MX2009011855A - Metodos de calificacion de rm de un tumor utilizando un medio de elaboracion de imagen que comprende 13c-piruvato hiperpolarizado. - Google Patents
Metodos de calificacion de rm de un tumor utilizando un medio de elaboracion de imagen que comprende 13c-piruvato hiperpolarizado.Info
- Publication number
- MX2009011855A MX2009011855A MX2009011855A MX2009011855A MX2009011855A MX 2009011855 A MX2009011855 A MX 2009011855A MX 2009011855 A MX2009011855 A MX 2009011855A MX 2009011855 A MX2009011855 A MX 2009011855A MX 2009011855 A MX2009011855 A MX 2009011855A
- Authority
- MX
- Mexico
- Prior art keywords
- tumor
- pyruvate
- metabolic profile
- imaging medium
- grading
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 4
- 238000003384 imaging method Methods 0.000 title abstract 3
- 230000002503 metabolic effect Effects 0.000 abstract 5
- LCTONWCANYUPML-VQEHIDDOSA-N pyruvic -2-13c acid Chemical compound C[13C](=O)C(O)=O LCTONWCANYUPML-VQEHIDDOSA-N 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
- A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
- A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
- A61B5/4375—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the male reproductive system
- A61B5/4381—Prostate evaluation or disorder diagnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
- G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- Radiology & Medical Imaging (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Signal Processing (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
La solicitud se refiere a un método de RM para calificar un tumor utilizando un medio de elaboración de imagen que comprende 13C-piruvato hiperpolarizado. En particular, se refiere a un método para determinar la calificación de un tumor, comprendiendo dicho método a) la detección por RM de un tumor en un sujeto utilizando un medio de elaboración de imagen que comprende 13C-piruvato hiperpolarizado en donde son detectadas las señales de 13C-piruvato y sus metabolitos de alanina, lactato y opcionalmente bicarbonato que contienen-13C; b) utilizando dichas señales y opcionalmente la señal total de carbono para generar un perfil metabólico del tumor; c) comparar el perfil metabólico del tumor generado en el paso b) con un perfil metabólico conocido de un tumor de cierta calificación; y d) determinar la calificación del tumor basada en las similitudes y diferencias entre el perfil metabólico del tumor y el perfil metabólico conocido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93846807P | 2007-05-17 | 2007-05-17 | |
| PCT/NO2008/000171 WO2008143519A1 (en) | 2007-05-17 | 2008-05-16 | Mr methods of grading a tumor using an imaging medium that comprises hyperpolarised 13c-pyruvate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009011855A true MX2009011855A (es) | 2009-11-18 |
Family
ID=39722634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009011855A MX2009011855A (es) | 2007-05-17 | 2008-05-16 | Metodos de calificacion de rm de un tumor utilizando un medio de elaboracion de imagen que comprende 13c-piruvato hiperpolarizado. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20110020235A1 (es) |
| EP (1) | EP2144561B1 (es) |
| JP (1) | JP2010529868A (es) |
| KR (2) | KR20150053819A (es) |
| CN (2) | CN101730504A (es) |
| AU (1) | AU2008253822B2 (es) |
| BR (1) | BRPI0811092A2 (es) |
| CA (1) | CA2683023C (es) |
| MX (1) | MX2009011855A (es) |
| RU (1) | RU2494672C2 (es) |
| WO (1) | WO2008143519A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2421610A1 (en) * | 2009-04-20 | 2012-02-29 | Koninklijke Philips Electronics N.V. | A control apparatus for controlling a therapeutic apparatus |
| DE102011082181B3 (de) * | 2011-09-06 | 2013-02-21 | Siemens Ag | Korrektur eines Bestrahlungsplans auf Grundlage von Magnetresonanzdaten |
| JP6507101B2 (ja) | 2013-01-31 | 2019-04-24 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | Ｍｒにおける代謝マーカーとしての過分極エステル |
| KR101516634B1 (ko) * | 2014-07-09 | 2015-05-06 | 연세대학교 산학협력단 | 13c-자기공명분광영상을 이용한 암 환자의 치료 예후를 예측하는 방법 |
| US10667718B2 (en) * | 2015-03-26 | 2020-06-02 | Case Western Reserve University | Quantitative prostate cancer imaging with magnetic resonance fingerprinting (MRF) |
| US10921397B2 (en) * | 2016-03-10 | 2021-02-16 | Memorial Sloan Kettering Cancer Center | Hyperpolarized micro-NMR system and methods |
| DE102016218715A1 (de) * | 2016-09-28 | 2018-03-29 | Siemens Healthcare Gmbh | Verbesserte Erzeugung kombinierter Magnetresonanzbilder |
| KR101939454B1 (ko) * | 2017-03-21 | 2019-01-16 | 전남대학교산학협력단 | 생체 내 과분극화 c13 피루베이트 자기공명분광법을 이용하여 새로운 정량적 생체지표를 통한 비알코올성 지방간질환 진단 방법 |
| EP3756024A1 (en) * | 2018-02-19 | 2020-12-30 | BRUKER FRANCE (Société par Actions Simplifiée) | Nuclear spin hyperpolarization in a porous matrix |
| CN117180458B (zh) * | 2023-08-31 | 2024-08-09 | 中国科学院精密测量科学与技术创新研究院 | 草酰乙酸在溶融动态核极化中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6009342A (en) * | 1997-02-28 | 1999-12-28 | The Regents Of The University Of California | Imaging method for the grading of tumors |
| RU2207808C2 (ru) * | 1998-04-09 | 2003-07-10 | Амершем Хелт АС | Применение контрастных агентов в форме частиц в диагностической визуализации для изучения физиологических параметров |
| US7742800B2 (en) * | 2004-05-10 | 2010-06-22 | General Electric Company | Methods and systems for detection and monitoring of neurodegenerative diseases using magnetic resonance spectroscopy |
| JP5362987B2 (ja) * | 2004-07-30 | 2013-12-11 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 腫瘍イメージングの方法 |
| MX2007001035A (es) * | 2004-07-30 | 2007-07-11 | Ge Healthcare As | Metodo para producir una composicion, la composicion y su uso. |
| PL1824523T3 (pl) * | 2004-11-19 | 2013-12-31 | Ge Healthcare As | Sposób obrazowania serca przy zastosowaniu hiperspolaryzowanego 13C-pirogronianu |
-
2008
- 2008-05-16 CA CA2683023A patent/CA2683023C/en not_active Expired - Fee Related
- 2008-05-16 MX MX2009011855A patent/MX2009011855A/es active IP Right Grant
- 2008-05-16 JP JP2010508326A patent/JP2010529868A/ja active Pending
- 2008-05-16 EP EP08753830.2A patent/EP2144561B1/en not_active Not-in-force
- 2008-05-16 US US12/599,976 patent/US20110020235A1/en not_active Abandoned
- 2008-05-16 CN CN200880015955A patent/CN101730504A/zh active Pending
- 2008-05-16 AU AU2008253822A patent/AU2008253822B2/en not_active Ceased
- 2008-05-16 KR KR1020157010919A patent/KR20150053819A/ko not_active Ceased
- 2008-05-16 RU RU2009137467/14A patent/RU2494672C2/ru active
- 2008-05-16 CN CN201510493890.9A patent/CN105054933A/zh active Pending
- 2008-05-16 KR KR1020097023876A patent/KR20100023802A/ko not_active Ceased
- 2008-05-16 WO PCT/NO2008/000171 patent/WO2008143519A1/en active Application Filing
- 2008-05-16 BR BRPI0811092-1A2A patent/BRPI0811092A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2683023A1 (en) | 2008-11-27 |
| CA2683023C (en) | 2016-10-11 |
| EP2144561A1 (en) | 2010-01-20 |
| CN105054933A (zh) | 2015-11-18 |
| US20110020235A1 (en) | 2011-01-27 |
| KR20150053819A (ko) | 2015-05-18 |
| EP2144561B1 (en) | 2017-09-20 |
| WO2008143519A1 (en) | 2008-11-27 |
| CN101730504A (zh) | 2010-06-09 |
| JP2010529868A (ja) | 2010-09-02 |
| KR20100023802A (ko) | 2010-03-04 |
| AU2008253822A1 (en) | 2008-11-27 |
| RU2494672C2 (ru) | 2013-10-10 |
| BRPI0811092A2 (pt) | 2014-12-09 |
| AU2008253822B2 (en) | 2013-01-31 |
| RU2009137467A (ru) | 2011-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |