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MX2019008872A - Prevencion y tratamiento de da?o o enfermedad osea y cartilago. - Google Patents

Prevencion y tratamiento de da?o o enfermedad osea y cartilago.

Info

Publication number
MX2019008872A
MX2019008872A MX2019008872A MX2019008872A MX2019008872A MX 2019008872 A MX2019008872 A MX 2019008872A MX 2019008872 A MX2019008872 A MX 2019008872A MX 2019008872 A MX2019008872 A MX 2019008872A MX 2019008872 A MX2019008872 A MX 2019008872A
Authority
MX
Mexico
Prior art keywords
bone
prevention
treatment
disease
cartilage damage
Prior art date
Application number
MX2019008872A
Other languages
English (en)
Inventor
Lundgren Åkerlund Evy
Uvebrant Christina
Talts Jan
Original Assignee
Xintela Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xintela Ab filed Critical Xintela Ab
Publication of MX2019008872A publication Critical patent/MX2019008872A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Microbiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Botany (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

Se describen composiciones y métodos para la prevención y/o tratamiento de condiciones que involucran enfermedad o daño en cartílago y hueso de mamífero, utilizando células madre mesenquimales aisladas con anticuerpos anti-integrina a10.
MX2019008872A 2017-01-27 2018-01-29 Prevencion y tratamiento de da?o o enfermedad osea y cartilago. MX2019008872A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762451372P 2017-01-27 2017-01-27
PCT/EP2018/052104 WO2018138322A1 (en) 2017-01-27 2018-01-29 Prevention and treatment of bone and cartilage damage or disease

Publications (1)

Publication Number Publication Date
MX2019008872A true MX2019008872A (es) 2019-09-18

Family

ID=61168072

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019008872A MX2019008872A (es) 2017-01-27 2018-01-29 Prevencion y tratamiento de da?o o enfermedad osea y cartilago.

Country Status (17)

Country Link
US (2) US11517593B2 (es)
EP (2) EP3573630B1 (es)
JP (1) JP7210829B2 (es)
KR (1) KR102580320B1 (es)
CN (1) CN110234329A (es)
AU (1) AU2018211504B2 (es)
BR (1) BR112019013508A2 (es)
CA (1) CA3050099C (es)
DK (1) DK3573630T3 (es)
ES (1) ES2870776T3 (es)
IL (1) IL266772B (es)
LT (1) LT3573630T (es)
MX (1) MX2019008872A (es)
PL (1) PL3573630T3 (es)
PT (1) PT3573630T (es)
SG (1) SG11201904535VA (es)
WO (1) WO2018138322A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102760654B1 (ko) 2017-06-07 2025-02-04 리제너론 파마슈티칼스 인코포레이티드 효소 내재화를 위한 조성물 및 방법
MA51796A (fr) 2018-02-07 2020-12-16 Regeneron Pharma Procédés et compositions pour l'administration de protéines thérapeutiques
SG11202011232VA (en) 2018-05-17 2020-12-30 Regeneron Pharma Anti-cd63 antibodies, conjugates, and uses thereof
WO2021092199A1 (en) * 2019-11-08 2021-05-14 Kansas State University Research Foundation Isolation, preservation, and expansion of canine umbilical cord mesenchymal stromal cells
CN112941021A (zh) * 2020-03-13 2021-06-11 深圳市第二人民医院(深圳市转化医学研究院) 一种骨关节炎关节液来源的间充质干细胞的培养方法
CN116018149A (zh) * 2020-05-07 2023-04-25 辛特拉股份公司 用于治疗呼吸障碍的干细胞
CN113667635A (zh) * 2020-05-14 2021-11-19 梦芊科技知识产权有限公司 无异源培养基及使用其扩增间充质干细胞的方法
CN112430269B (zh) * 2021-01-28 2021-04-20 中赛干细胞基因工程有限公司 一种促进脐带血干细胞成骨分化的组合物及其应用
EP4340854A1 (en) 2021-05-20 2024-03-27 Xintela AB Mesenchymal stem cells for use in the treatment of skin defects
CN118291375A (zh) * 2022-01-28 2024-07-05 北京达尔文细胞生物科技有限公司 一种细胞修复蛋白提取物及其制备方法和其应用
CN114540298A (zh) * 2022-03-25 2022-05-27 北京瑷格干细胞科技有限公司 一种干细胞无血清培养基及其制备方法
TW202421655A (zh) * 2022-10-05 2024-06-01 全福生物科技股份有限公司 用於骨頭/軟骨再生之包含pedf衍生短肽及間質幹細胞之組合物
CN115651076B (zh) * 2022-12-09 2023-09-29 北京大学口腔医学院 人骨髓间充质干细胞来源凋亡囊泡的表面标志物及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2353061T5 (es) * 2000-04-25 2014-04-07 Osiris Therapeutics, Inc. Reparación de articulaciones utilizando células madre mesenquimatosas
CA2489212C (en) * 2002-06-14 2012-08-14 Cartela Ab Marker for stem cells and its use
SE0301087D0 (sv) * 2003-04-14 2003-04-14 Cartela Ab New monoclonal antibody
WO2007099337A1 (en) * 2006-03-01 2007-09-07 Cartela R&D Ab Expansion and differentiation of mesenchymal stem cells
US20100055114A1 (en) 2006-12-15 2010-03-04 Evy Lundgren-Akerlund Use of integrin alpha 10 binding antibody to modulate extracellular matrix (cartilage) turnover
WO2009015343A2 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes

Also Published As

Publication number Publication date
LT3573630T (lt) 2021-05-25
JP7210829B2 (ja) 2023-01-24
WO2018138322A1 (en) 2018-08-02
SG11201904535VA (en) 2019-08-27
US11517593B2 (en) 2022-12-06
DK3573630T3 (da) 2021-06-07
KR102580320B1 (ko) 2023-09-19
US20230128397A1 (en) 2023-04-27
JP2020505916A (ja) 2020-02-27
CA3050099C (en) 2024-04-16
KR20190107686A (ko) 2019-09-20
EP3919064A1 (en) 2021-12-08
BR112019013508A2 (pt) 2020-01-07
CA3050099A1 (en) 2018-08-02
IL266772A (en) 2019-07-31
PT3573630T (pt) 2021-05-06
PL3573630T3 (pl) 2021-09-13
IL266772B (en) 2022-04-01
EP3573630B1 (en) 2021-03-17
EP3573630A1 (en) 2019-12-04
CN110234329A (zh) 2019-09-13
AU2018211504B2 (en) 2022-08-18
ES2870776T3 (es) 2021-10-27
US20200038449A1 (en) 2020-02-06
AU2018211504A1 (en) 2019-07-04

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