[go: up one dir, main page]

MX2020002010A - Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo. - Google Patents

Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.

Info

Publication number
MX2020002010A
MX2020002010A MX2020002010A MX2020002010A MX2020002010A MX 2020002010 A MX2020002010 A MX 2020002010A MX 2020002010 A MX2020002010 A MX 2020002010A MX 2020002010 A MX2020002010 A MX 2020002010A MX 2020002010 A MX2020002010 A MX 2020002010A
Authority
MX
Mexico
Prior art keywords
processes
oxopentanoate
diamino
butyl
preparation
Prior art date
Application number
MX2020002010A
Other languages
English (en)
Inventor
John F Traverse
Weihong Zhang
Maryll E Geherty
Michael J Zacuto
Kirsten Faye Johnson
Christopher Marton
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2020002010A publication Critical patent/MX2020002010A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/70—Compounds containing any of the groups, e.g. isoureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se proporcionan procesos para la preparación de 4,5-diamino-5-oxopentanoato de (S)-terc-butilo, o una sal, un solvato, un hidrato, un enantiómero, una mezcla de enantiómeros, o un isotopólogo de este. También se proporcionan formas sólidas de diversos productos intermedios y productos obtenidos a partir de los procesos.
MX2020002010A 2017-08-21 2018-08-20 Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo. MX2020002010A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762548268P 2017-08-21 2017-08-21
PCT/US2018/000358 WO2019040109A1 (en) 2017-08-21 2018-08-20 PROCESSES FOR THE PREPARATION OF (S) -TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE

Publications (1)

Publication Number Publication Date
MX2020002010A true MX2020002010A (es) 2020-07-13

Family

ID=63794593

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020002010A MX2020002010A (es) 2017-08-21 2018-08-20 Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.

Country Status (8)

Country Link
US (4) US10717703B2 (es)
EP (1) EP3672939A1 (es)
JP (2) JP7399846B2 (es)
CN (2) CN111032628A (es)
AU (1) AU2018321548B2 (es)
CA (1) CA3072735A1 (es)
MX (1) MX2020002010A (es)
WO (1) WO2019040109A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111606837A (zh) * 2020-06-15 2020-09-01 千辉药业（安徽）有限责任公司 一种维格列汀的合成方法
IL309839A (en) * 2021-07-26 2024-02-01 Arvinas Operations Inc Methods for producing a bifunctional compound
CN114478324B (zh) * 2021-12-30 2023-07-07 上海嘉莱多生物技术有限责任公司 一种活性化合物及其在侧链羧基类化合物保护的应用
US20250084056A1 (en) 2023-09-13 2025-03-13 Bristol-Myers Squibb Company Substituted oxoisoindolinyl piperidine-2,6-dione compounds

