX340924B (es) |
WO (1) | WO2012156711A1 (es) |
ZA (1) | ZA201308208B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201108039D0 (en) * | 2011-05-13 | 2011-06-29 | Mexichem Amanco Holding Sa | Compositions |
GB201306984D0 (en) | 2013-04-17 | 2013-05-29 | Mexichem Amanco Holding Sa | Composition |
GB2545025A (en) * | 2015-12-04 | 2017-06-07 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
CN112472689B (zh) * | 2015-12-04 | 2023-01-17 | 墨西哥氟石股份公司 | 药物组合物 |
GB2554092A (en) * | 2016-09-19 | 2018-03-28 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
CN105476961B (zh) * | 2015-12-16 | 2019-01-04 | 武汉同济现代医药科技股份有限公司 | 一种丙酸倍氯米松气雾剂及其制备方法 |
GB2554088A (en) * | 2016-09-19 | 2018-03-28 | Mexichem Fluor Sa De Cv | Pharmaceautical composition |
GB201620519D0 (en) * | 2016-12-02 | 2017-01-18 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
CN109789151A (zh) * | 2016-09-19 | 2019-05-21 | 墨西哥氟石股份公司 | 药物组合物 |
MX2019003099A (es) * | 2016-09-19 | 2019-06-10 | Mexichem Fluor Sa De Cv | Composicion farmaceutica. |
GB2558191A (en) * | 2016-09-19 | 2018-07-11 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
EP3515439B1 (en) * | 2016-09-19 | 2021-12-15 | Mexichem Fluor S.A. de C.V. | Pharmaceutical composition comprising tiotropium bromide |
US11260052B2 (en) * | 2016-09-19 | 2022-03-01 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
EP3915555B1 (en) * | 2016-09-19 | 2023-06-28 | Mexichem Fluor S.A. de C.V. | Pharmaceutical composition comprising glycopyrrolate |
GB2554091A (en) * | 2016-09-19 | 2018-03-28 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
US11521518B1 (en) | 2017-05-04 | 2022-12-06 | IngMar Medical, Ltd. | Airway simulation system |
GB201712159D0 (en) * | 2017-07-28 | 2017-09-13 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
CN112203649A (zh) * | 2018-06-07 | 2021-01-08 | 金德瓦药物控释有限公司 | 氟替卡松和维兰特罗制剂以及吸入器 |
GB2584686A (en) | 2019-06-11 | 2020-12-16 | Mexichem Fluor Sa De Cv | Methods |
IL294804A (en) | 2020-01-28 | 2022-09-01 | Chiesi Farm Spa | Pressurised metered dose inhalers comprising a buffered pharmaceutical formulation |
GEP20247642B (en) | 2020-02-20 | 2024-07-10 | Chiesi Farm Spa | Pressurised metered dose inhalers comprising buffered pharmaceutical formulation |
WO2024157282A1 (en) * | 2023-01-24 | 2024-08-02 | Cipla Limited | Pharmaceutical compositions of green propellant |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8828477D0 (en) | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
US5439670A (en) | 1989-11-28 | 1995-08-08 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
IE67185B1 (en) | 1990-02-02 | 1996-03-06 | Fisons Plc | Propellant compositions |
DE4003272A1 (de) | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
MX9203481A (es) * | 1990-10-18 | 1992-07-01 | Minnesota Mining & Mfg | Formulaciones. |
US7105152B1 (en) | 1991-12-18 | 2006-09-12 | 3M Innovative Properties Company | Suspension aerosol formulations |
CA2206782C (en) | 1994-12-22 | 2007-04-03 | Astra Aktiebolag | Aerosol drug formulations |
EP1769819A3 (en) * | 1995-04-14 | 2013-05-22 | GlaxoSmithKline LLC | Metered dose inhaler for fluticasone propionate |
ATE219355T1 (de) * | 1997-02-05 | 2002-07-15 | Jago Res Ag | Medizinische aerosolformulierungen |
NZ503464A (en) * | 1997-09-29 | 2002-05-31 | Inhale Therapeutic Syst | Perforated microparticles containing a bioactive agent for pulmonary delivery |
US6103266A (en) | 1998-04-22 | 2000-08-15 | Tapolsky; Gilles H. | Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues |
US6451285B2 (en) | 1998-06-19 | 2002-09-17 | Baker Norton Pharmaceuticals, Inc. | Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant |
