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MX2014012321A - Combinacion de analogos de somatostatina con inhibidores de 11-beta-hidroxilasa. - Google Patents

Combinacion de analogos de somatostatina con inhibidores de 11-beta-hidroxilasa.

Info

Publication number
MX2014012321A
MX2014012321A MX2014012321A MX2014012321A MX2014012321A MX 2014012321 A MX2014012321 A MX 2014012321A MX 2014012321 A MX2014012321 A MX 2014012321A MX 2014012321 A MX2014012321 A MX 2014012321A MX 2014012321 A MX2014012321 A MX 2014012321A
Authority
MX
Mexico
Prior art keywords
combination
11beta
somatostatin
analogs
hydroxylase inhibitors
Prior art date
Application number
MX2014012321A
Other languages
English (en)
Other versions
MX362533B (es
Inventor
Li Li
Germo Hans Gericke
Herbert Anton Schmid
Mario Roberto Maldonado Lutomirsky
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2014012321A publication Critical patent/MX2014012321A/es
Publication of MX362533B publication Critical patent/MX362533B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a una combinación que comprende: (a) un análogo de somatostatina, y (b) un inhibidor de 11-beta-hidroxilasa; cada uno en forma libre o en la forma de una sal farmacéuticamente aceptable de los mismos; al uso de esta combinación para la preparación de un medicamento para el tratamiento de las enfermedades asociadas con un aumento en los niveles de hormonas de estrés; a un paquete o producto comercial que comprende dicha combinación; y a un método de tratamiento de un animal de sangre caliente, en especial de un ser humano.
MX2014012321A 2012-04-12 2013-04-10 Combinacion de analogos de somatostatina con inhibidores de 11-beta-hidroxilasa. MX362533B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261623117P 2012-04-12 2012-04-12
PCT/EP2013/057515 WO2013153129A1 (en) 2012-04-12 2013-04-10 Combination of somatostatin-analogs with 11beta-hydroxylase inhibitors

Publications (2)

Publication Number Publication Date
MX2014012321A true MX2014012321A (es) 2015-09-24
MX362533B MX362533B (es) 2019-01-23

Family

ID=48289057

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014012321A MX362533B (es) 2012-04-12 2013-04-10 Combinacion de analogos de somatostatina con inhibidores de 11-beta-hidroxilasa.

Country Status (13)

Country Link
US (1) US9333234B2 (es)
EP (1) EP2836228B1 (es)
JP (1) JP6383352B2 (es)
KR (1) KR102136214B1 (es)
CN (1) CN104321074B (es)
AU (1) AU2013246908B2 (es)
BR (1) BR112014025058B1 (es)
CA (1) CA2869442C (es)
ES (1) ES2980806T3 (es)
IN (1) IN2014DN09240A (es)
MX (1) MX362533B (es)
RU (1) RU2663455C2 (es)
WO (1) WO2013153129A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20190064T1 (hr) * 2010-01-14 2019-03-08 Novartis Ag Uporaba sredstva za modifikaciju adrenalnog hormona
TWI707682B (zh) * 2014-07-07 2020-10-21 瑞士商瑞科戴迪股份有限公司 醫藥劑型
WO2016048984A1 (en) * 2014-09-25 2016-03-31 Cortendo Ab (Publ) Methods and compositions for the treatment of cushing's syndrome using 2s, 4r ketoconazole
EP3405101B1 (en) 2016-01-19 2020-12-23 Corcept Therapeutics, Inc. Differential diagnosis of ectopic cushing's syndrome

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006185A2 (en) * 1998-07-30 2000-02-10 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Methods of using lanreotide, a somatostatin analogue
IL158051A0 (en) * 2001-04-09 2004-03-28 Univ Tulane Somatostatin agonists
GT200600381A (es) * 2005-08-25 2007-03-28 Compuestos organicos
US8575160B2 (en) * 2009-11-30 2013-11-05 Novartis Ag Imidazole derivatives as aldosterone synthase inhibitors
HRP20190064T1 (hr) * 2010-01-14 2019-03-08 Novartis Ag Uporaba sredstva za modifikaciju adrenalnog hormona
WO2013131879A1 (en) * 2012-03-07 2013-09-12 Novartis Ag New application for pasireotide

Also Published As

Publication number Publication date
EP2836228A1 (en) 2015-02-18
AU2013246908A1 (en) 2014-10-23
RU2663455C2 (ru) 2018-08-06
CA2869442C (en) 2020-09-08
US20150087588A1 (en) 2015-03-26
ES2980806T3 (es) 2024-10-03
CA2869442A1 (en) 2013-10-17
WO2013153129A1 (en) 2013-10-17
RU2014145351A (ru) 2016-06-10
MX362533B (es) 2019-01-23
CN104321074B (zh) 2017-09-08
IN2014DN09240A (es) 2015-07-10
JP6383352B2 (ja) 2018-08-29
KR102136214B1 (ko) 2020-07-22
CN104321074A (zh) 2015-01-28
KR20150004831A (ko) 2015-01-13
JP2015512923A (ja) 2015-04-30
US9333234B2 (en) 2016-05-10
BR112014025058A2 (es) 2017-06-20
EP2836228B1 (en) 2024-03-20
BR112014025058B1 (pt) 2022-07-12
AU2013246908B2 (en) 2016-06-30

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