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MX2011012599A - Compuestos polimericos de agentes inmunomoduladores. - Google Patents

Compuestos polimericos de agentes inmunomoduladores.

Info

Publication number
MX2011012599A
MX2011012599A MX2011012599A MX2011012599A MX2011012599A MX 2011012599 A MX2011012599 A MX 2011012599A MX 2011012599 A MX2011012599 A MX 2011012599A MX 2011012599 A MX2011012599 A MX 2011012599A MX 2011012599 A MX2011012599 A MX 2011012599A
Authority
MX
Mexico
Prior art keywords
polymeric compounds
immunomodulatory agent
conjugates
synthetic nanocarriers
immunomodulatory agents
Prior art date
Application number
MX2011012599A
Other languages
English (en)
Inventor
Lloyd Johnston
Grayson B Lipford
Charles Zepp
Yun Gao
Fen-Ni Fu
Mark J Keegan
Sam Baldwin
Original Assignee
Selecta Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Selecta Biosciences Inc filed Critical Selecta Biosciences Inc
Publication of MX2011012599A publication Critical patent/MX2011012599A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

La invención se relaciona con composiciones, y compuestos y métodos relacionados, de conjugados de agentes inmunomoduladores y polímeros o unidades de los mismos; los conjugados pueden estar contenidos dentro de nanoportadores sintéticos y los agentes inmunomoduladores pueden liberarse de los nanoportadores sintéticos dependiendo del pH.
MX2011012599A 2009-05-27 2010-05-26 Compuestos polimericos de agentes inmunomoduladores. MX2011012599A (es)

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US21711609P 2009-05-27 2009-05-27
US21711709P 2009-05-27 2009-05-27
US21712909P 2009-05-27 2009-05-27
US21712409P 2009-05-27 2009-05-27
PCT/US2010/001561 WO2010138194A2 (en) 2009-05-27 2010-05-26 Immunomodulatory agent-polymeric compounds

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MX2014000083A MX350667B (es) 2009-05-27 2010-05-26 Nanoportadores que poseen componentes con diferentes tasas de liberacion.
MX2014000090A MX357630B (es) 2009-05-27 2010-05-26 Nanoportadores sintéticos objetivo con liberación sensible al ph de agentes inmunomoduladores.
MX2011012597A MX2011012597A (es) 2009-05-27 2010-05-26 Nanoportadores que poseen componentes con diferentes tasas de liberacion.
MX2011012598A MX2011012598A (es) 2009-05-27 2010-05-26 Nanoportadores sinteticos objetivos con liberacion sensible al ph de agentes inmunomoduladores.
MX2011012599A MX2011012599A (es) 2009-05-27 2010-05-26 Compuestos polimericos de agentes inmunomoduladores.

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MX2014000090A MX357630B (es) 2009-05-27 2010-05-26 Nanoportadores sintéticos objetivo con liberación sensible al ph de agentes inmunomoduladores.
MX2011012597A MX2011012597A (es) 2009-05-27 2010-05-26 Nanoportadores que poseen componentes con diferentes tasas de liberacion.
MX2011012598A MX2011012598A (es) 2009-05-27 2010-05-26 Nanoportadores sinteticos objetivos con liberacion sensible al ph de agentes inmunomoduladores.

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