[go: up one dir, main page]

MX340329B - Polipeptido de fusion presentador de una secuencia de aminoacidos y uso del mismo. - Google Patents

Polipeptido de fusion presentador de una secuencia de aminoacidos y uso del mismo.

Info

Publication number
MX340329B
MX340329B MX2013012688A MX2013012688A MX340329B MX 340329 B MX340329 B MX 340329B MX 2013012688 A MX2013012688 A MX 2013012688A MX 2013012688 A MX2013012688 A MX 2013012688A MX 340329 B MX340329 B MX 340329B
Authority
MX
Mexico
Prior art keywords
amino acid
polypeptide
acid sequence
fusion polypeptide
derived
Prior art date
Application number
MX2013012688A
Other languages
English (en)
Other versions
MX2013012688A (es
Inventor
Scholz Christian
Schraeml Michael
Andres Herbert
Casagolda Vallribera David
Duefel Hartmut
Gerg Michael
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013012688A publication Critical patent/MX2013012688A/es
Publication of MX340329B publication Critical patent/MX340329B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y502/00—Cis-trans-isomerases (5.2)
    • C12Y502/01—Cis-trans-Isomerases (5.2.1)
    • C12Y502/01008—Peptidylprolyl isomerase (5.2.1.8), i.e. cyclophilin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/99—Isomerases (5.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)

Abstract

La presente invención se refiere a un polipéptido de fusión para usarse en la inducción de una respuesta inmunológica en un animal experimental contra un polipéptido, en donde el polipéptido de fusión comprende un polipéptido de acuerdo con la fórmula I: NH2-S2-X1-S1-COOH (fórmula I), en donde: X1 comprende una secuencia de aminoácidos aleatorio o una secuencia de aminoácidos derivada de un primer polipéptido, S2 y S1 son secuencias de aminoácidos no solapantes derivadas de un segundo polipéptido, y se refiere a un enlace peptídico, en donde el segundo polipéptido se selecciona del grupo que consiste de FKBP12 humano, FKBP13 de Arabidopsis thaliana, SiyD de Thermococcus gemmatolerans, y en donde X1 está insertada en lugar del dominio de inserción en solapa (dominio IF) del segundo polipéptido, y en donde X1 es la secuencia de aminoácidos del polipéptido.
MX2013012688A 2011-05-05 2012-05-04 Polipeptido de fusion presentador de una secuencia de aminoacidos y uso del mismo. MX340329B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11164957 2011-05-05
EP12155742 2012-02-16
PCT/EP2012/058207 WO2012150320A1 (en) 2011-05-05 2012-05-04 Amino acid sequence presenting fusion polypeptide and its use

Publications (2)

Publication Number Publication Date
MX2013012688A MX2013012688A (es) 2013-12-02
MX340329B true MX340329B (es) 2016-07-06

Family

ID=46022284

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013012688A MX340329B (es) 2011-05-05 2012-05-04 Polipeptido de fusion presentador de una secuencia de aminoacidos y uso del mismo.

Country Status (17)

