MX2016010134A - Composicion farmaceutica que comprende compuesto de diaminocarboxamida heterociclica como ingrediente activo. - Google Patents
Composicion farmaceutica que comprende compuesto de diaminocarboxamida heterociclica como ingrediente activo.Info
- Publication number
- MX2016010134A MX2016010134A MX2016010134A MX2016010134A MX2016010134A MX 2016010134 A MX2016010134 A MX 2016010134A MX 2016010134 A MX2016010134 A MX 2016010134A MX 2016010134 A MX2016010134 A MX 2016010134A MX 2016010134 A MX2016010134 A MX 2016010134A
- Authority
- MX
- Mexico
- Prior art keywords
- axl
- cancer
- medicinal composition
- another embodiment
- active ingredient
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 239000004480 active ingredient Substances 0.000 title abstract 2
- -1 heterocyclic carboxamide compound Chemical class 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 6
- 201000011510 cancer Diseases 0.000 abstract 6
- 230000004913 activation Effects 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
[Problema] Proveer una composición farmacéutica para tratar cáncer relacionado con AXL, en otro aspecto, una composición farmacéutica para tratar cáncer con expresión elevada de AXL, e incluso en otro aspecto, una composición farmacéutica para tratar cáncer que tiene resistencia adquirida por la activación de AXL contra la terapia con un agente anticáncer. [Solución] Los presentes inventores han estudiado compuestos que tienen una acción inhibidora de AXL, y han encontrado que compuestos de diaminocarboxamida heterocíclica específicos tienen una acción inhibidora de AXL, y que las composiciones farmacéuticas que comprenden estos compuestos como un ingrediente activo tienen un efecto terapéutico sobre cáncer relacionado con AXL, en otro aspecto, cáncer con expresión elevada de AXL, e incluso en otro aspecto, cáncer que tiene resistencia adquirida por la activación de AXL contra la terapia con un agente anticáncer, con lo cual se completa la presente invención.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014019226 | 2014-02-04 | ||
| PCT/JP2015/053018 WO2015119122A1 (ja) | 2014-02-04 | 2015-02-03 | ジアミノヘテロ環カルボキサミド化合物を有効成分とする医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016010134A true MX2016010134A (es) | 2016-10-07 |
| MX363543B MX363543B (es) | 2019-03-27 |
Family
ID=53777926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016010134A MX363543B (es) | 2014-02-04 | 2015-02-03 | Composicion farmaceutica que comprende compuesto de diaminocarboxamida heterociclica como ingrediente activo. |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US11045468B2 (es) |
| EP (1) | EP3103453B1 (es) |
| JP (1) | JP6390626B2 (es) |
| KR (1) | KR102322338B1 (es) |
| CN (3) | CN113425727A (es) |
| AU (1) | AU2015215578B2 (es) |
| BR (1) | BR112016017897A8 (es) |
| CA (1) | CA2938818C (es) |
| CY (1) | CY1122968T1 (es) |
| DK (1) | DK3103453T3 (es) |
| EA (1) | EA033304B1 (es) |
| ES (1) | ES2788390T3 (es) |
| HR (1) | HRP20200662T1 (es) |
| HU (1) | HUE049437T2 (es) |
| IL (1) | IL247077B (es) |
| LT (1) | LT3103453T (es) |
| ME (1) | ME03775B (es) |
| MX (1) | MX363543B (es) |
| MY (1) | MY193536A (es) |
| PH (1) | PH12016501527B1 (es) |
| PL (1) | PL3103453T3 (es) |
| PT (1) | PT3103453T (es) |
| RS (1) | RS60150B1 (es) |
| SG (1) | SG11201606413RA (es) |
| SI (1) | SI3103453T1 (es) |
| SM (1) | SMT202000214T1 (es) |
| TW (1) | TWI655945B (es) |
| UA (1) | UA120607C2 (es) |
| WO (1) | WO2015119122A1 (es) |
| ZA (1) | ZA201605379B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3103453T3 (da) * | 2014-02-04 | 2020-04-20 | Astellas Pharma Inc | Medicinsk sammensætning omfattende heterocyklisk diamino-carboxamidforbindelse som aktiv bestanddel |
| EP3318259B1 (en) | 2015-07-03 | 2023-01-11 | Astellas Pharma Inc. | Stable pharmaceutical composition for oral administration |
| ES2894691T3 (es) * | 2015-11-04 | 2022-02-15 | Astellas Pharma Inc | Composición farmacéutica para propósitos de inmunoterapia y/o inmunoestimulación que contiene compuesto heterocíclico de diamino-carboxamida como principio activo |
| CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| TW202304908A (zh) * | 2021-04-14 | 2023-02-01 | 日商衛材R&D企管股份有限公司 | 四氫吡啶并嘧啶化合物 |
| WO2023129667A1 (en) | 2021-12-30 | 2023-07-06 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009215168A1 (en) * | 2008-02-12 | 2009-08-20 | Dana-Farber Cancer Institute | Fish assay for EML4 and ALK fusion in lung cancer |
| CN102036990B (zh) * | 2008-03-19 | 2015-09-30 | 凯姆桥公司 | 新型酪氨酸激酶抑制剂 |
| UY31800A (es) * | 2008-05-05 | 2009-11-10 | Smithkline Beckman Corp | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb |
| PT3009428T (pt) | 2009-05-08 | 2018-04-02 | Astellas Pharma Inc | Composto diamino-carboxamida heterocíclico |
| CN102408411B (zh) * | 2011-09-19 | 2014-10-22 | 北京康辰药业股份有限公司 | 一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用 |
| WO2013078271A1 (en) * | 2011-11-21 | 2013-05-30 | Immunogen, Inc. | Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate |
| UA113204C2 (xx) * | 2012-04-02 | 2016-12-26 | Селективна екстракція хлориду калію з відхідного шенітового розчину з використанням тартратної кислоти як безпечного м'якого екстрагента, придатного до рециркуляції | |
| ES2700231T3 (es) * | 2012-11-21 | 2019-02-14 | Janssen Biotech Inc | Anticuerpos de EGFR/c-Met biespecíficos |
| DK3103453T3 (da) * | 2014-02-04 | 2020-04-20 | Astellas Pharma Inc | Medicinsk sammensætning omfattende heterocyklisk diamino-carboxamidforbindelse som aktiv bestanddel |
| WO2015127234A1 (en) * | 2014-02-20 | 2015-08-27 | Board Of Regents, The University Of Texas System | Use of ibrutinib to treat egfr mutant cancer |
| EP3318259B1 (en) * | 2015-07-03 | 2023-01-11 | Astellas Pharma Inc. | Stable pharmaceutical composition for oral administration |
-
2015
- 2015-02-03 DK DK15746276.3T patent/DK3103453T3/da active
- 2015-02-03 KR KR1020167022660A patent/KR102322338B1/ko active Active
- 2015-02-03 CN CN202110880188.3A patent/CN113425727A/zh active Pending
- 2015-02-03 WO PCT/JP2015/053018 patent/WO2015119122A1/ja active Application Filing
- 2015-02-03 CN CN201580006772.9A patent/CN105939714A/zh active Pending
- 2015-02-03 UA UAA201609187A patent/UA120607C2/uk unknown
- 2015-02-03 SM SM20200214T patent/SMT202000214T1/it unknown
- 2015-02-03 RS RS20200432A patent/RS60150B1/sr unknown
- 2015-02-03 HR HRP20200662TT patent/HRP20200662T1/hr unknown
- 2015-02-03 ES ES15746276T patent/ES2788390T3/es active Active
- 2015-02-03 BR BR112016017897A patent/BR112016017897A8/pt not_active Application Discontinuation
- 2015-02-03 SG SG11201606413RA patent/SG11201606413RA/en unknown
- 2015-02-03 MY MYPI2016702813A patent/MY193536A/en unknown
- 2015-02-03 SI SI201531179T patent/SI3103453T1/sl unknown
- 2015-02-03 MX MX2016010134A patent/MX363543B/es unknown
- 2015-02-03 US US15/116,736 patent/US11045468B2/en active Active
- 2015-02-03 EA EA201691570A patent/EA033304B1/ru not_active IP Right Cessation
- 2015-02-03 LT LTEP15746276.3T patent/LT3103453T/lt unknown
- 2015-02-03 AU AU2015215578A patent/AU2015215578B2/en active Active
- 2015-02-03 CN CN202310702543.7A patent/CN116509866A/zh active Pending
- 2015-02-03 CA CA2938818A patent/CA2938818C/en active Active
- 2015-02-03 HU HUE15746276A patent/HUE049437T2/hu unknown
- 2015-02-03 ME MEP-2020-77A patent/ME03775B/me unknown
- 2015-02-03 JP JP2015560991A patent/JP6390626B2/ja active Active
- 2015-02-03 EP EP15746276.3A patent/EP3103453B1/en active Active
- 2015-02-03 PL PL15746276T patent/PL3103453T3/pl unknown
- 2015-02-03 PT PT157462763T patent/PT3103453T/pt unknown
- 2015-02-04 TW TW104103756A patent/TWI655945B/zh active
-
2016
- 2016-08-02 IL IL247077A patent/IL247077B/en active IP Right Grant
- 2016-08-03 PH PH12016501527A patent/PH12016501527B1/en unknown
- 2016-08-04 ZA ZA2016/05379A patent/ZA201605379B/en unknown
-
2020
- 2020-04-28 CY CY20201100384T patent/CY1122968T1/el unknown
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2021
- 2021-05-21 US US17/327,337 patent/US11925638B2/en active Active
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