MX2010003576A - Nuevos compuestos como antagonistas de los receptores a1 de adenosina. - Google Patents
Nuevos compuestos como antagonistas de los receptores a1 de adenosina.Info
- Publication number
- MX2010003576A MX2010003576A MX2010003576A MX2010003576A MX2010003576A MX 2010003576 A MX2010003576 A MX 2010003576A MX 2010003576 A MX2010003576 A MX 2010003576A MX 2010003576 A MX2010003576 A MX 2010003576A MX 2010003576 A MX2010003576 A MX 2010003576A
- Authority
- MX
- Mexico
- Prior art keywords
- optionally substituted
- straight
- branched
- group
- sup
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229940124258 Adenosine A1 receptor antagonist Drugs 0.000 title 1
- 239000002598 adenosine A1 receptor antagonist Substances 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
Estos compuestos corresponden a la f?rmula (I), en la que; R1 representa un grupo arilo o heteroarilo opcionalmente substituido con uno o m?s sustituyentes seleccionados del grupo formado por ?tomos de hal?geno, alquilos inferiores opcionalmente substituidos lineales o ramificados, cicloalquilos, hidroxi, alcoxi inferior opcionalmente substituido lineal o ramificado, ciano, o -CO2R?, en el que R? representa un ?tomo de hidr?geno, o un alquilo inferior opcionalmente substituido, lineal o ramificado; R2 representa un grupo seleccionado del grupo formado por: a) un grupo alquilo inferior lineal o ramificado substituido con uno o m?s grupos carboxilo (-COOH) y opcionalmente substituidos con uno o m?s ?tomos de hal?geno; b) un grupo cicloalquilo substituido con uno o m?s grupos carboxilo (-COOH) y opcionalmente substituidos con uno o m?s ?tomos de hal?geno; c) un grupo cicloalquilalquilo o alquilcicloalquilo lineal o ramificado substituido con uno o m?s grupos carboxilo (-CQOH) y opcionalmente substituidos con uno o m?s ?tomos de hal?geno.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200702643A ES2331220B1 (es) | 2007-10-02 | 2007-10-02 | Nuevos compuestos como antagonistas de los receptores a1 de adenosina. |
| PCT/IB2008/002556 WO2009044250A1 (en) | 2007-10-02 | 2008-09-30 | New compounds as adenosine a1 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010003576A true MX2010003576A (es) | 2010-04-22 |
Family
ID=40303525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010003576A MX2010003576A (es) | 2007-10-02 | 2008-09-30 | Nuevos compuestos como antagonistas de los receptores a1 de adenosina. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8410282B2 (es) |
| EP (1) | EP2197860B1 (es) |
| JP (1) | JP5463592B2 (es) |
| KR (1) | KR101312198B1 (es) |
| CN (1) | CN101835766B (es) |
| AT (1) | ATE510829T1 (es) |
| AU (1) | AU2008306553B2 (es) |
| BR (1) | BRPI0816554B8 (es) |
| CA (1) | CA2700526C (es) |
| CY (1) | CY1112079T1 (es) |
| DK (1) | DK2197860T3 (es) |
| EA (1) | EA022473B1 (es) |
| ES (2) | ES2331220B1 (es) |
| HR (1) | HRP20110557T1 (es) |
| MX (1) | MX2010003576A (es) |
| PL (1) | PL2197860T3 (es) |
| PT (1) | PT2197860E (es) |
| SI (1) | SI2197860T1 (es) |
| WO (1) | WO2009044250A1 (es) |
| ZA (1) | ZA201002139B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011076734A1 (en) * | 2009-12-21 | 2011-06-30 | Euroscreen S.A. | Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases |
| WO2014106861A1 (en) * | 2013-01-03 | 2014-07-10 | Council Of Scientific & Industrial Research | (4e)-4-(4-substituted benzylideneamino)-2,3-dihydro-3- substituted-2-thioxothiazole-5-carbonitriles as a2ar antagonist and process for preparation thereof |
| EP3016951B1 (en) | 2013-07-02 | 2017-05-31 | Bristol-Myers Squibb Company | Tricyclic pyrido-carboxamide derivatives as rock inhibitors |
| WO2015002926A1 (en) | 2013-07-02 | 2015-01-08 | Bristol-Myers Squibb Company | Tricyclic pyrido-carboxamide derivatives as rock inhibitors |
| ES2578363B1 (es) | 2015-01-22 | 2017-01-31 | Palobiofarma, S.L. | Moduladores de los receptores A3 de adenosina |
| ES2676535B1 (es) * | 2017-01-20 | 2019-04-29 | Palobiofarma Sl | Moduladores de los receptores a3 de adenosina |
