[go: up one dir, main page]

MX2019009625A - Dispositivo de administracion de farmacos con trayectoria de flujo de fluido esteril y metodo relacionado de ensamblaje. - Google Patents

Dispositivo de administracion de farmacos con trayectoria de flujo de fluido esteril y metodo relacionado de ensamblaje.

Info

Publication number
MX2019009625A
MX2019009625A MX2019009625A MX2019009625A MX2019009625A MX 2019009625 A MX2019009625 A MX 2019009625A MX 2019009625 A MX2019009625 A MX 2019009625A MX 2019009625 A MX2019009625 A MX 2019009625A MX 2019009625 A MX2019009625 A MX 2019009625A
Authority
MX
Mexico
Prior art keywords
assembly
drug delivery
seal member
delivery device
related method
Prior art date
Application number
MX2019009625A
Other languages
English (en)
Inventor
S Ring Lawrence
Damestani Yasaman
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2019009625A publication Critical patent/MX2019009625A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202Separating means
    • A61J1/2024Separating means having peelable seals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/1406Septums, pierceable membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A61M2005/14252Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type with needle insertion means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Se dan a conocer dispositivos de administración de fármacos y métodos relacionados de ensamblaje. El dispositivo de administración de fármacos puede incluir una carcasa y un recipiente dispuesto en la misma. El recipiente puede incluir un dispositivo que contiene un fármaco y un tapón móvil. Un primer elemento de sellado puede conectarse al recipiente en un extremo distal del depósito. Una primera membrana retirable puede cubrir una superficie exterior del primer elemento de sellado para mantener la esterilidad de esa superficie antes del funcionamiento del dispositivo. Un conjunto de trayectoria del fluido puede configurarse para establecer la comunicación del fluido con el depósito durante el funcionamiento del dispositivo. Un segundo elemento de sellado puede conectarse a un primer extremo del conjunto de trayectoria del fluido. Una segunda membrana retirable puede cubrir una superficie exterior del segundo elemento de sellado para mantener la esterilidad de esa superficie antes del funcionamiento del dispositivo.
MX2019009625A 2017-02-17 2018-01-17 Dispositivo de administracion de farmacos con trayectoria de flujo de fluido esteril y metodo relacionado de ensamblaje. MX2019009625A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762460559P 2017-02-17 2017-02-17
PCT/US2018/014014 WO2018151890A1 (en) 2017-02-17 2018-01-17 Drug delivery device with sterile fluid flowpath and related method of assembly

Publications (1)

Publication Number Publication Date
MX2019009625A true MX2019009625A (es) 2019-10-09

Family

ID=61157326

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019009625A MX2019009625A (es) 2017-02-17 2018-01-17 Dispositivo de administracion de farmacos con trayectoria de flujo de fluido esteril y metodo relacionado de ensamblaje.

Country Status (7)

