MX2024001377A - NEW ANTIVIRAL AGENTS DERIVED FROM SPIROPYRROLIDINE. - Google Patents
NEW ANTIVIRAL AGENTS DERIVED FROM SPIROPYRROLIDINE.Info
- Publication number
- MX2024001377A MX2024001377A MX2024001377A MX2024001377A MX2024001377A MX 2024001377 A MX2024001377 A MX 2024001377A MX 2024001377 A MX2024001377 A MX 2024001377A MX 2024001377 A MX2024001377 A MX 2024001377A MX 2024001377 A MX2024001377 A MX 2024001377A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- spiropyrrolidine
- pharmaceutically acceptable
- antiviral agents
- agents derived
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención describe compuestos de Fórmula (I), y sales farmacéuticamente aceptables de los mismos: (ver Fórmula) que inhiben la actividad de replicación del coronavirus. La invención se refiere además a composiciones farmacéuticas que comprenden un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable del mismo, y métodos para tratar o prevenir una infección por coronavirus en un sujeto que lo necesite, que comprenden administrar al sujeto una cantidad terapéuticamente efectiva de un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable del mismo.The present invention describes compounds of Formula (I), and pharmaceutically acceptable salts thereof: (see Formula) that inhibit the replication activity of coronavirus. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163227206P | 2021-07-29 | 2021-07-29 | |
| US17/479,248 US11325916B1 (en) | 2021-07-29 | 2021-09-20 | Spiropyrrolidine derived antiviral agents |
| US202263324367P | 2022-03-28 | 2022-03-28 | |
| PCT/US2022/024772 WO2023009187A1 (en) | 2021-07-29 | 2022-04-14 | Novel spiropyrrolidine derived antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2024001377A true MX2024001377A (en) | 2024-03-08 |
Family
ID=85025187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2024001377A MX2024001377A (en) | 2021-07-29 | 2022-04-14 | NEW ANTIVIRAL AGENTS DERIVED FROM SPIROPYRROLIDINE. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP4376834A4 (en) |
| JP (1) | JP2024529476A (en) |
| KR (1) | KR20240044452A (en) |
| AU (1) | AU2022319598A1 (en) |
| CA (1) | CA3173702A1 (en) |
| IL (1) | IL310246A (en) |
| MX (1) | MX2024001377A (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023086400A1 (en) * | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| CN118909031B (en) * | 2021-12-29 | 2025-05-27 | 上海柯君医药科技有限公司 | Anti-coronavirus compounds and compositions and uses thereof |
-
2022
- 2022-04-14 CA CA3173702A patent/CA3173702A1/en active Pending
- 2022-04-14 IL IL310246A patent/IL310246A/en unknown
- 2022-04-14 AU AU2022319598A patent/AU2022319598A1/en active Pending
- 2022-04-14 MX MX2024001377A patent/MX2024001377A/en unknown
- 2022-04-14 EP EP22850031.0A patent/EP4376834A4/en active Pending
- 2022-04-14 KR KR1020247006429A patent/KR20240044452A/en active Pending
- 2022-04-14 JP JP2024505183A patent/JP2024529476A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022319598A1 (en) | 2024-02-08 |
| KR20240044452A (en) | 2024-04-04 |
| EP4376834A4 (en) | 2025-06-18 |
| IL310246A (en) | 2024-03-01 |
| CA3173702A1 (en) | 2023-01-29 |
| EP4376834A1 (en) | 2024-06-05 |
| JP2024529476A (en) | 2024-08-06 |
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