Country Link
US (5) US9266962B2 (es)
EP (2) EP2705053B1 (es)
JP (3) JP5877893B2 (es)
KR (1) KR101632479B1 (es)
CN (2) CN103620031B (es)
AR (1) AR086250A1 (es)
AU (1) AU2012251584B2 (es)
BR (1) BR112013028134A2 (es)
CA (2) CA2834456A1 (es)
ES (1) ES2637667T3 (es)
IL (1) IL228983A0 (es)
MX (1) MX340329B (es)
MY (1) MY166542A (es)
RU (1) RU2630660C2 (es)
SG (1) SG194707A1 (es)
WO (2) WO2012150320A1 (es)
ZA (1) ZA201308251B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR086250A1 (es) * 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo
WO2014071978A1 (en) * 2012-11-08 2014-05-15 Roche Diagnostics Gmbh Nucleic acids encoding chimeric polypeptides for library screening
WO2014133093A1 (ja) * 2013-02-28 2014-09-04 独立行政法人国立がん研究センター 不溶性フィブリンに対する抗体
WO2014138733A2 (en) * 2013-03-08 2014-09-12 Dessain Scott K Compositions and methods for making human antibodies
WO2015044083A1 (en) * 2013-09-27 2015-04-02 F. Hoffmann-La Roche Ag Thermus thermophilus slyd fkbp domain specific antibodies
BR112016025056A2 (pt) * 2014-05-14 2018-02-20 F. Hoffmann-La Roche Ag uso de pelo menos um polipeptídeo, anticorpo biespecífico, anticorpo biespecífico isolado, anticorpo her3/her2 biespecífico, célula hospedeira, método de produção do anticorpo biespecífico her3/her2, imunoconjugado e formulação farmacêutica
KR20160145119A (ko) * 2014-05-14 2016-12-19 에프. 호프만-라 로슈 아게 Her1의 베타-헤어핀에 결합하는 her1 항원 결합 단백질
KR102353262B1 (ko) 2014-12-01 2022-01-18 피페넥스 인크. 펩티드 생산용 융합 파트너
US11193929B2 (en) * 2014-12-18 2021-12-07 Biomerieux Synthetic bi-epitope compound
ES2871624T3 (es) 2014-12-19 2021-10-29 Hoffmann La Roche Transglutaminasas microbianas, sustratos para las mismas y procedimientos para el uso de las mismas
KR101873201B1 (ko) * 2015-06-11 2018-07-02 주식회사 제넥신 변형된 인터루킨-7 단백질 및 이의 용도
CN106554420A (zh) * 2015-09-30 2017-04-05 上海众合医药科技股份有限公司 Pcsk9抗体、其抗原结合片段及其医药用途
KR102386735B1 (ko) 2015-11-06 2022-04-14 주식회사 제넥신 변형된 인터루킨-7 융합 단백질의 제형
KR102604595B1 (ko) 2015-12-04 2023-11-21 주식회사 제넥신 면역글로불린 Fc가 융합된 인터루킨-7 융합 단백질을 포함하는 인플루엔자 바이러스 감염의 예방 또는 치료용 약학적 조성물
WO2017095191A1 (ko) 2015-12-04 2017-06-08 주식회사 제넥신 면역글로불린 fc가 융합된 인터루킨-7 융합 단백질을 포함하는 사람 파필로마바이러스 유래 질환의 예방 또는 치료용 약학적 조성물
JP6967002B2 (ja) * 2015-12-15 2021-11-17 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft トランスグルタミナーゼ認識部位を有するｆｋｂｐドメイン
WO2018156180A1 (en) 2017-02-24 2018-08-30 Kindred Biosciences, Inc. Anti-il31 antibodies for veterinary use
JPWO2019167874A1 (ja) * 2018-02-27 2021-03-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ａｐｏａ４に対するモノクローナル抗体、免疫学的測定方法及び測定用キット
CN114430747B (zh) * 2019-09-26 2025-02-25 豪夫迈·罗氏有限公司 抗csf-1r抗体
JP2024525172A (ja) 2021-06-17 2024-07-10 エフ． ホフマン－ラ ロシュ アーゲー 熱安定性親和性ポリペプチド
EP4380955A1 (en) * 2021-08-06 2024-06-12 Roche Diagnostics GmbH Chimeric igg-fc-binding ligand polypeptide and uses thereof for igg affinity purification
JP2024534067A (ja) 2021-08-19 2024-09-18 エフ． ホフマン－ラ ロシュ アーゲー 多価抗バリアントｆｃ領域抗体および使用方法
CN116284220B (zh) * 2023-02-24 2024-08-20 浙江兴业集团有限公司 一种胆固醇酯酶抑制多肽组合及其制备方法、应用
CN118791609B (zh) * 2024-09-13 2024-11-26 江苏凯基生物技术股份有限公司 一种抗igf-1的单克隆抗体及制备方法及试剂盒及应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1232188A (en) * 1987-05-29 1988-12-01 Mallinckrodt, Inc. Novel pair of monoclonal antibodies to insulin-like growth factor i permits immunometric assay for igf-i
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US7276355B2 (en) 2000-12-26 2007-10-02 Sekisui Chemical Co., Ltd. Process for production of a recombinant protein and a fusion protein
AU2002317841A1 (en) * 2001-06-22 2003-01-08 Roche Diagnostics Gmbh Use of fkbp chaperones as expression tool
WO2004001041A1 (ja) * 2002-06-25 2003-12-31 Sekisui Chemical Co., Ltd. 発現ベクター、宿主、融合タンパク質、融合タンパク質の製造方法及びタンパク質の製造方法
EP1578793B1 (en) * 2002-12-20 2007-10-03 Roche Diagnostics GmbH Soluble complexes of target proteins and peptidyl prolyl isomerase chaperones and methods of making and using them
AU2004230803A1 (en) * 2003-04-18 2004-10-28 Chiba, Joe Immunogen, composition for immunological use and process for producing antibody using the same
US7732564B2 (en) * 2005-04-28 2010-06-08 London Health Sciences Centre Research Inc. Serum tumor marker in rodent prostate cancer models
EP2279726A3 (en) * 2005-05-26 2012-06-20 Biorest Ltd. Compositions and methods using same for delivering agents into a target organ protected by a blood barrier
EP1780282B1 (en) 2005-10-26 2010-12-08 Roche Diagnostics GmbH Recombinant expression of Rubella E1 envelope protein variants as chaperone fusion-proteins, and their use in the detection of anti-Rubella antibodies
US7604935B2 (en) * 2005-10-26 2009-10-20 Roche Diagnostics Operations, Inc. Soluble rubella E1 envelope protein variants
JP4871960B2 (ja) * 2006-01-03 2012-02-08 エフ．ホフマン−ラ ロシュ アーゲー 優れたシャペロン活性およびフォールディング活性を有するキメラ融合タンパク質
JP2009533028A (ja) * 2006-04-07 2009-09-17 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ 新生物疾患の治療のための抗体組成物および方法
AU2009312731B2 (en) * 2008-11-10 2012-12-20 Novartis Ag Antibodies to modified human IGF-1/E peptides
AR086250A1 (es) * 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo
JP6488854B2 (ja) * 2015-04-22 2019-03-27 住友電気工業株式会社 半導体積層体および受光素子

