MX2011012491A - Administracion continua de cilengitida en tratamientos contra el cancer. - Google Patents
Administracion continua de cilengitida en tratamientos contra el cancer.Info
- Publication number
- MX2011012491A MX2011012491A MX2011012491A MX2011012491A MX2011012491A MX 2011012491 A MX2011012491 A MX 2011012491A MX 2011012491 A MX2011012491 A MX 2011012491A MX 2011012491 A MX2011012491 A MX 2011012491A MX 2011012491 A MX2011012491 A MX 2011012491A
- Authority
- MX
- Mexico
- Prior art keywords
- continuous administration
- cilengitide
- cancer treatments
- therapy
- ligands
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- AMLYAMJWYAIXIA-VWNVYAMZSA-N cilengitide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CC1=CC=CC=C1 AMLYAMJWYAIXIA-VWNVYAMZSA-N 0.000 title 1
- 229950009003 cilengitide Drugs 0.000 title 1
- 102000006495 integrins Human genes 0.000 abstract 2
- 108010044426 integrins Proteins 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
La invención se relaciona con una terapia de combinación para el tratamiento de tumores y metástasis tumorales que comprende la administración continua de ligandos de integrina, preferiblemente antagonistas de integrina junto con un agente coterapéutico o formas de terapia que tengan eficacia sinergística cuando se administren de manera consecutiva con los ligandos, tales como agentes quimioterapéuticos y/o radioterapia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09006941 | 2009-05-25 | ||
PCT/EP2010/003162 WO2010136168A2 (en) | 2009-05-25 | 2010-05-25 | Continuous administration of integrin ligands for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011012491A true MX2011012491A (es) | 2011-12-14 |
Family
ID=43223150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011012491A MX2011012491A (es) | 2009-05-25 | 2010-05-25 | Administracion continua de cilengitida en tratamientos contra el cancer. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20120130146A1 (es) |
EP (1) | EP2445534A2 (es) |
JP (1) | JP2012528079A (es) |
KR (1) | KR20120104491A (es) |
CN (1) | CN102448497A (es) |
AU (1) | AU2010252280A1 (es) |
BR (1) | BRPI1011206A2 (es) |
CA (1) | CA2763275A1 (es) |
CL (1) | CL2011002962A1 (es) |
EA (1) | EA201101651A1 (es) |
EC (1) | ECSP11011552A (es) |
IL (1) | IL216537A0 (es) |
MX (1) | MX2011012491A (es) |
NZ (1) | NZ597339A (es) |
SG (1) | SG176103A1 (es) |
WO (1) | WO2010136168A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2011278700A1 (en) * | 2010-07-16 | 2013-02-28 | Merck Patent Gmbh | Peptide for use in the treatment of breast cancer and/or bone metastases |
WO2013009701A2 (en) | 2011-07-08 | 2013-01-17 | The University Of North Carolina At Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
EP2780363B1 (en) | 2011-11-17 | 2019-07-03 | Glia SP Z.O.O. | Compositions and methods for treating glioma |
KR101470700B1 (ko) * | 2011-11-25 | 2014-12-12 | 서울대학교산학협력단 | 표적 항암제의 내성 극복 방법 |
US10092589B2 (en) | 2014-04-04 | 2018-10-09 | Taiho Pharmaceutical Company Limited | Anti-tumor agent containing anti-tumor platinum complex, and anti-tumor effect enhancer |
CN110731961A (zh) | 2014-10-14 | 2020-01-31 | 芝加哥大学 | 金属有机框架、药物制剂及其在制备药物中的用途 |
US10806694B2 (en) | 2014-10-14 | 2020-10-20 | The University Of Chicago | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
US11246877B2 (en) | 2016-05-20 | 2022-02-15 | The University Of Chicago | Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof |
WO2019002947A1 (en) * | 2017-06-29 | 2019-01-03 | Insighten, Ltd. | ULTRASONIC FREQUENCY AND MICROBULLE SIZE OPTIMIZATION IN MICROBULLY ASSISTED ULTRASONIC TREATMENT |
