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MX2022009302A - Compuestos de unión a il-7r¿. - Google Patents

Compuestos de unión a il-7r¿.

Info

Publication number
MX2022009302A
MX2022009302A MX2022009302A MX2022009302A MX2022009302A MX 2022009302 A MX2022009302 A MX 2022009302A MX 2022009302 A MX2022009302 A MX 2022009302A MX 2022009302 A MX2022009302 A MX 2022009302A MX 2022009302 A MX2022009302 A MX 2022009302A
Authority
MX
Mexico
Prior art keywords
binding compounds
ligands
compounds
binding
agonists
Prior art date
Application number
MX2022009302A
Other languages
English (en)
Inventor
William J Dower
Michael C Needels
Ronald W Barrett
Alice V Bakker
Steven E Cwirla
Original Assignee
Medikine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medikine Inc filed Critical Medikine Inc
Publication of MX2022009302A publication Critical patent/MX2022009302A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen ligandos de IL-7Ra y compuestos que comprenden ligandos de IL-7Ra. Los compuestos de unión a IL-7Ra incluyen proteínas de fusión que comprenden los ligandos de IL-7Ra y pueden actuar como agonistas de IL-7R.
MX2022009302A 2020-02-03 2021-02-03 Compuestos de unión a il-7r¿. MX2022009302A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062969432P 2020-02-03 2020-02-03
PCT/US2021/016356 WO2021158619A1 (en) 2020-02-03 2021-02-03 IL-7Rα BINDING COMPOUNDS

Publications (1)

Publication Number Publication Date
MX2022009302A true MX2022009302A (es) 2022-11-16

Family

ID=77200522

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022009302A MX2022009302A (es) 2020-02-03 2021-02-03 Compuestos de unión a il-7r¿.

Country Status (12)

Country Link
US (2) US11254729B2 (es)
EP (1) EP4100046A4 (es)
JP (1) JP2023512687A (es)
KR (1) KR20220156533A (es)
CN (1) CN115297886A (es)
AU (1) AU2021217959A1 (es)
BR (1) BR112022014401A2 (es)
CA (1) CA3169452A1 (es)
IL (1) IL295303A (es)
MX (1) MX2022009302A (es)
TW (2) TWI823054B (es)
WO (1) WO2021158619A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3172359A1 (en) 2018-08-06 2020-02-13 Medikine, Inc. Il-2 receptor binding compounds
AU2020378282B2 (en) 2019-11-05 2023-05-18 Medikine, Inc. Dual IL-2R and IL-7R binding compounds
CN115087664A (zh) 2019-11-05 2022-09-20 麦地金公司 IL-2Rβγc结合化合物
CA3166816A1 (en) 2020-02-03 2021-08-12 William J. Dower Il-7r.alpha..gamma.c binding compounds
IL295303A (en) * 2020-02-03 2022-10-01 Medikine Inc 7-il alpha receptor binding compounds and preparations containing them
WO2023133595A2 (en) 2022-01-10 2023-07-13 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
US11999771B2 (en) * 2022-04-07 2024-06-04 Medikine, Inc. IL-7Rαγc ligand immunoglobulin fusion proteins
EP4572772A1 (en) 2022-08-17 2025-06-25 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
WO2024054874A1 (en) 2022-09-06 2024-03-14 Medikine, Inc. Use of il-2r-beta-gamma agonist peptides in cell manufacturing
WO2024054870A1 (en) 2022-09-06 2024-03-14 Medikine, Inc. Use of il-7r-alpha-gamma agonist peptides in cell manufacturing
WO2025029873A2 (en) * 2023-07-31 2025-02-06 Q32 Bio Inc. Treatment of hair-loss disorder
CN118406118B (zh) * 2024-05-30 2025-01-21 重庆大学 一种靶向il-7r的小蛋白sbp003501及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635597A (en) 1994-05-27 1997-06-03 Affymax Technologies, N.V. Peptides that bind IL-2 receptors
US6890734B2 (en) * 2000-11-10 2005-05-10 Schering Corporation Nucleic acids encoding a cytokine receptor complex
CA2469151C (en) 2001-12-04 2013-08-13 Merck Patent Gesellschaft Mit Beschraenkter Haftung Immunocytokines with modulated selectivity
US20050054054A1 (en) * 2002-11-12 2005-03-10 Foss Francine M. Interleukin-7 molecules with altered biological properties
DE602004013372T2 (de) 2003-12-30 2009-07-02 Merck Patent Gmbh Il-7-fusionsproteine mit antikörperportionen, deren herstellung und deren verwendung
JP4937132B2 (ja) * 2004-12-09 2012-05-23 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 免疫原性の低下したｉｌ−７変種
WO2010099084A2 (en) 2009-02-27 2010-09-02 Monsanto Technology Llc Isolated novel nucleic acid and protein molecules from corn and methods of using those molecules
PT2637694T (pt) 2010-11-12 2021-05-05 Nektar Therapeutics Conjugados de uma fração de il-2 e um polímero
EP2649094B1 (en) 2010-12-10 2016-04-27 University of Central Florida Research Foundation, Inc. Methods and compositions comprising il-7 receptor ligands
ES2989085T3 (es) 2011-01-18 2024-11-25 Bioniz Therapeutics Inc Composiciones para modular la actividad de citoquinas gamma-c
US10150802B2 (en) 2014-04-24 2018-12-11 The Board Of Trustees Of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
HUE046065T2 (hu) 2014-07-21 2020-01-28 Delinia Inc Szabályozó T-sejteket szelektíven aktiváló molekulák autoimmun betegségek kezelésére
CN107922496B (zh) 2015-08-06 2022-11-01 新加坡科技研究局 IL2Rβ/通用γ链抗体
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
KR20180117116A (ko) 2016-02-05 2018-10-26 워싱턴 유니버시티 표적화된 사이토카인 전달을 위한 조성물 및 방법들
CN110167957A (zh) 2016-11-08 2019-08-23 德里尼亚公司 用于治疗自身免疫疾病的il-2变体
AU2017378308A1 (en) 2016-12-13 2019-06-20 Delinia, Inc. Multivalent regulatory T cell modulators
CA3172359A1 (en) 2018-08-06 2020-02-13 Medikine, Inc. Il-2 receptor binding compounds
IL295303A (en) * 2020-02-03 2022-10-01 Medikine Inc 7-il alpha receptor binding compounds and preparations containing them
CA3166816A1 (en) * 2020-02-03 2021-08-12 William J. Dower Il-7r.alpha..gamma.c binding compounds
US11999771B2 (en) * 2022-04-07 2024-06-04 Medikine, Inc. IL-7Rαγc ligand immunoglobulin fusion proteins

Also Published As

Publication number Publication date
TW202417475A (zh) 2024-05-01
WO2021158619A1 (en) 2021-08-12
EP4100046A4 (en) 2024-03-06
US20210253669A1 (en) 2021-08-19
CA3169452A1 (en) 2021-08-12
US20220119493A1 (en) 2022-04-21
JP2023512687A (ja) 2023-03-28
BR112022014401A2 (pt) 2022-11-16
EP4100046A1 (en) 2022-12-14
CN115297886A (zh) 2022-11-04
WO2021158619A8 (en) 2022-04-28
IL295303A (en) 2022-10-01
TWI823054B (zh) 2023-11-21
TW202142559A (zh) 2021-11-16
AU2021217959A1 (en) 2022-08-18
US11254729B2 (en) 2022-02-22
KR20220156533A (ko) 2022-11-25

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