[go: up one dir, main page]

MX2020005857A - Formulaciones de composiciones de vacuna contra el virus del dengue. - Google Patents

Formulaciones de composiciones de vacuna contra el virus del dengue.

Info

Publication number
MX2020005857A
MX2020005857A MX2020005857A MX2020005857A MX2020005857A MX 2020005857 A MX2020005857 A MX 2020005857A MX 2020005857 A MX2020005857 A MX 2020005857A MX 2020005857 A MX2020005857 A MX 2020005857A MX 2020005857 A MX2020005857 A MX 2020005857A
Authority
MX
Mexico
Prior art keywords
dengue virus
formulations
virus vaccine
live attenuated
vaccine compositions
Prior art date
Application number
MX2020005857A
Other languages
English (en)
Inventor
Lynne Ann Isopi
Jeffrey Thomas Blue
Heidi Joanne Pixley
Erin J Green-Trexler
Michael S Ryan
Sherrie-Ann P Martin
Morrisa Jones
Justin Stanbro
Akhilesh Bhambhani
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2020005857A publication Critical patent/MX2020005857A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a formulaciones de vacuna contra el virus del dengue que comprenden al menos un virus del dengue vivo atenuado o flavivirus quimérico vivo atenuado, un amortiguador, un azúcar, un derivado de celulosa, un glicol o alcohol de azúcar, opcionalmente un álcali o sal alcalina y un aminoácido; y formulaciones de vacuna contra el virus del dengue que comprenden al menos un virus del dengue vivo atenuado o flavivirus quimérico vivo atenuado, un amortiguador, un azúcar de al menos 150 mg/ml, un portador, y opcionalmente, un álcali o sal alcalina y un aminoácido.
MX2020005857A 2017-12-07 2018-12-03 Formulaciones de composiciones de vacuna contra el virus del dengue. MX2020005857A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762595842P 2017-12-07 2017-12-07
PCT/US2018/063541 WO2019112921A1 (en) 2017-12-07 2018-12-03 Formulations of dengue virus vaccine compositions

Publications (1)

Publication Number Publication Date
MX2020005857A true MX2020005857A (es) 2020-09-09

Family

ID=66750326

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020005857A MX2020005857A (es) 2017-12-07 2018-12-03 Formulaciones de composiciones de vacuna contra el virus del dengue.

Country Status (26)

Country Link
US (3) US20200390877A1 (es)
EP (1) EP3720487A1 (es)
JP (1) JP7042341B2 (es)
KR (1) KR102494651B1 (es)
CN (2) CN111447947B (es)
AU (1) AU2018381213B2 (es)
BR (1) BR112020011205A8 (es)
CA (1) CA3083772A1 (es)
CL (1) CL2020001463A1 (es)
CO (1) CO2020006836A2 (es)
CR (1) CR20200242A (es)
DO (1) DOP2020000098A (es)
EA (1) EA202091398A1 (es)
EC (1) ECSP20032084A (es)
GE (1) GEP20237539B (es)
IL (2) IL274897B2 (es)
JO (1) JOP20200140A1 (es)
MA (1) MA51060A (es)
MX (1) MX2020005857A (es)
NI (1) NI202000039A (es)
PE (1) PE20210654A1 (es)
PH (1) PH12020550734A1 (es)
SG (1) SG11202005251VA (es)
UA (1) UA129245C2 (es)
WO (1) WO2019112921A1 (es)
ZA (1) ZA202407615B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7042341B2 (ja) 2017-12-07 2022-03-25 メルク・シャープ・アンド・ドーム・コーポレーション デングウイルスワクチン組成物の製剤
WO2022094816A1 (en) * 2020-11-04 2022-05-12 Janssen Pharmaceuticals, Inc. Solid formulation
CN118215488A (zh) * 2021-10-20 2024-06-18 舒万诺知识产权公司 含有磷酸盐和精氨酸的组合物以及此类组合物用于毒力抑制的递送
WO2024073362A2 (en) * 2022-09-29 2024-04-04 Board Of Regents, The University Of Texas System Methods and compositions for transport, storage, and delivery of nucleic acids and other molecules
CN120152737A (zh) 2022-10-18 2025-06-13 武田疫苗股份有限公司 登革热疫苗制剂
WO2024236132A1 (en) * 2023-05-17 2024-11-21 Boehringer Ingelheim International Gmbh Formulations to stabilize virus-based therapeutics
WO2024236136A1 (en) * 2023-05-17 2024-11-21 Boehringer Ingelheim International Gmbh Formulations to stabilize virus-based therapeutics
WO2025027616A1 (en) * 2023-08-01 2025-02-06 Serum Institute Of India Private Limited Freeze-dried viral vaccine compositions and method of manufacturing thereof
WO2025132735A1 (en) * 2023-12-20 2025-06-26 Intervet International B.V. A freeze-dried composition containing live attenuated pathogens, a process for preparing a freeze-dried composition, a vaccine, and a method of vaccinating a host animal
CN118853589B (zh) * 2024-07-03 2025-04-01 中国科学院武汉病毒研究所 一种黄热病毒疫苗株3’utr缺失突变体的拯救及在制备减毒活疫苗中的应用

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69233566T2 (de) 1991-09-19 2006-08-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimäre und/oder wachstumsgehemmte Flaviviren
FR2702660B1 (fr) * 1993-03-17 1995-05-24 Karl Simpson Compositions thérapeutiques stabilisées et leur procédé de préparation.
US6190859B1 (en) 1995-04-17 2001-02-20 The United States Of America As Represented By The Secretary Of The Army Method and kit for detection of dengue virus
US6254873B1 (en) 1995-04-17 2001-07-03 The United States Of America As Represented By The Secretary Of The Army Inactivated dengue virus vaccine
US6432411B1 (en) 1999-07-13 2002-08-13 Hawaii Biotechnology Group Recombinant envelope vaccine against flavivirus infection
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
CA3060687C (en) 2001-05-22 2021-05-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses
NZ535690A (en) * 2002-02-26 2009-04-30 Maxygen Inc Novel flavivirus antigens
US20040022760A1 (en) * 2002-03-26 2004-02-05 McKenna Hilary J. Methods of using Flt3-ligand in immunization protocols
BRPI0309631B1 (pt) 2002-05-03 2021-07-20 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Composição imunogênica tetravalente compreendendo vírus atenuado contra dengue e vacina tetravalente compreendendo a dita composição
US20050123550A1 (en) 2003-05-12 2005-06-09 Laurent Philippe E. Molecules enhancing dermal delivery of influenza vaccines
JP2008526870A (ja) 2005-01-05 2008-07-24 フイラデルフイア・ヘルス・アンド・エデユケーシヨン・コーポレーシヨン 送達ビヒクル、生体作用活性物質およびウイルスワクチン
AU2006261943B2 (en) 2005-06-24 2010-12-02 Intervet International B.V. Inactivated chimeric vaccines and related methods of use
CN101296705A (zh) * 2005-10-04 2008-10-29 阿尔克-阿贝洛有限公司 固体疫苗制剂
RU2008117396A (ru) 2005-10-04 2009-11-10 Альк-Абелло А/С (Dk) Твердая вакцинная композиция
CA3004991C (en) 2006-08-15 2022-08-30 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Development of dengue virus vaccine components
US20080275030A1 (en) * 2007-01-19 2008-11-06 Sveinbjorn Gizurarson Methods and Compositions for the Delivery of a Therapeutic Agent
DK2144998T3 (en) * 2007-04-06 2017-04-10 Takeda Vaccines Inc Methods and compositions for live attenuated viruses
EP2143440A1 (fr) * 2008-07-09 2010-01-13 Sanofi Pasteur Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués
JP5548207B2 (ja) * 2008-09-24 2014-07-16 メディミューン，エルエルシー ウイルスの精製方法
US10369204B2 (en) 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
RU2012140691A (ru) 2009-03-13 2014-03-27 Лентиген Корпорейшен Вакцины на основе неинтегрирующегося ретровирусного вектора
GB201002419D0 (en) * 2010-02-12 2010-03-31 Isis Innovation Stable live vaccine formulations
JP6018575B2 (ja) 2010-10-29 2016-11-02 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． デングウイルス組換えサブユニットスワクチン
AU2012260807B2 (en) 2011-05-26 2016-05-12 Glaxosmithkline Biologicals Sa Inactivated Dengue virus vaccine
WO2013119856A1 (en) * 2012-02-07 2013-08-15 Infectious Disease Research Institute Improved adjuvant formulations comprising tlr4 agonists and methods of using the same
US9314519B2 (en) * 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
US9974850B2 (en) * 2013-01-25 2018-05-22 Board Of Regents, The University Of Texas System Immunogenic compositions and uses thereof
US9254332B2 (en) * 2013-03-15 2016-02-09 Arecor Limited Stable aqueous formulations of adenovirus vectors
CN105246506A (zh) 2013-06-21 2016-01-13 默沙东公司 登革病毒疫苗组合物及其使用方法
US9782470B2 (en) 2013-10-16 2017-10-10 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
US10588957B2 (en) 2013-10-25 2020-03-17 Leukocare Ag Method for the production of stabile vaccines
EP3085357B1 (en) 2013-12-16 2019-02-13 Takeda Pharmaceutical Company Limited Microneedle
BR112016015422A2 (pt) * 2013-12-31 2017-10-24 Infectious Disease Res Inst formulações de vacina de frasco único
WO2015130157A1 (en) 2014-02-28 2015-09-03 Universiti Malaya Enhancement of dengue virus production
PH12017501165B1 (en) 2014-12-22 2023-02-22 Merck Sharp & Dohme Llc Dengue virus vaccine compositions and methods of use thereof
WO2016192670A1 (en) * 2015-06-04 2016-12-08 The University Of Hong Kong Live-attenuated virus and methods of production and use
US20180296663A1 (en) * 2015-06-17 2018-10-18 Curevac Ag Vaccine composition
US10004795B2 (en) 2015-09-08 2018-06-26 Fundacao Butantan Process for preparing an attenuated tetravalent dengue vaccine
KR20180041761A (ko) * 2015-09-30 2018-04-24 파나세아 바이오테크 리미티드 안정한 약독화된 재조합 뎅기 생백신
WO2017109698A1 (en) 2015-12-22 2017-06-29 Glaxosmithkline Biologicals Sa Immunogenic formulation
JP7155009B2 (ja) 2016-03-25 2022-10-18 ビステラ， インコーポレイテッド デングウイルスに対する抗体分子の製剤
MX2018012459A (es) * 2016-04-13 2019-06-06 Takeda Vaccines Inc Composiciones y metodos de vacunacion contra virus de dengue en niños y adultos jovenes.
TW202309276A (zh) 2016-08-03 2023-03-01 美商武田疫苗股份有限公司 用於與經改良之調配物一起穩定黃病毒的組成物及方法
CA3037337A1 (en) 2016-09-19 2018-03-22 Vaxess Technologies, Inc. Vaccine formulations with increased stability
EP3601544A4 (en) 2017-03-30 2021-01-27 Merck Sharp & Dohme Corp. Addition of nucleases directly to cell culture to facilitate digestion and clearance of host cell nucleic acids
UA127829C2 (uk) 2017-10-16 2024-01-17 Сірем Інстітьют Оф Індіа Прайвет Лімітед Стабільна ліофілізована імуногенна композиція, яка містить живий атенуйований рекомбінантний флавівірус, спосіб і набір для її отримання та застосування
JP7042341B2 (ja) * 2017-12-07 2022-03-25 メルク・シャープ・アンド・ドーム・コーポレーション デングウイルスワクチン組成物の製剤

Also Published As

Publication number Publication date
CN111447947B (zh) 2024-01-12
CN117752780A (zh) 2024-03-26
JOP20200140A1 (ar) 2022-10-30
AU2018381213B2 (en) 2022-03-17
IL316312A (en) 2024-12-01
JP2021505588A (ja) 2021-02-18
KR102494651B1 (ko) 2023-01-31
EA202091398A1 (ru) 2020-09-01
DOP2020000098A (es) 2020-08-31
NI202000039A (es) 2020-09-24
AU2018381213A1 (en) 2020-06-11
BR112020011205A8 (pt) 2023-02-07
WO2019112921A1 (en) 2019-06-13
US20240131144A1 (en) 2024-04-25
CR20200242A (es) 2020-07-17
CL2020001463A1 (es) 2020-09-25
EP3720487A1 (en) 2020-10-14
SG11202005251VA (en) 2020-07-29
IL274897A (en) 2020-07-30
CA3083772A1 (en) 2019-06-13
BR112020011205A2 (pt) 2020-11-17
MA51060A (fr) 2021-03-17
ECSP20032084A (es) 2020-08-31
US11883480B2 (en) 2024-01-30
PH12020550734A1 (en) 2021-04-19
US12208135B2 (en) 2025-01-28
US20200390877A1 (en) 2020-12-17
IL274897B2 (en) 2025-03-01
CN111447947A (zh) 2020-07-24
UA129245C2 (uk) 2025-02-26
US20230061673A1 (en) 2023-03-02
IL274897B1 (en) 2024-11-01
ZA202407615B (en) 2025-04-30
KR20200096272A (ko) 2020-08-11
JP7042341B2 (ja) 2022-03-25
CO2020006836A2 (es) 2020-06-19
PE20210654A1 (es) 2021-03-31
GEP20237539B (en) 2023-09-11

Similar Documents

Publication Publication Date Title
ZA202407615B (en) Formulations of dengue virus vaccine compositions
GEP20227374B (en) Novel, highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis b virus (hbv)
PH12020550478A1 (en) Creamer composition
PH12020550051B1 (en) Glp-1 compositions and uses thereof
EA201991041A1 (ru) Вакцина против свиного парвовируса и вируса свиного репродуктивного и респираторного синдрома и способы ее получения
PH12019550249A1 (en) Solid compositions for oral administration
MX2012003987A (es) Composiciones desinfectantes.
GB201216469D0 (en) Stabilisation of viral particles
MX359999B (es) Vacunas de virus bovino liquidas estables.
PH12021550705A1 (en) Stable semaglutide compositions and uses thereof
ZA201908610B (en) Il-15 protein complex pharmaceutical composition and uses thereof
EA201690859A1 (ru) Предотвращение инфекций, вызываемых staphylococcus aureus, гликопротеиновыми вакцинами, синтезированными в escherichia coli
GB2539148A (en) Vaccine compositions
GEP20237486B (en) Formulations of copanlisib
WO2016038521A8 (en) Pharmaceutical compositions of liraglutide
TW201613557A (en) Stable aqueous recombinant protein formulations
EA201991023A1 (ru) Фармацевтическая композиция для парентерального введения, содержащая карглумовую кислоту
SG10201909051QA (en) Compositions and methods for live, attenuated alphavirus formulations
PH12019501946A1 (en) Liquid composition containing pradofloxacin
MX388528B (es) Vacuna que comprende toxoides de clostridium.
CL2022002207A1 (es) Formulaciones de composiciones de vacuna contra el virus del dengue (divisional de solicitud 202001463).
WO2023092100A3 (en) Methods of administering chimeric vaccines
ZA201907789B (en) Solid compositions for oral administration