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MX2017002134A - Agente para el tratamiento y/o prevencion de enfermedades asociadas con anormalidades inmunes. - Google Patents

Agente para el tratamiento y/o prevencion de enfermedades asociadas con anormalidades inmunes.

Info

Publication number
MX2017002134A
MX2017002134A MX2017002134A MX2017002134A MX2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A
Authority
MX
Mexico
Prior art keywords
immune cells
multifunctionality
immune cell
biguanide
buformin
Prior art date
Application number
MX2017002134A
Other languages
English (en)
Other versions
MX384315B (es
Inventor
Udono Heiichiro
Eikawa Shingo
TOYOOKA Shin-ichi
Original Assignee
Nat Univ Corporation Okayama Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Univ Corporation Okayama Univ filed Critical Nat Univ Corporation Okayama Univ
Publication of MX2017002134A publication Critical patent/MX2017002134A/es
Publication of MX384315B publication Critical patent/MX384315B/es

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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
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  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

La presente invención proporciona un método para mejorar la función de células inmunes al reactivar varias células ex vivo y proporciona células inmunes con función mejorada; la invención adicionalmente proporciona un método de evaluación de multifuncionalidad relacionado a células inmunes; un fármaco antidiabético de biguanida seleccionado de metformina, fenformína, y buformina es capaz de mejorar la multifuncionalidad de células inmunes al incrementar células TCD8+ que tienen una alta habilidad para producir IL-2, TNF-a, e IFN?; la multifuncionalidad de células inmunes puede ser evaluada al comparar células inmunes tratadas con un fármaco antidiabético de biguanida seleccionado de metformina, fenformina, y buformina, contra células inmunes control que no fueron tratadas con el fármaco antidiabético de biguanida; cuando la multifuncionalidad de células inmunes tratadas con el fármaco antidiabético de biguanida seleccionado de metformina, fenformina, y buformina se determina que es incrementada significativamente en comparación con el control, se puede evaluar que la sensibilidad de las células inmunes al agente terapéutico es mejorada.
MX2017002134A 2014-08-19 2015-08-17 Agente para el tratamiento y/o prevención de enfermedades asociadas con anormalidades inmunes. MX384315B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014166593 2014-08-19
JP2015085556 2015-04-20
PCT/JP2015/073011 WO2016027764A1 (ja) 2014-08-19 2015-08-17 免疫細胞の機能増強方法及び免疫細胞の多機能性評価方法

Publications (2)

Publication Number Publication Date
MX2017002134A true MX2017002134A (es) 2017-09-13
MX384315B MX384315B (es) 2025-03-14

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MX2017002134A MX384315B (es) 2014-08-19 2015-08-17 Agente para el tratamiento y/o prevención de enfermedades asociadas con anormalidades inmunes.

Country Status (15)

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US (2) US20170231929A1 (es)
EP (2) EP3192517A4 (es)
JP (3) JP6629211B2 (es)
KR (1) KR20170042778A (es)
CN (1) CN107148274A (es)
AU (1) AU2015304448B2 (es)
BR (1) BR112017002807A2 (es)
CA (1) CA2958573A1 (es)
ES (1) ES2915849T3 (es)
IL (1) IL250639B (es)
MX (1) MX384315B (es)
PH (1) PH12017500224B1 (es)
RU (2) RU2731098C2 (es)
SG (2) SG10202005315SA (es)
WO (1) WO2016027764A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103059138B (zh) * 2005-05-09 2015-10-28 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
LT3081576T (lt) 2013-12-12 2019-10-25 Shanghai hengrui pharmaceutical co ltd Pd-1 antikūnas, antigeną surišantis jo fragmentas ir jų medicininis pritaikomumas
TW202436356A (zh) 2016-10-11 2024-09-16 美商艾吉納斯公司 抗ｌａｇ－３抗體及其使用方法
CN107082812B (zh) 2017-03-29 2018-11-13 上海科医联创生物科技有限公司 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用
RS65488B9 (sr) * 2017-06-02 2024-09-30 Bayer Healthcare Llc Kombinacija regorafeniba i nivolumaba za lečenje karcinoma
WO2019069449A1 (ja) * 2017-10-06 2019-04-11 純児 赤木 測定方法
WO2019124423A1 (ja) * 2017-12-19 2019-06-27 国立大学法人 岡山大学 がんの進行抑制、治療、予防及び／又は再発予防剤
JP2019112353A (ja) * 2017-12-25 2019-07-11 合同会社チューモス 自家腫瘍ワクチン及び免疫誘導方法
EP3734272A4 (en) * 2017-12-26 2022-01-12 Tamio Yamauchi METHOD, SYSTEM AND PROGRAM FOR PROVIDING IMMUNODYNAMIC INFORMATION
TR201900059A2 (tr) * 2018-01-05 2019-07-22 Gnt Biotech & Medicals Corp Bi̇r farmasöti̇k kombi̇nasyon ve tümör mi̇kroortaminin ve i̇mmünoterapi̇ni̇n regülasyonu i̇çi̇n yöntem
WO2019202473A1 (en) * 2018-04-16 2019-10-24 Université de Lausanne Ucp2 inducing agents for the treatment of cancer resistant to immune checkpoint blockade
KR20210119380A (ko) * 2018-11-09 2021-10-05 피어리언 바이오사이언스즈, 엘엘씨 종양 미세환경의 조성을 결정하기 위한 방법 및 조성물
WO2020118208A1 (en) * 2018-12-07 2020-06-11 Arizona Board Of Regents On Behalf Of The University Of Arizona A method of determining risk for skin cancer development and skin cancer therapeutic prevention by measuring pd-1/pd-l1 signaling pathway members
KR102510381B1 (ko) * 2019-10-16 2023-03-15 한국과학기술원 메트포민을 유효성분으로 포함하는 뇌암의 예방 또는 치료용 면역치료제 조성물
WO2022072745A1 (en) * 2020-10-01 2022-04-07 The Regents Of The University Of California Methods and compositions to treat and prevent viral infections and acute respiratory distress syndrome
CN112791182A (zh) * 2020-12-31 2021-05-14 中山大学 二甲双胍和抗pd-1抗体药物组合物在制备肝癌药物中的应用
JP7589052B2 (ja) * 2021-01-28 2024-11-25 キヤノンメディカルシステムズ株式会社 医用情報処理装置、医用情報処理システム、医用情報処理方法、及び医用情報処理プログラム
CN113421627B (zh) * 2021-05-11 2023-04-07 深圳市罗湖区人民医院 体外评估药物对nk细胞抗衰作用的系统
CN116606352B (zh) * 2023-07-14 2023-09-29 诺赛联合(北京)生物医学科技有限公司 一种抗菌修复功能的组合物凝胶在妇科疾病中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US5260275A (en) * 1990-08-14 1993-11-09 Amylin Pharmaceuticals, Inc. Hypoglycemics
CA2174132A1 (en) * 1993-10-14 1995-04-20 Immunex Corporation Fas antagonists and uses thereof
CN1635881A (zh) * 2000-08-07 2005-07-06 兰贝克赛标记有限公司 甲福明的液体制剂
SI2206517T1 (sl) * 2002-07-03 2023-12-29 Ono Pharmaceutical Co., Ltd. Imunopotencirni sestavki,ki obsegajo protitelesa proti PD-L1
CN103059138B (zh) 2005-05-09 2015-10-28 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
US8563500B2 (en) * 2007-09-05 2013-10-22 Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts Methods and compounds for treating diseases caused by reactive oxygen species
US20120220664A1 (en) * 2009-08-25 2012-08-30 President And Fellows Of Harvard College Use of metformin in cancer treatment and prevention
US20130059916A1 (en) * 2010-05-26 2013-03-07 Stephane Rocchi Biguanide compounds and its use for treating cancer
EP2663298A1 (en) * 2011-01-11 2013-11-20 Universität Basel Combination of syrosingopine and mitochondrial inhibitors for the treatment of cancer and immunosuppression
WO2013009535A1 (en) * 2011-07-08 2013-01-17 Merck Sharp & Dohme Corp. Il-23 antagonists for treatment or prevention of skin rash associated with treatment with p13k/akt pathway inhibitors
CN103371991A (zh) * 2012-04-18 2013-10-30 中国人民解放军第二军医大学 二甲双胍在制备预防或治疗肝细胞癌药物中的应用
WO2014009535A2 (en) * 2012-07-12 2014-01-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes
CA2881389C (en) * 2012-08-06 2022-01-04 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and kits for screening patients with a cancer
NZ631405A (en) * 2012-10-02 2017-01-27 Bristol Myers Squibb Co Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer
WO2014083095A1 (en) * 2012-11-29 2014-06-05 Universitaet Basel Combinations of metformin with other compounds for the treatment of cancer and for immunosuppression
TWI664976B (zh) * 2013-01-02 2019-07-11 美商迪科生物系統公司 使用細菌治療癌症之組成物和方法
JP6242071B2 (ja) * 2013-04-23 2017-12-06 国立大学法人 岡山大学 免疫疲弊ｃｄ８＋ｔ細胞の機能改善薬、がん治療薬及びメタボリック症候群の予防または治療薬

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