[go: up one dir, main page]

MX2013002784A - Heteroarilos fusionados y sus usos. - Google Patents

Heteroarilos fusionados y sus usos.

Info

Publication number
MX2013002784A
MX2013002784A MX2013002784A MX2013002784A MX2013002784A MX 2013002784 A MX2013002784 A MX 2013002784A MX 2013002784 A MX2013002784 A MX 2013002784A MX 2013002784 A MX2013002784 A MX 2013002784A MX 2013002784 A MX2013002784 A MX 2013002784A
Authority
MX
Mexico
Prior art keywords
fused heteroaryls
heteroaryls
fused
compositions
methods
Prior art date
Application number
MX2013002784A
Other languages
English (en)
Inventor
Weihan Zhang
Haibin Yang
Weiguo Su
Original Assignee
Hutchison Medipharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchison Medipharma Ltd filed Critical Hutchison Medipharma Ltd
Publication of MX2013002784A publication Critical patent/MX2013002784A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proveen ciertos heteroarilo fusionados, composiciones de los mismos y métodos de uso de los mismos.
MX2013002784A 2010-09-16 2011-09-15 Heteroarilos fusionados y sus usos. MX2013002784A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2010076996 2010-09-16
PCT/CN2011/079684 WO2012034526A1 (en) 2010-09-16 2011-09-15 Fused heteroaryls and their uses

Publications (1)

Publication Number Publication Date
MX2013002784A true MX2013002784A (es) 2013-04-24

Family

ID=45831015

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013002784A MX2013002784A (es) 2010-09-16 2011-09-15 Heteroarilos fusionados y sus usos.

Country Status (13)

Country Link
US (1) US9181264B2 (es)
EP (1) EP2616468A4 (es)
JP (1) JP5634609B2 (es)
KR (1) KR20130087020A (es)
AU (1) AU2011301518B2 (es)
BR (1) BR112013005855A2 (es)
CA (1) CA2810708A1 (es)
MX (1) MX2013002784A (es)
NZ (1) NZ607527A (es)
PH (1) PH12013500500A1 (es)
RU (1) RU2552114C2 (es)
SG (1) SG188302A1 (es)
WO (1) WO2012034526A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140014104A (ko) * 2010-12-06 2014-02-05 피라말 엔터프라이지즈 리미티드 치환된 이미다조퀴놀린 유도체
ES2637245T3 (es) 2012-06-29 2017-10-11 Pfizer Inc. Nuevas 4-(amino sustituido)-7H-pirrolo[2,3-d]pirimidinas como inhibidores de LRRK2
US9156831B2 (en) * 2013-01-23 2015-10-13 Astrazeneca Ab Chemical compounds
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
JP6487921B2 (ja) 2013-12-17 2019-03-20 ファイザー・インク ＬＲＲＫ２阻害薬としての新規の３，４−二置換−１Ｈ−ピロロ［２，３−ｂ］ピリジンおよび４，５−二置換−７Ｈ−ピロロ［２，３−ｃ］ピリダジン
ES2714100T3 (es) * 2014-07-14 2019-05-27 Advenchen Pharmaceuticals Nanjing Ltd Compuestos de quinolina fusionados como inhibidores de mTor, pi3k
AU2016293841B2 (en) * 2015-07-11 2020-10-08 Advenchen Pharmaceuticals, LLC Fused quinoline compunds as pi3k/mTor inhibitors
EP3350178B1 (en) * 2015-09-14 2021-10-20 Pfizer Inc. Novel imidazo [4,5-c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors
CA3008098A1 (en) * 2015-12-18 2017-06-22 Novartis Ag Tricyclic compounds and compositions as kinase inhibitors
AU2018206111B2 (en) * 2017-01-09 2022-07-21 Impact Therapeutics (Shanghai), Inc Substituted fused heteroaryl compound serving as a kinase inhibitor, and applications thereof
KR102143320B1 (ko) 2018-08-28 2020-08-12 주식회사 스템랩 합성 메신저 rna를 이용하여 소변세포를 신경줄기세포로 직접 역분화하는 방법
CN109810112B (zh) * 2019-02-01 2021-03-23 华侨大学 一种吲哚并[2,1-a]酞嗪衍生物的制备方法
CN109912606B (zh) * 2019-04-16 2021-05-04 新乡医学院 一种嘧啶并吲唑类化合物的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN160956B (es) * 1982-10-18 1987-08-22 Pfizer
AU706737B2 (en) * 1994-09-16 1999-06-24 Novo Nordisk A/S {1,2,4}triazolo{4,3-a}quinoxalinone derivatives, their preparation and use
BRPI0416801A (pt) * 2003-11-21 2007-01-09 Novartis Ag derivados de 1h-imidazoquinolina como inibidores de proteìna sinase
AR046845A1 (es) * 2003-11-21 2005-12-28 Novartis Ag Derivados de 1h-imidazo[4,5-c]quinolina para tratamiento de enfermedades dependientes de las proteino-quinasas
JP2009519955A (ja) * 2005-12-16 2009-05-21 コーリー ファーマシューティカル グループ，インコーポレイテッド 置換されたイミダゾキノリン、イミダゾナフチリジンおよびイミダゾピリジン、組成物ならびに方法
WO2009021961A1 (en) 2007-08-14 2009-02-19 Novartis Ag Pyrazoloquinoline and pyrazolonaphthyridine derivatives as gaba alpha ligands
US20110212053A1 (en) * 2008-06-19 2011-09-01 Dapeng Qian Phosphatidylinositol 3 kinase inhibitors
US20100078444A1 (en) 2008-09-30 2010-04-01 Thomas Gerard Shannon Compressed tissue product
WO2010038165A1 (en) * 2008-09-30 2010-04-08 Pfizer Inc. Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
WO2010054253A1 (en) * 2008-11-07 2010-05-14 Biotie Therapies Gmbh Triazine derivatives as inhibitors of phosphodiesterases
US20100120763A1 (en) * 2008-11-07 2010-05-13 Wyeth Imidazo[5,1-c][1,2,4]benzotriazine derivatives as inhibitors of phosphodiesterases
PH12012500674A1 (en) * 2009-10-06 2016-06-15 Millenium Pharmaceuticals Inc Heterocyclic compounds useful as pdk1 inhibitors
TW201204727A (en) * 2010-03-10 2012-02-01 Kalypsys Inc Heterocyclic inhibitors of histamine receptors for the treatment of disease

