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MX2010001358A - Compuestos de tiazolida sustituidos con alquilsulfonilo. - Google Patents

Compuestos de tiazolida sustituidos con alquilsulfonilo.

Info

Publication number
MX2010001358A
MX2010001358A MX2010001358A MX2010001358A MX2010001358A MX 2010001358 A MX2010001358 A MX 2010001358A MX 2010001358 A MX2010001358 A MX 2010001358A MX 2010001358 A MX2010001358 A MX 2010001358A MX 2010001358 A MX2010001358 A MX 2010001358A
Authority
MX
Mexico
Prior art keywords
alkylsulfonyl
compounds
thiazolide compounds
substituted
substituted thiazolide
Prior art date
Application number
MX2010001358A
Other languages
English (en)
Inventor
Jean-Francois Rossignol
J Edward Semple
Original Assignee
Romark Lab Lc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39791394&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010001358(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Romark Lab Lc filed Critical Romark Lab Lc
Publication of MX2010001358A publication Critical patent/MX2010001358A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Se describe una nueva clase de compuestos de tiazolida sustituidos con alquilsulfonilo. Estos compuestos muestran una fuerte actividad contra el virus de la hepatitis.
MX2010001358A 2007-08-03 2008-08-01 Compuestos de tiazolida sustituidos con alquilsulfonilo. MX2010001358A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95375807P 2007-08-03 2007-08-03
US4695608P 2008-04-22 2008-04-22
US5636908P 2008-05-27 2008-05-27
PCT/US2008/071990 WO2009035788A1 (en) 2007-08-03 2008-08-01 Alkylsulfonyl-substituted thiazolide compounds

Publications (1)

Publication Number Publication Date
MX2010001358A true MX2010001358A (es) 2010-04-09

Family

ID=39791394

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001358A MX2010001358A (es) 2007-08-03 2008-08-01 Compuestos de tiazolida sustituidos con alquilsulfonilo.

Country Status (15)

