MX2018005096A - Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular. - Google Patents
Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular.Info
- Publication number
- MX2018005096A MX2018005096A MX2018005096A MX2018005096A MX2018005096A MX 2018005096 A MX2018005096 A MX 2018005096A MX 2018005096 A MX2018005096 A MX 2018005096A MX 2018005096 A MX2018005096 A MX 2018005096A MX 2018005096 A MX2018005096 A MX 2018005096A
- Authority
- MX
- Mexico
- Prior art keywords
- gemcabene
- combinations
- treatment
- cardiovascular disease
- cardiovascular
- Prior art date
Links
- SDMBRCRVFFHJKR-UHFFFAOYSA-N 6-(5-carboxy-5-methylhexoxy)-2,2-dimethylhexanoic acid Chemical compound OC(=O)C(C)(C)CCCCOCCCCC(C)(C)C(O)=O SDMBRCRVFFHJKR-UHFFFAOYSA-N 0.000 title abstract 2
- 229950004781 gemcabene Drugs 0.000 title abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 238000008214 LDL Cholesterol Methods 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
Abstract
La presente invención proporciona composiciones farmacéuticas formuladas para incluir una estatina y gemcabeno, donde la composición es útil para tratar, prevenir o reducir los síntomas de indicaciones cardiovasculares y metabólicas que implican elevar los niveles de colesterol LDL, triglicéridos o ambos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562252195P | 2015-11-06 | 2015-11-06 | |
US201562252147P | 2015-11-06 | 2015-11-06 | |
PCT/US2016/060849 WO2017079755A1 (en) | 2015-11-06 | 2016-11-07 | Gemcabene combinations for the treatment of cardiovascular disease |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018005096A true MX2018005096A (es) | 2018-08-15 |
Family
ID=58663111
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018005096A MX2018005096A (es) | 2015-11-06 | 2016-11-07 | Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular. |
MX2018005540A MX2018005540A (es) | 2015-11-06 | 2016-11-07 | Tratamiento de dislipemia mixta. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018005540A MX2018005540A (es) | 2015-11-06 | 2016-11-07 | Tratamiento de dislipemia mixta. |
Country Status (16)
Country | Link |
---|---|
US (4) | US9849104B2 (es) |
EP (2) | EP3370713A4 (es) |
JP (2) | JP2018536710A (es) |
KR (2) | KR20180073597A (es) |
CN (2) | CN108348491A (es) |
AU (2) | AU2016348638A1 (es) |
BR (2) | BR112018009238A8 (es) |
CA (2) | CA3000016A1 (es) |
HK (2) | HK1257929A1 (es) |
IL (2) | IL258819A (es) |
MA (1) | MA43190A (es) |
MX (2) | MX2018005096A (es) |
PH (1) | PH12018500972A1 (es) |
RU (2) | RU2018120599A (es) |
SG (2) | SG11201803442UA (es) |
WO (2) | WO2017079748A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
CN113249297A (zh) | 2014-05-28 | 2021-08-13 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
CA2963704A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
BR112017009876A2 (pt) | 2014-11-14 | 2017-12-19 | Gemphire Therapeutics Inc | processos e intermediários para a preparação de éteres de dialcano terminados em ácido alfa,ômega-dicarboxílico |
MX2018005096A (es) * | 2015-11-06 | 2018-08-15 | Gemphire Therapeutics Inc | Combinaciones de gemcabeno para el tratamiento de enfermedad cardiovascular. |
EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
CA3030099A1 (en) | 2016-07-08 | 2018-01-11 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
KR102399254B1 (ko) | 2016-09-28 | 2022-05-17 | 아이거 바이오파마슈티컬스 인코포레이티드 | 비-알코올성 지방간염의 치료를 위한 방법 및 약제학적 조성물 |
US10668108B2 (en) | 2016-11-04 | 2020-06-02 | Children's Hospital Medical Center | Compositions and methods of treating liver disease |
KR20230110839A (ko) | 2016-12-05 | 2023-07-25 | 칠드런즈 호스피탈 메디칼 센터 | 결장 유사장기 및 이를 제조 및 사용하는 방법 |
EP3612171A4 (en) * | 2017-04-18 | 2020-10-21 | Gemphire Therapeutics Inc. | GEMCABENE, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, COMPOSITIONS THEREOF AND PROCEDURES FOR THE USE OF THE SAME |
WO2018193427A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
US20180338922A1 (en) * | 2017-05-26 | 2018-11-29 | Esperion Therapeutics, Inc. | Fixed dose formulations |
JP6937195B2 (ja) * | 2017-09-01 | 2021-09-22 | 興和株式会社 | 医薬組成物 |
US10538583B2 (en) | 2017-10-31 | 2020-01-21 | Staten Biotechnology B.V. | Anti-APOC3 antibodies and compositions thereof |
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