Also Published As

Publication number Publication date
KR20130087020A (ko) 2013-08-05
PH12013500500A1 (en) 2013-05-06
JP5634609B2 (ja) 2014-12-03
EP2616468A4 (en) 2014-02-26
WO2012034526A1 (en) 2012-03-22
RU2552114C2 (ru) 2015-06-10
NZ607527A (en) 2015-04-24
US9181264B2 (en) 2015-11-10
US20130190307A1 (en) 2013-07-25
EP2616468A1 (en) 2013-07-24
SG188302A1 (en) 2013-04-30
AU2011301518B2 (en) 2014-07-03
CA2810708A1 (en) 2012-03-22
AU2011301518A1 (en) 2013-03-14
RU2013108348A (ru) 2014-10-27
BR112013005855A2 (pt) 2016-05-17
JP2013537204A (ja) 2013-09-30

Similar Documents

Publication Publication Date Title
PH12013500500A1 (en) Fused heteroaryls and their uses
MY179933A (en) Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use thereof
EP4223770A3 (en) Novel fusion molecules and uses thereof
PH12013500870A1 (en) Heterocyclic compounds and uses thereof
SG10201700219XA (en) Certain amino-pyridazines, compositions thereof, and methods of their use
MX2013015311A (es) Polipeptidos de enlace de pcsk9 y metodos de uso.
IN2015DN00127A (es)
GB201218752D0 (en) Mineral complex, compositions thereof, and methods of using the same
HUE048815T2 (hu) Bizonyos amino-pirimidinek, ezeket tartalmazó készítmények és eljárás alkalmazásukra
EP2560488A4 (en) CERTAIN AMINOPYRIMIDINES AND AMINOTRIAZINES, COMPOSITIONS AND METHOD FOR THEIR USE
MY169141A (en) Biodegradable compositions, methods and uses thereof
MX2013008390A (es) Preparacion de estructuras de metal-triazolato.
IN2014DN06166A (es)
MX2011010012A (es) NUEVOS ANTICUERPOS ANTI-A5ß1 Y SUS USOS.
MX2011014019A (es) Derivados de diazahomoadamantano y sus metodos de uso.
MX2013011853A (es) Polipeptidos antibacterianos quimericos.
CR20120362A (es) Ciertas triazolopiridinas y triazolopirazinas, composiciones de estas y sus métodos de empleo
MY161601A (en) Films and compositions comprising the same
MX2012010127A (es) Derivados de aminoindanos, su preparacion y su aplicacion en terapeuticos.
WO2013155338A8 (en) Substituted benzamides and their uses
MX2013008559A (es) Derivados de leptina.
PH12012501547A1 (en) Methods of preparing thiazolidines
HK1233962A1 (en) Certain amino-pyridazines, compositions thereof, and methods of their use
UA70698U (ru) Применение 2-метил-3-фениламинометилхинолин-4-она как противогипоксического, актопротекторного и антиалкогольного средства
UA41660U (en) Use of jacton and mexidol as actoprotector

Legal Events

Date Code Title Description
FA Abandonment or withdrawal