MX2009011276A - Inhibidor de dpp-iv que incluye el grupo beta-amino, metodo para la preparacion del mismo y composicion farmaceutica que contiene el mismo para prevenir y tratar una diabetes o una obesidad. - Google Patents
Inhibidor de dpp-iv que incluye el grupo beta-amino, metodo para la preparacion del mismo y composicion farmaceutica que contiene el mismo para prevenir y tratar una diabetes o una obesidad.Info
- Publication number
- MX2009011276A MX2009011276A MX2009011276A MX2009011276A MX2009011276A MX 2009011276 A MX2009011276 A MX 2009011276A MX 2009011276 A MX2009011276 A MX 2009011276A MX 2009011276 A MX2009011276 A MX 2009011276A MX 2009011276 A MX2009011276 A MX 2009011276A
- Authority
- MX
- Mexico
- Prior art keywords
- dpp
- same
- obesity
- diabetes
- pharmaceutical composition
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 3
- 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 abstract 2
- 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención proporciona un nuevo compuesto heterocíclico que contiene un grupo beta-amino, un método para la preparación del mismo, y una composición farmacéutica que comprende el mismo compuesto heterociclico o una sal farmacéuticamente aceptable del mismo como un ingrediente activo. El compuesto heterociclico de la presente invención muestra excelente actividad inhibitoria de DPP-IV y excelente biodisponibilidad, y por lo tanto puede ser útil para la profilaxis o tratamiento de trastornos relacionados a DPP-IV tales como la diabetes o la obesidad.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20070038462 | 2007-04-19 | ||
| PCT/KR2008/002203 WO2008130151A1 (en) | 2007-04-19 | 2008-04-18 | Dpp-iv inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating a diabetes or an obesity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009011276A true MX2009011276A (es) | 2010-01-15 |
Family
ID=39875638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009011276A MX2009011276A (es) | 2007-04-19 | 2008-04-18 | Inhibidor de dpp-iv que incluye el grupo beta-amino, metodo para la preparacion del mismo y composicion farmaceutica que contiene el mismo para prevenir y tratar una diabetes o una obesidad. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8030315B2 (es) |
| EP (1) | EP2142519B1 (es) |
| JP (1) | JP5148686B2 (es) |
| KR (1) | KR101007497B1 (es) |
| CN (2) | CN101663282B (es) |
| AU (1) | AU2008241692B2 (es) |
| BR (1) | BRPI0810246B1 (es) |
| CA (1) | CA2683696C (es) |
| ES (1) | ES2526338T3 (es) |
| IL (1) | IL201524A (es) |
| MX (1) | MX2009011276A (es) |
| NZ (1) | NZ580701A (es) |
| PT (1) | PT2142519E (es) |
| RU (1) | RU2419615C1 (es) |
| WO (1) | WO2008130151A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101054911B1 (ko) * | 2008-10-17 | 2011-08-05 | 동아제약주식회사 | 디펩티딜펩티다아제-ⅳ의 활성을 저해하는 화합물 및 다른 항당뇨 또는 항비만 약물을 유효성분으로 함유하는 당뇨 또는 비만의 예방 및 치료용 약학적 조성물 |
| CA2800245C (en) * | 2009-03-30 | 2015-03-24 | Dong-A Pharmaceutical Co., Ltd. | Improved method for preparing dipeptidyl peptidase-iv inhibitor and intermediate |
| EP2669266B1 (en) | 2009-03-30 | 2016-02-24 | Dong-A ST Co., Ltd. | Improved Method for Manufacturing Dipeptidyl Peptidase-IV Inhibitor and Intermediate |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2549997A4 (en) * | 2010-03-24 | 2014-05-14 | Dong A Pharm Co Ltd | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF NON ALCOHOLIC HEALING STEATOSIS AND METHOD FOR THE PREVENTION OR TREATMENT OF NON ALCOHOLIC HEALING STEATOSIS USING THE SAME |
| KR101180174B1 (ko) | 2010-04-23 | 2012-09-05 | 동아제약주식회사 | 신규한 벤즈아미드 유도체 |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| KR101290029B1 (ko) | 2011-01-20 | 2013-07-30 | 에스티팜 주식회사 | 시타글립틴의 중간체 제조방법 |
| US20140336196A1 (en) * | 2011-05-27 | 2014-11-13 | Merck Sharp & Dohme Corp. | Phosphoric acid salts of sitagliptin |
| CN102321014A (zh) * | 2011-05-27 | 2012-01-18 | 沈阳亿灵医药科技有限公司 | 新型双苯基吡啶类衍生物 |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US20150297573A1 (en) | 2012-10-24 | 2015-10-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL |
| US10159667B2 (en) | 2013-06-26 | 2018-12-25 | Dong-A St Co., Ltd | Composition containing a DPP-IV inhibitor for preventing or treating renal diseases |
