[go: up one dir, main page]

MX2010008714A - Derivados de amida como moduladores alostericos positivos y metodos de uso de los mismos. - Google Patents

Derivados de amida como moduladores alostericos positivos y metodos de uso de los mismos.

Info

Publication number
MX2010008714A
MX2010008714A MX2010008714A MX2010008714A MX2010008714A MX 2010008714 A MX2010008714 A MX 2010008714A MX 2010008714 A MX2010008714 A MX 2010008714A MX 2010008714 A MX2010008714 A MX 2010008714A MX 2010008714 A MX2010008714 A MX 2010008714A
Authority
MX
Mexico
Prior art keywords
methods
amide derivatives
positive allosteric
allosteric modulators
compositions
Prior art date
Application number
MX2010008714A
Other languages
English (en)
Inventor
Diana L Nersesian
Chih-Hung Lee
Kathleen H Mortell
Michael R Schrimpf
Murali Gopalakrishnan
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2010008714A publication Critical patent/MX2010008714A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a derivados de amida novedosos que son PAMs de los receptores nicotínicos neuronales, a composiciones que comprenden los mismos, a procesos para preparar dichos compuestos y a métodos para utilizar dichos compuestos y composiciones.
MX2010008714A 2008-02-07 2009-02-06 Derivados de amida como moduladores alostericos positivos y metodos de uso de los mismos. MX2010008714A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2688608P 2008-02-07 2008-02-07
US14362809P 2009-01-09 2009-01-09
PCT/US2009/033329 WO2009100294A2 (en) 2008-02-07 2009-02-06 Amide derivatives as positive allosteric modulators and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2010008714A true MX2010008714A (es) 2010-09-24

Family

ID=40952708

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008714A MX2010008714A (es) 2008-02-07 2009-02-06 Derivados de amida como moduladores alostericos positivos y metodos de uso de los mismos.

Country Status (17)

Country Link
US (1) US8536221B2 (es)
EP (1) EP2250162B1 (es)
JP (1) JP2011511800A (es)
KR (1) KR20100124272A (es)
CN (1) CN101990537A (es)
AU (1) AU2009212259A1 (es)
BR (1) BRPI0907492A2 (es)
CA (1) CA2713519A1 (es)
CO (1) CO6290763A2 (es)
CR (1) CR11664A (es)
DO (1) DOP2010000241A (es)
EC (1) ECSP10010465A (es)
IL (1) IL207332A0 (es)
MX (1) MX2010008714A (es)
RU (1) RU2010137114A (es)
WO (1) WO2009100294A2 (es)
ZA (1) ZA201005514B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8829041B2 (en) 2006-06-23 2014-09-09 Abbvie Inc. Cyclopropyl amine derivatives
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
CA2721630A1 (en) * 2008-04-17 2009-10-22 Glaxo Group Limited Indoles as modulators of nicoticic acetylcholine receptor subtype alpha-7
NZ596390A (en) 2009-04-16 2013-08-30 Proximagen Ltd Indole derivative modulators of the alpha 7 nachr
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2012037258A1 (en) 2010-09-16 2012-03-22 Abbott Laboratories Processes for preparing 1,2-substituted cyclopropyl derivatives
TW201245185A (en) 2011-04-01 2012-11-16 Lundbeck & Co As H New positive allosteric modulators of nicotinic acetylcholine receptor
AR086791A1 (es) 2011-07-01 2014-01-22 Lundbeck & Co As H Moduladores alostericos positivos del receptor de acetilcolina nicotinico
WO2014049133A1 (en) * 2012-09-28 2014-04-03 H. Lundbeck A/S New positive allosteric modulators of nicotinic acetylcholine receptor
SI3071203T1 (sl) 2013-11-18 2021-07-30 Forma Therapeutics, Inc. Sestavki tetrahidrokinolina, kot zaviralci BET bromodomene
RU2720237C2 (ru) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Композиции, содержащие бензопиперазин, в качестве ингибиторов бромодоменов вет
ES2764660T3 (es) 2014-12-16 2020-06-04 Axovant Sciences Gmbh Compuestos de amida de quinuclidina sustituida geminal como agonistas de receptores alfa-7 nicotínicos de acetilcolina
US10370370B2 (en) 2015-06-10 2019-08-06 Axovant Sciences Gmbh Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors
WO2017027600A1 (en) 2015-08-12 2017-02-16 Forum Pharmaceuticals, Inc. GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS
WO2017144183A1 (en) * 2016-02-24 2017-08-31 Acesion Pharma Aps Novel potassium channel inhibitors
AR108586A1 (es) * 2016-06-10 2018-09-05 Lilly Co Eli Compuestos de 2,3-dihidro-1h-indol
BR112019001015B1 (pt) * 2016-07-18 2022-10-25 Oat Agrio Co., Ltd Composto de benzilamida, método para produção do mesmo, pesticida e miticida
WO2018051252A2 (en) * 2016-09-15 2018-03-22 Insecticides (India) Limited Novel amide compound, method for producing the same, and miticide
HU231333B1 (hu) 2018-07-13 2023-01-28 Richter Gedeon Nyrt Spirokromán származékok
HU231478B1 (hu) 2018-07-13 2024-02-28 Richter Gedeon Nyrt. Szubsztituált (aza)indol származékok
HU231414B1 (hu) 2018-07-13 2023-08-28 Richter Gedeon Nyrt. Tiadiazin származékok
WO2020096871A1 (en) * 2018-11-06 2020-05-14 Merck Sharp & Dohme Corp. Novel substituted tricyclic compounds as indoleamine 2,3-dioxygenase inhibitors
IL293340A (en) 2019-12-02 2022-07-01 Storm Therapeutics Ltd Polyheterocyclic compounds as mettl3 inhibitors
CN118496159B (zh) * 2024-07-18 2024-09-24 广州医科大学附属市八医院 一种化合物在制备具有预防和/或治疗肝纤维化作用的药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2240111A1 (en) 1995-12-14 1997-06-19 Wallace T. Ashton Antagonists of gonadotropin releasing hormone
GB9919411D0 (en) 1999-08-18 1999-10-20 Zeneca Ltd Chemical compounds
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
SE9903997D0 (sv) * 1999-11-03 1999-11-03 Astra Ab New compounds
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
AU2003266222B2 (en) 2002-09-30 2009-10-01 Neurosearch A/S Novel 1,4-diazabicycloalkane derivatives, their preparation and use
CA2521907A1 (en) * 2003-04-10 2004-10-21 Pfizer Inc. Bicyclic compounds as nr2b receptor antagonists
US20050065178A1 (en) * 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives
US20050137204A1 (en) * 2003-12-22 2005-06-23 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US20050245531A1 (en) * 2003-12-22 2005-11-03 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US20060106011A1 (en) * 2004-11-12 2006-05-18 Bock Mark G 2-(Bicyclo)alkylamino-derivatives as mediators of chronic pain and inflammation
US20100093767A1 (en) 2004-12-03 2010-04-15 Takeda San Diego, Inc. Mitotic Kinase Inhibitors
NZ596024A (en) 2006-08-07 2013-07-26 Ironwood Pharmaceuticals Inc Indole compounds

Also Published As

Publication number Publication date
CO6290763A2 (es) 2011-06-20
RU2010137114A (ru) 2012-03-20
AU2009212259A1 (en) 2009-08-13
EP2250162A4 (en) 2012-10-31
BRPI0907492A2 (pt) 2017-06-13
ZA201005514B (en) 2012-01-25
WO2009100294A2 (en) 2009-08-13
CA2713519A1 (en) 2009-08-13
EP2250162B1 (en) 2014-03-19
ECSP10010465A (es) 2010-10-30
US8536221B2 (en) 2013-09-17
CN101990537A (zh) 2011-03-23
DOP2010000241A (es) 2010-08-31
US20090270408A1 (en) 2009-10-29
JP2011511800A (ja) 2011-04-14
EP2250162A2 (en) 2010-11-17
WO2009100294A3 (en) 2009-11-12
IL207332A0 (en) 2010-12-30
KR20100124272A (ko) 2010-11-26
CR11664A (es) 2011-01-06

Similar Documents

Publication Publication Date Title
MX2010008714A (es) Derivados de amida como moduladores alostericos positivos y metodos de uso de los mismos.
WO2009145996A3 (en) Amide derivatives as positive allosteric modulators and methods of use thereof
MX2009004813A (es) Derivados de azaadamantano y sus usos como ligandos de receptores de acetilcolina nicotinicos.
PH12013500870A1 (en) Heterocyclic compounds and uses thereof
MX354402B (es) Inhibidores de molecula pequeña del dominio de homologia de pleckstrin y metodos para usar los mismos.
MX2010001754A (es) Derivados de azepina como inhibidores de gamma secretasa.
MX2011014019A (es) Derivados de diazahomoadamantano y sus metodos de uso.
MA32508B1 (fr) Composes organiques
MY160490A (en) Arylethynyl derivatives
MY153915A (en) Organic compounds
SG179085A1 (en) Pi3 kinase inhibitors and uses thereof
MX2012004780A (es) Inhibidores de akt.
MX356813B (es) Derivados de hidantoina utiles como inhibidores de kv3.
IN2012DN05125A (es)
WO2009089234A3 (en) Substituted dibenzhydrylpiperazines
JO2682B1 (en) Derivatives of alkynil-8.1-naphthayridone, preparations thereof and therapeutic use thereof
MX2009010174A (es) Derivados de aza-adamantano ester y carbamato y metodos de uso de los mismos.
ZA201003352B (en) Heterocyclic derivatives as modulators of ion channels
WO2009086163A3 (en) Thiazolylidine urea and amide derivatives and methods of use thereof
WO2010057088A3 (en) Pyrrolidinyl modulators of nicotinic acetylcholine receptors
MX2009010176A (es) Derivados de aza-adamantano 4-substituidos y metodos de uso de los mismos.
DK2271638T3 (da) Modulatorer af dopaminneurotransmission
IN2012DN03322A (es)
MX2010001075A (es) Derivados de n-piperidin-4-ilmetil-amida y su uso como inhibidores de recaptacion del neurotransmisor de monoamina.
MX2011008126A (es) Compuestos de indol sustituidos como moduladores del receptor 1 de bradiquinina.

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: ABBVIE INC.

FA Abandonment or withdrawal