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MX2021008592A - Composiciones de trem y usos de las mismas. - Google Patents

Composiciones de trem y usos de las mismas.

Info

Publication number
MX2021008592A
MX2021008592A MX2021008592A MX2021008592A MX2021008592A MX 2021008592 A MX2021008592 A MX 2021008592A MX 2021008592 A MX2021008592 A MX 2021008592A MX 2021008592 A MX2021008592 A MX 2021008592A MX 2021008592 A MX2021008592 A MX 2021008592A
Authority
MX
Mexico
Prior art keywords
trem
compositions
trna
relates generally
effector molecules
Prior art date
Application number
MX2021008592A
Other languages
English (en)
Inventor
David Arthur Berry
Theonie Anastassiadis
Noubar Boghos Afeyan
Christine Elizabeth Hajdin
Original Assignee
Flagship Pioneering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flagship Pioneering Inc filed Critical Flagship Pioneering Inc
Publication of MX2021008592A publication Critical patent/MX2021008592A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/50—Biochemical production, i.e. in a transformed host cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

En general, la invención se refiere a moléculas efectoras basadas en ARNt y métodos relacionados con las mismas.
MX2021008592A 2019-01-18 2020-01-17 Composiciones de trem y usos de las mismas. MX2021008592A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962794342P 2019-01-18 2019-01-18
US201962855547P 2019-05-31 2019-05-31
PCT/US2020/014092 WO2020150608A1 (en) 2019-01-18 2020-01-17 Trem compositions and uses thereof

Publications (1)

Publication Number Publication Date
MX2021008592A true MX2021008592A (es) 2021-12-15

Family

ID=69591755

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021008592A MX2021008592A (es) 2019-01-18 2020-01-17 Composiciones de trem y usos de las mismas.

Country Status (12)

Country Link
US (1) US20220112489A1 (es)
EP (1) EP3911745A1 (es)
JP (1) JP2022517275A (es)
KR (1) KR20210151049A (es)
CN (1) CN113795580A (es)
AU (1) AU2020209941A1 (es)
BR (1) BR112021013934A2 (es)
CA (1) CA3125567A1 (es)
IL (1) IL284878A (es)
MX (1) MX2021008592A (es)
SG (1) SG11202107206RA (es)
WO (1) WO2020150608A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022534988A (ja) * 2019-05-31 2022-08-04 フラッグシップ パイオニアリング， インコーポレイテッド ｔＲＮＡプールを調節するためのＴＲＥＭの使用
JP2023500116A (ja) * 2019-11-04 2023-01-04 フラッグシップ パイオニアリング， インコーポレイテッド ｃｏｎ－希少コドンのためのＴＲＥＭ組成物及び関連する使用
WO2021113218A1 (en) * 2019-12-02 2021-06-10 Shape Therapeutics Inc. Targeted transfer rnas for treatment of diseases
MX2022012955A (es) * 2020-04-14 2023-02-23 Flagship Pioneering Innovations Vi Llc Composiciones de trem y usos de las mismas.
US20230203509A1 (en) * 2020-05-29 2023-06-29 Flagship Pioneering Innovations Vi, Llc Trem compositions and methods relating thereto
CA3180101A1 (en) * 2020-05-29 2021-12-02 Flagship Pioneering Innovations Vi, Llc Trem compositions and methods relating thereto
US20240318173A1 (en) * 2020-12-31 2024-09-26 University Of Iowa Research Foundation Sense,suppressor transfer rna compositions and related uses and functions
EP4377457A1 (en) * 2021-07-26 2024-06-05 Flagship Pioneering Innovations VI, LLC Trem compositions and uses thereof
AU2023255614A1 (en) 2022-04-18 2024-10-24 Vertex Pharmaceuticals Incorporated Compositions and methods for enhancing aav therapy and decreasing tropism of aav to the liver.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801030A (en) 1995-09-01 1998-09-01 Genvec, Inc. Methods and vectors for site-specific recombination
US6693086B1 (en) 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
CN101091798A (zh) * 2007-04-17 2007-12-26 华东师范大学 反义miRNA－210的用途
US20120077224A1 (en) * 2009-06-05 2012-03-29 The Salk Institute For Biological Studies unnatural amino acid incorporation in eukaryotic cells
WO2012006551A2 (en) * 2010-07-08 2012-01-12 The Brigham And Women's Hospital, Inc. Neuroprotective molecules and methods of treating neurological disorders and inducing stress granules
JP6702866B2 (ja) 2013-11-18 2020-06-03 ルビウス セラピューティクス， インコーポレイテッド 合成膜−レシーバー複合体
RU2020136119A (ru) 2014-04-01 2021-05-17 Рубиус Терапьютикс, Инк. Способы и композиции для иммуномодуляции
WO2016115632A1 (en) * 2015-01-21 2016-07-28 Exerkine Corporation Method for treating mitochondrial disease
CA2881746A1 (en) * 2015-02-13 2016-08-13 Stealth Peptides International, Inc. Therapeutic compositions including mitochondrial fission inhibitor peptides, variants thereof, and methods of using the same to treat and prevent mitochondrial diseases and conditions
US20180135012A1 (en) 2015-05-13 2018-05-17 Rubius Therapeutics, Inc. Membrane-receiver complex therapeutics
CA3010510A1 (en) 2016-01-11 2017-07-20 Rubius Therapeutics, Inc. Compositions and methods related to multimodal therapeutic cell systems for immune indications
GB201600512D0 (en) * 2016-01-12 2016-02-24 Univ York Recombinant protein production
CA3029906A1 (en) 2016-07-07 2018-01-11 Rubius Therapeutics, Inc. Compositions and methods related to therapeutic cell systems expressing exogenous rna
CN110225756A (zh) 2016-12-02 2019-09-10 鲁比厄斯治疗法股份有限公司 与用于穿透实体瘤的细胞系统相关的组合物和方法
AU2018221227A1 (en) 2017-02-17 2019-08-15 Rubius Therapeutics, Inc. Functionalized erythroid cells
CN110869507A (zh) 2017-05-08 2020-03-06 旗舰先锋创新V股份有限公司 促进膜融合的组合物和其用途

Also Published As

Publication number Publication date
EP3911745A1 (en) 2021-11-24
SG11202107206RA (en) 2021-08-30
AU2020209941A1 (en) 2021-07-22
BR112021013934A2 (pt) 2021-09-21
KR20210151049A (ko) 2021-12-13
US20220112489A1 (en) 2022-04-14
JP2022517275A (ja) 2022-03-07
IL284878A (en) 2021-08-31
WO2020150608A1 (en) 2020-07-23
CA3125567A1 (en) 2020-07-23
CN113795580A (zh) 2021-12-14

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