Country Link
US (2) US11752258B2 (es)
EP (1) EP3582825A1 (es)
JP (2) JP7064501B2 (es)
AU (2) AU2018220538B2 (es)
CA (1) CA3048520A1 (es)
MX (1) MX2019009625A (es)
WO (1) WO2018151890A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1762259T3 (pl) 2005-09-12 2011-03-31 Unomedical As Urządzenie wprowadzające, przeznaczone do zestawu infuzyjnego, z pierwszą i drugą jednostką sprężynową
US10194938B2 (en) 2011-03-14 2019-02-05 UnoMedical, AS Inserter system with transport protection
CN115025331B (zh) 2017-05-05 2024-06-14 里珍纳龙药品有限公司 自动注射器和相关使用方法
IL271173B2 (en) * 2017-07-21 2024-04-01 Amgen Inc Gas permeable sealing element for drug container and methods of assembly
US11058605B2 (en) * 2018-03-08 2021-07-13 Flex Ltd. Sterilization fluid path with barrier removal
EP3539592A1 (en) 2018-03-15 2019-09-18 Tecpharma Licensing AG An injection or infusion device comprising an improved housing and release liner for removing sterile barrier films using the release liner
EP3545997A1 (en) 2018-03-27 2019-10-02 Tecpharma Licensing AG Patch delivery device with skin contact sensor
SG11202111673SA (en) 2019-05-20 2021-11-29 Unomedical As Rotatable infusion device and methods thereof
CN118846301A (zh) 2019-05-30 2024-10-29 贝克顿·迪金森公司 用于药物递送装置的阀组件
US11478406B1 (en) * 2019-09-09 2022-10-25 Chris C. Rutter Aseptic filling apparatus and method
CN111297683B (zh) * 2020-03-20 2021-05-07 江苏苏云医疗器材有限公司 一种安全型药液转移器
US11311666B1 (en) 2021-02-18 2022-04-26 Fresenius Kabi Deutschland Gmbh Modular wearable medicament delivery device and method of use thereof
US11872369B1 (en) 2021-02-18 2024-01-16 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with leakage and skin contact sensing and method of use thereof
US11464902B1 (en) 2021-02-18 2022-10-11 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with compressible reservoir and method of use thereof
US11344682B1 (en) 2021-02-19 2022-05-31 Fresenius Kabi Deutschland Gmbh Drug supply cartridge with visual use indicator and delivery devices that use the same
US11607505B1 (en) 2021-02-19 2023-03-21 Fresenius Kabi Deutschland Gmbh Wearable injector with sterility sensors
US11633537B1 (en) 2021-02-19 2023-04-25 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including a pre-filled cartridge
US11426523B1 (en) * 2021-02-19 2022-08-30 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including a removable cartridge
US11406755B1 (en) 2021-02-19 2022-08-09 Fresenius Kabi Deutschland Gmbh Sensing fluid flow irregularities in an on-body injector
US11413394B1 (en) 2021-02-19 2022-08-16 Fresenius Kabi Deutschland Gmbh Display for wearable drug delivery device
US11497847B1 (en) 2021-02-19 2022-11-15 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive substrate
US11351300B1 (en) 2021-04-30 2022-06-07 Fresenius Kabl Deutschland GmbH Drug dispensing system with replaceable drug supply cartridges
US11504470B1 (en) 2021-04-30 2022-11-22 Fresenius Kabi Deutschland Gmbh Deformable drug reservoir for wearable drug delivery device
US11529459B1 (en) 2021-04-30 2022-12-20 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive module
US11419976B1 (en) 2021-04-30 2022-08-23 Fresenius Kabi Deutschland Gmbh Wearable drug delivery device with pressurized fluid dispensing
US11717608B1 (en) 2021-05-03 2023-08-08 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including an adhesive pad
US11484646B1 (en) * 2021-05-04 2022-11-01 Fresenius Kabi Deutschland Gmbh Sealing systems for a reservoir of an on-body injector
WO2024038642A1 (ja) * 2022-08-18 2024-02-22 テルモ株式会社 薬液投与装置及び薬液投与装置の製造方法
WO2024238847A1 (en) * 2023-05-17 2024-11-21 Regeneron Pharmaceuticals, Inc. Auto-injector and related methods of use

Family Cites Families (177)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1063008A (en) 1913-03-15 1913-05-27 William E Budd Vehicle-tire.
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
KR850004274A (ko) 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
KR100221066B1 (ko) 1989-10-13 1999-10-01 스튜어트 엘.왓트 에리트로포이에틴 유사체와 그를 포함하는 제약학적 조성물
US7217689B1 (en) 1989-10-13 2007-05-15 Amgen Inc. Glycosylation analogs of erythropoietin
US5856298A (en) 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
US5330426A (en) * 1992-08-13 1994-07-19 Science Incorporated Mixing and delivery syringe assembly
US5810398A (en) 1992-10-02 1998-09-22 Pall Corporation Fluid delivery systems and methods and assemblies for making connections
IL192290A0 (en) 1993-08-17 2008-12-29 Kirin Amgen Inc Erythropoietin analogs
US5827262A (en) 1993-09-07 1998-10-27 Debiotech S.A. Syringe device for mixing two compounds
US6562596B1 (en) 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
US5773569A (en) 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5830851A (en) 1993-11-19 1998-11-03 Affymax Technologies N.V. Methods of administering peptides that bind to the erythropoietin receptor
US5885574A (en) 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
WO1996004925A1 (en) 1994-08-12 1996-02-22 Immunomedics, Inc. Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US5767078A (en) 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
US6753165B1 (en) 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
CA2296770A1 (en) 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
PT986644E (pt) 1997-07-23 2007-01-31 Roche Diagnostics Gmbh Preparação de eritropoietina por activação genética endógena com promotores virais
US6030086A (en) 1998-03-02 2000-02-29 Becton, Dickinson And Company Flash tube reflector with arc guide
US6310078B1 (en) 1998-04-20 2001-10-30 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
US20050181482A1 (en) 2004-02-12 2005-08-18 Meade Harry M. Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk
CA2330527A1 (en) 1998-06-15 1999-12-23 Genzyme Transgenics Corporation Erythropoietin analog-human serum albumin fusion
US6022339A (en) 1998-09-15 2000-02-08 Baxter International Inc. Sliding reconstitution device for a diluent container
JP3820105B2 (ja) 1998-10-23 2006-09-13 キリン−アムジエン・インコーポレーテツド Mp1受容体に結合し血小板生成活性を有する二量体トロンボポエチンペプチド模倣体
ES2347884T3 (es) 1998-10-23 2010-11-22 Amgen Inc. Metodo y composiciones para la prevenciã“n y tratamiento de la anemia.
NZ512122A (en) 1998-11-27 2003-12-19 Darwin Discovery Ltd Compositions and methods for increasing bone mineralization
EP1006184A1 (en) 1998-12-03 2000-06-07 F. Hoffmann-La Roche Ag IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
WO2000061637A1 (en) 1999-04-14 2000-10-19 Smithkline Beecham Corporation Erythropoietin receptor antibodies
US7297680B2 (en) 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
CZ299516B6 (cs) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
EP1226243A2 (en) 1999-10-22 2002-07-31 Millennium Pharmaceuticals, Inc. Nucleic acid molecules derived from rat brain and programmed cell death models
US20050202538A1 (en) 1999-11-12 2005-09-15 Merck Patent Gmbh Fc-erythropoietin fusion protein with improved pharmacokinetics
CA2391080A1 (en) 1999-11-12 2001-05-25 Merck Patent Gesellschaft Mit Beschraenkter Haftung Erythropoietin forms with improved properties
CA2398343A1 (en) 2000-01-21 2001-07-26 Biovex Limited Virus strains for the oncolytic treatment of cancer
AUPQ599700A0 (en) 2000-03-03 2000-03-23 Super Internet Site System Pty Ltd On-line geographical directory
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
EP1274728B1 (en) 2000-04-21 2008-05-14 Amgen Inc. Methods and compositions for the prevention and treatment of anemia
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US7078376B1 (en) 2000-08-11 2006-07-18 Baxter Healthcare S.A. Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects
KR20030061784A (ko) 2000-09-08 2003-07-22 그리폰 테라퓨틱스, 인코포레이티드 중합체-변형 합성 단백질
US7271689B1 (en) 2000-11-22 2007-09-18 Fonar Corporation Magnet structure
EP1345628B1 (en) 2000-12-20 2011-04-13 F. Hoffmann-La Roche AG Conjugates of erythropoietin (epo) with polyethylene glycol (peg)
