[go: up one dir, main page]

MX2017006866A - Pares de unión para producción de péptidos. - Google Patents

Pares de unión para producción de péptidos.

Info

Publication number
MX2017006866A
MX2017006866A MX2017006866A MX2017006866A MX2017006866A MX 2017006866 A MX2017006866 A MX 2017006866A MX 2017006866 A MX2017006866 A MX 2017006866A MX 2017006866 A MX2017006866 A MX 2017006866A MX 2017006866 A MX2017006866 A MX 2017006866A
Authority
MX
Mexico
Prior art keywords
fusion partners
peptide production
production
polypeptide
medicine
Prior art date
Application number
MX2017006866A
Other languages
English (en)
Inventor
R Bruck Torben
Chapman Adam
M Retallack Diane
Jin Hongfan
Original Assignee
Pfenex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfenex Inc filed Critical Pfenex Inc
Publication of MX2017006866A publication Critical patent/MX2017006866A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21009—Enteropeptidase (3.4.21.9), i.e. enterokinase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se relaciona con el campo de la medicina, en particular, con la traducción de grandes cantidades de un polipéptido recombinante soluble como parte de una proteína de fusión que comprende un par de fusión N-terminal enlazado al polipéptido de interés.
MX2017006866A 2014-12-01 2015-11-30 Pares de unión para producción de péptidos. MX2017006866A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462086119P 2014-12-01 2014-12-01
PCT/US2015/063027 WO2016089782A1 (en) 2014-12-01 2015-11-30 Fusion partners for peptide production

Publications (1)

Publication Number Publication Date
MX2017006866A true MX2017006866A (es) 2017-11-15

Family

ID=56092296

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017006866A MX2017006866A (es) 2014-12-01 2015-11-30 Pares de unión para producción de péptidos.

Country Status (17)

Country Link
US (2) US10118956B2 (es)
EP (1) EP3227455B1 (es)
JP (2) JP6817939B2 (es)
KR (1) KR102353262B1 (es)
CN (2) CN107532190B (es)
AR (1) AR102865A1 (es)
AU (1) AU2015355242B2 (es)
CA (1) CA2966358C (es)
DK (1) DK3227455T3 (es)
ES (1) ES2952405T3 (es)
HK (1) HK1245336A1 (es)
MX (1) MX2017006866A (es)
NZ (1) NZ732400A (es)
RU (1) RU2017123283A (es)
SG (1) SG11201704362VA (es)
TW (1) TWI702289B (es)
WO (1) WO2016089782A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3227455B1 (en) 2014-12-01 2023-07-12 Pfenex Inc. Fusion partners for peptide production
US9798758B2 (en) 2015-05-15 2017-10-24 Foogal Incorporated Food freshness notification from personal food inventory
JP7358347B2 (ja) 2017-10-27 2023-10-10 フェネックス インク． 組み換えＥ．ｃｏｌｉアスパラギナーゼの製造のための方法
CN111278852B (zh) * 2017-10-27 2024-07-16 菲尼克斯公司 重组欧氏杆菌天冬酰胺酶的生产方法
EP3741774A4 (en) 2018-01-19 2021-06-02 Pepgene Inc. N-TERMINAL FUSION APPROVED FOR THE PRODUCTION OF A RECOMBINANT POLYPEPTIDE, AND PROCESS FOR THE PRODUCTION OF A RECOMBINANT POLYPEPTIDE USING THE LATTER
CN108191981B (zh) * 2018-02-06 2020-11-03 美药星（南京）制药有限公司 一种利拉鲁肽中间体多肽的制备方法
KR102017542B1 (ko) * 2018-02-14 2019-09-03 주식회사 펩진 융합 폴리펩타이드를 이용하여 글루카곤 유사 펩타이드-2 또는 이의 유사체를 생산하는 방법
KR102009709B1 (ko) * 2018-02-14 2019-08-12 주식회사 펩진 융합 폴리펩타이드를 이용하여 인간 부갑상선 호르몬 1-84를 생산하는 방법
KR102017540B1 (ko) * 2018-02-14 2019-09-03 주식회사 펩진 융합 폴리펩타이드를 이용하여 글루카곤 유사 펩타이드-1 또는 이의 유사체를 생산하는 방법
CN108977423A (zh) * 2018-08-17 2018-12-11 集美大学 一种从猪肺中分离提纯血管紧张素转化酶的方法
KR102011291B1 (ko) * 2018-12-05 2019-10-21 주식회사 펩진 신규한 융합 폴리펩타이드 및 이를 이용하여 인간 부갑상선 호르몬 1-34를 생산하는 방법
CA3123078A1 (en) 2018-12-13 2020-06-18 Huya Bioscience International, Llc Sulcardine administration for treatment of acute atrial fibrillation
CN110305223B (zh) * 2019-06-26 2022-05-13 重庆派金生物科技有限公司 重组串联融合蛋白制备目标多肽的方法
KR20210010368A (ko) * 2019-07-19 2021-01-27 주식회사 펩진 글루카곤 유사 펩타이드-2 또는 이의 유사체 생산용 융합태그
KR20210010366A (ko) * 2019-07-19 2021-01-27 주식회사 펩진 글루카곤 유사 펩타이드-1 또는 이의 유사체 생산용 융합태그
KR20210010367A (ko) * 2019-07-19 2021-01-27 주식회사 펩진 인간부갑상선호르몬1-34 생산용 융합태그
CN113773400B (zh) * 2020-06-09 2023-08-18 宁波鲲鹏生物科技有限公司 一种门冬胰岛素衍生物及其应用
CN113151296B (zh) * 2021-03-22 2022-09-13 云南中烟工业有限责任公司 一种烟草热激蛋白相关的基因及其应用
CN113025599B (zh) * 2021-04-02 2023-09-12 重庆科润生物医药研发有限公司 一种重组溶组织梭菌i型胶原酶及其制备方法和应用
CN112941058B (zh) * 2021-04-02 2023-12-05 重庆科润生物医药研发有限公司 一种重组溶组织梭菌ii型胶原酶及其制备方法和应用
EP4352219A1 (en) * 2021-06-10 2024-04-17 Pelican Technology Holdings, Inc. Bacterial hosts for recombinant protein expression
WO2023049631A2 (en) * 2021-09-09 2023-03-30 Northwestern University Cell-free methods and compositions comprising tagless therapeutic hormones
CN114350587B (zh) * 2022-01-24 2023-10-31 修实生物医药(南通)有限公司 一种基因重组串联表达利那洛肽的工程菌
CN115109766A (zh) * 2022-02-14 2022-09-27 上海理工大学 一种耐高温金属蛋白酶及其编码基因和应用
WO2024035782A1 (en) * 2022-08-10 2024-02-15 Aav Gene Therapeutics, Inc. Aav-mediated intramuscular delivery of insulin

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769326A (en) 1980-02-29 1988-09-06 The Regents Of The University Of California Expression linkers
US4551433A (en) 1981-05-18 1985-11-05 Genentech, Inc. Microbial hybrid promoters
US4755465A (en) 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
US5281532A (en) 1983-07-27 1994-01-25 Mycogen Corporation Pseudomas hosts transformed with bacillus endotoxin genes
US4695455A (en) 1985-01-22 1987-09-22 Mycogen Corporation Cellular encapsulation of pesticides produced by expression of heterologous genes
US4695462A (en) 1985-06-28 1987-09-22 Mycogen Corporation Cellular encapsulation of biological pesticides
GB8517071D0 (en) 1985-07-05 1985-08-14 Hoffmann La Roche Gram-positive expression control sequence
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5128130A (en) 1988-01-22 1992-07-07 Mycogen Corporation Hybrid Bacillus thuringiensis gene, plasmid and transformed Pseudomonas fluorescens
US5055294A (en) 1988-03-03 1991-10-08 Mycogen Corporation Chimeric bacillus thuringiensis crystal protein gene comprising hd-73 and berliner 1715 toxin genes, transformed and expressed in pseudomonas fluorescens
US5169760A (en) 1989-07-27 1992-12-08 Mycogen Corporation Method, vectors, and host cells for the control of expression of heterologous genes from lac operated promoters
US7150974B1 (en) 1991-04-05 2006-12-19 The General Hospital Corporation Parathyroid hormone receptor binding method
JP3951062B2 (ja) 1991-09-19 2007-08-01 ジェネンテック・インコーポレーテッド 少なくとも遊離のチオールとして存在するシステインを有する抗体フラグメントの大腸菌での発現、２官能性Ｆ（ａｂ’）２抗体の産生のための使用
CA2125467C (en) 1993-07-06 2001-02-06 Heinz Dobeli Process for producing hydrophobic polypeptides, proteins or peptides
US5935824A (en) 1996-01-31 1999-08-10 Technologene, Inc. Protein expression system
CA2198966C (en) 1996-03-04 2011-06-21 Yuji Suzuki Method for cleaving chimeric protein using processing enzyme
JPH1175879A (ja) * 1997-07-08 1999-03-23 Toyota Central Res & Dev Lab Inc プロテインジスルフィドイソメラーゼを含有する融合タンパク質をコードするｄｎａ
US5989868A (en) 1997-09-12 1999-11-23 The Board Of Regents Of The University Of Oklahoma Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli
EP0978565B1 (en) 1998-01-30 2007-10-10 Asubio Pharma Co., Ltd. Process for producing peptide with the use of accessory peptide
US6242219B1 (en) 1999-03-18 2001-06-05 Xoma (Us) Llc Methods for recombinant peptide production
US6906176B2 (en) 2000-06-19 2005-06-14 Dyax Corp. Enterokinase cleavage sequences
JP2002262873A (ja) 2001-03-06 2002-09-17 Inst Of Physical & Chemical Res タンパク質ドメインの製造方法及びその方法により得られたドメインを用いるタンパク質の立体構造解析方法
EP2267452B8 (en) * 2001-06-22 2012-11-14 Roche Diagnostics GmbH A soluble complex comprising a retroviral surface glycoprotein
JP4088584B2 (ja) 2001-07-26 2008-05-21 アドバンスド プロテイン テクノロジーズ コーポレイション 融合タンパク質から目的タンパク質を分離する方法。
CN1678624B (zh) 2002-07-03 2011-10-26 陶氏环球技术公司 苯甲酸盐-和邻氨基苯甲酸盐-诱导的启动子
AU2003254680A1 (en) 2002-08-09 2004-02-25 National Research Council Of Canada Staphylococcal nuclease fusion proteins for the production of recombinant peptides
US7208585B2 (en) 2002-09-18 2007-04-24 Genencor International, Inc. Protein purification
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