Also Published As

Publication number Publication date
KR101632479B1 (ko) 2016-06-21
MX2013012688A (es) 2013-12-02
EP2705147B1 (en) 2019-08-07
CN103620031B (zh) 2016-11-23
EP2705053B1 (en) 2017-06-14
JP2014515761A (ja) 2014-07-03
JP2014520073A (ja) 2014-08-21
RU2630660C2 (ru) 2017-09-11
US20190367601A1 (en) 2019-12-05
NZ616871A (en) 2015-12-24
CN103649119B (zh) 2016-06-08
US20140178393A1 (en) 2014-06-26
US20160137728A1 (en) 2016-05-19
SG194707A1 (en) 2013-12-30
WO2012150320A1 (en) 2012-11-08
KR20140004802A (ko) 2014-01-13
JP2017048209A (ja) 2017-03-09
EP2705147A1 (en) 2014-03-12
CA2831162A1 (en) 2012-11-08
BR112013028134A2 (pt) 2016-11-29
RU2013152691A (ru) 2015-06-10
EP2705053A1 (en) 2014-03-12
JP5877893B2 (ja) 2016-03-08
AU2012251584A1 (en) 2013-11-07
ZA201308251B (en) 2014-08-27
WO2012150321A1 (en) 2012-11-08
MY166542A (en) 2018-07-16
JP6165713B2 (ja) 2017-07-19
IL228983A0 (en) 2013-12-31
US9273144B2 (en) 2016-03-01
CN103649119A (zh) 2014-03-19
CA2831162C (en) 2019-05-28
AR086250A1 (es) 2013-11-27
CN103620031A (zh) 2014-03-05
US9938340B2 (en) 2018-04-10
US20140120561A1 (en) 2014-05-01
US20160138004A1 (en) 2016-05-19
ES2637667T3 (es) 2017-10-16
US9266962B2 (en) 2016-02-23
AU2012251584B2 (en) 2016-07-28
US10301383B2 (en) 2019-05-28
US10647765B2 (en) 2020-05-12
CA2834456A1 (en) 2012-11-08

Similar Documents

Publication Publication Date Title
MX2013012688A (es) Polipeptido de fusion presentador de una secuencia de aminoacidos y uso del mismo.
MX2013001580A (es) Composiciones que comprenden un polipeptido que tiene actividad de incremento celulolitico y un licor, y usos de las mismas.
MY160552A (en) Low protein infant formula with increased essential amino acids
NZ702053A (en) Anti-human trop-2 antibody having antitumor activity in vivo
GB2492267B (en) Yeast microorganisms with reduced by-product accumulation for improved production of fuels, chemicals and amino acids
MY170094A (en) The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of systemic sclerosis (ssc).
EP2540825A3 (en) Cleaning compositions comprising amylase variants reference to a sequence listing
MY188723A (en) Oleanoyl peptide composition and collagen enhancement
IN2014DN09922A (es)
IN2014DN07017A (es)
MX355170B (es) Variantes de enzimas mejoradas.
WO2013021212A3 (en) Modified osteopontin peptides having an inactivated rgd domain and uses thereof
WO2014004540A8 (en) Method for engineering proteases and protein kinases
PH12013500411A1 (en) Treatment of myocardial infarction using tgf - beta antagonists
MX354156B (es) Dipeptido que comprende un aminoacido no proteogenico.
NZ604412A (en) Vaccine and methods to reduce campylobacter infection
EA201492068A1 (ru) Гидрохлоридная соль пептида и ее применение в комбинации с другими пептидами в иммунотерапии
NZ749998A (en) Tfpi inhibitors and methods of use
NZ600818A (en) Cyclic peptides for the regulation of vectorial ion channels
WO2013156458A8 (en) Reduction of formation of amidated amino acids in cell lines for protein expression
RU2012110908A (ru) Синтетические пептиды с ненаркотическим типом анальгетического действия
RU2507212C3 (ru) Способ получения рекомбинантного пептида и полученный пептид
MX357911B (es) Peptido mejorador de sabor.
WO2012103263A3 (en) Compositions and methods for malate and fumarate production
WO2012160713A8 (en) Learning and memory improver

Legal Events

Date Code Title Description
FG Grant or registration