ME00502B (me) 2001-01-05 2011-10-10 Amgen Fremont Inc Antitjela za insulinu sličan receptor faktora i rasta
CA2443373A1 (en) 2001-04-04 2002-10-31 Genodyssee New polynucleotides and polypeptides of the erythropoietin gene
DK1385882T3 (da) 2001-05-11 2008-02-11 Amgen Inc Peptider og relaterede molekyler, der binder til TALL-1
DK2270052T3 (en) 2001-06-26 2018-07-02 Amgen Inc Antibodies to OPGL
US6900292B2 (en) 2001-08-17 2005-05-31 Lee-Hwei K. Sun Fc fusion proteins of human erythropoietin with increased biological activities
US7247304B2 (en) 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
ES2375271T3 (es) 2001-08-23 2012-02-28 Genmab A/S Anticuerpos humanos espec�?ficos para interleuquina 15 (il-15).
US6930086B2 (en) 2001-09-25 2005-08-16 Hoffmann-La Roche Inc. Diglycosylated erythropoietin
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
AU2002351746A1 (en) 2001-12-21 2003-07-15 Maxygen Aps Erythropoietin conjugates
WO2003059951A2 (fr) 2002-01-18 2003-07-24 Pierre Fabre Medicament Anticorps anti-igf-ir et leurs applications
US7241444B2 (en) 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
GB0202252D0 (en) 2002-01-31 2002-03-20 Oxford Biomedica Ltd Anemia
WO2003064664A1 (en) 2002-01-31 2003-08-07 Oxford Biomedica (Uk) Limited Physiologically regulated erythropoietin- exprressing vector for the treatment of anaemia
DE60220451T2 (de) 2002-03-26 2008-01-24 Lek Pharmaceutical And Chemical Co. D.D. Verfahren für die herstellung eines gewünschten profils von erythropoietin glyko-isoformen
EP1496123B1 (en) 2002-03-29 2009-06-24 Kumiai Chemical Industry Co., Ltd. Genes encoding acetolactate synthase
EP1572079A4 (en) 2002-03-29 2006-09-06 Centocor Inc MAMMAL-CDR MIMETIC BODIES, COMPOSITIONS, PROCESSES AND APPLICATION PURPOSES
AU2003232122A1 (en) 2002-05-13 2003-11-11 Technion Entrepreneurial Incubator Company Ltd. Ctp-extended erythropoietin
KR101086533B1 (ko) 2002-05-24 2011-11-23 쉐링 코포레이션 중화 사람 항-igfr 항체, 이를 제조하는 방법 및 이를 포함하는 조성물
US8034904B2 (en) 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
US7538195B2 (en) 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
AU2003280130B2 (en) 2002-06-28 2009-06-11 Centocor, Inc. Mammalian CH1 deleted mimetibodies, compositions, methods and uses
EP1575499A2 (en) 2002-06-28 2005-09-21 Centocor, Inc. Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses
WO2004009627A1 (en) 2002-07-19 2004-01-29 Cangene Corporation Pegylated erythropoietic compounds
TW200413406A (en) 2002-08-26 2004-08-01 Kirin Brewery Peptides and drugs containing the same
CN104178491B (zh) 2002-09-06 2018-07-03 安姆根有限公司 治疗性人抗-il-1r1单克隆抗体
KR101174510B1 (ko) 2002-09-11 2012-08-16 프레제니우스 카비 도이치란트 게엠베하 하이드록시알킬전분화 폴리펩티드, 특히 하이드록시알킬전분화 에리트로포이에틴
US6919426B2 (en) 2002-09-19 2005-07-19 Amgen Inc. Peptides and related molecules that modulate nerve growth factor activity
TWI320716B (en) 2002-10-14 2010-02-21 Abbott Lab Erythropoietin receptor binding antibodies
US20040071694A1 (en) 2002-10-14 2004-04-15 Devries Peter J. Erythropoietin receptor binding antibodies
US7396913B2 (en) 2002-10-14 2008-07-08 Abbott Laboratories Erythropoietin receptor binding antibodies
WO2004034988A2 (en) 2002-10-16 2004-04-29 Amgen Inc. Human anti-ifn-ϝ neutralizing antibodies as selective ifn-ϝ pathway inhibitors
US20040091961A1 (en) 2002-11-08 2004-05-13 Evans Glen A. Enhanced variants of erythropoietin and methods of use
ATE496938T1 (de) 2002-12-20 2011-02-15 Amgen Inc Myostatin hemmende bindungsstoffe
WO2004083248A1 (en) 2003-03-14 2004-09-30 Pharmacia Corporation Antibodies to igf-i receptor for the treatment of cancers
CA2519113C (en) 2003-04-02 2012-06-05 F. Hoffmann-La Roche Ag Antibodies against insulin-like growth factor i receptor and uses thereof
US7220410B2 (en) 2003-04-18 2007-05-22 Galaxy Biotech, Llc Monoclonal antibodies to hepatocyte growth factor
JP2007535895A (ja) 2003-05-01 2007-12-13 イムクローン システムズ インコーポレイティド ヒトインシュリン様成長因子−1受容体に対する完全ヒト抗体
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
KR101227666B1 (ko) 2003-05-12 2013-01-31 아피맥스, 인크. 에리스로포이에틴 수용체에 결합하는 펩티드
CA2525464A1 (en) 2003-05-12 2004-11-25 Qun Yin Novel poly(ethylene glycol) modified compounds and uses thereof