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989812A (en) 1974-08-09 1976-11-02 Smithkline Instruments, Inc. Folic acid derivatives and use in radio-assay
CH613709A5 (en) 1975-12-10 1979-10-15 Ciba Geigy Ag Process for the preparation of glucosamine derivatives
JPS55111499A (en) 1979-02-21 1980-08-28 Takeda Chem Ind Ltd Glucosamine derivative and its preparation
US4406889A (en) 1980-02-15 1983-09-27 Ciba-Geigy Corporation Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
US4481190A (en) 1982-12-21 1984-11-06 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
JPS611651A (ja) 1984-06-12 1986-01-07 Toyama Chem Co Ltd Ｎ−アシル酸性アミノ酸ジアミド類およびその製造法並びにそれらを含有する抗潰瘍剤
US4690916A (en) 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
US5556982A (en) 1985-01-14 1996-09-17 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4897255A (en) 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5175343A (en) 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
HUT46044A (en) 1986-11-21 1988-09-28 Richter Gedeon Vegyeszet Process for producing immunstimulant peptides inhibiting multiplication of leukaemic cells and pharmaceutics comprising same
US4988496A (en) 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
IN173794B (es) 1988-12-15 1994-07-16 Council Of Scient & Ind Res Ra
US5270302A (en) 1988-12-21 1993-12-14 Abbott Laboratories Derivatives of tetrapeptides as CCK agonists
HU205147B (en) 1989-06-29 1992-03-30 Sandoz Ag Process for producing muramyl dipeptide derivative and pharmaceutical compostions comprising same
IN177680B (es) 1990-05-08 1997-02-15 Council Scient Ind Res
US5312831A (en) 1993-05-12 1994-05-17 American Cyanamid Company Urethanes and ureas that induce cytokine production
GB9326518D0 (en) 1993-12-29 1994-03-02 Sandoz Ltd Organic compounds
GB9408936D0 (en) 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
DE19505932B4 (de) * 1995-02-21 2005-06-23 Degussa Ag Verfahren zur Herstellung von Oxazolidinonen, neue Oxazolidinone sowie Verwendung von Oxazolidinonen
US5710129A (en) 1995-02-23 1998-01-20 Ariad Pharmaceuticals, Inc. Inhibitors of SH2-mediated processes
US5635504A (en) 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
IN184769B (es) 1995-07-20 2000-09-30 Council Scient Ind Res
JPH09165370A (ja) 1995-10-13 1997-06-24 Fuji Yakuhin Kogyo Kk ラクタム誘導体およびその塩
GB9524267D0 (en) 1995-11-28 1996-01-31 Isis Innovation Enzyme inhibitor and method
AU2277597A (en) 1996-02-23 1997-09-10 Ariad Pharmaceuticals, Inc. New inhibitors of sh2-mediated processes
US6117896A (en) 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
US6153596A (en) 1996-12-18 2000-11-28 Emory University Polycationic oligomers
EP1103560B1 (en) 1998-07-28 2006-12-27 Santen Pharmaceutical Co., Ltd. Novel thiazolidine derivatives
JP2000219663A (ja) 1998-11-24 2000-08-08 Taiho Yakuhin Kogyo Kk Ｎδ−置換アミノオルニチン誘導体及びその塩
WO2001079268A2 (en) 2000-04-18 2001-10-25 Eli Lilly And Company A glycopeptide and preparation thereof
CA2406952A1 (en) 2000-04-18 2001-10-25 Eli Lilly And Company Process for preparing lipid ii
US7662960B2 (en) 2001-04-26 2010-02-16 Choongwae Pharma Corporation Beta-strand mimetics and method relating thereto
AU2002950136A0 (en) 2002-07-11 2002-09-12 La Trobe University N-methyl amino acids
CN100506189C (zh) 2002-08-22 2009-07-01 维克多姆人体机械公司 用于膝上截肢患者的动力假腿
CN100522995C (zh) 2003-10-22 2009-08-05 中国医学科学院药物研究所 胞壁酰-丙氨酰-d-异谷氨酰胺衍生物、制法和其药物组合物与用途
US20050187138A1 (en) 2004-02-24 2005-08-25 The Regents Of The University Of California, A California Corporation Peptide beta-strand mimics based on pyridinones, pyrazinones, pyridazinones, and triazinones
WO2005100334A1 (en) 2004-04-14 2005-10-27 Pfizer Products Inc. Dipeptidyl peptidase-iv inhibitors
US7405237B2 (en) 2004-07-28 2008-07-29 Celgene Corporation Isoindoline compounds and methods of their use
DE102005014245A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
PE20070505A1 (es) 2005-07-11 2007-05-15 Wyeth Corp Inhibidores de glutamato de metaloproteinasas de matriz y agrecanasas
CN1943341B (zh) 2006-08-04 2012-05-09 华南农业大学 氨基酸与农药的藕合物及其制备方法与作为农药的应用
ZA200901950B (en) 2006-09-26 2010-06-30 Celgene Corp 5-substituted quinazolinone derivatives as antitumor agents
WO2008156701A2 (en) 2007-06-13 2008-12-24 The Brigham And Women's Hospital, Inc. Hydroxamate inhibitors of insulin-degrading enzyme and uses thereof
WO2009078040A2 (en) 2007-12-17 2009-06-25 Debatosh Datta Compounds inducing reperfusion in ischaemic tissues
US20100280120A1 (en) 2007-12-17 2010-11-04 Green Cross Therapeutics Private Limited Compound inducing angiogenesis response in ischaemic tissues
CZ305066B6 (cs) * 2008-02-25 2015-04-22 Zentiva, K.S. Způsob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu
WO2009131643A1 (en) 2008-04-21 2009-10-29 Monabio, Inc. Immunoassay for specific determination of s-adenosymethionine and analogs thereof in biological samples
UY31923A (es) 2008-06-23 2010-01-29 Astrazeneca Ab Nuevos heterociclos para su uso como inhibidores de trombina
US8168756B2 (en) 2008-10-24 2012-05-01 Ark Diagnostics, Inc. Levetiracetam immunoassays
KR101532760B1 (ko) 2008-12-09 2015-06-30 샌즈 이노베이션즈 프러프라이어터리 리미티드 분배 용기
LT2536706T (lt) 2010-02-11 2017-10-25 Celgene Corporation Arilmetoksiizoindolino dariniai ir juos apimančios kompozicijos bei jų panaudojimo būdai
GB201007286D0 (en) * 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
CN102219834A (zh) 2011-04-14 2011-10-19 北京市丰硕维康技术开发有限责任公司 一种制备罗莫肽的方法
TWI547496B (zh) * 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物
IN2015DN00845A (es) 2012-08-09 2015-06-12 Celgene Corp
WO2014116573A1 (en) 2013-01-22 2014-07-31 Celgene Corporation Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof
US10189805B2 (en) 2014-09-09 2019-01-29 Vanderbilt University Metabolism probes for therapy and diagnosis
DK3643709T3 (da) * 2014-10-30 2021-12-20 Kangpu Biopharmaceuticals Inc Isoindolinderivat, mellemprodukt, fremgangsmåde til fremstilling, farmaceutisk sammensætning og anvendelse deraf
CN104826544B (zh) 2015-04-02 2016-09-28 中国石油大学(华东) 含有偶氮苯光敏基团的脂肽分子表面活性剂及其合成方法

