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MX2017001979A - Metodo y aparato in vitro para analizar el comportamiento de sustancias en ambiente fisiologico simulado. - Google Patents

Metodo y aparato in vitro para analizar el comportamiento de sustancias en ambiente fisiologico simulado.

Info

Publication number
MX2017001979A
MX2017001979A MX2017001979A MX2017001979A MX2017001979A MX 2017001979 A MX2017001979 A MX 2017001979A MX 2017001979 A MX2017001979 A MX 2017001979A MX 2017001979 A MX2017001979 A MX 2017001979A MX 2017001979 A MX2017001979 A MX 2017001979A
Authority
MX
Mexico
Prior art keywords
fluid
behavior
substances
physiological environment
appliance
Prior art date
Application number
MX2017001979A
Other languages
English (en)
Other versions
MX375546B (es
Inventor
Jagdish JERE Dhananjay
Christian MAHLER Hanns-
Patel Sulabh
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP14181653.8A external-priority patent/EP2988110A1/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2017001979A publication Critical patent/MX2017001979A/es
Publication of MX375546B publication Critical patent/MX375546B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G01N33/559—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody through a gel, e.g. Ouchterlony technique
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
    • G01N2013/003—Diffusion; diffusivity between liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se relaciona con un método y aparato in vitro para analizar el comportamiento de sustancias en un ambiente fisiológico simulado. El método comprende las etapas de proporcionar un primer fluido, una matriz de gel y un segundo fluido, separar el primer fluido y la matriz de gel mediante por al menos una primera membrana semipermeable y separar la matriz de gel y el segundo fluido mediante por al menos una segunda membrana semipermeable. El método además comprende las etapas de inyectar una sustancia en el primer fluido, dejar que la sustancia emigre desde el primer fluido a través de por lo menos un primera membrana semipermeable, a través de la matriz de gel, a través de por lo menos la segunda membrana semipermeable y en el segundo fluido, y determinar la depuración de la sustancia del primer fluido.
MX2017001979A 2014-08-20 2015-08-19 Método y aparato in vitro para analizar el comportamiento de sustancias en ambiente fisiológico simulado. MX375546B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14181653.8A EP2988110A1 (en) 2014-08-20 2014-08-20 In vitro method and apparatus for analysing the behaviour of substances in simulated physiological environment
EP15165825 2015-04-30
PCT/EP2015/068981 WO2016026877A1 (en) 2014-08-20 2015-08-19 In vitro method and apparatus for analysing the behaviour of substances in simulated physiological environment

Publications (2)

Publication Number Publication Date
MX2017001979A true MX2017001979A (es) 2017-05-04
MX375546B MX375546B (es) 2025-03-06

Family

ID=54062716

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017001979A MX375546B (es) 2014-08-20 2015-08-19 Método y aparato in vitro para analizar el comportamiento de sustancias en ambiente fisiológico simulado.

Country Status (11)

Country Link
US (2) US10458891B2 (es)
EP (1) EP3183554B1 (es)
JP (2) JP6705808B2 (es)
KR (1) KR102354931B1 (es)
CN (1) CN106574887B (es)
BR (1) BR112017003167B1 (es)
CA (1) CA2957332A1 (es)
HK (1) HK1232297A1 (es)
MX (1) MX375546B (es)
RU (1) RU2694406C2 (es)
WO (1) WO2016026877A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102354931B1 (ko) * 2014-08-20 2022-01-24 에프. 호프만-라 로슈 아게 모사된 생리학적 환경에서 물질의 거동을 분석하기 위한 시험관내 방법 및 장치
SG11201806348PA (en) * 2016-01-28 2018-08-30 Chia Tai Tianqing Pharmaceutical Group Co Ltd Steroid derivative fxr agonist
IT201800020242A1 (it) * 2018-12-19 2020-06-19 Milano Politecnico Substrato tridimensionale per le colture microbiche
KR102224065B1 (ko) * 2018-12-28 2021-03-05 포항공과대학교 산학협력단 다공성 마이크로웰 및 이를 구비한 멤브레인과 그 제조 방법
DE102020101584B4 (de) * 2020-01-23 2024-10-02 Lts Lohmann Therapie-Systeme Ag Modifizierte Franz-Zelle
EP4476709A1 (en) * 2022-02-11 2024-12-18 Lonza Ltd. In-vitro method for simulating and analyzing behavior of an ophthalmological drug in an eye
WO2023230575A1 (en) * 2022-05-26 2023-11-30 University Of Kansas Emulator of subcutaneous absorption and release

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4740309A (en) * 1986-08-29 1988-04-26 Iprx, Inc. Methods and apparatus for determining the rate of movement of a study substance through a membrane
JPH03205017A (ja) * 1989-12-17 1991-09-06 Keiichi Kikuchi 容器型二重フィルターのコーヒーバッグ
US6821419B2 (en) 2002-01-28 2004-11-23 Hanson Research Corporation Diffusion cell with quick release clamp
JP2006527366A (ja) 2003-03-28 2006-11-30 アルザ・コーポレーション 拡散試料採取装置用の静止拡散セル
TW200732644A (en) * 2005-10-25 2007-09-01 Rohm & Haas Dissolution test equipment and methods for testing having improved filtration system
AU2007253702A1 (en) 2006-05-22 2007-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
US8322193B2 (en) 2009-11-23 2012-12-04 Logan Instruments Corp. Transdermal diffusion cell testing arrangements and methods
GB201217675D0 (en) 2012-10-03 2012-11-14 Matharu Manmit S TTL adjustable binocular loupes device
GB201217768D0 (en) * 2012-10-04 2012-11-14 Univ Bath Methods and apparatus for the in vitro modelling of subcutaneous injection
KR102354931B1 (ko) * 2014-08-20 2022-01-24 에프. 호프만-라 로슈 아게 모사된 생리학적 환경에서 물질의 거동을 분석하기 위한 시험관내 방법 및 장치

Also Published As

Publication number Publication date
BR112017003167A2 (pt) 2017-11-28
WO2016026877A1 (en) 2016-02-25
US10746644B2 (en) 2020-08-18
US20200025664A1 (en) 2020-01-23
JP2017527797A (ja) 2017-09-21
RU2017108426A (ru) 2018-09-20
US20170268976A1 (en) 2017-09-21
BR112017003167B1 (pt) 2021-06-22
EP3183554B1 (en) 2019-02-20
JP6705808B2 (ja) 2020-06-03
HK1232297A1 (zh) 2018-01-05
US10458891B2 (en) 2019-10-29
CN106574887B (zh) 2020-09-08
EP3183554A1 (en) 2017-06-28
KR102354931B1 (ko) 2022-01-24
CN106574887A (zh) 2017-04-19
KR20170046153A (ko) 2017-04-28
RU2017108426A3 (es) 2019-02-19
MX375546B (es) 2025-03-06
CA2957332A1 (en) 2016-02-25
JP6993463B2 (ja) 2022-01-13
RU2694406C2 (ru) 2019-07-12
JP2020126081A (ja) 2020-08-20

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