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MX339692B - Moduladores de los receptores 5-ht y metodos de uso de los mismos. - Google Patents

Moduladores de los receptores 5-ht y metodos de uso de los mismos.

Info

Publication number
MX339692B
MX339692B MX2012012279A MX2012012279A MX339692B MX 339692 B MX339692 B MX 339692B MX 2012012279 A MX2012012279 A MX 2012012279A MX 2012012279 A MX2012012279 A MX 2012012279A MX 339692 B MX339692 B MX 339692B
Authority
MX
Mexico
Prior art keywords
octahydropyrazino
methods
compounds
modulators
receptors
Prior art date
Application number
MX2012012279A
Other languages
English (en)
Other versions
MX2012012279A (es
Inventor
W Djuric Stevan
Akritopoulou-Zanze Irini
Braje Wilfried
Wang Ying
T Brewer Jason
Pohlki Frauke
Relo Ana-Lucia
Original Assignee
Abbvie Inc *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc * filed Critical Abbvie Inc *
Publication of MX2012012279A publication Critical patent/MX2012012279A/es
Publication of MX339692B publication Critical patent/MX339692B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/22—Anxiolytics
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    • A61P25/24—Antidepressants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A61P25/36—Opioid-abuse
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/30—Hydrogen technology
    • Y02E60/32—Hydrogen storage

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
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  • Obesity (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente solicitud se refiere a derivados de 1 ,2,3,4)4a,5,6,7-octahidropirazino[1 ,2-a][1 ,4]benzodiacepina, 1, 2, 3, 4, 4a, 5, 6, 7-octahidropirazino[1)2-a][1 ,5jbenzodiazepina, 1, 2, 3, 4, 4a, 5, 6, 7, 11 b-octahidro-1 H-pirido[3,4-d(][2]benzazepina,1 ,2 ,3 ,4 ,4ª ,5 ,6 ,7-octahidropirazino[1 ,2-a][1]benzazepina, 1 ,2 ,3 ,4 ,4ª ,5-hexahidro-7H-pirazino[1 ,2-a][4, 1]benzoxazepina, y 2,3,4,4a,5,6- hexahidro-1 H-pirazino[2,l-d][1 ,5]benzoxazepina, y 5 ,6 ,7 ,7ª ,8,9 ,10, 11 -octahídropirazino[1 ,2-d]pirido[3,2-6][l ,4]diazepina de la fórmula (I) en la cual R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, y Y3 son como se definen en la descripción. La presente solicitud también se refiere a composiciones que comprenden dichos compuestos, y a métodos para tratar condiciones patológicas utilizando dichos compuestos y composiciones, y a métodos para identificar dichos compuestos.
MX2012012279A 2010-04-22 2010-10-21 Moduladores de los receptores 5-ht y metodos de uso de los mismos. MX339692B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/765,034 US8518933B2 (en) 2009-04-23 2010-04-22 Modulators of 5-HT receptors and methods of use thereof
PCT/US2010/053530 WO2011133182A1 (en) 2010-04-22 2010-10-21 Modulators of 5-ht receptors and methods of use thereof

Publications (2)

Publication Number Publication Date
MX2012012279A MX2012012279A (es) 2013-03-08
MX339692B true MX339692B (es) 2016-06-06

Family

ID=44834964

Family Applications (2)

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MX2016002648A MX347948B (es) 2010-04-22 2010-10-21 Moduladores de los receptores 5-ht y metodos de uso de los mismos.
MX2012012279A MX339692B (es) 2010-04-22 2010-10-21 Moduladores de los receptores 5-ht y metodos de uso de los mismos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016002648A MX347948B (es) 2010-04-22 2010-10-21 Moduladores de los receptores 5-ht y metodos de uso de los mismos.

Country Status (8)

Country Link
US (4) US8518933B2 (es)
EP (2) EP2560973B1 (es)
JP (2) JP6049610B2 (es)
CN (2) CN102958932B (es)
CA (1) CA2797019C (es)
ES (1) ES2616087T3 (es)
MX (2) MX347948B (es)
WO (1) WO2011133182A1 (es)

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CA2797019A1 (en) 2011-10-27
US8518933B2 (en) 2013-08-27
CA2797019C (en) 2018-03-20
US8846663B2 (en) 2014-09-30
ES2616087T3 (es) 2017-06-09
US9701679B2 (en) 2017-07-11
EP2560973A4 (en) 2013-09-04
US20130310368A1 (en) 2013-11-21
JP2013525350A (ja) 2013-06-20
EP2560973A1 (en) 2013-02-27
US20150175611A1 (en) 2015-06-25
EP2560973B1 (en) 2016-11-16
US20100273767A1 (en) 2010-10-28
WO2011133182A1 (en) 2011-10-27
MX2012012279A (es) 2013-03-08
CN105367578A (zh) 2016-03-02
EP3150607A1 (en) 2017-04-05
JP6049610B2 (ja) 2016-12-21
US20180127423A1 (en) 2018-05-10
CN102958932B (zh) 2015-11-25
JP2016040249A (ja) 2016-03-24

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