[go: up one dir, main page]

MX2022016532A - Polipeptidos que comprenden polipeptidos de il-2 modificados y usos de los mismos. - Google Patents

Polipeptidos que comprenden polipeptidos de il-2 modificados y usos de los mismos.

Info

Publication number
MX2022016532A
MX2022016532A MX2022016532A MX2022016532A MX2022016532A MX 2022016532 A MX2022016532 A MX 2022016532A MX 2022016532 A MX2022016532 A MX 2022016532A MX 2022016532 A MX2022016532 A MX 2022016532A MX 2022016532 A MX2022016532 A MX 2022016532A
Authority
MX
Mexico
Prior art keywords
polypeptides
modified
agonize
polypeptide
bind
Prior art date
Application number
MX2022016532A
Other languages
English (en)
Inventor
Katelyn M Willis
Bryan Becklund
Brendan P Eckelman
John C Timmer
Florian Sulzmaier
Original Assignee
Inhibrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibrx Inc filed Critical Inhibrx Inc
Publication of MX2022016532A publication Critical patent/MX2022016532A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)

Abstract

En el presente se proporcionan polipéptidos que comprenden una IL-2 modificada, en los que la IL-2 modificada tiene una afinidad reducida por el receptor de IL-2 en relación con la IL-2 de tipo natural; en algunas modalidades, se proporcionan polipéptidos que comprenden una IL-2 modificada que se une y agoniza las células T activadas; también se proporcionan usos de los polipéptidos que comprenden una IL-2 modificada.
MX2022016532A 2020-07-02 2021-07-01 Polipeptidos que comprenden polipeptidos de il-2 modificados y usos de los mismos. MX2022016532A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063047681P 2020-07-02 2020-07-02
PCT/US2021/040061 WO2022006380A2 (en) 2020-07-02 2021-07-01 Polypeptides comprising modified il-2 polypeptides and uses thereof

Publications (1)

Publication Number Publication Date
MX2022016532A true MX2022016532A (es) 2023-04-12

Family

ID=77127075

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022016532A MX2022016532A (es) 2020-07-02 2021-07-01 Polipeptidos que comprenden polipeptidos de il-2 modificados y usos de los mismos.

Country Status (12)

Country Link
US (1) US20230235005A1 (es)
EP (1) EP4175979A2 (es)
JP (1) JP2023532904A (es)
KR (1) KR20230035076A (es)
CN (1) CN116615440A (es)
AR (1) AR122863A1 (es)
AU (1) AU2021299552A1 (es)
CA (1) CA3184618A1 (es)
IL (1) IL299542A (es)
MX (1) MX2022016532A (es)
TW (1) TW202216745A (es)
WO (1) WO2022006380A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022087458A1 (en) 2020-10-23 2022-04-28 Asher Biotherapeutics, Inc. Fusions with cd8 antigen binding molecules for modulating immune cell function
GB2638094A (en) 2021-05-19 2025-08-13 Asher Biotherapeutics Inc Il-21 Polypeptides And Targeted Constructs
US20250109203A1 (en) * 2022-01-05 2025-04-03 Inhibrx Biosciences, Inc. Gamma Delta T-Cell-Targeted Modified IL-2 Polypeptides and Uses Thereof
MX2024009715A (es) * 2022-02-11 2024-08-19 Jiangsu Hengrui Pharmaceuticals Co Ltd Inmunoconjugado y su uso del mismo.
EP4514397A2 (en) * 2022-04-27 2025-03-05 Asher Biotherapeutics, Inc. Combination of cytokine fusion proteins with cd8 antigen binding molecules
TW202413442A (zh) 2022-06-16 2024-04-01 美商希佛隆有限責任公司 抗pd-1抗體減弱之il-2免疫結合物及其用途
TW202402784A (zh) * 2022-07-06 2024-01-16 中國商科望（上海）生物醫藥科技有限公司 Il2突變蛋白及其用途
CN116041539B (zh) * 2022-10-31 2023-07-21 山东博安生物技术股份有限公司 Il-2突变体免疫缀合物
IL322269A (en) * 2023-02-06 2025-09-01 Merck Patent Gmbh VHH-based NKP46 binding agents
TW202515918A (zh) 2023-08-30 2025-04-16 美商艾希利歐發展股份有限公司 Ｖｈｈ遮蔽之細胞介素及其使用方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
DE69233254T2 (de) 1991-06-14 2004-09-16 Genentech, Inc., South San Francisco Humanisierter Heregulin Antikörper
ATE531812T1 (de) 1997-12-05 2011-11-15 Scripps Research Inst Humanisierung von nager-antikörpern
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
DK1678314T3 (da) 2003-10-22 2012-12-03 Keck Graduate Inst Fremgangsmåde til syntetisering af heteromultimere polypeptider i gær ved anvendelse af en haploid parringsstrategi
JP2007527242A (ja) * 2004-03-05 2007-09-27 カイロン コーポレーション 治療剤の患者耐容性を予測するためのインビトロ試験システム
MXPA06011199A (es) 2004-03-31 2007-04-16 Genentech Inc Anticuerpos anti-tgf-beta humanizados.
CN106659757B (zh) * 2014-04-24 2022-01-28 利兰斯坦福初级大学董事会 白介素2的超级激动剂、部分激动剂和拮抗剂
EP3280725B1 (en) * 2016-05-04 2020-08-26 Amgen Inc. Interleukin-2 muteins for the expansion of t-regulatory cells
CN117024560A (zh) * 2016-12-22 2023-11-10 库尔生物制药有限公司 T细胞调节性多聚体多肽及其使用方法
JP7637415B2 (ja) * 2018-06-22 2025-02-28 キュージーン インコーポレイテッド インターロイキン－２バリアントおよびその使用方法
WO2020060122A1 (ko) * 2018-09-17 2020-03-26 (주)지아이이노베이션 Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 이의 용도
CN113924311A (zh) * 2019-01-07 2022-01-11 印希比股份有限公司 包含修饰的il-2多肽的多肽及其用途
WO2020247843A2 (en) * 2019-06-05 2020-12-10 Asher Biotherapeutics, Inc. Fusions of mutant interleukin-2 polypeptides with antigen binding molecules for modulating immune cell function

