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MX2015008177A - Evaluacion de la actividad de la via de señalizacion celular utilizando combinacion(es) lineal(es) de expresiones de genes objetivo. - Google Patents

Evaluacion de la actividad de la via de señalizacion celular utilizando combinacion(es) lineal(es) de expresiones de genes objetivo.

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Publication number
MX2015008177A
MX2015008177A MX2015008177A MX2015008177A MX2015008177A MX 2015008177 A MX2015008177 A MX 2015008177A MX 2015008177 A MX2015008177 A MX 2015008177A MX 2015008177 A MX2015008177 A MX 2015008177A MX 2015008177 A MX2015008177 A MX 2015008177A
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MX
Mexico
Prior art keywords
activity
cellular signaling
expressions
evaluation
linear combination
Prior art date
Application number
MX2015008177A
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English (en)
Other versions
MX376594B (es
Inventor
Hendrik Jan Van Ooijen
Wilhelmus Franciscus Johannes Verhaegh
Paul Arnold Van De Wiel
Original Assignee
Koninkl Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninkl Philips Nv filed Critical Koninkl Philips Nv
Publication of MX2015008177A publication Critical patent/MX2015008177A/es
Publication of MX376594B publication Critical patent/MX376594B/es

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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N5/00—Computing arrangements using knowledge-based models
    • G06N5/04—Inference or reasoning models
    • G06N5/048—Fuzzy inferencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
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  • Spectroscopy & Molecular Physics (AREA)
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  • Wood Science & Technology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Mathematical Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Fuzzy Systems (AREA)
  • Computational Linguistics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente solicitud se refiere principalmente a métodos específicos para inferir la actividad de una vía de señalización celular en el tejido y/o las células de un sujeto médico con base por lo menos en los niveles de expresión de uno o más genes objetivo de la vía de señalización celular medios en una muestra extraída del tejido y/o las células del sujeto médico, aparato que comprende un compresor digital configurado para realizar estos métodos y un medio de almacenamiento no transitorio que almacena instrucciones que son ejecutables por dispositivo de procesamiento digital para realizar estos métodos.
MX2015008177A 2012-12-26 2013-12-18 Evaluacion de la actividad de la via de señalizacion celular utilizando combinacion(es) lineal(es) de expresiones de genes objetivo. MX376594B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261745839P 2012-12-26 2012-12-26
PCT/IB2013/061066 WO2014102668A2 (en) 2012-12-26 2013-12-18 Assessment of cellular signaling pathway activity using linear combination(s) of target gene expressions;

Publications (2)

Publication Number Publication Date
MX2015008177A true MX2015008177A (es) 2015-09-16
MX376594B MX376594B (es) 2025-03-07

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MX2015008177A MX376594B (es) 2012-12-26 2013-12-18 Evaluacion de la actividad de la via de señalizacion celular utilizando combinacion(es) lineal(es) de expresiones de genes objetivo.

Country Status (13)

Country Link
US (2) US11306360B2 (es)
EP (1) EP2938745B1 (es)
JP (2) JP6449779B2 (es)
KR (1) KR102279844B1 (es)
CN (2) CN111961726A (es)
AU (2) AU2013368945B2 (es)
BR (1) BR112015015131A2 (es)
CA (1) CA2896414C (es)
DK (1) DK2938745T3 (es)
ES (1) ES2878196T3 (es)
MX (1) MX376594B (es)
RU (1) RU2721130C2 (es)
WO (1) WO2014102668A2 (es)

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EP3461916A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat3 cellular signaling pathway activity using mathematical modelling of target gene expression
CA3077501A1 (en) 2017-10-02 2019-04-11 Koninklijke Philips N.V. Determining functional status of immune cells types and immune response
EP3502279A1 (en) 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression
CN108187050A (zh) * 2018-01-18 2018-06-22 石河子大学 抑制食管癌细胞增殖的药物
CN113490850B (zh) * 2018-08-17 2024-12-06 基因泰克公司 用于治疗乳腺癌的诊断和治疗方法
WO2020225155A1 (en) 2019-05-03 2020-11-12 Koninklijke Philips N.V. Methods of prognosis in high-grade serous ovarian cancer
EP3812474A1 (en) 2019-10-22 2021-04-28 Koninklijke Philips N.V. Methods of prognosis in high-grade serous ovarian cancer
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EP3835433A1 (en) 2019-12-12 2021-06-16 Koninklijke Philips N.V. Notch signaling pathway activity as prognostic marker in bladder cancer
CN111166884B (zh) * 2020-01-15 2021-12-03 广州中医药大学第一附属医院 Foxf1基因在制备用于骨质疏松症药物中的应用
EP3882363A1 (en) 2020-03-17 2021-09-22 Koninklijke Philips N.V. Prognostic pathways for high risk sepsis patients
EP4136261B1 (en) 2020-04-16 2025-04-02 InnoSIGN B.V. Prognostic pathways for viral infections
EP3978628A1 (en) 2020-10-01 2022-04-06 Koninklijke Philips N.V. Prognostic pathways for viral infections
EP3940704A1 (en) 2020-07-14 2022-01-19 Koninklijke Philips N.V. Method for determining the differentiation state of a stem cell
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CN112466403B (zh) * 2020-12-31 2022-06-14 广州基迪奥生物科技有限公司 一种细胞通讯分析方法及系统
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CN114015709B (zh) * 2021-11-04 2023-04-25 塔里木大学 绵羊ctsd基因在调控初情期启动中的应用
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Publication number Publication date
EP2938745B1 (en) 2020-10-07
KR102279844B1 (ko) 2021-07-21
AU2013368945A1 (en) 2015-08-13
WO2014102668A2 (en) 2014-07-03
DK2938745T3 (da) 2020-11-30
JP6721665B2 (ja) 2020-07-15
CA2896414C (en) 2023-06-20
CA2896414A1 (en) 2014-07-03
ES2878196T3 (es) 2021-11-18
US20230030858A1 (en) 2023-02-02
EP2938745A2 (en) 2015-11-04
AU2020202706B2 (en) 2022-06-16
US11306360B2 (en) 2022-04-19
BR112015015131A2 (pt) 2017-07-11
JP6449779B2 (ja) 2019-01-09
AU2020202706A1 (en) 2020-05-14
RU2015131009A (ru) 2017-01-30
CN105074005A (zh) 2015-11-18
CN111961726A (zh) 2020-11-20
RU2721130C2 (ru) 2020-05-18
AU2013368945B2 (en) 2020-01-23
MX376594B (es) 2025-03-07
KR20150100896A (ko) 2015-09-02
WO2014102668A3 (en) 2014-08-21
US20150347672A1 (en) 2015-12-03
JP2016509472A (ja) 2016-03-31
JP2019076096A (ja) 2019-05-23

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