MX2012001089A - Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos. - Google Patents
Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos.Info
- Publication number
- MX2012001089A MX2012001089A MX2012001089A MX2012001089A MX2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A
- Authority
- MX
- Mexico
- Prior art keywords
- heterocyclic compounds
- bicyclic heterocyclic
- diseases
- stereoselective synthesis
- salts
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010020718 hyperplasia Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invención se refiere a un procedimiento para la preparación estereoselectiva de compuestos de las fórmulas (lA) y (IB) (ver fórmula (1A) y (1B)) y de sus sales, en particular sus sales fisiológicamente compatibles con ácidos y bases inorgánicos u orgánicos, las cuales muestran propiedades farmacéuticas valiosas, en particular un efecto inhibidor sobre la transducción de señales mediadas por tirosinquinasas, a su utilización para el tratamiento de enfermedades, en particular enfermedades tumorales, tales como la hiperplasia benigna de próstata (HBP), enfermedades pulmonares y de las vías respiratorias.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09167393A EP2289881A1 (de) | 2009-08-06 | 2009-08-06 | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
| PCT/EP2010/061096 WO2011015526A1 (de) | 2009-08-06 | 2010-07-30 | Verfahren zur stereoselektiven synthese bicyclischer heterocyclen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012001089A true MX2012001089A (es) | 2012-02-28 |
Family
ID=41205591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012001089A MX2012001089A (es) | 2009-08-06 | 2010-07-30 | Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8658790B2 (es) |
| EP (2) | EP2289881A1 (es) |
| JP (1) | JP2013501025A (es) |
| KR (1) | KR20120049248A (es) |
| CN (1) | CN102471288B (es) |
| AR (1) | AR077797A1 (es) |
| AU (1) | AU2010280852B2 (es) |
| BR (1) | BR112012002104A2 (es) |
| CA (1) | CA2767963A1 (es) |
| CL (1) | CL2012000159A1 (es) |
| DK (1) | DK2462126T3 (es) |
| EA (1) | EA023562B1 (es) |
| ES (1) | ES2549770T3 (es) |
| HU (1) | HUE025400T2 (es) |
| IL (1) | IL216969A (es) |
| MX (1) | MX2012001089A (es) |
| NZ (1) | NZ597698A (es) |
| PL (1) | PL2462126T3 (es) |
| TW (1) | TW201120013A (es) |
| UY (1) | UY32830A (es) |
| WO (1) | WO2011015526A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2289881A1 (de) * | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
| SG192216A1 (en) | 2011-02-01 | 2013-09-30 | Boehringer Ingelheim Int | 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof |
| AU2013218119A1 (en) * | 2012-02-09 | 2014-07-17 | Boehringer Ingelheim International Gmbh | Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecanes |
| EP2875020B1 (en) * | 2012-07-19 | 2017-09-06 | Boehringer Ingelheim International GmbH | Process for the preparation of a fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one |
| US20230150978A1 (en) | 2020-03-30 | 2023-05-18 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| US11680403B2 (en) * | 2020-09-21 | 2023-06-20 | Amp Ip Llc | Multi-purpose structural panels and systems for assembling structures |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200813014A (en) | 2002-03-28 | 2008-03-16 | Astrazeneca Ab | Quinazoline derivatives |
| WO2008095847A1 (de) * | 2007-02-06 | 2008-08-14 | Boehringer Ingelheim International Gmbh | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| TWI421070B (zh) * | 2007-10-26 | 2014-01-01 | Japan Tobacco Inc | 螺化合物及其醫藥用途 |
| AU2009211523B2 (en) * | 2008-02-07 | 2014-03-13 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles, medicaments containing said compounds, use thereof and method for their production |
| EP2313377B1 (de) * | 2008-08-08 | 2016-01-06 | Boehringer Ingelheim International Gmbh | Verfahren zur stereoselektiven synthese bicyclischer heterocyclen |
| EP2289881A1 (de) * | 2009-08-06 | 2011-03-02 | Boehringer Ingelheim International GmbH | Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen |
| SG192216A1 (en) * | 2011-02-01 | 2013-09-30 | Boehringer Ingelheim Int | 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof |
| AU2013218119A1 (en) * | 2012-02-09 | 2014-07-17 | Boehringer Ingelheim International Gmbh | Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecanes |
-
2009
- 2009-08-06 EP EP09167393A patent/EP2289881A1/de not_active Withdrawn
-
2010
- 2010-07-30 ES ES10737572.7T patent/ES2549770T3/es active Active
- 2010-07-30 US US12/846,943 patent/US8658790B2/en active Active
- 2010-07-30 AU AU2010280852A patent/AU2010280852B2/en not_active Ceased
- 2010-07-30 WO PCT/EP2010/061096 patent/WO2011015526A1/de active Application Filing
- 2010-07-30 DK DK10737572.7T patent/DK2462126T3/en active
- 2010-07-30 JP JP2012523298A patent/JP2013501025A/ja not_active Ceased
- 2010-07-30 KR KR1020127003126A patent/KR20120049248A/ko not_active Withdrawn
- 2010-07-30 HU HUE10737572A patent/HUE025400T2/en unknown
- 2010-07-30 PL PL10737572T patent/PL2462126T3/pl unknown
- 2010-07-30 BR BR112012002104A patent/BR112012002104A2/pt not_active IP Right Cessation
- 2010-07-30 CA CA2767963A patent/CA2767963A1/en not_active Abandoned
- 2010-07-30 CN CN201080034450.2A patent/CN102471288B/zh not_active Expired - Fee Related
- 2010-07-30 MX MX2012001089A patent/MX2012001089A/es active IP Right Grant
- 2010-07-30 EP EP10737572.7A patent/EP2462126B1/de not_active Not-in-force
- 2010-07-30 NZ NZ597698A patent/NZ597698A/en not_active IP Right Cessation
- 2010-07-30 EA EA201200219A patent/EA023562B1/ru not_active IP Right Cessation
- 2010-08-05 UY UY0001032830A patent/UY32830A/es not_active Application Discontinuation
- 2010-08-05 TW TW099126149A patent/TW201120013A/zh unknown
- 2010-08-05 AR ARP100102887A patent/AR077797A1/es unknown
-
2011
- 2011-12-14 IL IL216969A patent/IL216969A/en not_active IP Right Cessation
-
2012
- 2012-01-19 CL CL2012000159A patent/CL2012000159A1/es unknown
-
2014
- 2014-01-14 US US14/154,441 patent/US8993753B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PL2462126T3 (pl) | 2015-11-30 |
| KR20120049248A (ko) | 2012-05-16 |
| CN102471288A (zh) | 2012-05-23 |
| NZ597698A (en) | 2014-03-28 |
| UY32830A (es) | 2011-03-31 |
| BR112012002104A2 (pt) | 2015-09-15 |
| IL216969A (en) | 2015-06-30 |
| EP2289881A1 (de) | 2011-03-02 |
| AR077797A1 (es) | 2011-09-21 |
| CL2012000159A1 (es) | 2012-08-31 |
| AU2010280852B2 (en) | 2015-04-02 |
| EP2462126B1 (de) | 2015-07-15 |
| WO2011015526A1 (de) | 2011-02-10 |
| DK2462126T3 (en) | 2015-09-07 |
| US8993753B2 (en) | 2015-03-31 |
| CN102471288B (zh) | 2014-10-22 |
| JP2013501025A (ja) | 2013-01-10 |
| CA2767963A1 (en) | 2011-02-10 |
| US8658790B2 (en) | 2014-02-25 |
| EP2462126A1 (de) | 2012-06-13 |
| HUE025400T2 (en) | 2016-02-29 |
| IL216969A0 (en) | 2012-02-29 |
| US20140135495A1 (en) | 2014-05-15 |
| ES2549770T3 (es) | 2015-11-02 |
| EA201200219A1 (ru) | 2012-11-30 |
| AU2010280852A1 (en) | 2012-02-09 |
| TW201120013A (en) | 2011-06-16 |
| EA023562B1 (ru) | 2016-06-30 |
| US20110183987A1 (en) | 2011-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |