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MX2012003514A - Metodos para tratamiento de inflamaciones. - Google Patents

Metodos para tratamiento de inflamaciones.

Info

Publication number
MX2012003514A
MX2012003514A MX2012003514A MX2012003514A MX2012003514A MX 2012003514 A MX2012003514 A MX 2012003514A MX 2012003514 A MX2012003514 A MX 2012003514A MX 2012003514 A MX2012003514 A MX 2012003514A MX 2012003514 A MX2012003514 A MX 2012003514A
Authority
MX
Mexico
Prior art keywords
methods
mif
treating inflammation
cxcr2
cxcr4
Prior art date
Application number
MX2012003514A
Other languages
English (en)
Inventor
Christian Weber
Joshua Robert Schultz
Benedikt Vollrath
Alma Zernecke
Court Turner
Jurgen Bernhagen
Sergio Duron
Original Assignee
Carolus Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carolus Therapeutics Inc filed Critical Carolus Therapeutics Inc
Publication of MX2012003514A publication Critical patent/MX2012003514A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se divulgan aquí, en algunas realizaciones, métodos para tratar un trastorno mediado por MIF. En algunas realizaciones, el método comprende administrar un agente que inhibe (i) el enlazamiento de MIF a CXCR2 y CXCR4 y/o (ii) la activación por MIF de CXCR2 y CXCR4; (iii) la capacidad del MIF para formar un homomultímero; o una combinación de los mismos.
MX2012003514A 2009-09-23 2010-09-23 Metodos para tratamiento de inflamaciones. MX2012003514A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24521409P 2009-09-23 2009-09-23
US31903910P 2010-03-30 2010-03-30
PCT/US2010/050047 WO2011038149A2 (en) 2009-09-23 2010-09-23 Methods of treating inflammation

Publications (1)

Publication Number Publication Date
MX2012003514A true MX2012003514A (es) 2012-04-19

Family

ID=43796491

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012003514A MX2012003514A (es) 2009-09-23 2010-09-23 Metodos para tratamiento de inflamaciones.

Country Status (9)

Country Link
EP (1) EP2480579A4 (es)
KR (1) KR20120105429A (es)
CN (1) CN102725311A (es)
AU (1) AU2010298249A1 (es)
BR (1) BR112012006468A2 (es)
CA (1) CA2773978A1 (es)
IN (1) IN2012DN02423A (es)
MX (1) MX2012003514A (es)
WO (1) WO2011038149A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9238689B2 (en) 2011-07-15 2016-01-19 Morpho Sys AG Antibodies that are cross-reactive for macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (D-DT)
US9328174B2 (en) * 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
RU2636820C2 (ru) * 2012-05-17 2017-11-28 Сайон Терапьютикс Инк. Способы и применения ингибиторов пропротеиновой конвертазы субтилизин кексин типа 9(pcsk9)
AR098418A1 (es) * 2013-11-14 2016-05-26 Baxter Healthcare Sa Factor inhibitorio de imigración de macrófago (mif) como objetivo terapéutico
MX386771B (es) 2016-03-11 2025-03-19 Ardea Biosciences Inc Inhibidores de cxcr-2 para tratamiento de trastornos de artropatía por cristales.
JP2021532167A (ja) 2018-06-05 2021-11-25 アンジ ファーマ（ユーエス）エルエルシー 膵炎を治療するための組成物及び方法
MX2021007604A (es) * 2018-12-26 2021-08-11 Colgate Palmolive Co Biomarcadores de desregulacion de neutrofilos como diagnostico de gingivitis.
KR20220166809A (ko) * 2020-03-11 2022-12-19 바이오라인알엑스 리미티드 급성 호흡곤란 증후군 및 바이러스 감염 치료를 위한 cxcr4 억제제
WO2021219495A1 (en) * 2020-04-28 2021-11-04 Dalcor Pharma Uk Ltd., Leatherhead, Zug Branch Methods for treating or preventing a viral infection or inhibiting viral replication
CN112656934A (zh) * 2021-01-22 2021-04-16 深圳市图微安创科技开发有限公司 多肽at03在治疗原发性胆汁性胆管炎药物中的应用
EP4378319A1 (en) * 2022-12-01 2024-06-05 Bioiberica, S.A.U. Composition comprising bioactive peptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534605B2 (en) * 1999-06-08 2009-05-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
WO2003072753A2 (en) * 2002-02-27 2003-09-04 Emory University Multimeric binding complexes
ES2350477T5 (es) * 2002-03-01 2020-05-06 Immunomedics Inc Internalización de anticuerpos anti-CD74 y métodos de uso
WO2005065328A2 (en) * 2003-12-30 2005-07-21 The United States Of America, As Represented By The Department Of Veterans Affairs Macrophage migration inhibitory factor (mif) as marker for urological inflammatory disease
US7612181B2 (en) * 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EA201001529A1 (ru) * 2008-03-20 2011-06-30 Каролус Терапьютикс, Инк. Способ и композиция для лечения mif-опосредованных расстройств
WO2010056910A2 (en) * 2008-11-12 2010-05-20 Carolus Therapeutics, Inc. Methods of treating cardiovascular disorders

Also Published As

Publication number Publication date
BR112012006468A2 (pt) 2016-08-09
CN102725311A (zh) 2012-10-10
CA2773978A1 (en) 2011-03-31
KR20120105429A (ko) 2012-09-25
EP2480579A2 (en) 2012-08-01
EP2480579A4 (en) 2013-07-31
WO2011038149A2 (en) 2011-03-31
WO2011038149A3 (en) 2011-10-27
AU2010298249A1 (en) 2012-04-19
IN2012DN02423A (es) 2015-08-21

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