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MX2021010536A - Uso de microparticulas y celulas endoteliales con organos y tejidos descelularizados. - Google Patents

Uso de microparticulas y celulas endoteliales con organos y tejidos descelularizados.

Info

Publication number
MX2021010536A
MX2021010536A MX2021010536A MX2021010536A MX2021010536A MX 2021010536 A MX2021010536 A MX 2021010536A MX 2021010536 A MX2021010536 A MX 2021010536A MX 2021010536 A MX2021010536 A MX 2021010536A MX 2021010536 A MX2021010536 A MX 2021010536A
Authority
MX
Mexico
Prior art keywords
microparticles
endothelial cells
tissues
lumen diameter
decellularized
Prior art date
Application number
MX2021010536A
Other languages
English (en)
Inventor
Jeffrey Ross
Dominique Seetapun
Original Assignee
Miromatrix Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miromatrix Medical Inc filed Critical Miromatrix Medical Inc
Publication of MX2021010536A publication Critical patent/MX2021010536A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La invención proporciona un método para mantener el diámetro del lumen capilar, reducir una disminución en el diámetro del lumen del vaso capilar o expandir el diámetro del lumen del vaso capilar en un injerto de órgano o tejido re-endotelializado descelularizado con una red vascular de matriz extracelular intacta. El método se basa en la administración de células endoteliales y macropartículas a la ECM descelularizadas.
MX2021010536A 2013-03-15 2015-09-15 Uso de microparticulas y celulas endoteliales con organos y tejidos descelularizados. MX2021010536A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361790118P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
MX2021010536A true MX2021010536A (es) 2021-10-01

Family

ID=50736149

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015013152A MX2015013152A (es) 2013-03-15 2014-03-13 Uso de microparticulas y celulas endoteliales con organos y tejidos descelularizados.
MX2021010536A MX2021010536A (es) 2013-03-15 2015-09-15 Uso de microparticulas y celulas endoteliales con organos y tejidos descelularizados.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2015013152A MX2015013152A (es) 2013-03-15 2014-03-13 Uso de microparticulas y celulas endoteliales con organos y tejidos descelularizados.

Country Status (12)

Country Link
US (1) US20160030637A1 (es)
EP (1) EP2968672B1 (es)
JP (1) JP6491187B2 (es)
KR (2) KR102417995B1 (es)
CN (1) CN105188786B (es)
AU (1) AU2014251336B2 (es)
BR (1) BR112015023641A2 (es)
CA (1) CA2907144C (es)
HK (1) HK1218888A1 (es)
MX (2) MX2015013152A (es)
SG (1) SG11201507673WA (es)
WO (1) WO2014168719A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE552007T1 (de) 2005-08-26 2012-04-15 Univ Minnesota Dezellularisierung und rezellularisierung von organen und geweben
EP2611472B1 (en) 2010-09-01 2016-02-10 Regents of the University of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
KR20240104179A (ko) 2013-03-15 2024-07-04 미로매트릭스 메디칼 인크. 섬 세포 재세포화를 위한 관류 탈세포화된 간의 용도
EP3265104A4 (en) * 2015-03-03 2018-11-07 President and Fellows of Harvard College Methods of generating functional human tissue
US10731135B2 (en) 2015-09-11 2020-08-04 The General Hospital Corporation Regeneration of a functional pulmonary vascular bed
ES2953657T3 (es) * 2016-02-12 2023-11-15 Univ Ottawa Estructuras de pared celular descelularizadas de plantas y hongos y su utilización como materiales de andamiaje
EP3509651B1 (en) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Use of resected liver serum for whole liver engineering
CN108295311A (zh) * 2018-03-07 2018-07-20 南京市第医院 一种温敏型肾脏细胞外基质水凝胶的制备方法
CN110343659A (zh) * 2018-04-08 2019-10-18 生物角（厦门）科技有限公司 一种间充质干细胞完全培养基组合物
GB201807788D0 (en) * 2018-05-14 2018-06-27 Ucl Business Plc Method
WO2019236622A1 (en) * 2018-06-04 2019-12-12 Miromatrix Medical Inc. Methods of liver recellularization
CN110732041A (zh) * 2019-10-12 2020-01-31 广东省人民医院(广东省医学科学院) 一种脱细胞小口径血管支架及其制备方法
CN111518755A (zh) * 2020-05-09 2020-08-11 苏州大学 一种仿生骨膜、骨膜-骨替代物及制备方法
CN218059021U (zh) * 2022-09-22 2022-12-16 舩本诚一 一种医用材料处理用高压设备

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101366978B (zh) * 2008-09-03 2013-06-05 陕西瑞盛生物科技有限公司 可注射用的微粒组织充填材料及其制备方法
WO2012005760A1 (en) 2010-06-30 2012-01-12 Miromatrix Medical Inc. Use of perfusion decellularized organs for matched recellularization
CN102477172B (zh) * 2010-11-29 2016-01-13 吴忠仕 壳聚糖-肝素纳米颗粒以及用该纳米颗粒处理的去细胞基质的生物材料

Also Published As

Publication number Publication date
KR102417995B1 (ko) 2022-07-06
CA2907144A1 (en) 2014-10-16
AU2014251336B2 (en) 2017-03-16
KR20160026840A (ko) 2016-03-09
EP2968672A1 (en) 2016-01-20
KR20210095722A (ko) 2021-08-02
AU2014251336A1 (en) 2015-10-29
WO2014168719A1 (en) 2014-10-16
CN105188786A (zh) 2015-12-23
SG11201507673WA (en) 2015-10-29
MX2015013152A (es) 2016-06-21
KR102282769B1 (ko) 2021-07-29
CN105188786B (zh) 2017-12-26
BR112015023641A2 (pt) 2017-07-18
HK1218888A1 (zh) 2017-03-17
CA2907144C (en) 2022-10-11
WO2014168719A8 (en) 2015-04-23
JP6491187B2 (ja) 2019-03-27
EP2968672B1 (en) 2019-02-06
JP2016513654A (ja) 2016-05-16
US20160030637A1 (en) 2016-02-04

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