MX2011000301A - A method of lightening skin. - Google Patents

Abstract

The invention relates to a method and a product for lightening of skin and also for blemish removal on the skin. The invention provides for a method of lightening skin comprising the sequential steps, in any order, of; a) applying an alcohol having carbon chain length of 2 to 4, to the skin; and b) applying a skin lightening agent to said skin. The invention also provides for a kit for skin lightening comprising an alcohol having carbon chain length of 2 to 4 and a separately packaged skin lightening agent, along with instructions for their use. It is particularly preferred that the alcohol is impregnated in porous water-insoluble substrate.

Description

A METHOD TO CLEAR SKIN technical field The present invention relates to a method for clarifying Background and prior art Many people, especially those from regions other than Asia and Africa have darker skin compared to those living far from the tropics. These dark skin have the desire to have a skin color more part, people who live far from the tropics as aq and North America, who were usually born with ara, like to have a darker skin appearance. To achieve this by sun-tanning. Such attempts at tanning dark uneven or ma nchas on your skin, the rs n s find undesirable l. P r rboxylic acids such as azelaic acid and kojic acid, droquinone extracts, etc. Niacinamide, which is a compound of, is one of such skin lightening agents broadly composition for topical application. The second lightening ingredient of the skin is a sunscreen, which is skin color against ultra-violet (UV) radiation, known to cause tanning of the skin. These screens are either absorbing or blocking UV rays incident sunscreen arrays can be either inorganic in nature; They may occur naturally or may occur synthetically. Skin lightening agents and sunscreen agents have been combined into skin compactors to provide synergistic benefits.

A popular skin lightening composition is based on 0 186 (Unilever, 1990). This patent discloses a colander of the ia com yielding niacinamide one or both of them. The present inventors have been working for a few years now and have consistently realized that a two-step process, one of which involves applying an alcohol to the skin, Preferably at the cleaner and another step comprising applying to the skin or skin laver, it provides an internal skin rinse compared to known methods. Good results are taken regardless of the order of the sequence.

WO 01/78678 (Procter &Gamble, 2001) discloses a di-formed for delivering skin benefit agents, the device comprising a solid gel sheet having opposite opposite surfaces, wherein the gel sheet comprises a gel. gelling agents and at least 10% of hydrologically acceptable solvent, characterized in that the surface is at least partially coated with a component of ethanol, perfume and others. Therefore, skin is maintained with a sense of freshness that is claimed, cleaners that contain alcohol are also known However, none of the prior art shows a two-step, one step involving applying an alcohol and or contemplating applying a skin lightening agent, intensifying skin lightening techniques.

Thus, an object of the present invention to develop a method that provides internal skin rinsing is compared to known methods.

Another objective of the present invention is to provide a skin laver that is more effective in lightening the skin that matches the available products.

Another objective of the present invention is to provide a skin lightening product that is effective in rem l l i. skin laver follow the step of applying alcohol.

According to another aspect of the present invention, a skin lightening kit comprising a chain length of 2 to 4 is provided, and an agent lightens the packing separately, together with instructions for its use.

Detailed description of the invention All parts herein are by weight unless otherwise stated.

The invention provides a two-step method for a. This method gives the skin lightening, which is better than currently known. One step comprises applying to the skin another step comprising applying to the same area of skin or skin laver. In this way it is a method that can be done first., I will continue. However, the above-mentioned sequence is to be used in the method of the invention as ethyl or opropyl alcohol. Alcohol can be formulated in a spirit. Suitable forms of the alcoholic composition alone, mouse, aerosol spray, bar, powder or granule, the alcohol is impregnated in an insoluble substrate. It is desirable that the amount of alcohol applied on tea in the range of 5 mg to 50 mg per cm2 of the skin area. When the alcohol is delivered through a alcoholic beverage, the alcohol is preferably present from 10% by weight of said alcoholic composition.

A preferred method for applying alcohol to water-insoluble, porous pi sas, such sheets are also cleaning agents. Material suitable for construction is made of woven or non-woven polymeric sheets or natural materials such as cellulose, for example, cotton or natural materials such as wool or laminated silk.

The are selected from sunscreens, rinse agents, vitamins, pharmaceutical actives, skin enhancers, skin texture enhancers, anti-oxidants, flaming agents or emollients. The agent of benefit for the substance preferably from 0.1% to 10% by weight of the alc to bind to a theory, it is believed that the benefit agent delivered through the alcohol is better transported by higher penetration or by any other mechanism to the target on the skin. Additional benefit agents, which are not compatible in emulsion-based compositions, may be delivered through the present invention.

Alcohol can also be applied to the skin by aerosol spray. In this method, the mixture of pressurized pressurizers is compressed and filled in a can, viewed with a metering valve, which can be read skin laradora. The skin lightening agents are vitamin B3 compounds. Suitable compounds are selected from niacin, niacinamide, cotinil, or derivatives or salts thereof. The most preferred skin rinse agent is niacinamide. The body lightening agent is preferably 0.05% to 10% in lightening weight of the skin. The most preferred amount 1% to 10%, the most preferred amount is from 0.2% hast of the composition.

Other vitamins that act as lightening agents can be advantageously included in the composition to clarify the skin to provide additional skin lightening effects including vitamin B6, vitamin C and vitamin A or their vitamin levels can also be used. . One additional specific vitamin is Vitamin B6. inositol, kojic acid, lactic acid, linoleic acid extract, magnesium ascorbyl phosphate, 5-octanoyl acid derivatives of 2,4-resorcinol, 3,5-resorcinol derivatives, 3,4,5-trihydroxybenzyl acid derivatives, and mixtures thereof.

The lightening composition of the skin includes option to sunscreen. Ultraviolet light is a predominant cause of skin darkening. Thus for purposes of clarification of the arrangements comprising UVA and / or U seables sunscreen. Organic sunscreen / sunblock can be used properly in composting Preferred sunscreens useful in the present 2 n-ethylhexyl-p-methoxycinnamate, butylmethoxydibenzoylmethane, 2-methoxybenzophenone, octyldimethyl-p-aminobenzoic acid and myself. The particularly preferred sunscreen is hexyl-p-methoxycin amato, 4-t-butyl-4'-methoxydibenzoyl-methoxyl thereof. l-lone-benzoxazole and mixtures of these compounds.

A safe and effective amount of sunscreen to be incorporated into the compositions used in the present invention preferably comprises from about 10%, more preferably about 0.1% to about 5%, of a solar screen.

Useful inorganic blockers can also be used in the present invention. These include, for example, iron oxide, silica, such as fumed silica and di-anium.

The ultrathin titanium dioxide in any of its two titanium dioxide dispersible in water and dioxide d spersable in oil, is especially suitable for the invention titanium oxide dispersible in water is titanium dioxide ultra By "ultrathin titanium dioxide" it wants to say, titanium particles having an average particle size of less than, preferably 70 nm or less, more preferably 1 0, most preferably from 1 to 25 nm.

By topical application to the skin of a mixture of both ultrathin d dispersion in water and oil-dispersible titanium dioxide, intensified protection of the skin harmful effects of both UV-A and UV-B rays is achievable.

Ultrathin titanium dioxide is a preferred organic blocking agent. The total amount of single-reference blocker is incorporated into the composition according to expiration from 0. 1 to 5% by weight of the composition.

The skin lightening composition preferably cosmetically acceptable compound to act as an ispersant or carrier for other materials present in order to facilitate its distribution when uids or solids, solvents, humectants, thickeners and emulsifiers of each of these types of vehicle, which can be used alone or as mixtures of one or more vehicles, are emollients, such as stearyl alcohol, monericino icerilo, mink oil , cetyl alcohol, stearic isostearate, isobutyl palmitate, isocetyl stearate, eyl, isopropyl laurate, hexyl laurate, tadecan-2-ol oleate, isocetyl alcohol, eicosanilic alcohol, henyl, cetyl palmitate, oils of silicone, methylpolysiloxane, di-n-butyl sebacate, my isomer of isopropyl lmitate, isopropyl stearate, l-stearyl stearate, triethylene glycol, lanolin, cocoa butter, cottonseed oil, olive oil , soma oil, rapeseed oil, cártam seed oil, herb, soybean oil, touring seed oil Powders, such as chalk, talcum, fuller's earth, kaolin, more, colloidal silica , sodium polyacrylate, tea or trilalkyl aryl ammonium smectites, chemically modified aluminum magnesium silicate, organically modified montmorillonite clay, hydrated aluminum, smoked silica, sodium carboxymethyl cellulose polymer and ethylene glycol monostearate.

The cosmetically acceptable vehicle is usually from 10 to 99.9%, preferably from 50 to 99% in lightening setting of the skin and can, in the absence of cosmetics, form the balance of the composition. optional cosmetic ingredients The compositions of the present invention can co wide range of other optional components. Examples of antioxidants, binders, biological additives, mortar agents are important astringent molecules, and the contents of the two separate packages have aldos. The instructions also include the time of the second packing must be used from the contents of the first package.

In the kit, the alcohol composition is preprepared by a plurality of water-insoluble, porous sheets. From erna, the alcoholic composition is packed in a can of propellant.

The invention is now described in the manner of non-limiting types. emplos Emplos 1 to 3: Efficacy of the system method as it is with the known method in a short test.

A trial was conducted for 5 days with 1 6 volunteers. He followed the procedure as described below: A similar specific portion of the forearm of the arcade volunt and washed with a soap once each morning during d washing consisted of rubbing a bar of soap 1 0 times over the arcade followed by rinsing the marked portion of soap free of water to remove all soap. Once rinsed and the area was dried, the same clarify composition as used in Example 1, was applied five times to z every about 1.5 hours. 3 A similar specific portion of the forearm of the vol u nt with a muslin cloth soaked with 0.1 ml of an ethyl alcohol) once a day in the morning. The skin compactor as used in Example 1 was applied daily, once every 1 to 5 hours.

The acl plowing rate of the skin was average per bla 1 Final example of five days 1 - . 1 -0.18 2 - . 2 -0.1 8 3 - . 3 -0.27 The data in Table 1 indicate that a significant degree of skin rinsing is observed using the method (example 3) as compared to terior methods. em plos 4 a 6: Efficacy of the system method as a known method in a prolonged trial.

A trial was conducted for 8 weeks with 36 volunteers, consisting of the procedure as described below.

A different portion of the dorsal forearm of the arcade and was cleaned with a cotton swab containing ethyl alcohol once a day in the morning. A skin coater as used in Example 4 was subsequently in this marked portion after 15 min. Complete procedure of cleaning with the cleanser soaked and guided by applying the skin lightening composition, repeating after a lapse of time. four hours 6 A similar treatment to Example 5 was performed on a third of the dorsal forearm of the volunteer except that he had 3% ascorbic acid.

The skin lightening rating was average per perto use a color ruler on a scale of 1 to 10. Table 2 summarizes the lightening rating of the skin. abla 2 The data in Table 2 indicate that a significant degree of skin rinsing is obtained using the method (examples 5 and 6) as compared to the above method.

Examples 7 and 8: Effect of the sequence of steps An assay was performed for 5 days with 5 volunta nsayo consisted of the procedure as described below. skin lightening setting as used in the example. Fifteen minutes after this, the same area was a cloth of muslin soaked with 0.1 ml of ethyl alcohol and was repeated five times a day, every 5 hours.

The skin rinse rating in the portions is measured by expert assessors using a color ruler from 1 to 10. The data in Table 3 summarizes the average skin thickness that is the color change from the skin color to the skin color. Initial skin color on day zero. An egativa rating indicates a higher degree of skin lightening. abla 3 Final Example of 5 days of est 7 -. 7 -0.375 - One trial was conducted for 8 weeks with 1 6 volunt sayo consisted of the procedure as follows.

An indentation on the cheek of a numbered volunt. The spot color was graduated using a spot color on a scale of 0.5 to 1 0.

Example 9 Approximately 0.25 g of "Fair &Lovely Skin" Commercial product having 1.25% niacinamide as the skin clarifier was applied in the spot of interest.

Example 10 The procedure consisted in cleaning the stain of interest astonishing the wet cotton with approximately two minutes. U how many seconds later (2 to 5 seconds) of bla 4 The data in table 4 indicates that the method of the i provides a better rinsing of the skin of spots as n known methods even in use over a prolonged period

Claims (1)

1. CLAIMS I A method to clarify the skin that includes the facts, in any order, of: a) apply an alcohol having a chain length of 2 to 4, to the skin; Y b) applying a skin lightening agent to said skin, where the second step is performed from 2 second inutes, after the first step. A method as claimed in claim 1, which step (a) followed by step (b). A method as claimed in claim 1 or reivi wherein said alcohol is ethyl alcohol or isopropyl alcohol A method as claimed in any of the claims, wherein said alcohol is impregnated in a porous, water soluble. of them. A method as claimed in any of the claims, wherein the skin's drying agent is delivered through a lightening composition of the skin. A method as claimed in claim 8, in vitamin B34 position is present from 0.2% to 5% of the skin lightening composition. . A method as claimed in claims 8 of the skin lightening composition comprises 0.1% by weight of sunscreen. . A method as claimed in any one of claims 8 to 10, wherein the lightening composition d mines (i) 5-25% by weight of C2-C2o fatty acids and 00 weight of fatty acid soap.