CN111194232B (zh) | 2017-08-02 | 2023-01-31 | 芝加哥大学 | 纳米级金属有机层和金属有机纳米片 |
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EA002822B1 (ru) | 1997-12-17 | 2002-10-31 | Мерк Энд Ко., Инк. | Антагонисты рецептора интегрина |
US6048861A (en) | 1997-12-17 | 2000-04-11 | Merck & Co., Inc. | Integrin receptor antagonists |
AU736026B2 (en) | 1997-12-17 | 2001-07-26 | Merck & Co., Inc. | Integrin receptor antagonists |
JP2002508326A (ja) | 1997-12-17 | 2002-03-19 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体拮抗薬 |
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WO2000006169A1 (en) | 1998-07-29 | 2000-02-10 | Merck & Co., Inc. | Integrin receptor antagonists |
CA2338878A1 (en) | 1998-08-13 | 2000-02-24 | Merck & Co., Inc. | Integrin receptor antagonists |
DE19842415A1 (de) | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
BR9916518A (pt) | 1998-12-23 | 2002-01-29 | Searle & Co | Método para tratar ou prevenir um distúrbio de neoplasia em um mamìfero em necessidade de tal tratamento ou prevenção, e, combinação compreendendo um inibidor de ciclooxigenase-2 e um ou mais agentes anti-neoplásticos |
KR20020021380A (ko) | 1999-06-02 | 2002-03-20 | 폴락 돈나 엘. | 알파 v 인테그린 수용체 길항제 |
US6773897B2 (en) | 2000-09-29 | 2004-08-10 | The Johns Hopkins University School Of Medicine | Method of predicting the clinical response to chemotherapeutic treatment with alkylating agents |
CN101370522A (zh) * | 2006-01-18 | 2009-02-18 | 默克专利有限公司 | 使用整联蛋白配体治疗癌症的特别疗法 |
PT2101805E (pt) * | 2007-01-18 | 2013-01-31 | Merck Patent Gmbh | Terapia específica e medicamento usando ligandos integrina para tratar o cancro |
-
2010
- 2010-05-25 CN CN2010800227000A patent/CN102448497A/zh active Pending
- 2010-05-25 NZ NZ597339A patent/NZ597339A/xx not_active IP Right Cessation
- 2010-05-25 MX MX2011012491A patent/MX2011012491A/es not_active Application Discontinuation
- 2010-05-25 JP JP2012511202A patent/JP2012528079A/ja active Pending
- 2010-05-25 EA EA201101651A patent/EA201101651A1/xx unknown
- 2010-05-25 BR BRPI1011206A patent/BRPI1011206A2/pt not_active Application Discontinuation
- 2010-05-25 US US13/322,391 patent/US20120130146A1/en not_active Abandoned
- 2010-05-25 SG SG2011084381A patent/SG176103A1/en unknown
- 2010-05-25 EP EP20100721342 patent/EP2445534A2/en not_active Withdrawn
- 2010-05-25 WO PCT/EP2010/003162 patent/WO2010136168A2/en active Application Filing
- 2010-05-25 AU AU2010252280A patent/AU2010252280A1/en not_active Abandoned
- 2010-05-25 KR KR1020117030945A patent/KR20120104491A/ko not_active Withdrawn
- 2010-05-25 CA CA2763275A patent/CA2763275A1/en not_active Abandoned
-
2011
- 2011-11-22 IL IL216537A patent/IL216537A0/en unknown
- 2011-11-24 CL CL2011002962A patent/CL2011002962A1/es unknown
- 2011-12-23 EC EC2011011552A patent/ECSP11011552A/es unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI1011206A2 (pt) | 2016-03-15 |
EA201101651A1 (ru) | 2012-08-30 |
CA2763275A1 (en) | 2010-12-02 |
AU2010252280A1 (en) | 2012-01-19 |
US20120130146A1 (en) | 2012-05-24 |
IL216537A0 (en) | 2012-02-29 |
SG176103A1 (en) | 2011-12-29 |
CL2011002962A1 (es) | 2012-06-01 |
ECSP11011552A (es) | 2012-01-31 |
NZ597339A (en) | 2013-10-25 |
KR20120104491A (ko) | 2012-09-21 |
CN102448497A (zh) | 2012-05-09 |
JP2012528079A (ja) | 2012-11-12 |
EP2445534A2 (en) | 2012-05-02 |
WO2010136168A3 (en) | 2011-07-07 |
WO2010136168A8 (en) | 2011-09-22 |
WO2010136168A2 (en) | 2010-12-02 |
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