MX2017010958A - COMPOSITION TO PREVENT OR TREAT CALCIFICATION OF THE VALVE CONTAINING THE DPP-4 INHIBITOR. - Google Patents
COMPOSITION TO PREVENT OR TREAT CALCIFICATION OF THE VALVE CONTAINING THE DPP-4 INHIBITOR.Info
- Publication number
- MX2017010958A MX2017010958A MX2017010958A MX2017010958A MX2017010958A MX 2017010958 A MX2017010958 A MX 2017010958A MX 2017010958 A MX2017010958 A MX 2017010958A MX 2017010958 A MX2017010958 A MX 2017010958A MX 2017010958 A MX2017010958 A MX 2017010958A
- Authority
- MX
- Mexico
- Prior art keywords
- dpp
- inhibitor
- composition
- prevent
- valve containing
- Prior art date
Links
- 229940090124 dipeptidyl peptidase 4 (dpp-4) inhibitors for blood glucose lowering Drugs 0.000 title abstract 3
- 230000002308 calcification Effects 0.000 title abstract 2
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 4
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 abstract 4
- 239000004055 small Interfering RNA Substances 0.000 abstract 4
- 108700011259 MicroRNAs Proteins 0.000 abstract 2
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 2
- 108091027967 Small hairpin RNA Proteins 0.000 abstract 2
- 108020004459 Small interfering RNA Proteins 0.000 abstract 2
- 230000009368 gene silencing by RNA Effects 0.000 abstract 2
- 239000002679 microRNA Substances 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- 108091023037 Aptamer Proteins 0.000 abstract 1
- -1 Diprotin Chemical compound 0.000 abstract 1
- DVJAMEIQRSHVKC-BDAKNGLRSA-N Dutogliptin Chemical compound OB(O)[C@@H]1CCCN1C(=O)CN[C@H]1CNCC1 DVJAMEIQRSHVKC-BDAKNGLRSA-N 0.000 abstract 1
- LCDDAGSJHKEABN-MLGOLLRUSA-N Evogliptin Chemical compound C1CNC(=O)[C@@H](COC(C)(C)C)N1C(=O)C[C@H](N)CC1=CC(F)=C(F)C=C1F LCDDAGSJHKEABN-MLGOLLRUSA-N 0.000 abstract 1
- ZWPRRQZNBDYKLH-VIFPVBQESA-N Gemigliptin Chemical compound C([C@@H](N)CC(=O)N1CC2=C(C(=NC(=N2)C(F)(F)F)C(F)(F)F)CC1)N1CC(F)(F)CCC1=O ZWPRRQZNBDYKLH-VIFPVBQESA-N 0.000 abstract 1
- LTXREWYXXSTFRX-QGZVFWFLSA-N Linagliptin Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 LTXREWYXXSTFRX-QGZVFWFLSA-N 0.000 abstract 1
- 229960001667 alogliptin Drugs 0.000 abstract 1
- ZSBOMTDTBDDKMP-OAHLLOKOSA-N alogliptin Chemical compound C=1C=CC=C(C#N)C=1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1 ZSBOMTDTBDDKMP-OAHLLOKOSA-N 0.000 abstract 1
- 229950009977 anagliptin Drugs 0.000 abstract 1
- LDXYBEHACFJIEL-HNNXBMFYSA-N anagliptin Chemical compound C=1N2N=C(C)C=C2N=CC=1C(=O)NCC(C)(C)NCC(=O)N1CCC[C@H]1C#N LDXYBEHACFJIEL-HNNXBMFYSA-N 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 229940093265 berberine Drugs 0.000 abstract 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 abstract 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 abstract 1
- 229950003693 dutogliptin Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229950011259 evogliptin Drugs 0.000 abstract 1
- 229960002458 gemigliptin Drugs 0.000 abstract 1
- 229960002397 linagliptin Drugs 0.000 abstract 1
- MQYXUWHLBZFQQO-QGTGJCAVSA-N lupeol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C MQYXUWHLBZFQQO-QGTGJCAVSA-N 0.000 abstract 1
- PKGKOZOYXQMJNG-UHFFFAOYSA-N lupeol Natural products CC(=C)C1CC2C(C)(CCC3C4(C)CCC5C(C)(C)C(O)CCC5(C)C4CCC23C)C1 PKGKOZOYXQMJNG-UHFFFAOYSA-N 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 229960004937 saxagliptin Drugs 0.000 abstract 1
- QGJUIPDUBHWZPV-SGTAVMJGSA-N saxagliptin Chemical compound C1C(C2)CC(C3)CC2(O)CC13[C@H](N)C(=O)N1[C@H](C#N)C[C@@H]2C[C@@H]21 QGJUIPDUBHWZPV-SGTAVMJGSA-N 0.000 abstract 1
- 108010033693 saxagliptin Proteins 0.000 abstract 1
- 229960004034 sitagliptin Drugs 0.000 abstract 1
- MFFMDFFZMYYVKS-SECBINFHSA-N sitagliptin Chemical compound C([C@H](CC(=O)N1CC=2N(C(=NN=2)C(F)(F)F)CC1)N)C1=CC(F)=C(F)C=C1F MFFMDFFZMYYVKS-SECBINFHSA-N 0.000 abstract 1
- 229960001254 vildagliptin Drugs 0.000 abstract 1
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 abstract 1
Classifications
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A—HUMAN NECESSITIES
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a composition for preventing or treating valve calcification, containing a dipeptidyl peptidase-4 (DPP-4) inhibitor. The DPP-4 inhibitor according to the present invention may include all of what can inhibit the expression of DPP-4 nucleotides or the activity of DPP-4 proteins, wherein: DPP-4 antibodies, sitagliptin, vildagliptin, saxagliptin, linagliptin, dutogliptin, gemigliptin, alogliptin, Anagliptin, evogliptin, Berberine, Diprotin, or Lupeol; DPP-4 mRNA anti-sense nucleotides, aptamers, small interfering RNA (siRNA), short hairpin RNA (shRNA), and microRNA (miRNA), or RNA interference (RNAi); or the like can be used.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2015/001902 WO2016137037A1 (en) | 2015-02-27 | 2015-02-27 | Composition for preventing or treating valve calcification, containing dpp-4 inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017010958A true MX2017010958A (en) | 2018-03-14 |
| MX382875B MX382875B (en) | 2025-03-13 |
Family
ID=56789550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017010958A MX382875B (en) | 2015-02-27 | 2015-02-27 | COMPOSITION FOR PREVENTING OR TREATING VALVE CALCIFICATION CONTAINING THE DPP-4 INHIBITOR. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP3263134B1 (en) |
| JP (1) | JP6467583B2 (en) |
| KR (1) | KR102060728B1 (en) |
| CN (2) | CN113209295A (en) |
| AU (1) | AU2015384339B2 (en) |
| BR (1) | BR112017018329A2 (en) |
| CA (1) | CA2977939C (en) |
| ES (1) | ES2869463T3 (en) |
| IL (1) | IL254169B (en) |
| MX (1) | MX382875B (en) |
| NZ (1) | NZ735710A (en) |
| PL (1) | PL3263134T3 (en) |
| RU (1) | RU2680527C1 (en) |
| SG (1) | SG11201707008SA (en) |
| WO (1) | WO2016137037A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110433282B (en) * | 2018-05-04 | 2023-03-14 | 上海交通大学医学院附属瑞金医院 | Application of glucagon-like peptide-1 in preparation of medicine for treating calcified aortic valve diseases |
| CN113481168A (en) * | 2018-12-26 | 2021-10-08 | 重庆精准生物技术有限公司 | Agent for enhancing homing ability of CAR-T cells to solid tumor tissue and use thereof |
| CN111321107A (en) * | 2019-02-01 | 2020-06-23 | 南方医科大学南方医院 | Method for separating and culturing human aortic valve interstitial cells |
| KR102531265B1 (en) * | 2019-10-24 | 2023-05-12 | 가톨릭대학교 산학협력단 | Composition for preventing or treating valvular heart diseases comprising RSPO3 inhbitors |
| CN111012772B (en) * | 2020-01-06 | 2023-06-02 | 华中科技大学同济医学院附属协和医院 | Use of phenethyl caffeate in the treatment of aortic valve calcification |
| KR20210123692A (en) * | 2020-04-03 | 2021-10-14 | 연세대학교 산학협력단 | Composition for diagnosing, preventing or treating cancer comprising EphA10 inhibitor and uses thereof |
| WO2022066847A1 (en) * | 2020-09-24 | 2022-03-31 | Alnylam Pharmaceuticals, Inc. | Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof |
| WO2023208876A1 (en) * | 2022-04-26 | 2023-11-02 | Recardio Inc. | Novel dutogliptin formulations and their preparation |
| CN116790603B (en) * | 2023-08-18 | 2023-10-31 | 成都中科奥格生物科技有限公司 | sgRNA and CRISPR/Cas9 vector as well as construction method and application thereof |
| CN117849342B (en) * | 2024-01-09 | 2024-10-22 | 首都医科大学附属北京友谊医院 | Application of XOR protein or its encoding gene as a target in the preparation of drugs for preventing and/or treating vascular calcification |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010037408A1 (en) * | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
| EA029759B1 (en) * | 2009-02-13 | 2018-05-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Antidiabetic medications comprising dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetic agents |
| EP2411005A1 (en) * | 2009-03-27 | 2012-02-01 | Bristol-Myers Squibb Company | Methods for preventing major adverse cardiovascular events with dpp-iv inhibitors |
| ES2431300T3 (en) * | 2009-04-16 | 2013-11-25 | Taisho Pharmaceutical Co., Ltd. | Pharmaceutical composition containing (1S) -1,5-anhydro-1- [5- (4-ethoxybenzyl) -2-methoxy-4-methylphenyl] -1-thio-D-glucitol and metformin and uses thereof in the diabetes treatment |
| CN101899047B (en) * | 2009-05-26 | 2016-01-20 | 盛世泰科生物医药技术(苏州)有限公司 | Be used for the treatment of as depeptidyl peptidase inhibitors or the beta-amino tetrahydrochysene pyrazine of prevent diabetes, tetrahydropyrimidine and tetrahydropyridine |
| WO2011016220A1 (en) * | 2009-08-03 | 2011-02-10 | 株式会社カネカ | Dipeptidyl peptidase-4 inhibitor |
| KR101598612B1 (en) * | 2013-08-29 | 2016-02-26 | 재단법인 아산사회복지재단 | Composition for prophylaxis or treatment of vascular or cardiac valvular calcification comprising dipeptidyl peptidase-4 inhibitor |
-
2015
- 2015-02-27 WO PCT/KR2015/001902 patent/WO2016137037A1/en active Application Filing
- 2015-02-27 AU AU2015384339A patent/AU2015384339B2/en active Active
- 2015-02-27 PL PL15883426T patent/PL3263134T3/en unknown
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- 2015-02-27 CA CA2977939A patent/CA2977939C/en active Active
- 2015-02-27 CN CN202110168749.7A patent/CN113209295A/en active Pending
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| CA2977939C (en) | 2020-12-29 |
| SG11201707008SA (en) | 2017-09-28 |
| MX382875B (en) | 2025-03-13 |
| JP6467583B2 (en) | 2019-02-13 |
| EP3263134B1 (en) | 2021-05-05 |
| JP2018507912A (en) | 2018-03-22 |
| PL3263134T3 (en) | 2021-10-18 |
| ES2869463T3 (en) | 2021-10-25 |
| NZ735710A (en) | 2019-02-22 |
| RU2680527C1 (en) | 2019-02-22 |
| CN107530446B (en) | 2021-03-05 |
| CN113209295A (en) | 2021-08-06 |
| WO2016137037A1 (en) | 2016-09-01 |
| IL254169A0 (en) | 2017-10-31 |
| CN107530446A (en) | 2018-01-02 |
| AU2015384339A1 (en) | 2017-10-12 |
| KR102060728B1 (en) | 2019-12-30 |
| BR112017018329A2 (en) | 2018-08-07 |
| KR20170123665A (en) | 2017-11-08 |
| EP3263134A4 (en) | 2018-09-26 |
| AU2015384339B2 (en) | 2018-08-09 |
| EP3263134A1 (en) | 2018-01-03 |
| CA2977939A1 (en) | 2016-09-01 |
| IL254169B (en) | 2021-08-31 |
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