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MX2023006711A - Entrega oral de conjugados antisentido que tienen por blanco a pcsk9. - Google Patents

Entrega oral de conjugados antisentido que tienen por blanco a pcsk9.

Info

Publication number
MX2023006711A
MX2023006711A MX2023006711A MX2023006711A MX2023006711A MX 2023006711 A MX2023006711 A MX 2023006711A MX 2023006711 A MX2023006711 A MX 2023006711A MX 2023006711 A MX2023006711 A MX 2023006711A MX 2023006711 A MX2023006711 A MX 2023006711A
Authority
MX
Mexico
Prior art keywords
oral delivery
targeting pcsk9
conjugates targeting
antisense conjugates
civi
Prior art date
Application number
MX2023006711A
Other languages
English (en)
Inventor
Henrik Oerum
Stewart Alwyn Noble
Charles Lester Shear
Original Assignee
Civi Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Civi Biopharma Inc filed Critical Civi Biopharma Inc
Publication of MX2023006711A publication Critical patent/MX2023006711A/es

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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract

La presente divulgación proporciona composiciones farmacéuticas para la administración oral que comprenden un oligonucleótido antisentido (por ejemplo, CIVI 008) y un agente de administración oral tal como 5-CNAC. En algunos aspectos, la divulgación proporciona una cápsula que comprende una mezcla seca de CIVI 008 y 5-CNAC, y opcionalmente, una estatina.
MX2023006711A 2020-12-11 2021-12-10 Entrega oral de conjugados antisentido que tienen por blanco a pcsk9. MX2023006711A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063124581P 2020-12-11 2020-12-11
US202163134884P 2021-01-07 2021-01-07
US202163178340P 2021-04-22 2021-04-22
US202163261505P 2021-09-22 2021-09-22
PCT/US2021/062831 WO2022125913A1 (en) 2020-12-11 2021-12-10 Oral delivery of antisense conjugates targeting pcsk9

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MX2023006711A true MX2023006711A (es) 2023-08-18

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EP (1) EP4259799A4 (es)
JP (1) JP2024500367A (es)
KR (1) KR20230132442A (es)
AU (1) AU2021396376A1 (es)
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CL (1) CL2023001639A1 (es)
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CR (1) CR20230308A (es)
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MX (1) MX2023006711A (es)
PE (1) PE20240887A1 (es)
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WO2023065231A1 (en) * 2021-10-21 2023-04-27 Guangzhou Dazhou Biomedicine Ltd. Oral delivery of therapeutic agents

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WO2007031091A2 (en) * 2005-09-15 2007-03-22 Santaris Pharma A/S Rna antagonist compounds for the modulation of p21 ras expression
PL2059260T3 (pl) * 2006-08-31 2014-03-31 Novartis Ag Kompozycja farmaceutyczna obejmująca hGH do dostarczania doustnego
CN104884065B (zh) * 2012-09-21 2019-01-01 强烈治疗剂公司 治疗癌症的方法
WO2014089484A1 (en) * 2012-12-06 2014-06-12 Novamedica Limited Liability Company Oligonucleotide formulation
DK3013959T3 (da) * 2013-06-27 2020-02-17 Roche Innovation Ct Copenhagen As Antisense-oligomerer og konjugater målrettet pcsk9
EP3151839A4 (en) * 2014-06-06 2018-02-28 Ionis Pharmaceuticals, Inc. Compositions and methods for enhanced intestinal absorption of conjugated oligomeric compounds
CN104095828A (zh) * 2014-07-29 2014-10-15 中国药科大学 一种降钙素口服肠溶组合物及其制备方法
AU2019350765A1 (en) * 2018-09-28 2021-05-27 Alnylam Pharmaceuticals, Inc. Transthyretin (TTR) iRNA compositions and methods of use thereof for treating or preventing TTR-associated ocular diseases

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IL303462A (en) 2023-08-01
CR20230308A (es) 2023-09-08
WO2022125913A9 (en) 2023-06-08
EP4259799A1 (en) 2023-10-18
AU2021396376A1 (en) 2023-06-29
EP4259799A4 (en) 2024-11-13
KR20230132442A (ko) 2023-09-15
CO2023009176A2 (es) 2023-11-10
WO2022125913A1 (en) 2022-06-16
JP2024500367A (ja) 2024-01-09
PE20240887A1 (es) 2024-04-24
CL2023001639A1 (es) 2023-10-30
US20240067965A1 (en) 2024-02-29
US20220213476A1 (en) 2022-07-07
TW202237846A (zh) 2022-10-01
CA3200564A1 (en) 2022-06-16

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