Also Published As

Publication number Publication date
EP3672939A1 (en) 2020-07-01
JP7399846B2 (ja) 2023-12-18
CA3072735A1 (en) 2019-02-28
WO2019040109A1 (en) 2019-02-28
US20240246899A1 (en) 2024-07-25
CN118638025A (zh) 2024-09-13
US11912644B2 (en) 2024-02-27
AU2018321548B2 (en) 2023-03-09
US11505522B2 (en) 2022-11-22
JP2020531500A (ja) 2020-11-05
US20190084924A1 (en) 2019-03-21
US20200299228A1 (en) 2020-09-24
US10717703B2 (en) 2020-07-21
US20230234914A1 (en) 2023-07-27
AU2018321548A1 (en) 2020-03-05
CN111032628A (zh) 2020-04-17
JP2024037802A (ja) 2024-03-19

Similar Documents

Publication Publication Date Title
USD785228S1 (en) Luminaire
USD768326S1 (en) Luminaire
USD773712S1 (en) Linear light fixture and block-out structure
CL2022000698A1 (es) Compuestos de anillo fusionado. (divisional de solicitud 202101171)
USD768327S1 (en) Luminaire
USD785227S1 (en) Luminaire
EP3459925A4 (en) PROCESS FOR THE PREPARATION OF 2-HYDROXYL-4- (BENZYLOXY 2,3-DISUBSTITUTED) -5-SUBSTITUTED BENZALDEHYDE DERIVATIVE
USD768903S1 (en) Luminaire
CO2022002637A2 (es) Proceso de fabricación de moduladores de cftr
MX2020002010A (es) Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo.
CO2017000064A2 (es) Compuestos de [1,2,4]triazol sustituido
DK3497081T3 (da) Fremgangsmåde til fremstilling af 4-ammonium-2,2,6,6-tetraalkylpiperidinylsalte
WO2018029711A3 (en) Process for the preparation of venetoclax
EP3725782A4 (en) NEW PROCESS FOR THE PRODUCTION OF 4,5-DIHYDROISOXAZOLE 5,5-DISUBSTITUTED
ES2837136R1 (es) Proceso para la preparación de 3alfa-hidroxi-5alfa-pregnan-20-ona (Brexanolona)
EP3582773A4 (en) PROCESSES FOR THE PREPARATION OF AG-10, ITS INTERMEDIARIES AND CORRESPONDING SALTS
CL2019000050A1 (es) Procesos para la preparacion de oxipicolinamidas 4 - alkoxi - (acil o aquil).
CL2019001804A1 (es) Activador de nrf2.
DK3397621T3 (da) Fremgangsmåde til fremstilling af 1,1,3-trioxo-1,2-benzothiazol-6-carboxamid
EP3546439A4 (en) Method for producing (z)-1-chloro-2,3,3-trifluoro-1-propene
CL2016001745A1 (es) Ácido (s)-3'-metil-abscísico y ésteres del mismo
GB202101302D0 (en) Method of generating 3,5- Dihydroxy -4-Methoxybenzyl alcohol from plankton
WO2016042171A3 (en) A xanthene compound, and a colorant comprising the same
DK3592723T3 (da) Fremgangsmåde til fremstilling af 3,3,3-trifluorprop-1-en
IL284159A (en) Synthesis of 3-methyl-4,2,1-thiadiazole-5-carboxyhydrazide or derivatives of its form deuterium methyl-d3