MX2024009948A - Moleculas de union anti-tdp-43 humanizadas y usos de las mismas. - Google Patents
Moleculas de union anti-tdp-43 humanizadas y usos de las mismas.Info
- Publication number
- MX2024009948A MX2024009948A MX2024009948A MX2024009948A MX2024009948A MX 2024009948 A MX2024009948 A MX 2024009948A MX 2024009948 A MX2024009948 A MX 2024009948A MX 2024009948 A MX2024009948 A MX 2024009948A MX 2024009948 A MX2024009948 A MX 2024009948A
- Authority
- MX
- Mexico
- Prior art keywords
- tdp
- disease
- humanized anti
- binding molecules
- present
- Prior art date
Links
- 230000027455 binding Effects 0.000 title abstract 2
- 102100040347 TAR DNA-binding protein 43 Human genes 0.000 abstract 3
- 101710150875 TAR DNA-binding protein 43 Proteins 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 abstract 2
- 201000011240 Frontotemporal dementia Diseases 0.000 abstract 2
- 208000018737 Parkinson disease Diseases 0.000 abstract 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
- 208000017004 dementia pugilistica Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000014644 Brain disease Diseases 0.000 abstract 1
- 102000052510 DNA-Binding Proteins Human genes 0.000 abstract 1
- 101710096438 DNA-binding protein Proteins 0.000 abstract 1
- 208000032274 Encephalopathy Diseases 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención pertenece al campo de las proteínas de unión a ADN de respuesta transactiva con un peso molecular de 43 kDa (TARDB o también TDP-43). Se describen moléculas de unión a TDP-43 humanizadas específicas, en particular a anticuerpos anti-TDP-43 humanizadas o un fragmento de unión a antígeno o un derivado de los mismos y sus usos. Asimismo se proveen medios y métodos para diagnosticar, prevenir, aliviar y/o tratar una enfermedad, un trastorno y/o una anomalía asociada con agregados de TDP-43 que incluye, pero en un sentido no taxativo, demencia frontotemporal (FTD), esclerosis lateral amiotrófica (ALS), enfermedad de Alzheimer (AD), enfermedad de Parkinson (PD), encefalopatía traumática crónica (CTE) y encefalopatía TDP-43 con predominio límbico relacionada con la edad (LATE).
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22157150 | 2022-02-16 | ||
| EP22177361 | 2022-06-06 | ||
| EP23152958 | 2023-01-23 | ||
| EP23153165 | 2023-01-24 | ||
| PCT/EP2023/053940 WO2023156549A1 (en) | 2022-02-16 | 2023-02-16 | Humanized anti-tdp-43 binding molecules and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2024009948A true MX2024009948A (es) | 2024-08-22 |
Family
ID=85239102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2024009948A MX2024009948A (es) | 2022-02-16 | 2023-02-16 | Moleculas de union anti-tdp-43 humanizadas y usos de las mismas. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP4479426A1 (es) |
| KR (1) | KR20240150774A (es) |
| AR (1) | AR128540A1 (es) |
| AU (1) | AU2023221539A1 (es) |
| CL (1) | CL2024002383A1 (es) |
| CR (1) | CR20240378A (es) |
| IL (1) | IL315043A (es) |
| MX (1) | MX2024009948A (es) |
| TW (1) | TW202342519A (es) |
| WO (1) | WO2023156549A1 (es) |
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-
2023
- 2023-02-16 KR KR1020247029734A patent/KR20240150774A/ko active Pending
- 2023-02-16 MX MX2024009948A patent/MX2024009948A/es unknown
- 2023-02-16 IL IL315043A patent/IL315043A/en unknown
- 2023-02-16 CR CR20240378A patent/CR20240378A/es unknown
- 2023-02-16 AU AU2023221539A patent/AU2023221539A1/en active Pending
- 2023-02-16 TW TW112105586A patent/TW202342519A/zh unknown
- 2023-02-16 EP EP23705273.3A patent/EP4479426A1/en active Pending
- 2023-02-16 AR ARP230100367A patent/AR128540A1/es unknown
- 2023-02-16 WO PCT/EP2023/053940 patent/WO2023156549A1/en active Application Filing
-
2024
- 2024-08-08 CL CL2024002383A patent/CL2024002383A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2024002383A1 (es) | 2025-01-03 |
| AU2023221539A1 (en) | 2024-08-22 |
| KR20240150774A (ko) | 2024-10-16 |
| AR128540A1 (es) | 2024-05-22 |
| TW202342519A (zh) | 2023-11-01 |
| WO2023156549A1 (en) | 2023-08-24 |
| IL315043A (en) | 2024-10-01 |
| CR20240378A (es) | 2024-10-03 |
| EP4479426A1 (en) | 2024-12-25 |
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