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MX2011006959A - Compuestos substituidos de 5,6-dihidro-6-fenilbenzo [f] isoquinolina-2-amina. - Google Patents

Compuestos substituidos de 5,6-dihidro-6-fenilbenzo [f] isoquinolina-2-amina.

Info

Publication number
MX2011006959A
MX2011006959A MX2011006959A MX2011006959A MX2011006959A MX 2011006959 A MX2011006959 A MX 2011006959A MX 2011006959 A MX2011006959 A MX 2011006959A MX 2011006959 A MX2011006959 A MX 2011006959A MX 2011006959 A MX2011006959 A MX 2011006959A
Authority
MX
Mexico
Prior art keywords
phenylbenzo
isoquinolin
dihydro
substituted
amine compounds
Prior art date
Application number
MX2011006959A
Other languages
English (en)
Inventor
Mark Ashwell
Syed Ali
Yanbin Liu
Manish Tandon
Rui-Yang Yang
David Vensel
Sudharshan Eathiraj
Rocio Palma
Jean-Marc Lapierre
Neil Westlund
Hui Wu
Nivedita Namdev
Eugene Kelleher
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of MX2011006959A publication Critical patent/MX2011006959A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Pest Control & Pesticides (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con compuestos sustituidos de 5,6-dihidro-6-fenilbenzo (f) isoquinolina2- amino y métodos para sintetizar estos compuestos. La presente invención también se relaciona con composiciones farmacéuticas que contienen compuestos sustituidos de 5,6-dihidro-6-fenilbenzo (f) isoquinolina2-amino y métodos para el tratamiento de desordenes celulares proliferativos tales como el cáncer, mediante la administración de estos compuestos y composiciones farmacéuticos a sujetos que tienen necesidad de los mismos.
MX2011006959A 2008-12-30 2009-12-30 Compuestos substituidos de 5,6-dihidro-6-fenilbenzo [f] isoquinolina-2-amina. MX2011006959A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14143908P 2008-12-30 2008-12-30
US26050509P 2009-11-12 2009-11-12
PCT/US2009/069813 WO2010078421A1 (en) 2008-12-30 2009-12-30 Substituted 5,6-dihydro-6-phenylbenzo[f] isoquinolin-2-amine compounds

Publications (1)

Publication Number Publication Date
MX2011006959A true MX2011006959A (es) 2011-12-06

Family

ID=41682678

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011006959A MX2011006959A (es) 2008-12-30 2009-12-30 Compuestos substituidos de 5,6-dihidro-6-fenilbenzo [f] isoquinolina-2-amina.

Country Status (14)

Country Link
US (1) US8357694B2 (es)
EP (1) EP2379506B1 (es)
JP (1) JP5739820B2 (es)
KR (1) KR101714799B1 (es)
CN (1) CN102325755B (es)
BR (1) BRPI0923786C8 (es)
CA (1) CA2748491C (es)
DK (1) DK2379506T3 (es)
ES (1) ES2554623T3 (es)
IL (1) IL213787A (es)
MX (1) MX2011006959A (es)
TW (1) TWI461410B (es)
WO (1) WO2010078421A1 (es)
ZA (1) ZA201104706B (es)

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Also Published As

Publication number Publication date
CA2748491A1 (en) 2010-07-08
TWI461410B (zh) 2014-11-21
TW201035055A (en) 2010-10-01
IL213787A (en) 2014-08-31
CN102325755A (zh) 2012-01-18
IL213787A0 (en) 2011-07-31
ES2554623T3 (es) 2015-12-22
CA2748491C (en) 2019-08-06
US8357694B2 (en) 2013-01-22
WO2010078421A8 (en) 2011-10-27
BRPI0923786A2 (pt) 2016-07-26
JP5739820B2 (ja) 2015-06-24
CN102325755B (zh) 2015-07-01
KR101714799B1 (ko) 2017-03-09
KR20110099790A (ko) 2011-09-08
ZA201104706B (en) 2012-08-29
WO2010078421A1 (en) 2010-07-08
JP2012514045A (ja) 2012-06-21
BRPI0923786B1 (pt) 2020-11-24
EP2379506A1 (en) 2011-10-26
AU2009335010A1 (en) 2011-07-21
EP2379506B1 (en) 2015-09-02
BRPI0923786C8 (pt) 2021-05-25
US20100239525A1 (en) 2010-09-23
DK2379506T3 (en) 2015-12-14
BRPI0923786C1 (pt) 2021-05-11
AU2009335010A8 (en) 2011-08-11

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