OA13164A (en) 2003-05-12 2006-12-13 Affymax Inc Novel peptides that bind to the erythropoietin receptor.
US7074755B2 (en) 2003-05-17 2006-07-11 Centocor, Inc. Erythropoietin conjugate compounds with extended half-lives
US6995245B2 (en) 2003-05-30 2006-02-07 Centocor, Inc. Formation of novel erythropoietin conjugates using transglutaminase
US20050037390A1 (en) 2003-06-04 2005-02-17 Irm Llc, A Delaware Limited Liability Company Methods and compositions for modulating erythropoietin expression
EP1646412B1 (en) 2003-07-08 2007-03-28 Novo Nordisk A/S Portable drug delivery device having an encapsulated needle
EP1495775A1 (en) 2003-07-08 2005-01-12 Novo Nordisk A/S Portable drug delivery device having an encapsulated needle
US7579157B2 (en) 2003-07-10 2009-08-25 Hoffmann-La Roche Inc. Antibody selection method against IGF-IR
NZ599196A (en) 2003-07-15 2014-01-31 Amgen Inc Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors
ES2523837T3 (es) 2003-07-18 2014-12-01 Amgen Inc. Agentes de unión específica al factor de crecimiento de hepatocitos
US20050019914A1 (en) 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
US20070275871A1 (en) 2003-08-28 2007-11-29 Biorexis Technology, Inc. Epo Mimetic Peptides and Fusion Proteins
CN1882355A (zh) 2003-09-09 2006-12-20 沃伦药品公司 保持内源性促红细胞生成素组织保护活性的长效促红细胞生成素
UA89481C2 (uk) 2003-09-30 2010-02-10 Центокор, Инк. Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування
AU2004316266A1 (en) 2003-09-30 2005-09-09 Centocor, Inc. Human hinge core mimetibodies, compositions, methods and uses
BRPI0416603A (pt) 2003-11-07 2007-01-30 Immunex Corp anticorpo que se liga ao receptor interleucina-4 (il-4) humano
AR046639A1 (es) 2003-11-21 2005-12-14 Schering Corp Combinaciones terapeuticas de anticuerpo anti- igfr1
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
NZ547168A (en) 2003-11-24 2010-05-28 Biogenerix Ag Glycopegylated erythropoietin
WO2005058967A2 (en) 2003-12-16 2005-06-30 Pierre Fabre Medicament Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof
EP1548031A1 (en) 2003-12-22 2005-06-29 Dubai Genetics FZ-LLC Nature-identical erythropoietin
CA2551131A1 (en) 2003-12-31 2005-07-21 Centocor, Inc. Novel recombinant proteins with n-terminal free thiol
AU2004309063B2 (en) 2003-12-31 2010-10-28 Merck Patent Gmbh Fc-erythropoietin fusion protein with improved pharmacokinetics
US7423139B2 (en) 2004-01-20 2008-09-09 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
WO2005070451A1 (en) 2004-01-22 2005-08-04 Zafena Aktiebolag Pharmaceutical composition comprising non-glycosylated erythropoietin
WO2005084711A1 (fr) 2004-03-02 2005-09-15 Chengdu Institute Of Biological Products Erythropoietine recombinante pegylee a activite in vivo
AR048918A1 (es) 2004-03-11 2006-06-14 Fresenius Kabi De Gmbh Conjugados de almidon de hidroxietilo y eritropoyetina
US20060002929A1 (en) 2004-03-23 2006-01-05 Khare Sanjay D Monoclonal antibodies
US20050227289A1 (en) 2004-04-09 2005-10-13 Reilly Edward B Antibodies to erythropoietin receptor and uses thereof
EP1737888A2 (en) 2004-04-23 2007-01-03 Cambridge Antibody Technology LTD Erythropoietin protein variants
AU2005259689B2 (en) 2004-07-07 2011-10-06 H. Lundbeck A/S Novel carbamylated EPO and method for its production
FR2873699B1 (fr) 2004-07-29 2009-08-21 Pierre Fabre Medicament Sa Nouveaux anticorps anti igf ir rt leurs utilisations
WO2006029094A2 (en) 2004-09-02 2006-03-16 Xencor, Inc. Erythropoietin derivatives with altered immunogenicity
CA2586915A1 (en) 2004-11-10 2006-05-18 Aplagen Gmbh Molecules which promote hematopoiesis
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
CA2589860A1 (en) 2005-01-24 2006-08-03 Amgen Inc. Humanized anti-amyloid antibody
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
SI2100618T1 (sl) 2005-06-17 2014-03-31 Imclone Llc Antagonisti receptorja za zdravljenje metastaznega kostnega raka
WO2007000328A1 (en) 2005-06-27 2007-01-04 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof
EP2397497A3 (en) 2005-07-18 2013-11-27 Amgen, Inc Human anti-B7RP1 neutralizing antibodies
FR2888850B1 (fr) 2005-07-22 2013-01-11 Pf Medicament Nouveaux anticorps anti-igf-ir et leurs applications
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
GB0603683D0 (en) 2006-02-23 2006-04-05 Novartis Ag Organic compounds
TWI395754B (zh) 2006-04-24 2013-05-11 Amgen Inc 人類化之c-kit抗體
US7851438B2 (en) 2006-05-19 2010-12-14 GlycoFi, Incorporated Erythropoietin compositions
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
US20100150937A1 (en) 2006-11-07 2010-06-17 Sparrow Carl P Antagonists of pcsk9
US20100040610A1 (en) 2006-11-07 2010-02-18 Ayesha Sitlani Antagonists of pcsk9
EP2083859A4 (en) 2006-11-07 2010-11-24 Merck Sharp & Dohme ANTAGONISTS OF PCSK9
US20100136028A1 (en) 2006-11-07 2010-06-03 Sparrow Carl P Antagonists of pcsk9
AR064333A1 (es) 2006-12-14 2009-04-01 Schering Corp Anticuerpo anti-tslp de diseno
BRPI0810551A2 (pt) 2007-04-13 2019-09-03 Novartis Ag moléculas e métodos para modulação da pró-proteína convertase subtilisina/quexina tipo 9 (pcsk9)
CN102027012A (zh) 2007-06-20 2011-04-20 Irm责任有限公司 用于治疗变应性疾病的方法和组合物
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
US20130072665A1 (en) 2007-08-23 2013-03-21 Simon Mark Jackson Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
US8598320B2 (en) 2007-10-26 2013-12-03 Merck Sharp & Dohme Corp. Anti-PCSK9 and methods for treating lipid and cholesterol disorders
AR070316A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9)
AR070315A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Anticuerpos 1b20 antagonistas de pcsk9
WO2009131740A2 (en) 2008-04-23 2009-10-29 Amgen Inc. Neutralizing proprotein convertase subtilisin kexin type 9 (pcsk9) variants and uses thereof
TWI445716B (zh) 2008-09-12 2014-07-21 Rinat Neuroscience Corp Pcsk9拮抗劑類
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
JO3382B1 (ar) 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
US20120219558A1 (en) 2009-09-25 2012-08-30 Yan Ni Antagonists of pcsk9
JP2013509194A (ja) 2009-10-30 2013-03-14 メルク・シャープ・エンド・ドーム・コーポレイション Ax213およびax132pcsk9アンタゴニストおよびバリアント
AU2010313381A1 (en) 2009-10-30 2012-04-12 Merck Sharp & Dohme Corp. AX1 and AX189 PCSK9 antagonists and variants
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
CN105218674A (zh) 2010-03-11 2016-01-06 瑞纳神经科学公司 呈pH依赖性抗原结合的抗体
WO2012054438A1 (en) 2010-10-22 2012-04-26 Schering Corporation Anti-pcsk9
US8613308B2 (en) 2010-12-10 2013-12-24 Uop Llc Process for transferring heat or modifying a tube in a heat exchanger
AR084456A1 (es) 2010-12-22 2013-05-15 Genentech Inc Anticuerpo anti-pcsk9 y metodos de uso
CN103269730B (zh) 2010-12-31 2015-09-16 诺沃—诺迪斯克有限公司 医用注射装置
JP6290625B2 (ja) 2011-01-17 2018-03-07 アクティヴパック, インコーポレイテッド 無菌カートリッジおよび分配装置
ES2873273T3 (es) 2011-01-28 2021-11-03 Sanofi Biotechnology Composiciones farmacéuticas que comprenden anticuerpos humanos contra PCSK9
EA201391157A1 (ru) 2011-02-11 2014-02-28 АйАрЭм ЭлЭлСи Антагонисты pcsk9
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
DK2731643T4 (da) 2011-09-13 2019-08-19 Unitract Syringe Pty Ltd Steril fluidledende forbindelse til lægemiddelbeholdere til lægemiddeltilførselspumper
EA039663B1 (ru) 2012-05-03 2022-02-24 Амген Инк. Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств
CN104768598B (zh) 2012-10-25 2018-04-06 诺和诺德股份有限公司 预填充一次性注射装置
ES2875957T3 (es) 2012-12-20 2021-11-11 Amgen Inc Agonistas del receptor APJ y usos de los mismos
US20140274874A1 (en) 2013-03-14 2014-09-18 Amgen Inc. Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
AU2014236683B2 (en) 2013-03-14 2018-09-27 Amgen Inc. Variants of tissue inhibitor of metalloproteinase type three (TIMP-3), compositions and methods
CA2906508A1 (en) 2013-03-15 2014-09-25 Amgen, Inc. Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9
JP6195978B2 (ja) 2013-05-31 2017-09-13 バレリタス, インコーポレイテッド 挿入可能事前装填カートリッジを有する流体送達デバイス
US20150004174A1 (en) 2013-06-28 2015-01-01 Amgen Inc. Methods for treating homozygous familial hypercholesterolemia
EP2832390A1 (en) 2013-07-30 2015-02-04 Sensile Pat AG Drug delivery device with needle actuation mechanism
CN105658257B (zh) 2013-08-23 2019-06-25 尤尼特拉克特注射器公司 用于药物输送泵的集成的可刺破密封流体通路连接件和药物容器
MX2017010466A (es) 2015-02-17 2018-06-06 Amgen Inc Dispositivo de administracion de farmacos con sujecion asistida de vacio y/o respuestas.
CA2978017A1 (en) 2015-03-02 2016-09-09 Amgen Inc. Device and method for making aseptic connections

Also Published As

Publication number Publication date
US20190374707A1 (en) 2019-12-12
AU2018220538A1 (en) 2019-06-27
JP7064501B2 (ja) 2022-05-10
AU2024201705A1 (en) 2024-04-04
US20230372607A1 (en) 2023-11-23
JP2020508096A (ja) 2020-03-19
JP2022101637A (ja) 2022-07-06
US11752258B2 (en) 2023-09-12
WO2018151890A1 (en) 2018-08-23
CA3048520A1 (en) 2018-08-23
JP7405897B2 (ja) 2023-12-26
EP3582825A1 (en) 2019-12-25
AU2018220538B2 (en) 2023-12-14

Similar Documents

Publication Publication Date Title
MX2019009625A (es) Dispositivo de administracion de farmacos con trayectoria de flujo de fluido esteril y metodo relacionado de ensamblaje.
EP4249119A3 (en) System for maintaining sterility of a specimen container
MX2021015409A (es) Dispositivo y metodo para realizar conexiones asepticas.
MX2016007050A (es) Dispositivo para medicamento.
CA2951474C (en) Disinfectant caps
GB2522167A (en) Auto-injector assembly
AR109529A1 (es) Dispositivo de muestreo de fluido
MX2020011560A (es) Porcion del cartucho de un aparato y metodo de administracion transdermica de medicamentos.
MX2023011540A (es) Conjunto de accionamiento y separador para sistema de suministro de farmacos.
EP2949228A3 (en) Cartridge for electronic cigarette
PH12018501329A1 (en) A beverage capsule
MX2021008173A (es) Metodo y aparato de administracion transdermica de medicamentos.
MX2018004624A (es) Conector medico luer.
MX2017004191A (es) Cigarrillo electronico con deposito desechable, metodo de manufactura y metodo de uso.
EP4233961A3 (en) Medical apparatus for fluid communication
EP4458385A3 (en) Drug delivery insertion apparatuses and system
MX2021005603A (es) Aparato y métodos para dispositivos de vaporización con varios atomizadores, de varias cámaras.
MX2016007172A (es) Aparatos y metodos para suministrar medicamento en bajos volumenes.
MX2024005627A (es) Conector para la transferencia aseptica de fluido.
WO2018031240A8 (en) ANTISEPTIC ADMINISTRATION DEVICE AND METHOD OF USE
BR112017023054A2 (pt) sistema e método para descontaminação de um dispositivo de lúmen
WO2015168572A3 (en) Delivery device and related methods
PH12017501087A1 (en) Port, and medical liquid bag
MX2019008119A (es) Aparato medico aplicador para piel.
ZA201605908B (en) Hermetic closing plug for a sealed sterile vial containing medical or nutritional active substances, suitable for the sterile connection to a container of liquid diluent solution, and sterile connection system using said closing plug