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MX2020007479A - Profármacos de ketamina, composiciones y usos de los mismos. - Google Patents

Profármacos de ketamina, composiciones y usos de los mismos.

Info

Publication number
MX2020007479A
MX2020007479A MX2020007479A MX2020007479A MX2020007479A MX 2020007479 A MX2020007479 A MX 2020007479A MX 2020007479 A MX2020007479 A MX 2020007479A MX 2020007479 A MX2020007479 A MX 2020007479A MX 2020007479 A MX2020007479 A MX 2020007479A
Authority
MX
Mexico
Prior art keywords
ketamine
prodrugs
compositions
isotopically labeled
compounds
Prior art date
Application number
MX2020007479A
Other languages
English (en)
Inventor
Jia - Ning XIANG
Xuesong Xu
Wai-Si Eng
Hao-Wei Shih
Original Assignee
Xwpharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xwpharma Ltd filed Critical Xwpharma Ltd
Publication of MX2020007479A publication Critical patent/MX2020007479A/es

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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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Abstract

La presente invención se refiere a profármacos de (S)- o (R)-ketamina, que incluyen ketamina isotópicamente etiquetada, composiciones y usos de los mismos. Los compuestos que tienen la Fórmula (Ia) o (Ib) como los profármacos de (S)- o (R)-ketamina, que incluyen ketamina isotópicamente etiquetada, y composiciones farmacéuticas que comprenden los compuestos proporcionados en la presente su usan para tratar o prevenir una enfermedad del SNC. Más particularmente, las enfermedades relacionadas incluyen depresión y dolor. (ver formula).
MX2020007479A 2018-01-10 2019-01-08 Profármacos de ketamina, composiciones y usos de los mismos. MX2020007479A (es)

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