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MX2009004910A - Compuestos sustituidos de 3-isobutil-9,10-dimetoxi-1,3,4,6,7,11-b- hexahidro-2h-pirido[2,1-a] isoquinolin-2-ol y métodos que se relacionan al mismo. - Google Patents

Compuestos sustituidos de 3-isobutil-9,10-dimetoxi-1,3,4,6,7,11-b- hexahidro-2h-pirido[2,1-a] isoquinolin-2-ol y métodos que se relacionan al mismo.

Info

Publication number
MX2009004910A
MX2009004910A MX2009004910A MX2009004910A MX2009004910A MX 2009004910 A MX2009004910 A MX 2009004910A MX 2009004910 A MX2009004910 A MX 2009004910A MX 2009004910 A MX2009004910 A MX 2009004910A MX 2009004910 A MX2009004910 A MX 2009004910A
Authority
MX
Mexico
Prior art keywords
compounds
isoquinolin
pyrido
hexahydro
dimethoxy
Prior art date
Application number
MX2009004910A
Other languages
English (en)
Inventor
Kyle W Gano
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39110526&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009004910(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of MX2009004910A publication Critical patent/MX2009004910A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los compuestos sustituidos de 3-isobutil-9,10-dimetoxi-1,3,4,6,7,1 1-b-hexahidro-2H-pirido[2,1-a]isoquinolin-2-ol son descritos como inhibidores del transportador vasicular de monoamina 2 (VMAT). Los compuestos de la presente invención tienen la estructura (I): donde R1 es tal y como fue definido aquí dentro, incluyendo estereoisómeros y sales farmacéuticamente aceptable y solvatos de la misma. También fueron descritas las composiciones que contienen un compuesto de la presente invención en combinación con un transportador aceptable, así como métodos que se relacionan al uso en un sujeto en necesidad del mismo.
MX2009004910A 2006-11-08 2007-11-08 Compuestos sustituidos de 3-isobutil-9,10-dimetoxi-1,3,4,6,7,11-b- hexahidro-2h-pirido[2,1-a] isoquinolin-2-ol y métodos que se relacionan al mismo. MX2009004910A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86494406P 2006-11-08 2006-11-08
PCT/US2007/084176 WO2008058261A1 (en) 2006-11-08 2007-11-08 Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-2-ol compounds and methods relating thereto

Publications (1)

Publication Number Publication Date
MX2009004910A true MX2009004910A (es) 2009-07-24

Family

ID=39110526

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004910A MX2009004910A (es) 2006-11-08 2007-11-08 Compuestos sustituidos de 3-isobutil-9,10-dimetoxi-1,3,4,6,7,11-b- hexahidro-2h-pirido[2,1-a] isoquinolin-2-ol y métodos que se relacionan al mismo.

Country Status (16)

Country Link
US (2) US8039627B2 (es)
EP (1) EP2081929B1 (es)
JP (1) JP5290185B2 (es)
KR (1) KR101500766B1 (es)
CN (1) CN101553487B (es)
AU (1) AU2007317242B2 (es)
BR (1) BRPI0718247B1 (es)
CA (1) CA2668689C (es)
DK (1) DK2081929T3 (es)
EA (1) EA018378B1 (es)
ES (1) ES2402220T3 (es)
IL (1) IL198250A0 (es)
MX (1) MX2009004910A (es)
PL (1) PL2081929T3 (es)
PT (1) PT2081929E (es)
WO (1) WO2008058261A1 (es)

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Also Published As

Publication number Publication date
DK2081929T3 (da) 2013-04-15
US20080167337A1 (en) 2008-07-10
CA2668689C (en) 2015-12-29
BRPI0718247B1 (pt) 2021-09-21
US20120077839A1 (en) 2012-03-29
JP5290185B2 (ja) 2013-09-18
JP2010509366A (ja) 2010-03-25
PL2081929T3 (pl) 2013-06-28
EA200970461A1 (ru) 2009-12-30
KR101500766B1 (ko) 2015-03-16
US8357697B2 (en) 2013-01-22
KR101500766B9 (ko) 2024-09-25
CN101553487A (zh) 2009-10-07
AU2007317242A1 (en) 2008-05-15
KR20090079257A (ko) 2009-07-21
ES2402220T8 (es) 2021-12-23
US8039627B2 (en) 2011-10-18
WO2008058261A1 (en) 2008-05-15
CN101553487B (zh) 2012-06-13
AU2007317242B2 (en) 2013-08-01
ES2402220T3 (es) 2013-04-29
CA2668689A1 (en) 2008-05-15
BRPI0718247A2 (pt) 2014-01-07
EA018378B1 (ru) 2013-07-30
EP2081929B1 (en) 2013-01-09
IL198250A0 (en) 2009-12-24
PT2081929E (pt) 2013-04-15
EP2081929A1 (en) 2009-07-29

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