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MX2019010648A - Derivados aminofosfinicos para prevenir y tratar la inflamacion ocular. - Google Patents

Derivados aminofosfinicos para prevenir y tratar la inflamacion ocular.

Info

Publication number
MX2019010648A
MX2019010648A MX2019010648A MX2019010648A MX2019010648A MX 2019010648 A MX2019010648 A MX 2019010648A MX 2019010648 A MX2019010648 A MX 2019010648A MX 2019010648 A MX2019010648 A MX 2019010648A MX 2019010648 A MX2019010648 A MX 2019010648A
Authority
MX
Mexico
Prior art keywords
ocular inflammation
preventing
ocular
treating ocular
compounds
Prior art date
Application number
MX2019010648A
Other languages
English (en)
Inventor
Poras Hervé
Wurm Michel
MELIK PARSADANIANTZ Stéphane
REAUX-LE GOAZIGO Annabelle
Original Assignee
Pharmaleads
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR1751912A external-priority patent/FR3063635B1/fr
Application filed by Pharmaleads filed Critical Pharmaleads
Publication of MX2019010648A publication Critical patent/MX2019010648A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)

Abstract

La invención se refiere a compuestos de fórmula (I): (I) R1-NH-CH(R2)-P(=O)(OH)-CH2-C(R3)(R4)-CONH-C(R5)(R6)-COOR7 en donde R1 a R7 son como se definen en las reivindicaciones, para usarlos en el tratamiento y/o prevención de la inflamación ocular, y más particularmente para mejorar el proceso de curación del ojo; así, los compuestos de la fórmula (I) son principalmente útiles para prevenir la neovascularización, o para prevenir o tratar la inflamación ocular relacionada con queratitis, escleritis, epiescleritis, uveitis, una catarata, una sinequia, un edema macular, un desprendimiento de la retina, una hipertensión ocular y la degeneración del nervio óptico causada por glaucoma.
MX2019010648A 2017-03-09 2018-03-09 Derivados aminofosfinicos para prevenir y tratar la inflamacion ocular. MX2019010648A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1751912A FR3063635B1 (fr) 2017-03-09 2017-03-09 Derives aminophosphiniques pour la prevention et le traitement de l'inflammation oculaire
FR1759005 2017-09-28
PCT/FR2018/050545 WO2018162860A1 (fr) 2017-03-09 2018-03-09 Dérivés aminophosphiniques pour la prévention et le traitement de l'inflammation oculaire

Publications (1)

Publication Number Publication Date
MX2019010648A true MX2019010648A (es) 2019-10-15

Family

ID=61764047

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019010648A MX2019010648A (es) 2017-03-09 2018-03-09 Derivados aminofosfinicos para prevenir y tratar la inflamacion ocular.

Country Status (12)

Country Link
US (1) US11090317B2 (es)
EP (1) EP3592361B1 (es)
JP (2) JP7316938B2 (es)
KR (1) KR102675216B1 (es)
CN (1) CN110352060A (es)
BR (1) BR112019016458A2 (es)
CA (1) CA3055461A1 (es)
IL (1) IL269143B (es)
MX (1) MX2019010648A (es)
TW (1) TWI771386B (es)
WO (1) WO2018162860A1 (es)
ZA (1) ZA201906154B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024113061A1 (en) * 2022-12-02 2024-06-06 Sapieha Przemyslaw Targeting innate immune memory and ap-1 or atf3 for the treatment of ocular diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2755135B1 (fr) 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent
PA8802501A1 (es) * 2007-10-31 2009-06-23 Janssen Pharmaceutica Nv Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno, hidrolasa
FR2934267B1 (fr) 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
FR3044227B1 (fr) * 2015-11-30 2017-11-24 Pharmaleads Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires

Also Published As

Publication number Publication date
IL269143A (en) 2019-11-28
JP2020510025A (ja) 2020-04-02
US20210213036A1 (en) 2021-07-15
KR20190127786A (ko) 2019-11-13
EP3592361C0 (fr) 2023-09-13
WO2018162860A1 (fr) 2018-09-13
TWI771386B (zh) 2022-07-21
JP7316938B2 (ja) 2023-07-28
KR102675216B1 (ko) 2024-06-13
CN110352060A (zh) 2019-10-18
BR112019016458A2 (pt) 2020-04-07
EP3592361A1 (fr) 2020-01-15
IL269143B (en) 2021-12-01
EP3592361B1 (fr) 2023-09-13
CA3055461A1 (fr) 2018-09-13
US11090317B2 (en) 2021-08-17
JP2023067982A (ja) 2023-05-16
ZA201906154B (en) 2021-05-26
TW201840321A (zh) 2018-11-16

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