| ES2805743T3 (es) | 2015-03-24 | 2021-02-15 | Inst Nat Sante Rech Med | Método y composición farmacéutica para uso en el tratamiento de la diabetes |
| KR101709127B1 (ko) | 2015-06-16 | 2017-02-22 | 경동제약 주식회사 | Dpp-iv 억제제의 제조를 위한 신규 중간체, 이의 제조방법 및 이를 이용한 dpp-iv 억제제의 제조방법 |
| CN107382757A (zh) * | 2017-08-11 | 2017-11-24 | 苏州信恩医药科技有限公司 | 不对称烯丙基取代反应在依格列汀中间体合成中的应用 |
| CN107417554A (zh) * | 2017-08-15 | 2017-12-01 | 苏州信恩医药科技有限公司 | 一种依格列汀中间体的合成方法 |
| KR20220165346A (ko) | 2021-06-08 | 2022-12-15 | 동아에스티 주식회사 | 에보글립틴의 안정성이 개선된 제제 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100599125B1 (ko) * | 2000-05-25 | 2006-07-12 | 에프. 호프만-라 로슈 아게 | 치환된 1-아미노알킬-락탐 및 무스카린성 수용체 길항제로서의 용도 |
| MXPA02011418A (es) * | 2000-05-25 | 2003-04-25 | Hoffmann La Roche | 1-aminoalquil-lactamas sustituidas y su uso como antagonistas del receptor muscarinico. |
| JP2002088070A (ja) * | 2000-09-18 | 2002-03-27 | Mitsubishi Rayon Co Ltd | 新規ピペラジノン誘導体およびその製造方法 |
| AU2003275404A1 (en) * | 2002-10-07 | 2004-05-04 | Merck & Co., Inc. | Antidiabetic beta-amino heterocyclic dipeptidyl peptidase inhibitors |
| PL216527B1 (pl) | 2002-10-18 | 2014-04-30 | Merck & Co Inc | Związki ß-aminoheterocykliczne i kompozycja farmaceutyczna |
| US7259160B2 (en) | 2003-07-31 | 2007-08-21 | Merck & Co., Inc. | Hexahydrodiazepinones as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
| EP1541143A1 (en) * | 2003-12-09 | 2005-06-15 | Graffinity Pharmaceuticals Aktiengesellschaft | Dpp-iv inhibitors |
| KR101146849B1 (ko) * | 2003-12-11 | 2012-05-16 | 미쓰비시 타나베 파마 코퍼레이션 | α-아미노산 유도체 및 그 의약 용도 |
| EP1593671A1 (en) * | 2004-03-05 | 2005-11-09 | Graffinity Pharmaceuticals AG | DPP-IV inhibitors |
| EP1604989A1 (en) * | 2004-06-08 | 2005-12-14 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | DPP-IV inhibitors |
| GB0413389D0 (en) * | 2004-06-16 | 2004-07-21 | Astrazeneca Ab | Chemical compounds |
| WO2006104997A2 (en) | 2005-03-29 | 2006-10-05 | Merck & Co., Inc. | Tartaric acid salts of a dipeptidyl peptidase-iv inhibitor |
| JP2008031064A (ja) * | 2006-07-27 | 2008-02-14 | Astellas Pharma Inc | ジアシルピペラジン誘導体 |
-
2008
- 2008-04-18 CA CA2683696A patent/CA2683696C/en active Active
- 2008-04-18 AU AU2008241692A patent/AU2008241692B2/en active Active
- 2008-04-18 JP JP2010503979A patent/JP5148686B2/ja active Active
- 2008-04-18 KR KR1020080036052A patent/KR101007497B1/ko active Active
- 2008-04-18 CN CN2008800126267A patent/CN101663282B/zh active Active
- 2008-04-18 CN CN201110329468.1A patent/CN102516184B/zh active Active
- 2008-04-18 BR BRPI0810246-5A patent/BRPI0810246B1/pt active IP Right Grant
- 2008-04-18 NZ NZ580701A patent/NZ580701A/en unknown
- 2008-04-18 PT PT87414488T patent/PT2142519E/pt unknown
- 2008-04-18 MX MX2009011276A patent/MX2009011276A/es active IP Right Grant
- 2008-04-18 ES ES08741448.8T patent/ES2526338T3/es active Active
- 2008-04-18 EP EP08741448.8A patent/EP2142519B1/en active Active
- 2008-04-18 US US12/596,281 patent/US8030315B2/en active Active
- 2008-04-18 RU RU2009142602/04A patent/RU2419615C1/ru active
- 2008-04-18 WO PCT/KR2008/002203 patent/WO2008130151A1/en active Application Filing
-
2009
- 2009-10-14 IL IL201524A patent/IL201524A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN102516184A (zh) | 2012-06-27 |
| CA2683696C (en) | 2012-05-22 |
| EP2142519A4 (en) | 2011-07-13 |
| ES2526338T3 (es) | 2015-01-09 |
| IL201524A (en) | 2014-09-30 |
| JP5148686B2 (ja) | 2013-02-20 |
| NZ580701A (en) | 2011-07-29 |
| EP2142519A1 (en) | 2010-01-13 |
| BRPI0810246B1 (pt) | 2021-11-30 |
| CN102516184B (zh) | 2015-03-25 |
| PT2142519E (pt) | 2014-12-11 |
| JP2011500508A (ja) | 2011-01-06 |
| KR20080094604A (ko) | 2008-10-23 |
| HK1172613A1 (en) | 2013-04-26 |
| US8030315B2 (en) | 2011-10-04 |
| HK1138272A1 (en) | 2010-08-20 |
| WO2008130151A1 (en) | 2008-10-30 |
| AU2008241692A1 (en) | 2008-10-30 |
| AU2008241692B2 (en) | 2011-02-10 |
| KR101007497B1 (ko) | 2011-01-12 |
| BRPI0810246A2 (pt) | 2015-08-18 |
| EP2142519B1 (en) | 2014-09-24 |
| CN101663282A (zh) | 2010-03-03 |
| IL201524A0 (en) | 2010-05-31 |
| CN101663282B (zh) | 2012-02-15 |
| US20100120790A1 (en) | 2010-05-13 |
| CA2683696A1 (en) | 2008-10-30 |
| RU2419615C1 (ru) | 2011-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |