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MX2022001469A - Determinacion de modificaciones de bases de acidos nucleicos. - Google Patents

Determinacion de modificaciones de bases de acidos nucleicos.

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Publication number
MX2022001469A
MX2022001469A MX2022001469A MX2022001469A MX2022001469A MX 2022001469 A MX2022001469 A MX 2022001469A MX 2022001469 A MX2022001469 A MX 2022001469A MX 2022001469 A MX2022001469 A MX 2022001469A MX 2022001469 A MX2022001469 A MX 2022001469A
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Mexico
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biomarker
embryo
correlating
characteristic
signal
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MX2022001469A
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English (en)
Inventor
Kwan Chee Chan
Yuk- Ming Dennis Lo
Rossa Wai Kwun Chiu
Peiyong Jiang
Suk Hang Cheng
Wenlei Peng
On Yee Tse
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Univ Hong Kong Chinese
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=74567577&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2022001469(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of MX2022001469A publication Critical patent/MX2022001469A/es

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Abstract

Se describen en la presente sistemas y métodos para usar la determinación de la modificación de bases para analizar moléculas de ácido nucleico y adquirir datos para el análisis de moléculas de ácido nucleico. Las modificaciones de bases pueden incluir metilaciones. Los métodos para determinar las modificaciones de bases pueden incluir el uso de características derivadas de la secuenciación. Estas características pueden incluir el ancho del pulso de una señal óptica a partir de la secuenciación de bases, la duración entre pulsos de las bases y la identidad de las bases. Los modelos de aprendizaje automático pueden entrenarse para detectar las modificaciones de bases mediante el uso de estas características. Los niveles de modificación o metilación relativos entre haplotipos pueden indicar un trastorno. También pueden usarse estados de modificación o metilación para detectar moléculas quiméricas.
MX2022001469A 2019-08-16 2021-01-22 Determinacion de modificaciones de bases de acidos nucleicos. MX2022001469A (es)

Applications Claiming Priority (5)

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US201962887987P 2019-08-16 2019-08-16
US202062970586P 2020-02-05 2020-02-05
US202062991891P 2020-03-19 2020-03-19
US202063019790P 2020-05-04 2020-05-04
US202063051210P 2020-07-13 2020-07-13

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MX2021000931A MX389993B (es) 2019-08-16 2020-08-17 Determinación de modificaciones de bases de ácidos nucleicos
MX2022001470A MX2022001470A (es) 2019-08-16 2021-01-22 Determinacion de modificaciones de bases de acidos nucleicos.
MX2022001469A MX2022001469A (es) 2019-08-16 2021-01-22 Determinacion de modificaciones de bases de acidos nucleicos.

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MX2022001470A MX2022001470A (es) 2019-08-16 2021-01-22 Determinacion de modificaciones de bases de acidos nucleicos.

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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230148447A9 (en) 2008-12-11 2023-05-11 Pacific Biosciences Of California, Inc. Classification of nucleic acid templates
MX389993B (es) 2019-08-16 2025-03-20 Univ Hong Kong Chinese Determinación de modificaciones de bases de ácidos nucleicos
US11920190B2 (en) 2019-12-30 2024-03-05 Industrial Technology Research Institute Method of amplifying and determining target nucleotide sequence
US20220237502A1 (en) * 2021-01-25 2022-07-28 Paypal, Inc. Systems and methods for training and modifying a computer-based model to perform classification
EP4323539A4 (en) * 2021-04-12 2025-02-05 The Chinese University of Hong Kong ANALYSIS OF BASE MODIFICATION USING ELECTRICAL SIGNALS
CN113409885B (zh) * 2021-06-21 2022-09-20 天津金域医学检验实验室有限公司 一种自动化数据处理以及作图方法及系统
CN113981548B (zh) * 2021-11-24 2023-07-11 竹石生物科技(苏州)有限公司 Dna甲基化测序文库的制备方法和甲基化检测方法
US20230313314A1 (en) 2022-02-07 2023-10-05 Centre For Novostics Limited Fragmentation for measuring methylation and disease
AU2023240410A1 (en) * 2022-03-25 2024-10-10 The Penn State Research Foundation Analysis of genomic word frameworks on genomic methylation data
KR102491322B1 (ko) * 2022-03-29 2023-01-27 주식회사 아이엠비디엑스 암 진단을 위한 다중 분석 예측 모델의 제조 방법
AU2023245692A1 (en) * 2022-03-29 2024-10-17 Ahead Intelligence Ltd. Methods and devices of processing cytometric data
WO2023225004A1 (en) * 2022-05-16 2023-11-23 Bioscreening & Diagnostics Llc Prediction of alzheimer's disease
US20240018581A1 (en) * 2022-07-15 2024-01-18 Massachusetts Institute Of Technology Mixture deconvolution method for identifying dna profiles
EP4566072A2 (en) * 2022-08-05 2025-06-11 The Board of Trustees of the Leland Stanford Junior University Systems and methods for cancer screening
WO2024081649A1 (en) * 2022-10-11 2024-04-18 Illumina, Inc. Detecting and correcting methylation values from methylation sequencing assays
WO2024129712A1 (en) * 2022-12-12 2024-06-20 Flagship Pioneering Innovations, Vi, Llc Phased sequencing information from circulating tumor dna
CN116168761B (zh) * 2023-04-18 2023-06-30 珠海圣美生物诊断技术有限公司 核酸序列特征区域确定方法、装置、电子设备及存储介质
WO2025034461A1 (en) 2023-08-04 2025-02-13 Pacific Biosciences Of California, Inc. Detection of 5-methylcytosine
WO2025078657A1 (en) * 2023-10-13 2025-04-17 F. Hoffmann-La Roche Ag Amplification-free target enrichment workflow for direct detection of nucleic acid modifications
KR102774172B1 (ko) * 2023-10-25 2025-02-28 서울대학교산학협력단 Rna 변형의 모든 주변 서열을 포함하는 광범위한 rna 변형 라이브러리 설계법 및 그 이용
WO2025128580A1 (en) * 2023-12-11 2025-06-19 Foundation Medicine, Inc. Methods and systems for determining methylation state categories
CN119229980B (zh) * 2024-11-28 2025-02-18 北京大学第三医院(北京大学第三临床医学院) 一种基于机器学习的母源污染去除方法及相关设备