Country Link
US (2) US8124632B2 (es)
EP (1) EP2178852B9 (es)
JP (1) JP5676258B2 (es)
CN (1) CN101835765B (es)
AR (1) AR068334A1 (es)
AU (1) AU2008299781B2 (es)
BR (1) BRPI0815057B8 (es)
CA (1) CA2695517C (es)
CL (1) CL2008002295A1 (es)
EA (1) EA019357B1 (es)
ES (1) ES2550755T3 (es)
MX (1) MX2010001358A (es)
PT (1) PT2178852E (es)
TW (1) TWI453018B (es)
WO (1) WO2009035788A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2395840T (pt) 2009-02-13 2020-07-06 Romark Laboratories Lc Formulações farmacêuticas de libertação controlada de nitazoxanida
ES2528946T3 (es) 2009-03-20 2015-02-13 University Of Virginia Patent Foundation Benzotiofeno-nitrotiazolida y otros antimicrobianos de amplio espectro
JP2012522013A (ja) * 2009-03-27 2012-09-20 ザ ユーエービー リサーチ ファウンデーション 調節ｉｒｅｓ媒介翻訳
AU2010247816B2 (en) * 2009-05-12 2015-12-17 Romark Laboratories L.C. Haloalkyl heteroaryl benzamide compounds
JP5932640B2 (ja) 2009-06-26 2016-06-08 ロマーク ラボラトリーズ エル．シー． インフルエンザを治療するための化合物および方法
WO2012040170A2 (en) 2010-09-20 2012-03-29 University Of Virginia Patent Foundation Compositions and methods for treating tuberculosis
MX2013004724A (es) 2010-11-01 2013-08-29 Romark Lab Lc Compuestos de tiazolida alquilsulfinilo-sustituidos.
TW201619142A (zh) 2014-11-11 2016-06-01 羅馬克實驗室有限公司 利用替唑尼特（ｔｉｚｏｘａｎｉｄｅ）、其類似物或鹽類之前驅藥的組成物及治療方法
ES2879639T3 (es) * 2014-12-01 2021-11-22 Syngenta Participations Ag Derivados de amida heterocíclicos activos como plaguicidas con sustituyentes con contenido en azufre
CN105777808B (zh) * 2014-12-23 2018-11-09 中国人民解放军军事医学科学院毒物药物研究所 替唑尼特磷酸酯和烷基磺酸酯及其在药学中的应用
SI3436074T1 (sl) 2016-03-31 2020-09-30 Romark Laboratories, L.C. Tiazolidne spojine za zdravljenje virusnih infekcij
HUE060671T2 (hu) 2016-04-11 2023-04-28 Genfit Eljárás fibrotikus betegségek kezelésére
CN106565626B (zh) * 2016-10-10 2022-06-10 淮海工学院 2-氨基-4-芳基-5-甲硫基噻唑类化合物的合成方法
CN108610301B (zh) * 2016-12-12 2021-08-31 中山大学 一类手性芳杂胺类衍生物及其合成方法和应用
WO2018107332A1 (zh) * 2016-12-12 2018-06-21 中山大学 一类手性芳杂胺类衍生物及其合成方法和应用
WO2018195035A1 (en) 2017-04-18 2018-10-25 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase a3
WO2019241376A1 (en) 2018-06-14 2019-12-19 The Trustees Of Columbia University In The City Of New York Treatment of cognitive disorders using nitazoxanide (ntz), nitazoxanide (ntz) analogs, and metabolites thereof
WO2020221074A1 (zh) * 2019-04-30 2020-11-05 南京海璞医药科技有限公司 一种含稠环的化合物、其应用及含其的药物组合物
CN112480104B (zh) * 2019-09-11 2024-06-18 绍兴君科臻元医药科技有限公司 硝唑尼特衍生物及其医药用途
US20230140290A1 (en) * 2020-01-26 2023-05-04 The Board Of Regents Of The University Of Texas Sy Salicylamide derivatives and related methods of making
JP2023537237A (ja) 2020-07-20 2023-08-31 ロマーク ラボラトリーズ，リミティド カンパニー チゾキサニドおよび２－ヒドロキシ－ｎ－（５－クロロ－１，３－チアゾル－２－イル）ベンズアミド（ｒｍ－４８４８）とエタノールアミン、モルホリン、プロパノールアミン、ピペラジン、およびｎ－メチルピペラジンの結晶塩
US20230330069A1 (en) 2020-08-24 2023-10-19 Romark Laboratories, L.C. Use of thiazolides against coronaviruses
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
US12215102B2 (en) 2023-02-28 2025-02-04 Reglagene, Inc. Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437800A (en) * 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
US4343945A (en) 1979-01-23 1982-08-10 Olin Corporation 5-Benzamido-3-trichloromethyl-1,2,4-thiadiazoles and their use as herbicides, fungicides and insecticides
US4337081A (en) 1979-01-23 1982-06-29 Olin Corporation 5-Amido-3-trihalomethyl-1,2,4-thiadiazoles and their use as herbicides
SU910628A1 (ru) 1980-04-22 1982-03-07 Гродненский государственный медицинский институт Способ получени 2-ациламинотиазолов
JPS56158703A (en) 1980-05-10 1981-12-07 Sankyo Co Ltd Fungicide
US4416683A (en) 1980-09-16 1983-11-22 Eli Lilly And Company Benzamides, compositions and agricultural method
JPS619978A (ja) 1984-06-22 1986-01-17 Nippon Steel Corp 溶接用フラツクスの循環使用方法
US4874864A (en) * 1988-05-24 1989-10-17 Pfizer Inc. Benzamide protease inhibitors
US5169846A (en) * 1989-10-12 1992-12-08 Crooks Michael J Non-aqueous micellar solutions of anthelmintic benzimidazoles, closantel, or phenothiazine, and insect growth regulators
CA2187110C (en) 1994-04-13 2002-03-19 Jean-Francois Rossignol Benzamide derivative, compositions containing said derivative and use thereof
US5578621A (en) * 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives
MX9604483A (es) * 1994-09-08 1998-02-28 Jean-Francois Rossignol Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
GB9725298D0 (en) 1997-11-28 1998-01-28 Zeneca Ltd Insecticidal thiazole derivatives
EP1095016B1 (en) 1998-07-08 2005-11-09 Sanofi-Aventis Deutschland GmbH Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
US6849254B1 (en) * 1999-04-19 2005-02-01 Schering Corporation HCV combination therapy
US6136835A (en) * 1999-05-17 2000-10-24 The Procter & Gamble Company Methods of treatment for viral infections
PT1347971E (pt) 2000-12-21 2006-06-30 Bristol Myers Squibb Co Inibidores tiazolilicos de tirosina-cinases da familia tec
DE60208630T2 (de) * 2001-05-11 2006-08-17 Pfizer Products Inc., Groton Thiazolderivate und ihre Verwendung als cdk-Inhibitoren
WO2002092584A1 (fr) 2001-05-14 2002-11-21 Nihon Nohyaku Co., Ltd. Derives du thiadiazole, pesticides a usage agricole et horticole, et leurs utilisations
SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
JP2003335680A (ja) 2002-05-21 2003-11-25 Otsuka Pharmaceut Factory Inc Ａｃａｔ−１阻害剤
JPWO2003103648A1 (ja) 2002-06-05 2005-10-06 株式会社医薬分子設計研究所 糖尿病治療薬
US20040242518A1 (en) 2002-09-28 2004-12-02 Massachusetts Institute Of Technology Influenza therapeutic
US6737382B1 (en) 2002-10-23 2004-05-18 Nippon Soda Co. Ltd. Insecticidal aminothiazole derivatives
US7807174B2 (en) * 2002-11-22 2010-10-05 Nexbio, Inc. Class of therapeutic protein based molecules
NZ541824A (en) 2003-02-26 2010-04-30 Banyu Pharma Co Ltd Heteroarylcarbamoylbenzene derivatives as glucokinase activators
US20050090506A1 (en) * 2003-10-24 2005-04-28 Nippon Soda Co., Ltd. Insecticidal perfluoroalkylthiazole derivatives
UA90864C2 (en) * 2004-09-09 2010-06-10 Ромарк Лебораториз, Л.К. Halogenated benzamide derivatives
US20060194853A1 (en) * 2004-10-08 2006-08-31 Rossignol Jean F Alkyl benzamides
US8357664B2 (en) * 2004-10-26 2013-01-22 Avi Biopharma, Inc. Antisense antiviral compound and method for treating influenza viral infection
JP2008540537A (ja) 2005-05-09 2008-11-20 アキリオン ファーマシューティカルズ，インコーポレーテッド チアゾール化合物および使用方法
WO2007130075A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
TW200711649A (en) 2005-06-17 2007-04-01 Combinatorx Inc Combination therapy for the treatment of immunoinflammatory disorders
EP1910307A1 (en) * 2005-06-27 2008-04-16 Exelixis, Inc. Pyrazole based lxr modulators
WO2007008541A2 (en) * 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
MX2008001605A (es) * 2005-08-02 2008-04-14 Irm Llc Compuestos y composiciones de tiazol-2-il amino 5-substituido como inhibidores de cinasa proteica.
ES2378473T3 (es) 2005-12-21 2012-04-12 Abbott Laboratories Compuestos antivirales
WO2007125103A2 (en) 2006-04-28 2007-11-08 Transtech Pharma, Inc. Benzamide glucokinase activators
US20100009970A1 (en) * 2008-03-19 2010-01-14 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US20100081713A1 (en) 2008-03-19 2010-04-01 CombinatoRx, (Singapore) Pte. Ltd. Compositions and methods for treating viral infections
ES2528946T3 (es) 2009-03-20 2015-02-13 University Of Virginia Patent Foundation Benzotiofeno-nitrotiazolida y otros antimicrobianos de amplio espectro

