MX2022001469A - Determinacion de modificaciones de bases de acidos nucleicos. - Google Patents
Determinacion de modificaciones de bases de acidos nucleicos.Info
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- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
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Abstract
Se describen en la presente sistemas y métodos para usar la determinación de la modificación de bases para analizar moléculas de ácido nucleico y adquirir datos para el análisis de moléculas de ácido nucleico. Las modificaciones de bases pueden incluir metilaciones. Los métodos para determinar las modificaciones de bases pueden incluir el uso de características derivadas de la secuenciación. Estas características pueden incluir el ancho del pulso de una señal óptica a partir de la secuenciación de bases, la duración entre pulsos de las bases y la identidad de las bases. Los modelos de aprendizaje automático pueden entrenarse para detectar las modificaciones de bases mediante el uso de estas características. Los niveles de modificación o metilación relativos entre haplotipos pueden indicar un trastorno. También pueden usarse estados de modificación o metilación para detectar moléculas quiméricas.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962887987P | 2019-08-16 | 2019-08-16 | |
US202062970586P | 2020-02-05 | 2020-02-05 | |
US202062991891P | 2020-03-19 | 2020-03-19 | |
US202063019790P | 2020-05-04 | 2020-05-04 | |
US202063051210P | 2020-07-13 | 2020-07-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022001469A true MX2022001469A (es) | 2022-02-22 |
Family
ID=74567577
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021000931A MX389993B (es) | 2019-08-16 | 2020-08-17 | Determinación de modificaciones de bases de ácidos nucleicos |
MX2022001470A MX2022001470A (es) | 2019-08-16 | 2021-01-22 | Determinacion de modificaciones de bases de acidos nucleicos. |
MX2022001469A MX2022001469A (es) | 2019-08-16 | 2021-01-22 | Determinacion de modificaciones de bases de acidos nucleicos. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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MX2021000931A MX389993B (es) | 2019-08-16 | 2020-08-17 | Determinación de modificaciones de bases de ácidos nucleicos |
MX2022001470A MX2022001470A (es) | 2019-08-16 | 2021-01-22 | Determinacion de modificaciones de bases de acidos nucleicos. |
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US (4) | US11091794B2 (es) |
EP (3) | EP3827092B1 (es) |
JP (4) | JP7264534B2 (es) |
KR (4) | KR102658592B1 (es) |
CN (5) | CN116694746A (es) |
AU (4) | AU2020323958B2 (es) |
BR (1) | BR122021009560B1 (es) |
CA (1) | CA3110884A1 (es) |
DK (2) | DK3827092T3 (es) |
ES (2) | ES3003866T3 (es) |
GB (13) | GB2620069B (es) |
IL (3) | IL294153B2 (es) |
MX (3) | MX389993B (es) |
NZ (4) | NZ786185A (es) |
PH (1) | PH12021550223A1 (es) |
SG (1) | SG11202101070QA (es) |
TW (5) | TWI752593B (es) |
WO (1) | WO2021032060A1 (es) |
ZA (1) | ZA202100887B (es) |
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US20230148447A9 (en) | 2008-12-11 | 2023-05-11 | Pacific Biosciences Of California, Inc. | Classification of nucleic acid templates |
MX389993B (es) | 2019-08-16 | 2025-03-20 | Univ Hong Kong Chinese | Determinación de modificaciones de bases de ácidos nucleicos |
US11920190B2 (en) | 2019-12-30 | 2024-03-05 | Industrial Technology Research Institute | Method of amplifying and determining target nucleotide sequence |
US20220237502A1 (en) * | 2021-01-25 | 2022-07-28 | Paypal, Inc. | Systems and methods for training and modifying a computer-based model to perform classification |
EP4323539A4 (en) * | 2021-04-12 | 2025-02-05 | The Chinese University of Hong Kong | ANALYSIS OF BASE MODIFICATION USING ELECTRICAL SIGNALS |
CN113409885B (zh) * | 2021-06-21 | 2022-09-20 | 天津金域医学检验实验室有限公司 | 一种自动化数据处理以及作图方法及系统 |
CN113981548B (zh) * | 2021-11-24 | 2023-07-11 | 竹石生物科技(苏州)有限公司 | Dna甲基化测序文库的制备方法和甲基化检测方法 |
US20230313314A1 (en) | 2022-02-07 | 2023-10-05 | Centre For Novostics Limited | Fragmentation for measuring methylation and disease |
AU2023240410A1 (en) * | 2022-03-25 | 2024-10-10 | The Penn State Research Foundation | Analysis of genomic word frameworks on genomic methylation data |
KR102491322B1 (ko) * | 2022-03-29 | 2023-01-27 | 주식회사 아이엠비디엑스 | 암 진단을 위한 다중 분석 예측 모델의 제조 방법 |
AU2023245692A1 (en) * | 2022-03-29 | 2024-10-17 | Ahead Intelligence Ltd. | Methods and devices of processing cytometric data |
WO2023225004A1 (en) * | 2022-05-16 | 2023-11-23 | Bioscreening & Diagnostics Llc | Prediction of alzheimer's disease |
US20240018581A1 (en) * | 2022-07-15 | 2024-01-18 | Massachusetts Institute Of Technology | Mixture deconvolution method for identifying dna profiles |
EP4566072A2 (en) * | 2022-08-05 | 2025-06-11 | The Board of Trustees of the Leland Stanford Junior University | Systems and methods for cancer screening |
WO2024081649A1 (en) * | 2022-10-11 | 2024-04-18 | Illumina, Inc. | Detecting and correcting methylation values from methylation sequencing assays |
WO2024129712A1 (en) * | 2022-12-12 | 2024-06-20 | Flagship Pioneering Innovations, Vi, Llc | Phased sequencing information from circulating tumor dna |
CN116168761B (zh) * | 2023-04-18 | 2023-06-30 | 珠海圣美生物诊断技术有限公司 | 核酸序列特征区域确定方法、装置、电子设备及存储介质 |
WO2025034461A1 (en) | 2023-08-04 | 2025-02-13 | Pacific Biosciences Of California, Inc. | Detection of 5-methylcytosine |
WO2025078657A1 (en) * | 2023-10-13 | 2025-04-17 | F. Hoffmann-La Roche Ag | Amplification-free target enrichment workflow for direct detection of nucleic acid modifications |
KR102774172B1 (ko) * | 2023-10-25 | 2025-02-28 | 서울대학교산학협력단 | Rna 변형의 모든 주변 서열을 포함하는 광범위한 rna 변형 라이브러리 설계법 및 그 이용 |
WO2025128580A1 (en) * | 2023-12-11 | 2025-06-19 | Foundation Medicine, Inc. | Methods and systems for determining methylation state categories |
CN119229980B (zh) * | 2024-11-28 | 2025-02-18 | 北京大学第三医院(北京大学第三临床医学院) | 一种基于机器学习的母源污染去除方法及相关设备 |
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AU2002214811B2 (en) * | 2000-11-13 | 2004-09-09 | Human Genetic Signatures Pty Ltd | Detection of methylated DNA molecules |
AU2003900368A0 (en) * | 2003-01-24 | 2003-02-13 | Human Genetic Signatures Pty Ltd | Assay for nucleic acid molecules |
DE602004018801D1 (de) * | 2003-09-04 | 2009-02-12 | Human Genetic Signatures Pty | Nukleinsäurenachweistest |
EP2557518B1 (en) | 2007-07-23 | 2017-03-15 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
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CA2746632C (en) | 2008-12-11 | 2020-06-30 | Pacific Biosciences Of California, Inc. | Characterization of modified nucleic acids |
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WO2012112606A1 (en) | 2011-02-15 | 2012-08-23 | Bio-Rad Laboratories, Inc. | Detecting methylati0n in a subpopulation of genomic dna |
US9016970B2 (en) * | 2011-06-08 | 2015-04-28 | United States Postal Service | Elastomeric force mitigating joint |
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WO2013170429A1 (zh) * | 2012-05-14 | 2013-11-21 | 深圳华大基因健康科技有限公司 | 确定胎儿基因组中预定区域碱基信息的方法、系统和计算机可读介质 |
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WO2014153757A1 (zh) * | 2013-03-28 | 2014-10-02 | 深圳华大基因研究院 | 确定胚胎基因组中预定区域碱基信息的方法、系统和计算机可读介质 |
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EP3169813B1 (en) | 2014-07-18 | 2019-06-12 | The Chinese University Of Hong Kong | Methylation pattern analysis of tissues in dna mixture |
EP4063517A1 (en) * | 2015-07-20 | 2022-09-28 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
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MX389993B (es) | 2019-08-16 | 2025-03-20 | Univ Hong Kong Chinese | Determinación de modificaciones de bases de ácidos nucleicos |
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