Also Published As

Publication number Publication date
IL299542A (en) 2023-02-01
KR20230035076A (ko) 2023-03-10
CA3184618A1 (en) 2022-01-06
CN116615440A (zh) 2023-08-18
US20230235005A1 (en) 2023-07-27
WO2022006380A2 (en) 2022-01-06
TW202216745A (zh) 2022-05-01
AR122863A1 (es) 2022-10-12
EP4175979A2 (en) 2023-05-10
JP2023532904A (ja) 2023-08-01
AU2021299552A1 (en) 2023-02-02
WO2022006380A3 (en) 2022-02-24

Similar Documents

Publication Publication Date Title
MX2022016532A (es) Polipeptidos que comprenden polipeptidos de il-2 modificados y usos de los mismos.
MX2021008147A (es) Polipeptidos que comprenden polipeptidos con il-2 modificada y usos de los mismos.
WO2020247843A3 (en) Fusions of mutant interleukin-2 polypeptides with antigen binding molecules for modulating immune cell function
WO2020142659A3 (en) Multi-specific protein molecules and uses thereof
MX2011012184A (es) Polipeptidos bifuncionales.
WO2020160156A3 (en) Anti-gal3 antibodies and uses thereof
NZ553118A (en) Anti-FC-gamma RIIB receptor antibody and uses therefor
MX2020010241A (es) Composiciones de inmunoterapia celular y usos de las mismas.
MX2009008230A (es) Epitopes de celulas t reguladoras, composiciones y usos para los mismos.
NZ775714A (en) Interleukin-2 muteins for the expansion of t-regulatory cells
CR20220512A (es) Inmunoconjugados
MA40609B1 (fr) Agents de liaison cd123 et leurs utilisations
IL190705A0 (en) A method for the production of a permanent human cell line
NZ602634A (en) Vista regulatory t cell mediator protein, vista binding agents and use thereof
WO2021188374A9 (en) Interleukin-2 receptor βeta (il-2rβ) binding polypeptides
WO2022140321A3 (en) Mage-b2-specific t-cell receptors
WO2023056193A3 (en) Il-18 variants and uses thereof
WO2020028572A3 (en) ANTIBODY-COUPLED T CELL RECEPTORS (ACTRs) IN COMBINATION WITH TRANS CO-STIMULATORY MOLECULES AND THERAPEUTIC USES THEREOF
WO2023280307A9 (en) Mutant il-15 compositions and methods thereof
WO2011056954A8 (en) Haemophilus parasuis polypeptides and methods of use
WO2022226054A3 (en) Antigen presenting polypeptide complexes bearing tgf-beta and methods of use thereof
MX2022016494A (es) Anticuerpos anti-il13ra2.
WO2020037181A3 (en) Cell sorting systems and methods of use
MX2022013840A (es) Polipéptidos de unión a pd-1 canina y usos de los mismos.
CR20230219A (es) Polipéptidos de interleucina-2 mutante dependientes del ph