PT1102579E (pt) | 1998-08-04 | 2003-07-31 | Jago Res Ag | Formulacoes de aerossol medicinais |
DZ2947A1 (fr) * | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
GB2354007B (en) * | 1999-09-11 | 2003-10-22 | Glaxo Group Ltd | Pharmaceutical formulation of fluticasone propionate |
GB2392164B (en) * | 1999-09-11 | 2004-04-07 | Glaxo Group Ltd | Pharmaceutical formulation of fluticasone propionate |
US6432415B1 (en) * | 1999-12-17 | 2002-08-13 | Axrix Laboratories, Inc. | Pharmaceutical gel and aerosol formulations and methods to administer the same to skin and mucosal surfaces |
CN1144582C (zh) | 2000-11-28 | 2004-04-07 | 中国药科大学 | 治疗呼吸系统疾病的无氟里昂药用气雾剂 |
GB2389530B (en) * | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
GB0323684D0 (en) * | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
GB0323685D0 (en) | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
WO2006004646A1 (en) | 2004-06-28 | 2006-01-12 | Nektar Therapeutics | Aerosol formulation comprising nicotine salt |
WO2007020204A2 (en) | 2005-08-12 | 2007-02-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Hfc solution formulations for inhalation containing salbutamol hydrochloride or salbutamol citrate |
GB0915106D0 (en) | 2009-08-28 | 2009-10-07 | Glaxo Group Ltd | Process |
WO2012093252A1 (en) | 2011-01-06 | 2012-07-12 | Cipla Limited | Pharmaceutical composition |
GB201108039D0 (en) * | 2011-05-13 | 2011-06-29 | Mexichem Amanco Holding Sa | Compositions |
-
2011
- 2011-05-13 GB GBGB1108039.7A patent/GB201108039D0/en not_active Ceased
-
2012
- 2012-05-11 BR BR112013029202-4A patent/BR112013029202B1/pt active IP Right Grant
- 2012-05-11 AU AU2012257546A patent/AU2012257546C1/en active Active
- 2012-05-11 EP EP12727901.6A patent/EP2706987B8/en active Active
- 2012-05-11 JP JP2014509839A patent/JP5904613B2/ja active Active
- 2012-05-11 ES ES12727901.6T patent/ES2541417T3/es active Active
- 2012-05-11 MX MX2013012975A patent/MX340924B/es active IP Right Grant
- 2012-05-11 CN CN201710367505.5A patent/CN107252415B/zh active Active
- 2012-05-11 WO PCT/GB2012/051059 patent/WO2012156711A1/en active Application Filing
- 2012-05-11 CN CN201280022952.2A patent/CN103517706A/zh active Pending
- 2012-05-11 US US14/117,340 patent/US20140234229A1/en not_active Abandoned
- 2012-05-11 CA CA2835810A patent/CA2835810C/en active Active
-
2013
- 2013-10-30 ZA ZA2013/08208A patent/ZA201308208B/en unknown
-
2016
- 2016-02-09 JP JP2016022722A patent/JP6125679B2/ja active Active
- 2016-08-29 US US15/250,319 patent/US10258568B2/en active Active
- 2016-09-20 US US15/270,519 patent/US10258569B2/en active Active
-
2019
- 2019-01-16 US US16/249,133 patent/US10668018B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US10258568B2 (en) | 2019-04-16 |
AU2012257546B2 (en) | 2015-06-18 |
WO2012156711A1 (en) | 2012-11-22 |
BR112013029202B1 (pt) | 2022-04-12 |
AU2012257546C1 (en) | 2015-12-24 |
EP2706987B1 (en) | 2015-04-08 |
EP2706987B8 (en) | 2015-05-27 |
US10258569B2 (en) | 2019-04-16 |
ZA201308208B (en) | 2014-06-25 |
EP2706987A1 (en) | 2014-03-19 |
BR112013029202A2 (pt) | 2017-02-14 |
US20170027867A1 (en) | 2017-02-02 |
US20190142750A1 (en) | 2019-05-16 |
JP2016138107A (ja) | 2016-08-04 |
AU2012257546A1 (en) | 2013-11-28 |
CN107252415A (zh) | 2017-10-17 |
JP5904613B2 (ja) | 2016-04-13 |
CN103517706A (zh) | 2014-01-15 |
JP6125679B2 (ja) | 2017-05-10 |
MX2013012975A (es) | 2013-12-12 |
CA2835810C (en) | 2016-08-09 |
ES2541417T3 (es) | 2015-07-20 |
US10668018B2 (en) | 2020-06-02 |
JP2014513146A (ja) | 2014-05-29 |
GB201108039D0 (en) | 2011-06-29 |
US20170007701A1 (en) | 2017-01-12 |
CA2835810A1 (en) | 2012-11-22 |
US20140234229A1 (en) | 2014-08-21 |
CN107252415B (zh) | 2020-08-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |