MX2022011932A - Novedosa l-ramnosa isomerasa. - Google Patents
Novedosa l-ramnosa isomerasa.Info
- Publication number
- MX2022011932A MX2022011932A MX2022011932A MX2022011932A MX2022011932A MX 2022011932 A MX2022011932 A MX 2022011932A MX 2022011932 A MX2022011932 A MX 2022011932A MX 2022011932 A MX2022011932 A MX 2022011932A MX 2022011932 A MX2022011932 A MX 2022011932A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- cho
- rhamnose
- isomerase
- recognizing
- Prior art date
Links
- 108010001469 L-rhamnose isomerase Proteins 0.000 title abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- ZAQJHHRNXZUBTE-UHFFFAOYSA-N D-threo-2-Pentulose Natural products OCC(O)C(O)C(=O)CO ZAQJHHRNXZUBTE-UHFFFAOYSA-N 0.000 abstract 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-IVMDWMLBSA-N D-allopyranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@H](O)[C@@H]1O WQZGKKKJIJFFOK-IVMDWMLBSA-N 0.000 abstract 1
- LKDRXBCSQODPBY-JDJSBBGDSA-N D-allulose Chemical compound OCC1(O)OC[C@@H](O)[C@@H](O)[C@H]1O LKDRXBCSQODPBY-JDJSBBGDSA-N 0.000 abstract 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 abstract 1
- ZAQJHHRNXZUBTE-NQXXGFSBSA-N D-ribulose Chemical compound OC[C@@H](O)[C@@H](O)C(=O)CO ZAQJHHRNXZUBTE-NQXXGFSBSA-N 0.000 abstract 1
- 241000588698 Erwinia Species 0.000 abstract 1
- 108090000769 Isomerases Proteins 0.000 abstract 1
- 102000004195 Isomerases Human genes 0.000 abstract 1
- 208000007976 Ketosis Diseases 0.000 abstract 1
- LKDRXBCSQODPBY-NSHGFSBMSA-N L-fructose Chemical compound OCC1(O)OC[C@H](O)[C@H](O)[C@H]1O LKDRXBCSQODPBY-NSHGFSBMSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-JFNONXLTSA-N L-mannopyranose Chemical compound OC[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O WQZGKKKJIJFFOK-JFNONXLTSA-N 0.000 abstract 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 abstract 1
- QZNPNKJXABGCRC-FUTKDDECSA-N L-rhamnulose Chemical compound C[C@H](O)[C@H](O)[C@@H](O)C(=O)CO QZNPNKJXABGCRC-FUTKDDECSA-N 0.000 abstract 1
- ZAQJHHRNXZUBTE-WVZVXSGGSA-N L-xylulose Chemical compound OC[C@H](O)[C@@H](O)C(=O)CO ZAQJHHRNXZUBTE-WVZVXSGGSA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-YUPRTTJUSA-N aldehydo-L-lyxose Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-YUPRTTJUSA-N 0.000 abstract 1
- PNNNRSAQSRJVSB-BXKVDMCESA-N aldehydo-L-rhamnose Chemical compound C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O PNNNRSAQSRJVSB-BXKVDMCESA-N 0.000 abstract 1
- GZCGUPFRVQAUEE-OMMKOOBNSA-N aldehydo-L-talose Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-OMMKOOBNSA-N 0.000 abstract 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 1
- MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical compound OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 abstract 1
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- BJHIKXHVCXFQLS-LFRDXLMFSA-N keto-L-tagatose Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)C(=O)CO BJHIKXHVCXFQLS-LFRDXLMFSA-N 0.000 abstract 1
- 150000002584 ketoses Chemical class 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/24—Preparation of compounds containing saccharide radicals produced by the action of an isomerase, e.g. fructose
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y503/00—Intramolecular oxidoreductases (5.3)
- C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
- C12Y503/01014—L-Rhamnose isomerase (5.3.1.14)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/18—Erwinia
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se describe una L-ramnosa isomerasa altamente segura, altamente activa y resistente al calor y un mutante sustituido por aminoácidos de la misma, un microorganismo que la produce, o un método para producir una aldosa o una cetosa, todos los cuales son capaces de ser usados en la industria alimentaria. L-ramnosa isomerasa, que puede ser obtenida a partir de un microorganismo perteneciente al género Erwinia, tiene una masa molecular de subunidad de 48 kDa medida por SDS-PAGE, y tiene las siguientes especificidades de sustrato (A) y (B). (A) Una actividad de isomerasa para reconocer y reaccionar con un grupo CHO de C1 y un grupo OH de C2 de una aldosa para convertir el grupo CHO de C1 en un grupo OH y el grupo OH de C2 en un grupo CO, alternativamente, para reconocer y reaccionar con un grupo OH de C1 y un grupo CO de C2 de una cetosa para convertir el grupo OH de C1 en un grupo CHO y el grupo CO de C2 en un grupo OH. (B) Una actividad para catalizar una reacción de isomerización entre L-ramnosa y L-ramnulosa, entre L-lixosa y L-xilulosa, entre L-manosa y L-fructosa, entre D-ribosa y D-ribulosa, entre L-talosa y L-tagatosa, y entre D-alosa y D-alulosa.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020055308 | 2020-03-26 | ||
| PCT/JP2021/012989 WO2021193949A1 (ja) | 2020-03-26 | 2021-03-26 | 新規ｌ－ラムノースイソメラーゼ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022011932A true MX2022011932A (es) | 2022-10-20 |
Family
ID=77892291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022011932A MX2022011932A (es) | 2020-03-26 | 2021-03-26 | Novedosa l-ramnosa isomerasa. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4130278A4 (es) |
| JP (1) | JPWO2021193949A1 (es) |
| KR (1) | KR20220157985A (es) |
| CN (1) | CN115349018A (es) |
| MX (1) | MX2022011932A (es) |
| WO (1) | WO2021193949A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4257687A4 (en) * | 2020-11-30 | 2024-12-18 | National University Corporation Kagawa University | Novel l-rhamnose isomerase |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4943839B1 (es) | 1968-06-10 | 1974-11-25 | ||
| JPS5330976B1 (es) | 1971-07-22 | 1978-08-30 | ||
| JPS5317055B2 (es) | 1972-08-09 | 1978-06-06 | ||
| EP0020961B1 (de) | 1979-06-20 | 1982-05-12 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Vorrichtung zum Nachweis von Mikroorganismen |
| AU2003235403A1 (en) | 2002-05-22 | 2003-12-02 | Fushimi Pharmaceutical Co., Ltd. | Method of utilizing physiological activity of rare saccharide and compositions containing rare saccharide |
| KR100480018B1 (ko) | 2002-12-11 | 2005-03-31 | (주) 대호바콘텍 | 콘크리트 말뚝용 헤드커버 및 그를 이용한 말뚝 기초구조물의 시공방법 |
| JP2008109933A (ja) * | 2003-01-10 | 2008-05-15 | Kishoto Seisan Gijutsu Kenkyusho:Kk | 新しい触媒機能を有するｌ−ラムノースイソメラーゼの用途 |
| JP4724824B2 (ja) | 2004-03-19 | 2011-07-13 | 国立大学法人 香川大学 | 希少糖のｔリンパ球の増殖抑制への使用 |
| WO2005115408A1 (ja) | 2004-05-26 | 2005-12-08 | National University Corporation Kagawa University | 血管内皮細胞の増殖抑制・管腔形成阻害方法 |
| EP1788089B1 (en) * | 2004-08-24 | 2014-01-29 | Matsutani Chemical Industry Co., Ltd. | Sequence of thermotolerant l-rhamnose isomerase gene and use of the same |
| EP1860195B1 (en) * | 2005-03-04 | 2018-01-03 | National University Corporation Kagawa University | Complex crystalline sugar comprising d-psicose and d-allose and process for production of the same |
| US8440619B2 (en) | 2005-08-31 | 2013-05-14 | National University Corporation Kagawa University | Utilization of hypertension/hypercardia-preventing effect of D-allose |
| JP5317055B2 (ja) | 2006-11-09 | 2013-10-16 | 国立大学法人 香川大学 | 希少糖の筋萎縮性側索硬化症に起因する運動障害の発症または進行を遅延するための医薬品 |
| KR101556988B1 (ko) * | 2006-11-20 | 2015-10-02 | 고쿠리츠다이가쿠호우징 카가와다이가쿠 | 데옥시케토헥소스 아이소머라제 및 그것을 이용한 데옥시케토헥소스 및 그 유도체의 제조 방법 |
| JP2009269887A (ja) | 2008-05-09 | 2009-11-19 | Kagawa Univ | 希少糖を含有する腹膜劣化抑制剤、腹膜透析液および腹膜透析法 |
| US9125409B2 (en) | 2008-08-18 | 2015-09-08 | Mitsui Chemicals Agro, Inc. | Plant disease control agent comprising D-tagatose as active ingredient, and plant disease control method |
| WO2014069537A1 (ja) * | 2012-10-30 | 2014-05-08 | 松谷化学工業株式会社 | Ｄ－アロースの生産方法 |
| PL3298127T3 (pl) | 2015-05-22 | 2022-05-30 | Archer Daniels Midland Company | Zastosowanie enzymów epimerazy do konwersji fruktozy do allulozy |
| JP2019052195A (ja) | 2016-01-15 | 2019-04-04 | 株式会社Moresco | 滑水性コート材料 |
| JP2019058477A (ja) | 2017-09-27 | 2019-04-18 | 株式会社サンセイアールアンドディ | 遊技機 |
-
2021
- 2021-03-26 CN CN202180024419.9A patent/CN115349018A/zh active Pending
- 2021-03-26 WO PCT/JP2021/012989 patent/WO2021193949A1/ja active Application Filing
- 2021-03-26 JP JP2022510758A patent/JPWO2021193949A1/ja active Pending
- 2021-03-26 KR KR1020227034672A patent/KR20220157985A/ko active Pending
- 2021-03-26 MX MX2022011932A patent/MX2022011932A/es unknown
- 2021-03-26 EP EP21773444.1A patent/EP4130278A4/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2021193949A1 (es) | 2021-09-30 |
| EP4130278A4 (en) | 2024-06-26 |
| CN115349018A (zh) | 2022-11-15 |
| WO2021193949A1 (ja) | 2021-09-30 |
| EP4130278A1 (en) | 2023-02-08 |
| KR20220157985A (ko) | 2022-11-29 |
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