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002214811B2 (en) * 2000-11-13 2004-09-09 Human Genetic Signatures Pty Ltd Detection of methylated DNA molecules
AU2003900368A0 (en) * 2003-01-24 2003-02-13 Human Genetic Signatures Pty Ltd Assay for nucleic acid molecules
DE602004018801D1 (de) * 2003-09-04 2009-02-12 Human Genetic Signatures Pty Nukleinsäurenachweistest
EP2557518B1 (en) 2007-07-23 2017-03-15 The Chinese University of Hong Kong Determining a nucleic acid sequence imbalance
EP2326733A2 (en) 2008-09-05 2011-06-01 Pacific Biosciences of California, Inc. Engineering polymerases and reaction conditions for modified incorporation properties
US8486630B2 (en) * 2008-11-07 2013-07-16 Industrial Technology Research Institute Methods for accurate sequence data and modified base position determination
US9175338B2 (en) 2008-12-11 2015-11-03 Pacific Biosciences Of California, Inc. Methods for identifying nucleic acid modifications
CA2746632C (en) 2008-12-11 2020-06-30 Pacific Biosciences Of California, Inc. Characterization of modified nucleic acids
AU2010315037B9 (en) 2009-11-05 2015-04-23 Sequenom, Inc. Fetal genomic analysis from a maternal biological sample
WO2012112606A1 (en) 2011-02-15 2012-08-23 Bio-Rad Laboratories, Inc. Detecting methylati0n in a subpopulation of genomic dna
US9016970B2 (en) * 2011-06-08 2015-04-28 United States Postal Service Elastomeric force mitigating joint
US9238836B2 (en) 2012-03-30 2016-01-19 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing modified nucleic acids
US9175348B2 (en) 2012-04-24 2015-11-03 Pacific Biosciences Of California, Inc. Identification of 5-methyl-C in nucleic acid templates
WO2013170429A1 (zh) * 2012-05-14 2013-11-21 深圳华大基因健康科技有限公司 确定胎儿基因组中预定区域碱基信息的方法、系统和计算机可读介质
WO2013185137A1 (en) 2012-06-08 2013-12-12 Pacific Biosciences Of California, Inc. Modified base detection with nanopore sequencing
AU2013274002A1 (en) * 2012-06-15 2015-02-05 Harry Stylli Methods of detecting diseases or conditions
WO2014153757A1 (zh) * 2013-03-28 2014-10-02 深圳华大基因研究院 确定胚胎基因组中预定区域碱基信息的方法、系统和计算机可读介质
CN105593683B (zh) 2013-10-01 2018-11-30 考利达基因组股份有限公司 鉴定基因组中的变异的定相和连接方法
AU2014332241B2 (en) 2013-10-07 2021-04-29 Sequenom, Inc. Methods and processes for non-invasive assessment of chromosome alterations
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
EP3169813B1 (en) 2014-07-18 2019-06-12 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in dna mixture
EP4063517A1 (en) * 2015-07-20 2022-09-28 The Chinese University Of Hong Kong Methylation pattern analysis of haplotypes in tissues in dna mixture
US10465232B1 (en) 2015-10-08 2019-11-05 Trace Genomics, Inc. Methods for quantifying efficiency of nucleic acid extraction and detection
MX389993B (es) 2019-08-16 2025-03-20 Univ Hong Kong Chinese Determinación de modificaciones de bases de ácidos nucleicos

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