| RS62089B1 (sr) | 2017-03-06 | 2021-08-31 | Palobiofarma Sl | Aminska so (1r,3s)-3-(5-cijano-4-fenil-1,3-triazol-2-ylkarbamoil) ciklopentan karboksilne kiseline |
| CN107739350B (zh) * | 2017-09-26 | 2020-12-22 | 天津大学 | 一种合成2-氨基噻唑衍生物的方法 |
| EA202190558A1 (ru) | 2018-09-17 | 2022-02-03 | Янгчжин Фарм. Ко., Лтд. | Новые производные тиазола и их фармацевтически приемлемые соли |
| EP3882240A1 (en) | 2020-03-16 | 2021-09-22 | Palobiofarma, S.L. | Cocrystals of (1r,3s)-3-(5-cyano-4-phenyl-1,3-thiazol-2-ylcabamoyl)cyclopentane carboxylic acid |
| EP3957308A1 (en) | 2020-08-21 | 2022-02-23 | Palobiofarma, S.L. | (1r,3s)-3-((5-cyano-4-phenylthiazol-2-yl)carbamoyl)cyclopentane-1-carboxylic acid and derivatives thereof for use in the treatment of airway diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003039451A2 (en) * | 2001-11-08 | 2003-05-15 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole pyridazinones as adenosine antagonists |
| KR101010905B1 (ko) * | 2002-01-18 | 2011-01-25 | 아스텔라스세이야쿠 가부시키가이샤 | 2-아실아미노티아졸 유도체 또는 그 염 |
| CA2645072A1 (en) * | 2006-03-08 | 2007-09-13 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole derivatives with anti-hcv activity |
| WO2007116106A1 (es) * | 2006-04-12 | 2007-10-18 | Palobiofarma, S.L. | Nuevos compuestos como antagonistas de los receptores a1 de adenosina |
-
2007
- 2007-10-02 ES ES200702643A patent/ES2331220B1/es not_active Expired - Fee Related
-
2008
- 2008-09-30 PT PT08835072T patent/PT2197860E/pt unknown
- 2008-09-30 WO PCT/IB2008/002556 patent/WO2009044250A1/en active Application Filing
- 2008-09-30 ES ES08835072T patent/ES2366075T3/es active Active
- 2008-09-30 CN CN2008801126777A patent/CN101835766B/zh active Active
- 2008-09-30 SI SI200830350T patent/SI2197860T1/sl unknown
- 2008-09-30 PL PL08835072T patent/PL2197860T3/pl unknown
- 2008-09-30 BR BRPI0816554A patent/BRPI0816554B8/pt active IP Right Grant
- 2008-09-30 MX MX2010003576A patent/MX2010003576A/es active IP Right Grant
- 2008-09-30 US US12/679,941 patent/US8410282B2/en active Active
- 2008-09-30 HR HR20110557T patent/HRP20110557T1/hr unknown
- 2008-09-30 KR KR1020107008768A patent/KR101312198B1/ko active Active
- 2008-09-30 AU AU2008306553A patent/AU2008306553B2/en not_active Ceased
- 2008-09-30 EA EA201000393A patent/EA022473B1/ru not_active IP Right Cessation
- 2008-09-30 AT AT08835072T patent/ATE510829T1/de active
- 2008-09-30 JP JP2010527561A patent/JP5463592B2/ja active Active
- 2008-09-30 DK DK08835072.3T patent/DK2197860T3/da active
- 2008-09-30 EP EP08835072A patent/EP2197860B1/en active Active
- 2008-09-30 CA CA2700526A patent/CA2700526C/en active Active
-
2010
- 2010-03-25 ZA ZA2010/02139A patent/ZA201002139B/en unknown
-
2011
- 2011-08-22 CY CY20111100805T patent/CY1112079T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0816554B1 (pt) | 2019-04-09 |
| JP5463592B2 (ja) | 2014-04-09 |
| ES2331220A1 (es) | 2009-12-23 |
| KR20100058653A (ko) | 2010-06-03 |
| CA2700526C (en) | 2014-03-18 |
| CY1112079T1 (el) | 2015-11-04 |
| CN101835766A (zh) | 2010-09-15 |
| BRPI0816554B8 (pt) | 2022-08-30 |
| AU2008306553A1 (en) | 2009-04-09 |
| HRP20110557T1 (hr) | 2011-09-30 |
| JP2010540615A (ja) | 2010-12-24 |
| PT2197860E (pt) | 2011-08-26 |
| ES2331220B1 (es) | 2010-09-23 |
| CA2700526A1 (en) | 2009-04-09 |
| BRPI0816554A2 (pt) | 2015-11-24 |
| PL2197860T3 (pl) | 2011-09-30 |
| US8410282B2 (en) | 2013-04-02 |
| CN101835766B (zh) | 2013-09-25 |
| EA201000393A1 (ru) | 2010-08-30 |
| KR101312198B1 (ko) | 2013-09-27 |
| DK2197860T3 (da) | 2011-08-15 |
| ATE510829T1 (de) | 2011-06-15 |
| WO2009044250A1 (en) | 2009-04-09 |
| EA022473B1 (ru) | 2016-01-29 |
| ZA201002139B (en) | 2011-06-29 |
| SI2197860T1 (sl) | 2011-09-30 |
| US20100311703A1 (en) | 2010-12-09 |
| EP2197860B1 (en) | 2011-05-25 |
| EP2197860A1 (en) | 2010-06-23 |
| ES2366075T3 (es) | 2011-10-17 |
| AU2008306553B2 (en) | 2011-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |