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MX2019014861A - Compuestos de quinolinilciclohexilpropanamida sustituidos y metodos mejorados para su preparacion. - Google Patents

Compuestos de quinolinilciclohexilpropanamida sustituidos y metodos mejorados para su preparacion.

Info

Publication number
MX2019014861A
MX2019014861A MX2019014861A MX2019014861A MX2019014861A MX 2019014861 A MX2019014861 A MX 2019014861A MX 2019014861 A MX2019014861 A MX 2019014861A MX 2019014861 A MX2019014861 A MX 2019014861A MX 2019014861 A MX2019014861 A MX 2019014861A
Authority
MX
Mexico
Prior art keywords
compounds
cyclohexylpropanamide
quinolinyl
substitute
preparation
Prior art date
Application number
MX2019014861A
Other languages
English (en)
Other versions
MX383313B (es
Inventor
M Cohen Benjamin
Plake Beck Hilary
J Delmonte Albert
Osipov Maksim
Patrick Powers Jay
Ross Walker James
Zibinsky Mikhail
Paul Shunatona Hunter
Kay Reilly Maureen
Scott Young Ian
Joseph Fraunhoffer Kenneth
Kolotuchin Sergei
Gonzalez-Bobes Francisco
Louis Beutner Gregory
Joseph Freitag Adam
Scott Bultman Michael
Fan Yu
Maity Prantik
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2019014861A publication Critical patent/MX2019014861A/es
Publication of MX383313B publication Critical patent/MX383313B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)

Abstract

La presente invención se refiere a métodos mejorados para preparar compuestos de quinolinilciclohexilpropanamida sustituidos.
MX2019014861A 2017-06-30 2018-06-29 Compuestos de quinolinilciclohexilpropanamida sustituidos y metodos mejorados para su preparacion MX383313B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762527835P 2017-06-30 2017-06-30
US201762527821P 2017-06-30 2017-06-30
US201862649155P 2018-03-28 2018-03-28
PCT/US2018/040276 WO2019006292A1 (en) 2017-06-30 2018-06-29 SUBSTITUTED QUINOLINYCYCLOHEXYLPROPANAMIDE COMPOUNDS AND IMPROVED PROCESSES FOR THE PREPARATION THEREOF

Publications (2)

Publication Number Publication Date
MX2019014861A true MX2019014861A (es) 2020-02-13
MX383313B MX383313B (es) 2025-03-13

Family

ID=64741905

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019014861A MX383313B (es) 2017-06-30 2018-06-29 Compuestos de quinolinilciclohexilpropanamida sustituidos y metodos mejorados para su preparacion

Country Status (12)

Country Link
US (3) US11236048B2 (es)
EP (1) EP3645008A4 (es)
JP (1) JP7315483B2 (es)
KR (1) KR102669173B1 (es)
CN (1) CN111655264B (es)
AU (1) AU2018291021B2 (es)
BR (1) BR112019027156A2 (es)
CA (1) CA3066260A1 (es)
IL (1) IL271233B (es)
MX (1) MX383313B (es)
SG (1) SG11201911936YA (es)
WO (1) WO2019006292A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX391848B (es) * 2017-06-30 2025-03-19 Bristol Myers Squibb Co Formas amorfas y cristalinas de inhibidores de indolamina 2,3-dioxigenasa (ido)
CN110357813A (zh) * 2018-04-09 2019-10-22 信达生物制药(苏州)有限公司 一种新型吲哚胺2,3-双加氧酶抑制剂及其制备方法和用途
MX2022006134A (es) * 2019-11-26 2022-06-17 Bristol Myers Squibb Co Sales/cocristales de (r)-n-(4-clorofenil)-2-((1s,4s)-4-(6-fluoroqu inolin-4-il)ciclohexil)propanamida.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53149910A (en) * 1977-06-02 1978-12-27 Sagami Chem Res Center Preparation of 1,3-dicarbonyl compound derivatives
JPS6034940B2 (ja) * 1980-11-13 1985-08-12 ダイキン工業株式会社 フルオロマロン酸誘導体およびその製法
US6133472A (en) * 1998-01-20 2000-10-17 Alliedsignal Inc. Fluorinated oxyvinyl compounds and methods of preparing and using same
US20010041700A1 (en) * 1999-07-30 2001-11-15 Younes Bekkali Novel succinate derivative compounds useful as cysteine protease inhibitors
US20040171614A1 (en) 2002-02-06 2004-09-02 Schering-Plough Corporation Novel gamma secretase inhibitors
JP4936048B2 (ja) 2006-07-11 2012-05-23 日東電工株式会社 多官能化合物、光記録材料、光記録媒体、光記録再生装置、光導波路材料、および光配向膜材料
JP4888766B2 (ja) * 2006-07-11 2012-02-29 日東電工株式会社 多官能化合物の製造方法
US8329732B2 (en) 2008-09-02 2012-12-11 Novartis Ag Kinase inhibitors and methods of their use
US9150555B2 (en) * 2010-10-14 2015-10-06 Mitsubishi Tanabe Pharma Corporation Amide derivative and use thereof
SG11201601467SA (en) * 2013-11-01 2016-05-30 Novartis Ag Aminoheteroaryl benzamides as kinase inhibitors
JP6847666B2 (ja) * 2014-05-28 2021-03-24 アジェナス インコーポレイテッド 抗ｇｉｔｒ抗体及びその使用法
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
AR102537A1 (es) 2014-11-05 2017-03-08 Flexus Biosciences Inc Agentes inmunomoduladores
CN109475594A (zh) 2016-07-19 2019-03-15 百时美施贵宝公司 用于成像ido1酶的放射性配体
WO2018039512A1 (en) * 2016-08-26 2018-03-01 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
MX391848B (es) * 2017-06-30 2025-03-19 Bristol Myers Squibb Co Formas amorfas y cristalinas de inhibidores de indolamina 2,3-dioxigenasa (ido)

Also Published As

Publication number Publication date
US11919863B2 (en) 2024-03-05
SG11201911936YA (en) 2020-01-30
JP2020526504A (ja) 2020-08-31
IL271233A (en) 2020-01-30
EP3645008A4 (en) 2020-12-09
WO2019006292A8 (en) 2019-12-26
CN111655264A (zh) 2020-09-11
KR102669173B1 (ko) 2024-05-23
US20200123109A1 (en) 2020-04-23
IL271233B (en) 2022-09-01
JP7315483B2 (ja) 2023-07-26
WO2019006292A1 (en) 2019-01-03
EP3645008A1 (en) 2020-05-06
BR112019027156A2 (pt) 2020-06-30
AU2018291021B2 (en) 2022-07-28
MX383313B (es) 2025-03-13
US20220127233A1 (en) 2022-04-28
CA3066260A1 (en) 2019-01-03
AU2018291021A1 (en) 2020-02-06
KR20200024252A (ko) 2020-03-06
US11236048B2 (en) 2022-02-01
CN111655264B (zh) 2023-08-15
US20220267273A1 (en) 2022-08-25

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