WO2004092221A1 (ja) 2003-04-18 2004-10-28 Sekisui Chemical Co. Ltd. 免疫原及び免疫用組成物、並びにそれらを使用する抗体の製造方法
JP2005110591A (ja) 2003-10-08 2005-04-28 Sekisui Chem Co Ltd 蛋白質の分離方法
BRPI0416744A (pt) 2003-11-19 2007-01-16 Dow Global Technologies Inc sistemas de expressão de proteìna aperfeiçoados
EP2336153B1 (en) 2003-11-21 2016-03-30 Pfenex Inc. Improved expression systems with SEC-system secretion
CA2545024A1 (en) 2003-11-24 2005-06-02 Novo Nordisk A/S Fusion proteins and methods of cleavage of such proteins
KR101183720B1 (ko) 2004-01-16 2012-09-17 다우 글로벌 테크놀로지스 엘엘씨 슈도모나스 플루오레센스에서의 포유류 단백질의 발현
WO2006078273A2 (en) 2004-04-26 2006-07-27 The United States Of America As Represented By Teh Secretary Of Health And Human Services, Nih Methods and compositions for producing recombinant proteins
WO2005113768A1 (ja) 2004-05-21 2005-12-01 Takara Bio Inc. ポリペプチドの製造方法
AU2005269527B2 (en) * 2004-07-26 2011-12-01 Pfenex Inc. Process for improved protein expression by strain engineering
WO2006016370A2 (en) 2004-08-11 2006-02-16 Ramot At Tel Aviv University Ltd. Soluble fusion proteins comprising heterologous polypeptides
JP4897792B2 (ja) 2005-04-20 2012-03-14 ビロメッド カンパニー， リミテッド 融合タンパク質の分離のための組成物および方法
CN101193906B (zh) 2005-06-06 2012-09-05 陶氏环球技术公司 细菌宿主细胞中甘露糖醇诱导的启动子系统
WO2007142954A2 (en) 2006-05-30 2007-12-13 Dow Global Technologies Inc. Codon optimization method
WO2008027099A2 (en) 2006-05-30 2008-03-06 Dow Global Technologies Inc. Rpa optimization
EP1873251A1 (en) 2006-06-29 2008-01-02 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Expression vector(s) for enhanced expression of a protein of interest in eukaryotic or prokaryotic host cells
KR101491867B1 (ko) 2007-01-31 2015-02-10 피페넥스 인크. 증가된 발현을 위한 박테리아 리더 서열
CA2964910C (en) 2007-04-27 2018-01-09 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2173768B1 (en) 2007-08-09 2014-03-05 USV Limited Novel orthogonal process for purification of recombinant human parathyroid hormone (rhpth) (1-34)
CN101939435A (zh) * 2007-09-21 2011-01-05 巴斯夫植物科学有限公司 具有增加的产量的植物
US7943733B2 (en) 2007-12-20 2011-05-17 University Of Southern California Spacers to increase the expression of recombinant fusion proteins
EP2127678A1 (en) 2008-05-26 2009-12-02 Roche Diagnostics GmbH SlpA as a tool for recombinant protein and enzyme technology
JP2010006745A (ja) * 2008-06-27 2010-01-14 Sekisui Chem Co Ltd 融合タンパク質、融合タンパク質固定化担体、化合物のスクリーニング方法、スクリーニング用組成物、並びに、スクリーニング用キット
EP2370470B1 (en) * 2008-12-04 2016-10-05 Korea Research Institute of Bioscience and Biotechnology Screening of abundantly secreted proteins and their use as fusion partners for the production of recombinant proteins
AU2011235210B2 (en) 2010-04-01 2015-07-16 Pfenex Inc. Methods for G-CSF production in a Pseudomonas host cell
WO2011151714A1 (en) 2010-06-04 2011-12-08 Lupin Limited Modified sak gene for the production of recombinant proteins
AR086250A1 (es) 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
EP3227455B1 (en) 2014-12-01 2023-07-12 Pfenex Inc. Fusion partners for peptide production
CA2974343A1 (en) 2015-02-13 2016-08-18 Sekisui Chemical Co., Ltd. Nucleic acid, fusion protein, recombined cell, and isoprene or cyclic terpene production method

Also Published As

Publication number Publication date
EP3227455A1 (en) 2017-10-11
JP7148579B2 (ja) 2022-10-05
US20160159877A1 (en) 2016-06-09
EP3227455B1 (en) 2023-07-12
EP3227455A4 (en) 2018-07-04
AU2015355242B2 (en) 2020-10-08
SG11201704362VA (en) 2017-06-29
CA2966358A1 (en) 2016-06-09
AR102865A1 (es) 2017-03-29
JP2017536835A (ja) 2017-12-14
CA2966358C (en) 2021-12-07
HK1245336A1 (zh) 2018-08-24
CN113444183A (zh) 2021-09-28
TWI702289B (zh) 2020-08-21
US10118956B2 (en) 2018-11-06
JP2021003117A (ja) 2021-01-14
US10981968B2 (en) 2021-04-20
CN107532190B (zh) 2021-07-09
ES2952405T3 (es) 2023-10-31
KR20170085129A (ko) 2017-07-21
BR112017011662A2 (pt) 2018-02-27
US20190135889A1 (en) 2019-05-09
WO2016089782A1 (en) 2016-06-09
DK3227455T3 (da) 2023-08-21
JP6817939B2 (ja) 2021-01-20
CN107532190A (zh) 2018-01-02
TW201629226A (zh) 2016-08-16
RU2017123283A (ru) 2019-01-09
AU2015355242A1 (en) 2017-06-22
KR102353262B1 (ko) 2022-01-18
NZ732400A (en) 2021-07-30

Similar Documents

Publication Publication Date Title
MX2017006866A (es) Pares de unión para producción de péptidos.
PH12020550205A1 (en) IL-22 POLYPEPTIDES AND IL-22 Fc FUSION PROTEINS AND METHODS OF USE
CY1124309T1 (el) Τροποποιημενα πολυπεπτιδια fgf-21 και χρησεις εξ αυτων
MX2023008559A (es) Proteínas de fusión fc heterodiméricas il15/il15ra.
WO2013184939A3 (en) Fusion polypeptides comprising an active protein linked to a mucin-domain polypeptide
SA520412669B1 (ar) تصنيع ذيفانات عصبية ناتجة عن معاودة الارتباط الجيني من المطثية الوشيقية
MX2016008539A (es) Variantes de region fc con propiedades de union a receptor fc neonatal (fcrn) modificadas y de union a proteina a mantenidas.
SG10201909716RA (en) Modified j-chain
MX363788B (es) Métodos para la producción de polipéptidos procesados proteolíticamente.
PH12016501937A1 (en) Method for improving solubility of protein and peptide by using immunoglobulin fc fragment linkage
EP3543335A3 (en) Soluble intein fusion proteins and methods for purifying biomolecules
MX2016008355A (es) Anticuerpos que comprenden extensiones de polipeptidos de cadena ligera en el extremo c y conjugados y metodos de uso de estos.
MX2021000155A (es) Moleculas de proteina multifuncionales que comprenden decorina y su uso.
MX366178B (es) Proteinas de btnl3, acidos nucleicos, y anticuerpos y los usos de los mismos.
PH12016500403A1 (en) An anti serum albumin fab-effector moiety fusion construct, and the preparing method thereof
MD20150109A2 (ro) Construcţii proteice mitocondriale şi utilizările acestora
SG10201805039UA (en) Protease resistant peptides
MX2017008406A (es) Conjugados de aminoacidos y peptidos y sus usos.
MX2018005411A (es) Polipeptidos anti il-23.
WO2014111509A3 (en) Fusion peptides for enhancing protein expression
MY184085A (en) Method of protein manufacture
MX2016012428A (es) Aumento de la expresion de proteina recombinante con cobre.
NZ744289A (en) Composition containing amino acids
MX2018003445A (es) Expresion de proteinas que contienen fc.
WO2014169274A3 (en) Modified proteins and methods of use thereof