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MX2022000410A - Formacion de comprimidos de estabilizadores de polimeros especificos. - Google Patents

Formacion de comprimidos de estabilizadores de polimeros especificos.

Info

Publication number
MX2022000410A
MX2022000410A MX2022000410A MX2022000410A MX2022000410A MX 2022000410 A MX2022000410 A MX 2022000410A MX 2022000410 A MX2022000410 A MX 2022000410A MX 2022000410 A MX2022000410 A MX 2022000410A MX 2022000410 A MX2022000410 A MX 2022000410A
Authority
MX
Mexico
Prior art keywords
tablet
polymer
starting material
punch
polymer stabilizer
Prior art date
Application number
MX2022000410A
Other languages
English (en)
Inventor
Heinz Herbst
Shyam Sundar Sathyanarayana
Yean Yik Geoerg
Thomas Georg Gfroerer
Holger Ruckdaeschel
Lothar Seidemann
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of MX2022000410A publication Critical patent/MX2022000410A/es

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    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/13—Phenols; Phenolates
    • C08K5/134—Phenols containing ester groups
    • C08K5/1345—Carboxylic esters of phenolcarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • C—CHEMISTRY; METALLURGY
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    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/20—Compounding polymers with additives, e.g. colouring
    • C08J3/22—Compounding polymers with additives, e.g. colouring using masterbatch techniques
    • C08J3/223—Packed additives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
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    • C08K3/22—Oxides; Hydroxides of metals
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    • C08K5/005—Stabilisers against oxidation, heat, light, ozone
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    • C08K5/101—Esters; Ether-esters of monocarboxylic acids
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    • C08K5/34—Heterocyclic compounds having nitrogen in the ring
    • C08K5/3412—Heterocyclic compounds having nitrogen in the ring having one nitrogen atom in the ring
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    • C08K5/3435—Piperidines
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    • C08K5/34—Heterocyclic compounds having nitrogen in the ring
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    • C08K5/3492—Triazines
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    • C08K5/00—Use of organic ingredients
    • C08K5/49—Phosphorus-containing compounds
    • C08K5/51—Phosphorus bound to oxygen
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    • C08K5/51—Phosphorus bound to oxygen
    • C08K5/52—Phosphorus bound to oxygen only
    • C08K5/524—Esters of phosphorous acids, e.g. of H3PO3
    • C08K5/526—Esters of phosphorous acids, e.g. of H3PO3 with hydroxyaryl compounds
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    • C08L25/00—Compositions of, homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Compositions of derivatives of such polymers
    • C08L25/02—Homopolymers or copolymers of hydrocarbons
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    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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    • C08K5/34—Heterocyclic compounds having nitrogen in the ring
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    • C08K5/3472—Five-membered rings
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  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
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Abstract

La invención se refiere a un proceso para elaborar un comprimido, que comprende las etapas de (A) colocar un material de inicio, que está en una forma sólida, en una primera cavidad abierta, formada por un primer punzón y una matriz, para obtener una segunda cavidad abierta, que se llena al menos de manera parcial con el material de inicio, (B) cerrar la segunda cavidad abierta con un segundo punzón para obtener una primera cavidad cerrada, (C) comprimir el material de inicio a una temperatura de compresión menor de 37°C al mover al menos uno del primer punzón y el segundo punzón para obtener una segunda cavidad cerrada, que tiene un volumen menor que la primera cavidad cerrada, lo que da como resultado la formación de un comprimido atrapado del material de inicio en la segunda cavidad cerrada, (D) retirar el comprimido atrapado para obtener el comprimido, que tiene una temperatura de comprimido menor de 37°C directamente luego de su retiro, en donde el material de inicio es sólido a 37°C y 101.32 KPa y consiste en (i) 60 a 100% en peso de un primer estabilizador de polímero seleccionado de una lista de varios miembros, (ii) 0 a 40% en peso de un segundo estabilizador de polímero, que es estearato de Zn, Ca o Mg, (iii) 0 a 34% en peso de un tercer estabilizador de polímero, que es óxido de zinc, hidrotalcita o benzoato de sodio, (iv) 0 a 20% en peso de un ingrediente adicional, que es diferente al primer estabilizador de polímero, el segundo estabilizador de polímero y el tercer estabilizador de polímero, en donde la suma de los componentes (i), (ii), (iii) y (iv) es 100% en peso, y el comprimido tiene un peso mayor de 20 mg y menor de 330 mg y una dimensión de la sección transversal mayor de 3 mm y menor de 18 mm. Además, se divulga un método para estabilizar un polímero, que es una poliolefina, un poliestireno o una mezcla de estos, que comprende la dosificación del comprimido al polímero. El comprimido es útil para un manejo libre de polvillo de sus componentes en la elaboración del polímero estabilizado.
MX2022000410A 2019-07-09 2020-07-06 Formacion de comprimidos de estabilizadores de polimeros especificos. MX2022000410A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19185298 2019-07-09
PCT/EP2020/069016 WO2021005011A1 (en) 2019-07-09 2020-07-06 Tableting of specific polymer stabilizers

Publications (1)

Publication Number Publication Date
MX2022000410A true MX2022000410A (es) 2022-02-10

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MX2022000410A MX2022000410A (es) 2019-07-09 2020-07-06 Formacion de comprimidos de estabilizadores de polimeros especificos.

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US (1) US20220249383A1 (es)
EP (1) EP3996690B1 (es)
JP (1) JP2022539815A (es)
KR (1) KR20220034817A (es)
CN (1) CN114080420B (es)
AU (1) AU2020312165A1 (es)
BR (1) BR112021024128B1 (es)
CA (1) CA3146198A1 (es)
MX (1) MX2022000410A (es)
TW (1) TWI859268B (es)
WO (1) WO2021005011A1 (es)

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WO2024194289A1 (en) * 2023-03-21 2024-09-26 Ineos Styrolution Group Gmbh Process for the preparation of a thermoplastic molding composition with good color stability

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CA3146198A1 (en) 2021-01-14
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