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MX2015004362A - Derivados de ketamina. - Google Patents

Derivados de ketamina.

Info

Publication number
MX2015004362A
MX2015004362A MX2015004362A MX2015004362A MX2015004362A MX 2015004362 A MX2015004362 A MX 2015004362A MX 2015004362 A MX2015004362 A MX 2015004362A MX 2015004362 A MX2015004362 A MX 2015004362A MX 2015004362 A MX2015004362 A MX 2015004362A
Authority
MX
Mexico
Prior art keywords
ketamine derivatives
methods
derivatives
ketamine
formula
Prior art date
Application number
MX2015004362A
Other languages
English (en)
Inventor
James Wallace Sleigh
William Alexander Denny
Jiney Jose
Swarnalatha Akuratiya Gamage
Martyn Gregory Harvey
Logan James Voss
Original Assignee
Auckland Uniservices Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auckland Uniservices Ltd filed Critical Auckland Uniservices Ltd
Publication of MX2015004362A publication Critical patent/MX2015004362A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)

Abstract

La presente invención se refiere a derivados de ketamina de la fórmula (I), o composiciones farmacéuticas que comprenden los mismos, y métodos para tratar dolor, que comprende administrar las mismas, y su uso en la fabricación de medicamentos para tratar dolor. La presente invención se refiere también a los métodos para anestesiar y métodos para sedar a un sujeto que comprende administrar derivados de ketamina de la fórmula (II).
MX2015004362A 2012-10-08 2013-10-08 Derivados de ketamina. MX2015004362A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ60288512 2012-10-08
NZ61120213 2013-05-28
PCT/IB2013/059191 WO2014057414A1 (en) 2012-10-08 2013-10-08 Ketamine derivatives

Publications (1)

Publication Number Publication Date
MX2015004362A true MX2015004362A (es) 2015-12-08

Family

ID=50476991

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015004362A MX2015004362A (es) 2012-10-08 2013-10-08 Derivados de ketamina.

Country Status (13)

Country Link
US (3) US20150259277A1 (es)
EP (1) EP2903963A4 (es)
JP (2) JP6309957B2 (es)
KR (1) KR20150065873A (es)
CN (1) CN104837810B (es)
AU (1) AU2013328280B2 (es)
BR (1) BR112015007647A2 (es)
CA (1) CA2922340A1 (es)
EA (1) EA201590697A1 (es)
HK (1) HK1212673A1 (es)
IN (1) IN2015DN03854A (es)
MX (1) MX2015004362A (es)
WO (1) WO2014057414A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015004362A (es) * 2012-10-08 2015-12-08 Auckland Uniservices Ltd Derivados de ketamina.
US20160332962A1 (en) * 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
US11191734B2 (en) 2015-06-27 2021-12-07 Shenox Pharmaceuticals, Llc Ketamine transdermal delivery system
US11827606B2 (en) 2015-11-18 2023-11-28 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them
US11111210B2 (en) 2015-11-18 2021-09-07 Spirify Pharma Inc. Phenyl cyclohexanone derivatives and methods of making and using them
JP7603368B2 (ja) * 2016-03-25 2024-12-20 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ （２ｒ，６ｒ）－ヒドロキシノルケタミン塩酸塩の結晶形態
JP7167168B2 (ja) * 2018-01-10 2022-11-08 エックスダブリューファルマ リミテッド ケタミンのプロドラッグ、組成物及びそれらの使用
WO2019186357A1 (en) * 2018-03-26 2019-10-03 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
EP3802480B1 (en) * 2018-06-04 2023-08-02 The United States of America, as represented by the Secretary, Department of Health and Human Services Process for synthesis and purification of (2r,6r)-hydroxynorketamine
CN112125816A (zh) * 2020-03-17 2020-12-25 国药集团工业有限公司 一种氯胺酮、其衍生物或其盐的消旋化方法
DE102021105268A1 (de) * 2021-03-04 2022-09-08 Lts Lohmann Therapie-Systeme Ag. Oraler Dünnfilm
EP4559522A3 (en) 2021-08-13 2025-07-16 XWPharma Ltd. Pharmaceutical compositions and oral dosage forms of ketamine derivatives
CN115677444A (zh) * 2022-10-26 2023-02-03 公安部第三研究所 同位素毒品代谢物标记化合物及其制备方法、用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3254124A (en) * 1962-06-29 1966-05-31 Parke Davis & Co Aminoketones and methods for their production
GB1134146A (en) * 1967-09-15 1968-11-20 Parke Davis & Co New organic amines and methods for their production
US5019583A (en) 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5466700A (en) 1993-08-30 1995-11-14 Glaxo Wellcome Inc. Anesthetic use of N-phenyl-N-(4-piperidinyl)amides
US5866591A (en) 1996-09-11 1999-02-02 Glaxo Wellcome Inc. Stable formulations of remifentanil
IL150929A0 (en) * 2000-01-28 2003-06-24 Rohm & Haas Pharmaceutical compounds comprising a pharmaceutically active moiety and a moiety comprising a substituent that enhances its properties
US20040248963A1 (en) 2001-11-23 2004-12-09 Bueno Melendo Ana Belen Prodrugs of excitatory amino acids
DE60335428D1 (de) * 2002-01-31 2011-02-03 Randox Lab Ltd Immunogene, Antikörper und Konjugate für Ketamin und dessen Metaboliten
DE60327883D1 (de) * 2002-11-18 2009-07-16 Yaupon Therapeutics Inc Analgetische verwendung von (s)-norketamin
PL1928405T3 (pl) * 2005-09-28 2015-03-31 Auris Medical Ag Kompozycje farmaceutyczne do leczenia zaburzeń ucha wewnętrznego
CN101765582A (zh) * 2007-04-26 2010-06-30 奥斯拜客斯制药有限公司 氘标记的氯胺酮
ES2886361T3 (es) 2011-10-14 2021-12-17 The Us Secretary Department Of Health & Human Services Uso de (2R,6R)-hidroxinorketamina y otros metabolitos hidroxilados estereoisómeros de (R,S)-ketamina en el tratamiento de depresión y dolor neuropático
MX2015004362A (es) * 2012-10-08 2015-12-08 Auckland Uniservices Ltd Derivados de ketamina.

Also Published As

Publication number Publication date
US20150259277A1 (en) 2015-09-17
US10239825B2 (en) 2019-03-26
CN104837810A (zh) 2015-08-12
EA201590697A1 (ru) 2015-09-30
JP2018127466A (ja) 2018-08-16
EP2903963A4 (en) 2016-05-25
CN104837810B (zh) 2019-08-06
JP6309957B2 (ja) 2018-04-11
US20190169113A1 (en) 2019-06-06
US20170190653A1 (en) 2017-07-06
IN2015DN03854A (es) 2015-10-02
JP2015535847A (ja) 2015-12-17
BR112015007647A2 (pt) 2017-07-04
KR20150065873A (ko) 2015-06-15
CA2922340A1 (en) 2014-04-17
HK1212673A1 (zh) 2016-06-17
WO2014057414A9 (en) 2014-12-18
AU2013328280B2 (en) 2017-12-21
EP2903963A1 (en) 2015-08-12
AU2013328280A1 (en) 2015-05-14
WO2014057414A1 (en) 2014-04-17

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