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MX2022006489A - Derivado de anillo de piridina fusionado, metodo de preparacion y usos farmaceuticos del mismo. - Google Patents

Derivado de anillo de piridina fusionado, metodo de preparacion y usos farmaceuticos del mismo.

Info

Publication number
MX2022006489A
MX2022006489A MX2022006489A MX2022006489A MX2022006489A MX 2022006489 A MX2022006489 A MX 2022006489A MX 2022006489 A MX2022006489 A MX 2022006489A MX 2022006489 A MX2022006489 A MX 2022006489A MX 2022006489 A MX2022006489 A MX 2022006489A
Authority
MX
Mexico
Prior art keywords
preparation
method therefor
pyridine ring
ring derivative
pharmaceutical use
Prior art date
Application number
MX2022006489A
Other languages
English (en)
Inventor
Feng He
Xiaomin Zhang
Weimin Hu
Chaobaihui Ye
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2022006489A publication Critical patent/MX2022006489A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un derivado de anillo de piridina fusionado está representado por la fórmula general (I), un método de preparación, por lo tanto, una composición farmacéutica que contiene el derivado, y un uso del mismo como agente terapéutico, en particular, en la preparación de medicamentos para prevenir y/o tratar el VIH. infección. (ver Fórmula).
MX2022006489A 2019-11-29 2020-11-27 Derivado de anillo de piridina fusionado, metodo de preparacion y usos farmaceuticos del mismo. MX2022006489A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201911198968 2019-11-29
CN202010104095 2020-02-20
CN202010500013 2020-06-04
CN202010656009 2020-07-09
PCT/CN2020/132026 WO2021104413A1 (zh) 2019-11-29 2020-11-27 稠合吡啶环衍生物、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
MX2022006489A true MX2022006489A (es) 2022-07-04

Family

ID=76129126

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022006489A MX2022006489A (es) 2019-11-29 2020-11-27 Derivado de anillo de piridina fusionado, metodo de preparacion y usos farmaceuticos del mismo.

Country Status (11)

Country Link
US (1) US20230023968A1 (es)
EP (1) EP4067349A4 (es)
JP (1) JP2023503672A (es)
KR (1) KR20220108086A (es)
CN (1) CN114929685B (es)
AU (1) AU2020390305A1 (es)
BR (1) BR112022010204A2 (es)
CA (1) CA3162126A1 (es)
MX (1) MX2022006489A (es)
TW (1) TW202128660A (es)
WO (1) WO2021104413A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118159529A (zh) 2021-05-28 2024-06-07 江苏恒瑞医药股份有限公司 一种稠合吡啶环衍生物的可药用盐、晶型及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4351053B2 (ja) * 2001-10-26 2009-10-28 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ジヒドロキシピリミジンカルボキサミド系ｈｉｖインテグラーゼ阻害薬
US7642277B2 (en) * 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
US7429604B2 (en) * 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
EP2729448B1 (en) 2011-07-06 2015-09-09 Gilead Sciences, Inc. Compounds for the treatment of hiv
TW201443037A (zh) * 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
TWI706945B (zh) 2013-03-01 2020-10-11 美商基利科學股份有限公司 供治療反轉錄病毒科病毒感染之治療性化合物
PT3186239T (pt) * 2014-08-29 2019-01-10 Gilead Sciences Inc Agentes antirretrovirais
SI3597646T1 (sl) * 2016-08-19 2023-10-30 Gilead Sciences, Inc. Terapevtske spojine, uporabne za profilaktično ali terapevtsko zdravljenje okužbe z virusom hiv
UY37710A (es) * 2017-05-02 2018-11-30 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicación del virus de la inmunodeficiencia humana
AR112413A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas sólidas de un inhibidor de la cápside del vih
CN111836805B (zh) 2018-02-15 2023-07-14 吉利德科学公司 吡啶衍生物及其用于治疗hiv感染的用途

Also Published As

Publication number Publication date
EP4067349A1 (en) 2022-10-05
US20230023968A1 (en) 2023-01-26
KR20220108086A (ko) 2022-08-02
JP2023503672A (ja) 2023-01-31
CA3162126A1 (en) 2021-06-03
EP4067349A4 (en) 2022-12-21
TW202128660A (zh) 2021-08-01
BR112022010204A2 (pt) 2022-09-06
CN114929685B (zh) 2023-12-12
AU2020390305A1 (en) 2022-07-07
CN114929685A (zh) 2022-08-19
WO2021104413A1 (zh) 2021-06-03

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