Also Published As

Publication number Publication date
EA201070182A1 (ru) 2010-10-29
US8895752B2 (en) 2014-11-25
JP5676258B2 (ja) 2015-02-25
BRPI0815057B1 (pt) 2020-11-10
US20120122939A1 (en) 2012-05-17
CN101835765B (zh) 2013-05-29
JP2010535712A (ja) 2010-11-25
WO2009035788A1 (en) 2009-03-19
CN101835765A (zh) 2010-09-15
EP2178852B1 (en) 2015-07-22
EA019357B1 (ru) 2014-03-31
AU2008299781B2 (en) 2013-11-14
TW200911239A (en) 2009-03-16
TWI453018B (zh) 2014-09-21
CL2008002295A1 (es) 2009-03-27
HK1147094A1 (en) 2011-07-29
US20090036467A1 (en) 2009-02-05
EP2178852B9 (en) 2016-06-22
CA2695517C (en) 2016-09-20
AR068334A1 (es) 2009-11-11
US8124632B2 (en) 2012-02-28
AU2008299781A1 (en) 2009-03-19
ES2550755T3 (es) 2015-11-12
PT2178852E (pt) 2015-11-12
EP2178852A1 (en) 2010-04-28
CA2695517A1 (en) 2009-03-19
BRPI0815057B8 (pt) 2021-05-25
BRPI0815057A2 (pt) 2015-07-28

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